Estradiol, the rate at which women are dependent on various factors responsible for the appearance, femininity and appropriate behavior. Estradiol - a female hormone, in which the shortage can not function reproductive system, and bone tissue becomes thinner and begins to rapidly deteriorate.
Estradiol is responsible for what
Estradiol is responsible for a number of biological and chemical processes in the body:
- The appearance of secondary sexual characteristics: the pubic hair, the accumulation of fat on the hips, breast growth.
- Maintaining the beauty and health of hair and skin.
- Formation of sexual desire, maintaining libido.
- Preparation of the reproductive system and the whole body for conception and gestation.
- The emergence and formation during the menstrual cycle the follicle.
- Strengthening of bones and joints.
- The growth of the uterine cavity and the active blood circulation during pregnancy.
- Balancing the concentration of bad cholesterol: excretion of surplus, prevention of subsidence on vascular walls. Increasing the number of good cholesterol, maintaining the tone and elasticity of the vessel walls, which is the prevention of preventing atherosclerotic processes.
- Maintaining the tone of the bladder.
- Slowing down the aging process.
- Replacing cubic vaginal epithelium layered.
- Formation of feminine tone of voice.
- Pigmentation of the nipples and external genital organs of the system.
- Good blood clotting.
- Normalization of the menstrual cycle.
- Improvement of nerve conduction tissues.
- During puberty prevents the development of pathologies of the heart muscle.
Responsible estradiol in females and for calm, balanced psycho-emotional state. This hormone (E2) is needed at any age, t. To. Prevents premature aging.
The role of the hormone during pregnancy
Estradiol is a direct impact on the process of child bearing. Its concentration in the blood of women is gradually increasing with the development of the fetus. Estradiol has the following features:
- acceleration of metabolic processes;
- increase in uterine cavity during fetal development;
- formation and growth of bone of the child;
- proper pre-natal development, and access to the fetus necessary nutrients and oxygen.
E2 provides the normal process of blood clotting, prevents the opening of excessive bleeding during labor.
Wobble hormone concentration in gestation period becomes a cause of weight gain, frequent and dramatic changes in mood. If a pregnant woman is not enough estradiol after birth it can result in complications such as postpartum depression.
The relationship with the menstrual cycle
Estradiol - hormone production and release into the blood which is carried out during the menstrual cycle, but the concentration of the substance varies depending on its phase. For hormone (production and synthesis) meet the ovaries and the adrenal cortical substance. A small amount of the hormone compounds produced by adipose tissue. In pregnant women, estradiol E2 is produced in the fetal position.
Female hormone has the lowest concentration during the follicular cycle. Its increase is more than 3 times before ovulation occurs. If fertilization occurs, the following month the amount again decreases to the minimum level.
When should you get tested
estradiol levels in women must always be within the normal range. Any deviations in the upward or downward indicate the development of pathological processes and diseases. Analysis is carried out at:
- hormonal failure;
- monthly cycle disorders;
- inability over a long period of time to conceive a child;
- dysfunction of the gonads;
- uterine bleeding not related to menstruation;
- polycystic;
- expressed signs of premenstrual syndrome;
- ovarian cancer;
- adrenal cancer.
Hormone estradiol necessarily checked in preparing women for in vitro fertilization. He is the agent responsible for the onset of conception.
symptoms
Estradiol - a hormone that is at fault, a negative impact on the whole organism, the general condition and appearance of women. Signs of lower concentration of the hormone:
- the inability to conceive or carry a child, all pregnancies end in spontaneous abortion;
- chronic fatigue syndrome;
- premature baldness;
- swelling;
- instability of mental and emotional states;
- pain and discomfort in the breast;
- rapid weight loss for no apparent reason;
- poor condition of the hair: dull and brittle;
- change in skin condition, dryness and flaking.
Raising standards of estradiol in the blood has the following symptoms:
- profuse acne, numerous acne all over the body;
- weight increase against the background of proper nutrition and regular sports;
- constant drowsiness, fatigue occurring even after a slight physical load;
- severe pain and profuse discharge during menstruation;
- chest pain;
- numbness and cooling fingers of the upper and lower extremities;
- digestive disorders;
- insomnia;
- frequent pain in the abdomen;
- convulsions.
The presence of at least a few of these symptoms requires a study on the content of estradiol.
The rules of analysis
Laboratory analysis is carried out on estradiol levels 4, 5 and on cycle day 6.
Earlier blood samples (2 and 3 day) show unreliable results, ie. K. Indicator will be on the lowest boundary and it will lubricate the diagnostic picture.
Re-control study conducted in the 20-21 day cycle. Blood volume from 5 to 10 ml is taken from a vein.
Survey Preparation
To obtain reliable results the woman should observe a number of rules and recommendations in preparation for the examination:
- a few days before the fence to limit the amount of biological material portions, avoiding overeating;
- 1 day limit physical activity;
- 24 hours to refuse sexual intercourse;
- 1 day to stop smoking and drinking alcoholic beverages.
For 1-2 days you need to stop taking any drugs. If this can not be done for medical reasons, you need to provide details of the technician preparation.
Blood for analysis only taken on an empty stomach. It is strictly forbidden to use anything to eat for 12 hours prior to the study. Allowed to drink only a little purified water.
Violation of these rules may adversely affect the results of the survey.
What should be the norm
estradiol norm depends on the condition of the reproductive system, the life cycle. These limits are in women over the age of the table:
| Age | Hormone E2 (pg / ml) |
| From the first days of birth to 12 months | Absent |
| 2-3 years | 0-22 |
| 4-6 years | 22 |
| 7 - 14 years | 22-30 |
| 14 - 55 years | 57-480 |
| From 55 years and older | 18-85 |
Not only changes the rate of estradiol in women by age, but according to the menstrual cycle phase. Hormonal values being represented in the table:
| Phase | Rate in pmol / l |
| follicular | 68-1265 |
| ovulatory | 130-1657 |
| corpus luteum | 90-860 |
Norms of estradiol in women during pregnancy:
| Trimester | Display, pg / ml |
| The first | 210-6300 |
| Second | 800-19000 |
| Third | 11800-37000 |
Indicator after pregnancy is 2-139 pg / ml. On day 4, the concentration starts to decrease.
Causes and treatment of abnormalities
estradiol hormone norm for women should not be reduced or increased. If the analysis shows deviations in any direction, it is necessary to conduct a comprehensive survey to assess the causes and conduct appropriate treatment to stabilize estradiol in women.
The level above the norm
Estradiol may increase due to the following reasons:
- liver diseases having severe course, including cirrhosis;
- overweight, obesity;
- presence in the body of malignant tumor genesis;
- regular consumption of alcoholic beverages, alcoholism;
- thyroid dysfunction;
- development of inflammatory processes in the uterus, ovaries and appendages;
- infectious diseases of the urinary system (in this case, the analysis will show a temporary increase in the hormone).
To restore hormonal balance and lead to normal estradiol indicators, it is necessary to eliminate the cause of the increase in its level. Appointed by drugs that a woman should take:
- Mastodinon - medicine based on herbal ingredients. This original purpose - treatment and prevention of mastitis. Taking it is recommended that if a high level of E2 provokes pain and discomfort in the breasts, heavy menstruation.
- Orgametril. Basis of preparation - gestogen - hormonal substances of synthetic origin. It stops ovulation, therefore, used as a means of contraception.
- Tamoxifen - used in the treatment of breast cancer. Long-term use of medication at a dose of less than the standard helps reduce the amount of E2.
- Indole - helps to restore the balance of hormones, making them the concentration of stable and balanced. Indole for the treatment of early stages of cancer diseases, takes 3-6 months.
In addition to drug therapy, in restoring estradiol plays a proper lifestyle management. It is necessary to give up smoking and alcohol, to observe the correct, balanced diet and be sure to go in for sports.
In many cases, the hormone increase due to the fact that the woman is a passive lifestyle, suffers from excess weight, obesity. If overweight - the only reason to increase the amount of hormone, it helps to normalize the diet and sports. To physical activity gave a positive result, you need to follow a series of recommendations:
- intensity of the load should be average. Duration of training - no more than 30 minutes. It recommended to choose those disciplines that involves all muscles: yoga, swimming, jogging, cycling.
- Sport should be fun. During a workout, it is necessary to eliminate stressful situations.
- Playing sports with the purpose of weight loss, we must not forget the need to simultaneously build muscle fibers.
Specific power to normalize the hormone is needed. It is important that the diet was correct, balanced and low-fat foods and natural.
To reduce the level of estradiol can be used decoctions of herbal and medicinal plants:
- Tsetrariya or Icelandic moss - is recommended to drink a decoction of the plant in the presence of fibro-glandular mastitis.
- Cuff - plant helps treat cancers normalize the functioning of the endocrine system, eliminates hormonal imbalance.
- Peruvian Maca - are present in the composition of vitamins C and B, minerals: potassium, iodine, zinc and manganese. Decoction of Peruvian Maca helps stop pain during menstruation, restores psycho-emotional background. The plant is a natural antioxidant, which cleanses the body of toxic substances.
All teas are prepared according to one recipe: 1 tbsp. l. ingredient necessary to pour 200 ml hot water, leave 20-30 minutes to filter.
Taking medication, a healthy lifestyle, a balanced diet, traditional methods will help to stabilize the rate of estradiol, which will meet the norm.
Levels below normal
On decrease of estradiol concentration in the blood is influenced by the following factors:
- Prolonged use of oral contraceptives hormonal group - depending on the individual reception of these means can lead to an increase and a decrease of estradiol.
- chemotherapy for the treatment of cancer.
- Compliance with the strict diet with insufficient nutrients. Especially dangerous is the dietary restrictions for women.
- Frequent consumption of alcoholic beverages.
- Long-term smoking.
- Miscarriage.
- Heavy physical work, excessive stress during exercise.
- Inflammation of the reproductive system organs.
If the decline in hormone insignificant, the situation can be corrected by changing the diet, by introducing the following products in the menu:
- olive oil;
- flax seeds;
- legumes, soybeans;
- Vegetables: beets, cabbage, tomatoes;
- fruit: citrus fruits, apricots, melon;
- coffee and dark chocolate;
- brown rice;
- tuna;
- parsley.
If low hormone began to take its toll on the general condition of the woman, causing dysfunction of internal organs, drug therapy performed:
- Estradiol valerate - natural hormone analog having a synthetic origin.
- Gemafemin - supplement, which is used to correct the condition in hormonal failures and violations of the psycho-emotional state. Used by women whose age is close to beginning of menopause.
- Proginova - synthetic hormone used for normalizing the hormonal balance after resection and ovaries during menopause.
- Premarin - consists of hormones, which are included in the estrogen group. It is used in gynecological diseases and in case of hormonal imbalance.
Well established in restoring the desired concentration of hormone popular methods are based on the treatment of herbs. Recommended recipes for increasing estradiol:
- 1 tbsp. l. a dried, crushed sage pour 200 ml of water at + 80 °... + 90 ° C. Infuse a decoction for 20 minutes, then drain. The mixed volume is divided into 3 parts, to drink throughout the day.
- In the cup of hot water, but not boiling water fill 1 tbsp. l. grass red brush. Capacity to put in a water bath, simmer for 1-3 minutes, but do not give fluids to boil. Insist 1-1,5 hours. Take 1/3 cup in the morning, afternoon and evening.
- Stir in 1 cup hot water Art. l. with slide colza. Stir, to insist 25 minutes. For 3 sets during the day to drink a decoction prepared.
Use boiling water when cooking broths impossible. Upon contact with water, the boiled herbs to lose some of their useful properties, ie. A. They reduce the content of vitamins and mineral elements.
