Sofosbuvir and Daklatasvir. Instructions for use, price, where to buy. treatment regimen, which manufacturer is better reviews, side effects

Medications with the newest generation sofosbuvir Daklatasvirom blocking reproduction of bacteria hepatitis "C" in human cells. When the therapy guarantee timely 98% cure, regardless of the complexity and nature of the disease.

Sofosbuvir and Daklatasvir: which manufacturer is better?

Sofosbuvir and Daklatasvir - drugs for the treatment of hepatitis "C". Developed by US pharmacists. Produced in the United States, India and Egypt. Sofosbuvir - inhibitor, a new generation of virus cells, acting at the level of destruction of enzymes, proteins, bacteria NSSA. Structure prevents pathogens mutating RNA - chains, replacing healthy human cells.

The original drug developed Sovaldi «Gilead Sciences» - the American pharmaceutical group, for the time being is the official distributor of the drug. Price tablets of approximately 140 thousand. rub.

In order to access to treatment of hepatitis, WHO issued patents for manufacture Indian generic manufacturers. Analogs are not different in composition and therapeutic qualities, but several times cheaper than the original.

Indian pharmaceutical companies producing generics and patented drug:

• Natro Pharma Limited (Hepcinat) - are of high quality, produced according to international standard. Is transported around the world.
• Zydus Group (SoviHep) - suspend the cell division of the virus. It is used in patients with genotypes 1-4.
• Strides Shasum (VIRSO) - appointed in antigepatitovoy therapy with Daklatasvirom. By the absence of adverse pathological conditions.
• Hetero Healthcare Limited (Sofovir) - the most affordable of generic medicines in the price range. The chemical composition repeats the original drug.
• Mylan Pharma (My Hep) - antiviral drug inhibiting RNA - dependent component of hepatitis "C".

Effective when the disease is accompanied by:

• cirrhotic liver disease;
• renal insufficiency;
• hepatic fibrosis;
• HIV infection.

Daklatasvir - tableted antiviral agent causes the body to resist infection by displacing therefrom polymerase NSSA. The original formulation was manufactured and produced American concern «Bristol - Myers Squibb». The medicament is transported around the world, included in the list of drugs for the treatment of hepatitis "C" from the 1st - 6th genotype.

Price is 110-140 thousand. rub.

Cheaper generic drugs produced by companies in India and Egypt:

• Beacon Pharmaceuticals (Daclavir) - blocks the spread of the virus of bacteria in healthy liver cells.
• Natro Pharma (Natdac) - clears the blood flow, eliminating the penetration of pathogens into liver vessels activates the red blood cells.
• Hetero (Dacla Hep) - used in the complications of hepatitis HIV infection, cirrhosis, fibrosis. It is most effective when combined therapy. It promises to recover to 97-99% depending on the degree of cell damage.

Where can I buy

Sofosbuvir Daklatasvir and can not currently be available in pharmacies in Russia. This is due to the recent development of drugs and registration in the number of drugs against hepatitis "C" in Russia are only a few years ago.

Buy medicines can be:

• Outside the borders of Russia. The capsules are sold freely across the European space, Asia and America. Unfortunately, the import into the territory of the Russian Federation to one person may only be the number of tablets required for 12-week course of treatment.
• Purchase directly in the producing country. The drug is available in the United States, India, Egypt, in almost any drugstore. Buy the drug can be in any amount, but customs regulations restrict the transportation of capsules.
• Through distributors of pharmaceutical companies. Representatives of Indian corporations operating around the world, including Russia.
• Through the online store. It can be purchased as original products on the websites of American drug companies, and analogs of the Indian and Egyptian production. To purchase is required to register, to order, to make 100% advance payment. Receiving drugs in this way is most advantageous because:
• of drugs sold at a fixed price:
• delivered anywhere in the world;
• the company guarantees the purchase only original capsules;
• There is an additional opportunity to become fully acquainted with the instructions to tablets.

Indications

Sofosbuvir and Daklatasvir affects the synthesis of viral hepatitis "C" in the human body. When the joint application guarantee the elimination of pathogenic microorganisms of 97%. Therapy wake of the patients of both sexes over 19 years of age.

Drugs effective against microbes, causing hepatitis "C" from the 1st - 6th genotype of both simple and complicated:

• HIV infection;
• liver fibrosis;
• cirrhotic liver pathology;
• carcinoma.

Tableted medications eliminate disease-causing cells, purify the blood cells, increased resistance to infection, prevent its spread and destruction of internal organs.

It prohibited the use of drugs in women awaiting baby during breastfeeding.

The components that make up the funds into the blood, placenta, mother's milk, causing fetal abnormalities. Laboratory studies have revealed risk of miscarriage and fetal death under influence of active substances and sofosbuvir Daklatasvira.

In conducting antigepatitovoy therapy in women and men of reproductive age are strongly encouraged use the most effective contraceptive properties or to comply with sexual rest during the whole process treatment. In case of pregnancy the embryo to remove from the danger of occurrence of subsequent miscarriage or malformations of the fetus at the DNA level.

Data on the effects of the components of medication for minor children are absentAs clinical trials have not been conducted in this area.

Tableted agents are forbidden to eat small children for fear of the occurrence of irreversible changes in the blood or body, as well as the possibility of poor tolerability of side effects associated with treatment. When the need for treatment of infections in neonatal nursing mother should be transferred to artificial feeding.

Sofosbuvir: description, price and composition

Sofosbuvir - medicinal drug appointed to destroy the virus of hepatitis "C". Once in the body, the active components of the drug blocks the pathogenic microorganisms, enzymes, polymerase NSSA, NSSB, creating genetic mutational RNA chains replacing healthy cells.

Original name Savaldi. For the first time made the American pharmaceutical company. Currently Indian Medicinal concerns WHO recommendations produce generic formulation having a similar composition and therapeutic qualities.

It represents tableted means, brown, consisting of:

• sofosbuvir;
• microcrystalline cellulose;
• magnesium stearate;
• mannitol;
• sodium prochnamellozy;
• colloidal silicon dioxide;
• meprosola;
• polyvinyl alcohol;
• titanium dioxide;
• talc;
• dye.

The weight of one capsule 400 mg.

Advantages of the drug:

• Very high efficiency. In treatment of hepatitis "C" with Daklatasvirom, Ledipasvirom, Velpatasvirom achieved 98% th guarantee of recovery for any initial forecast. Previously applied therapy gave only a 40% chance, depending on the stage of the disease.
• Therapeutic course takes about 3 months. Pharmacotherapy interferon held from 6 months and more.
• Rarely occurring side effects. The drug has no detrimental effect on the cells and tissues of the body.
• The possibility of cure for any disease development, including complicated:
• fibrosis;
• cirrhotic liver disease;
• cancer tumors;
• HIV infection.

Before applying medicament progressive decomposition baking meant death.

Disadvantages of the drug:

• High cost, making it virtually impossible to purchase tablets for people with low and middle incomes. Cost of 1 capsule 1 th original drug. US dollars on long-term treatment is required to spend more than 84 thousand. dollars.

Due to the production of generic drugs, it is now possible to buy cheaper analogues:

• Heplinalt from Natco Pharma - 180-200 dollars. USA;
• My Hep from Mylan Pharma - 190-200 dollars. USA;
• SoviHep from Zydus - 42-70 thousand. rub.;
• Sofovir of Hetero - 60-90 thousand. rub.

The price is for the entire three-month treatment period.

Adverse reactions

In the cases of deviation from the regimen, accepting uncontrolled drug, resulting in characteristics of the body, may cause:

• nausea;
• migraine;
• irritability;
• diarrhea;
• deviation homologous blood parameters;
• severe neuralgia suicidal direction, especially in individuals prone to depressive psychosis;
• irregular heartbeat;
• dry mouth;
• insomnia;
• iron deficiency anemia;
• vomiting;
• bloating and abdominal pain.

The most frequent adverse pathological defects arise at the same time taking with sofosbuvir Ribvirinom:

• reduction of hemoglobin in the blood fluid;
• increase in bilirubin;
• trouble falling asleep;
• nauseous reflex;
• dyspnea;
• depression;
• cough;
• convulsions;
• joint pain;
• hair loss.

Ribvirinom and interferon alpha:

• deviation of the blood parameters;
• nausea;
• dyspnea;
• dizziness;
• fever;
• wanton excitement;
• reducing the amount of subcutaneous adipose tissue;
• blurred vision;
• hair loss;
• frustration of a chair.

Penigterferonom and Ribvirinom:

• fatigue;
• allergic rash;
• chills;
• muscle pain;
• anemia.

Upon detection of the above symptoms need to stop taking the capsules immediately and seek medical attention. Treatment of symptomatic applied.

Smoking, alcohol, poor diet provoke side effects. It recommended during treatment to comply with sparing diet, engage in moderate sports loads, give up bad habits.

Contraindications

Do not receiving sofosbuvir at:

• Children under 17 years.
• Pregnant women. INSTALLATIONS provoking action of the components contained in the medicament in spontaneous abortion and missed abortion.
• Lactating mothers. It enters the blood and breast milk. Not studied the action of tablets on the body of young children.
• Persons suffering from allergic reactions to components of the capsules.
• Patients taking drugs with a similar composition.

Therapy is conducted under the strict supervision of a physician in case of:

• Cirrhotic hepatic lesions.
• A history of a patient or surgical liver transplantation surgery.
• Women of reproductive age and in the future want to have healthy children. Not studied the effect of constituent components of the drug on fertility. Intrauterine contraception is recommended in order to avoid conception.

antihepatitis standard therapeutic regimens used for elderly patients.

Instructions for use sofosbuvir

Sofosbuvir and Daklatasvir used jointly. In some cases the replacement of the second drug or Ledipasvirom Velpatasvirom. When integrated approach the probability of achieving curing 97 - 99% depending on the stage of the pathology.

reception scheme

Patients with HCV genotype 1 in all cases are drug therapy for 12 weeks.

When genotype 2 apply combinations sofosbuvir + Daklatasvir or Velpatasvir:

• simple hepatitis - sofosbuvir and Daklatasvir - 12 weeks;
• aggravated liver cirrhosis - sofosbuvir, Daklatasvir, Ribvirin - 24 weeks;
• HIV drugs with complex Ribvirinom - 12 weeks;
• previously uncured genotype of these medicines - 24 weeks.

Genotype 3 is not appointed Ledispavir to add Ribvirin therapy:

• first discovered - sofosbuvir, Daklatasvir, Ribvirin - 12 weeks;
• with cirrhotic syndrome - 24 weeks;
• adherence of HIV - 12 weeks;
• previously uncured interferon - 24 weeks.

Genotype 4 therapy is all of the above with the addition of drugs Penigterferona:

• first discovered - 12 weeks;
• accompanied by the destruction of liver - 24 weeks;
• in conjunction with HIV infection - 12 weeks;
• not completely healed before - 24 weeks.

Genotypes 5.6 treatable Solfosbuvirom together with Daklatasvirom, Ledipasvirom or Velpatasvirom.

You can add Ribvirina and interferon for medical recommendations:

• not complicated by extraneous pathologies - 12 weeks;
• with cirrhosis of liver lesions - 24 weeks;
• when infected with HIV - 12 weeks;
• the failure of the earlier treatment with interferon - 24 weeks.

Preparations guzzle 1 times a day, without being attached to food intake. Break must be exactly 24 hours. Skipping medications, chewing, crushing the capsule, an independent change of dosage is not allowed.

Strict adherence to medical instructions prevents overdose.

In the case of uncontrolled reception are possible:

• anaphylactic shock;
• confused mind;
• severe sleep disturbances;
• nausea;
• vomiting;
• pain in the gastrointestinal tract;
• diarrhea;
• depression with suicidal tendencies;
• migraine.

In the event of overdose gastric lavage is necessary, and receive absorbents.

Daklatasvir: description, price and composition

Daklatasvir - a drug that prevents reproduction of hepatitis "C". Protein Inhibits NSSA, immune suppressive properties of the body, prevents the formation of RNA mutational compounds. It is active against all genotypes of the disease. Administered in combination with or sofosbuvir Asunaprevirom.

Original name drug Daklinsa, first produced the American pharmaceutical company, "Bristol-Myers Squibb." It represents tablets from yellow-orange to a greenish color on the bog 60 and 30 mg.

The composition of the drug:

• daklatasvira hydrochloride;
• corn starch;
• water;
• titanium dioxide.

The cost of the original American product from 110,000 to 130,000 US dollars. From 2014 WHO issued the Egyptian and Indian pharmaceutical concerns patents for the manufacture of cheaper generics:

• Hepefit - 14,000 - 18,000 thousand. rub.;
• Daclitof - 12000-17000 thousand. rub.;
• DaciHep - 15000-19000 thousand. rub.

Advantages of the drug:

• High efficiency. It is active against all genotypes infection. When combination therapy is achieved by treatment in 98% of all cases, regardless of the orientation stage and prognosis pathology.
• Rarely occurring side effects.
• Easy portability body.
• The transit time of treatment of 12 to 24 months depending on the severity and complexity of pathology.

Minuses:

• Not sold in pharmacies in the Russian Federation. Order preparation is possible through the official supplier or visit an online store with 100% prepayment.
• Very high cost, which makes the drug is inaccessible for people of middle and low income.

Side effects

When receiving Daklatasvira may cause a variety of pathological states.

When combined with Asunaprevirom:

• migraine;
• nausea;
• pain in the muscles and joints;
• violations of the chair;
• abdominal cramps;
• Hematologic abnormalities in the blood;
• overstatement ALT and Assad;
• flu-like symptoms;
• itching and rashes on the skin;
• Iron-deficiency anemia;
• increased blood pressure;
• inflammation of the lining of the nasopharynx;
• increased gas formation in the intestine.

Together with Asunaprevirom, Penigterferonom, Ribvirinom:

• fatigue;
• depression;
• weakness, lethargy;
• fever;
• anemia;
• tightness of the skin;
• dyspnea;
• diarrhea.

With the development of side effects of drug therapy should be discontinued immediately. On the occurrence of undesirable symptoms affects the duration of treatment (long course of treatment provokes rejection by the body), presence addiction (nicotine, alcohol dependence), eating foods containing cholesterol, food preservatives, and dyes.

In the period of treatment is recommended to follow a low-carb diet, hiking, swimming and athletics.

Contraindications

It prohibits the use of medicines in the following cases:

• with special sensitivity of the patient to the drug component parts;
• women in the waiting period of the child;
• during breast-feeding a newborn;
• under the age of 18 years;
• at hypolactasia disease;
• malabsorption of glucose, lactose;
• simultaneous reception of phenobarbital, St. John's wort, rifabutin, carbamazepine, rifamptsina.

Treatment takes place under strict medical supervision if:

• hepatitis cirrhotic liver is complicated process;
• before transplantation or surgery in the patient's liver was carried out;
• treatment suffered by women and men of reproductive age. It is necessary to strengthen the means of contraception, or avoid sex because of a possible pregnancy.

Instructions for use Daklatasvira

Daklatasvir most often combined with sofosbuvir. In some cases drugs Ribvirinom addition, Penigterferonom.

Regimens:

1. Daklatasvir + Asunaprevir: genotype 1a and 1b therapy uncomplicated cirrhosis - 24 weeks.
2. Daklatasvir + sofosbuvir: genotype 1, 2, 3, 4, 5, 6 is not accompanied by the destruction of liver cells - 12 weeks; in the presence of cirrhotic defeat - 24 weeks; combined with HIV - 12 weeks; re-treatment after previous interferon therapy carried out with unsatisfactory results - 24 weeks.
3. Daklatasvir + + sofosbuvir Ribvirin: genotypes 2, 3, 4, 5, 6 cirrhosis complicated - 24 weeks.
4. Daklatasvir sofosbuvir + + + Ribvirin Penigterferon: Genotypes 3, 4, 5, 6 in the destruction of liver - 24 weeks; after failing therapy with interferon alpha - 24 weeks.

Regimen and set preparations physician chooses. Independently prohibited to stop taking the medicine course, to change the dosage.

In the case of uncontrolled consumption of a high probability of occurrence:

• toxicological destruction of the body;
• severe vomiting;
• spasms in the digestive tract;
• loss of consciousness;
• amplification depressive psychosis (suicide attempts are possible);
• redness of the skin, burning, itching;
• frustration of a chair;
• increased formation of gas in the intestine.

The medicament guzzle one-time a day with an interval of 24 hours. Taking medication does not depend on the use of food, drink half a glass of clean drinking water without gas content. It is forbidden to chew, crush, crush the capsule.

a new generation of drugs for the treatment of hepatitis "C" Daklatasvir sofosbuvir and, thanks to the latest developments, help heal the pathology, was considered incurable, prevent the complete destruction of the liver and slow death patient.

Helpful videos about the preparations and Daklatasvir sofosbuvir and their effectiveness

More about sofosbuvir:

How does Daklatasvir: