To make an accurate diagnosis, the physician may prescribe the patient to pass blood chemistry, which aims - to determine the amount of plasma creatine kinase.
A key indicator makes it possible to determine the development of certain diseases, one of the most dangerous among them - damage to the heart muscle (myocardium). Reasons that increased creatine kinase much (hypoglycemia, alcoholism) in the blood, the main thing - to properly install them.
The content of the article:
- 1 What is creatine and its function in the body
- 2 How and under what conditions is produced creatine kinase
- 3 Table index creatine OK
- 4 Symptoms index higher than normal creatine kinase
- 5 The reasons for increased rates of creatine kinase
- 6 Indications for investigation of CK index
- 7 How to determine the rate of creatine kinase
- 8 Preparation and analysis of creatine kinase indicator
- 9 At what index creatine should consult a doctor
- 10 How to bring back to normal indicator of creatine kinase
- 11 possible complications
- 12 Video of creatine kinase
What is creatine and its function in the body
An enzyme present in the mitochondria and the cytoplasm of all the major organs of the human body is called creatine kinase. Its maximum content is observed in the tissues of the heart muscle and skeleton, and less - in the brain.
During the formation of creatine kinase (CK for short), there release of energy necessary for proper muscle contraction.
A molecule of this enzyme has two parts: M - Muscle and B - the brain. These particles (subunits) can be combined to form three isomers, whereby possible to accurately determine its location:
- skeletal muscles and heart - MM;
- heart muscle - CF;
- brain - BB.
The biggest CPK enzyme activity is manifested in the skeletal muscles, and after descending: in the heart, in muscles genitals during pregnancy, the muscles genitals woman not hatched baby smooth muscles.
How and under what conditions is produced creatine kinase
elevated blood creatine kinase (causes may be different), when the cells of internal organs and muscles damaged. Most index increases due to the development of disease, disorders provoking muscle tissue integrity.
The amount of enzyme in the blood - a key indicator by which to determine the myocardial infarction. If there have been disruptions in blood flow of coronary artery, then a couple of hours index increases and decreases within a few days.
It often happens that a person is admitted to hospital and complaining of symptoms suggestive of heart attack, but after the electrocardiogram disease is not detected. Fast accurate diagnosis can quickly set the record if CPK.
The cardiologist may also recommend additional research to pass, for example, to determine the protein myoglobin and troponin to get more accurate information about the patient's condition.
In patients undergoing heart attack, a fairly high risk of another heart attack. The measure is used to monitor the course of disease.
Table index creatine OK
To determine the rate of the enzyme in the blood is taken into account the top of the indicators expressed in U / L and define them at a temperature of 370 degrees.
The table below shows the rate for children, teenagers, men and women:
| Age | Normal creatine kinase, U / L |
| Children first 2-5 days from birth | 652 |
| Infants 0 to 6 months. | 295 |
| Infants from 6 months. Up to 1 year | 203 |
| Kids 1-3 years | 228 |
| Preschool children 3-6 years of age | 149 |
| Students 6-12 years old male (male) | 247 |
| School children 6-12 years old (female) | 154 |
| Teens 12-17 years old (male) | 270 |
| Teens 12-17 years old (female) | 123 |
| Men older than 17 years | 270 |
| Women older than 17 years | 167 |
Symptoms index higher than normal creatine kinase
Increase this figure may be different factors:
- non-pathological (external influences);
- pathological (diseases development);
Determine the symptoms creatine kinase above standard indicators is difficult. If the reason lies in problems with the heart, can be shortness of breath, pain in the chest, tachycardia. When violations irritability observed in the functioning of the nervous system, insomnia, mood swings.
Only the results of the survey can accurately determine the high level of CPK.
The reasons for increased rates of creatine kinase
blood creatine kinase increased (causes include myocardial infarction), - it is not always talking about serious illness. In many cases this may be temporary, it passes without the use of drugs, of course.
The main reasons for that level may exceed the rate of enzyme are as follows:
- Drinking large quantities of alcoholic beverages. If a strong intoxication of an overvalued rate keeps a couple of days. But statistics show that in chronic alcoholics enzyme level rarely goes beyond the norm.
- In the appointment of intramuscular injections. The body reacts to the introduction of the drug into the muscle, and the rate increases.
- Transferred cavernous surgery or any other effect on muscle tissue. Such interference body perceives as trauma and shock, resulting from it, accompanied by a sharp increase in CK. Held rate at high elevation can be a few days.
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Hypoglycemia in the severe form. This disease has a detrimental effect on the muscles of the whole body condition, so it is very important to analyze.
The reason of increasing creatine kinase in the blood can be hypoglycaemia - blood creatine kinase increased (causes include hypothyroidism) - it can be identified by the analysis, which helps to detect malfunction of the endocrine system.
- Development of diseases afflicting the brain and nervous system. This can be: mental disorders, epilepsy, infection.
- Creatine kinase in the blood is increased (the reasons for this condition may be related to violation of the heart muscle power) - it stimulates the development of various diseases of the heart. Also, such a state may be a consequence of the presence of diseases such as tetanus or malignancy.
- During pregnancy, womenAs well as in people with powerful muscles. If there is a shortage of human muscle tissue, anorexia, the level of the enzyme is reduced on the contrary.
If a person has exceeded the norm, it is a serious reason to consult a doctor to get tested
Indications for investigation of CK index
Recommend conduct a survey to determine the level of enzyme may be a cardiologist, an internist, a neurologist, pediatrician, endocrinologist, oncologist, and other doctors.
Focus doctor issues, the presence of disease symptoms:
- myocardial infarction;
- ischemic;
- hyperthyroidism;
- Duchenne myopathy in the family, if the woman plans to conceive;
- myositis;
- myodystrophy.
Particular attention should be paid to what level of CPK in the blood in young infants.
How to determine the rate of creatine kinase
To perform this analysis, you will need to take blood from a vein, it is extremely important:
- Do not eat for 12 hours before blood sampling;
- not to worry, to eliminate the overload of any kind for 30 minutes to the fence;
- Do not smoke for 30 minutes to give a blood sample.
To conduct a study on the level of CPK direct and indirect methods can be used. In the first case, determine the creatinine, the second - phosphocreatine. To make it clearer, a specialist before and after reaction with kpeatinfocfokinazoy determines the substrate.
In addition, analysis of the activity of creatine kinase has some special features:
- In the direct method defined kpeatinfocfata level after hydrolysis kpeatinfocfokinazy - the level of organic phosphorus, formed after reaction.
- In the indirect method, taking into account the level of creatinine, which is determined by a colorimetric. The reactants are diacetyl and alpha-nafrol.
Hydrolysis and Colorimetric method help to ensure that the number of kpeatinfocfokinazy and its isoenzymes.
Preparation and analysis of creatine kinase indicator
blood CPK increased the reasons may be different, but the analysis in each case carried out the same way. You can contact any hospital laboratory. Determine the level of enzyme during the normal biochemical blood analysis.
To get enough of just one day. To carry out the blood taken from a vein in the analysis. Direction can give cardiologist, internist, oncologist and any other specialist.
Preparation for the analysis carried out in the same way as any other investigations:
- blood collection do on an empty stomach, it is not recommended to eat food 12 hours;
- three before putting better to limit yourself to drinking and drugs, no smoking.
Since the level of creatine kinase is directly related to physical activity, it is not recommended to engage in manual labor and sports. Deciphering the results of the analysis of creatine kinase Decoding of any analysis of the index should hold the doctor only.
Indicators above normal may indicate:
- muscle tension;
- skeletal tissue injury or cardiac muscle;
- inflammation of the brain tissue.
The doctor examines the results may suggest further study to determine the level of creatine kinase fractions if necessary. If there is suspicion of a heart attack, it is also important to know the rate of change of the enzyme content and nature of the changes.
Modern research methods allow find CK level with 100% accuracy.
At what index creatine should consult a doctor
In adults, the average performance level of the enzyme should be in the range of 20-200 U / L. In this case, women rate 167 U / L, while the strong half of humanity - 190. Slightly above normal values can be in their teens.
Any, even the most insignificant above the norm, it requires urgent treatment to the doctor, because only he will be able to find out exactly what is the cause of jumps, as well as select appropriate treatments.
How to bring back to normal indicator of creatine kinase
The treatment is chosen individually for each patient, depending on what is the reason for increase in creatine kinase provoked.
First of all, if a person has revealed the underlying disease, the first thing you need to treat it. It is also important to review the way of life, especially for food, it should be balanced. A man should lead a quiet life, to give up smoking and drinking.
It is recommended to go in for sports, but without any effort, classes should bring joy. Spend more time in the fresh air, which will help to normalize the nervous system. Be sure to include in the diet products, a positive effect on the heart and muscles. Among them are: seafood, garlic, oats, legumes, nuts.
Also make sure you take gingko biloba extract to vascular function normalized.
Be sure to minimize the consumption of sugar and salt. Sugar can interfere with the operation of the pancreas and as a consequence there will be failures in metabolic processes, as it will trigger the development of diabetes, entailing obesity. The vessels will be narrowed due to the formation of atherosclerotic plaques, a similar condition provokes disruptions in heart function.
Excess salt in the body can cause high blood pressure, as a result, various cardiovascular diseases and disorders of the heart, the development of the most complex of its pathologies.
Excellent help reduce the rate of Indian ginseng, reducing blood levels of cholesterol, normalizes thyroid function. It is sold mainly in the form of powder, and take it before going to sleep, a solution of 1 h. l. means in 250 ml of warm milk.
Reduce the level of enzyme will help strengthen the flow of urine. Effective this chamomile, which is not only able to display more urine, but also reduces inflammation and kills germs.
The pharmacy is sold in chamomile tea bags, drink it can be like a normal tea several times during the day for 3-5 days. Diuretics have also decoctions such drugs as oak bark, rosehips, nettle, possess excellent diuretic properties.
It is also important to take care of proper rest. It is known that when a person sleeps, slowing down all the vital processes in his body, respectively, will be reduced and the level of the enzyme. For this reason, experts recommend more sleep for the body to fully relax.
possible complications
In fact, the reasons for the high content of the enzyme may be different. But we must remember that in itself creatine kinase in the blood, the level of which is increased, is not considered a toxin, it can not cause serious harm to the body.
Bring threat of disease, provoking him jump. These include: oncology, heart, inflammation of muscle tissue, poisoning, hypothyroidism and others. Therefore, it is important to quickly find the cause of a rise in the rate and fix it to prevent the development of disease.
Often people do not realize what they are guilty of the jump index of creatine kinase in the blood. If CPK increased, and the cause is not identified, it is necessary to reconsider the original lifestyle and your diet. If nothing has changed, then an urgent need to see a specialist.
Registration of the article: Mila Friedan
Video of creatine kinase
The doctor will talk about creatine:
