The package containing Contrycal, instructions for use in pancreatitis invested fail. It shows the composition of funds, indications and contraindications, especially the dosage and duration of treatment.
Release form and composition of the drug
Contrycal - a drug normalizing pancreas work in acute pancreatitis. Made from lung tissue of cattle. Means available as a fluffy white powder for solution for injection. Sterile vials are packaged in plastic blisters and packed in a cardboard box. It is still included substrate 1 with ampoules containing saline. In a set of 10 vials of powder and the same number of vials. On sale are presented different options for packaging: ampoules may include 10,000, 30,000 and 50,000 units.
The main active ingredient kontrikala - aprotinin. As an additional component in the composition includes mannitol. The preparation is used for intravenous injection and, recommended in exacerbations pancreatitis, postoperative conditions, various shocks. Sold by prescription, the shelf life is indicated on each package. Preparations containing aprotinin, can be stored for 3 years, special conditions are required. After opening the ampoule contents should be used immediately. Agent refers to non-toxic and low-hazard, unclaimed medication disposed of with household waste.
Indications
Contrycal may only be used under the supervision of a physician. The drug is recommended for:
- acute phase of pancreatitis;
- chronic pancreatitis with a tendency to recur;
- pancreatic necrosis;
- traumatic, burn, or hemorrhagic toxic shock;
- operations on pancreas;
- extensive internal bleeding;
- angioedema;
- traumatic soft tissue injuries;
- postoperative mumps.
In acute or chronic pancreatitis, the drug is able:
- restore fibrin fiber fabrics;
- counteract protein degradation;
- normalize metabolic processes in tissues.
Contrycal can be used as a preventive measure. He warns complications after surgery on the pancreas and the organs located in the immediate vicinity. The medicine is prescribed, even newborn babies, the main thing - to choose the exact dosage. The main task of the drug - inhibition of enzyme protein by forming spatial patterns. The active substance is partially metabolized in the intestine, a large portion of output means together with the urine without being accumulated in the liver or kidney through 10 hours.
Contraindications and side effects
When choosing any drastic means should be considered contraindications. Contrycal not recommended for:
- polyvalent allergy;
- pregnancy up to 12 weeks;
- lactation;
- DIC;
- reduced blood pressure;
- Hypersensitivity to the active substance.
The drug is well combined with antispasmodics and analgesics. However, it should not be taken together with streptokinase and urokinase, as aprotinin will retard the activity of these funds.
The drug is not used in conjunction with antibiotics and solutions containing dextran, lipids and amino acids.
The most frequent side effect considered severe allergic reaction. The risk increases with repeated use of the drug. In case of overdose, the following unpleasant symptoms:
- tachycardia;
- hypotension;
- impaired consciousness;
- psychoses and hallucinations;
- bluish skin;
- increased creatinine in the blood;
- nausea and vomiting;
- dizziness.
In some cases, registers the development of local thrombophlebitis at the site of the vein puncture, accompanied by redness, swelling, tenderness. Unpleasant symptoms disappear within a few hours after drug administration. Remove the swelling, redness and itching, antihistamine tablets will help. However, with persistent negative reaction treatment must be canceled.
How to use
The drug is intended for intravenous administration. Dosage facilities is prescribed individually depending on the patient's condition. The best result demonstrates Contrycal early in the disease when treatment is carried out comprehensively, and the solution is introduced sufficiently large doses.
To prepare an injectable solution in a vial with a powder content of 1 mg administered with physiological saline, part of the set. The contents of the vial is shaken and filled into syringes. After mixing the liquid used immediately, it can not be stored. If ampoules were placed in a refrigerator, they are recommended to warm the hands to room temperature. In preparing the composition for the dropper, the contents of the vial are dissolved in 2 ml of saline, and then added to the finished infusion solution (Ringer's fluid, Hartman or glucose solution). Total liquid dropper determined by the physician.
Standard course in acute pancreatitis involves a one-time injection of a dosage of 200 000-300 000 IU. Thereafter, during the day the same dose is administered via IV. The next day the treatment is repeated. Treatment lasts until the complete elimination of symptoms characteristic of the acute phase of the disease. After the attack will be removed, you can move on to maintenance therapy by introducing up to 140 000-200 000 Atreus.
Dropper with pancreatitis often put in the hospital, but, if necessary, treatment can be organized at home by a doctor.
Injections with pancreatitis are doing very slowly, the patient should take the prone position. Intravenous administration requires great skill, so more likely to make an injection on an outpatient basis or cause home experienced nurse. The drug is of animal origin, so it is possible the occurrence of an allergic reaction. Before entering a larger dose, it is recommended to hold the sample entering the vein 1 vial contents mixed with saline.
To prevent postoperative complications introduced in the initial phase of 200,000 IU, and then for an injection days 100 000 IU every 6 hours. Children medication administered at the rate of 14,000 units per 1 kg of weight.
Treatment of acute and chronic pancreatitis
Patients with acute pancreatic inflammation usually sent to hospital. Often it is recommended operation, but a stable condition of the patient and the initial stage of the disease can be conservative therapy. The patient is assigned therapeutic hunger intravenously administered supporting body fluids: saline or glucose. Asked what dropper put pancreatitis, interested patients. The doctor prescribes Contrycal, reduces the activity of pancreatic juice enzymes simultaneously is recommended to take an antispasmodic, relieve tension of smooth muscles of the intestine, and pain. More often than prescribed Ketanov, Spazmolgon or No-Spa. Contrycal can replace Sandostatin, instruction manual which recommends the same dosage and concomitant therapy. The choice is your doctor who takes into account the individual patient's condition, the presence or absence of other chronic illnesses. Using inhibitors help keep the pancreas tissue and enhance the analgesic effect.
In the treatment of chronic pancreatitis is recommended combined therapy. Remove the attacks to help preparations containing diclofenac, ibuprofen, paracetamol. The names of specific drugs prompt the physician to use powerful drugs in its sole discretion is prohibited. A dose of painkillers is also controlled by a specialist, the reception is carried out against the background of intravenous kontrikala. The drug was dropped very slowly. Preferably, use an IV injection in this case is not suitable. During the pain of pancreatic secretion inhibitors will support the pancreas, it will provide peace. Treatment is continued until complete removal of the unpleasant symptoms.
Contrycal - effective drug to maintain activity of the pancreas, elimination of bleeding, swelling and internal states of shock. The drug is well combined with many potent drugs, and easily fits in most treatment regimens.
