Sometimes doctors, instead of the familiar Omeprazole is indicated for reducing the acidity of rabeprazole. Patients immediately begin to figure out what's better: rabeprazole or omeprazole. Despite the fact that both drugs are proton pump inhibitors, they have a different composition. Consider the similarities and differences of drugs specified in the instructions to the drugs.
Comparative characteristics
Comparison of rabeprazole and omeprazole begin with a description of similar qualities:
- Drug group. Refer to the STI;
- Effect on the body. Inhibit acid secretion, and reduce gastric acidity;
- The duration of the therapeutic effect of. Become effective after one hour after administration and therapeutic effect of the active ingredient is maintained throughout the day;
- Indications for use. Medications indicated for the treatment of peptic ulcer, esophagitis, heartburn and gastritis with high acidity.
Now consider the difference of omeprazole rabeprazole:
- Active substance. In rabeprazole - rabeprazole sodium, while omeprazole - omeprazole;
- Efficiency. Rabeprazole has a higher acidic range and helps relieve symptoms occurred with exponent hydrochloric acid to ph 4.9;
- The therapeutic dose. In the treatment of diseases with the same severity of symptoms the dose of omeprazole is required twice;
- Side effects. Responsive to receiving the medicines are the same, but, after receiving omeprazole they occur in 15% of cases, and after rabeprazole - 2%;
- release Form. Both drugs are produced in capsules, but only one of omeprazole adult dosage of 20 mg;
- Communication with the meal. Adopted after eating Omeprazole loses some of its activity and bioavailability of rabeprazole is not associated with the filling of the stomach;
- Discontinuation syndrome. The man stopped drinking omeprazole, acidity is restored within 3 days and may re-occurrence of pain and heartburn. After the abolition of rabeprazole acid secretion is reduced slowly (5-7 days) and withdrawal almost not observed;
- cost of. Omeprazole is worth almost 5 times less expensive and, unless otherwise stated, long-term therapy, most patients prefer the medicament.
Despite the fact that drugs are analogues, they differ in the active component. Often, to improve the therapeutic effect, prescribe drugs to drink together. Perhaps, in addition to joint use of rabeprazole (structural analogue - Pariet) and omeprazole (Similar drug - Omez) further other PPIs are assigned: Nolpaza, lansoprazole, pantoprazole or Esomeprazole.
What to choose
Omeprazole, rabeprazole is different from the composition and effects on the secretory function of the stomach. From comparison of the above it becomes clear that rabeprazole considered more effective drug with fewer side effects, however, choosing a drug, refer to the following rules:
- The severity of the disease. When much higher acidity is better to give preference to rabeprazole;
- Portability. If after receiving omeprazole having side effects, it is possible to continue therapy rabeprazole;
- Financial opportunities. Omeprazole is cheaper and, if tolerated, allowed a long treatment drug.
About what kind of drug is better to consult a doctor. It is not necessary to independently carry out the replacement of drugs to a cheaper or more effective - they are different in composition and can not be combined with other medicines to treat stomach ailments.
sources:
Vidal: https://www.vidal.ru/drugs/omeprazol__3120
GRLS: https://grls.rosminzdrav.ru/Grls_View_v2.aspx? routingGuid = 83097c54-4fcd-4122-b96d-1b90b38d8823 & t =
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