The antibiotic is produced in the powder to be diluted with 0.9% sodium chloride or anesthetic prior to administration. A person who is not familiar with medical concepts and features of drugs often interested in how many stores divorced Ceftriaxone and whether it is possible to prepare a solution in advance. Consider why the drug is released in the form of powder substance and what happens to the solution upon prolonged storage.
Features medication
The powder contains the active ingredient in an inactive form and, before replying to the question whether it is possible to store Ceftriaxone solution prepared or not, should understand what happens in the body after administration preparation:
- depending on the method of administration (one hour after intravenous and 3 - intramuscular) indicates the maximum concentration of drug in the circulatory system;
- Ceftriaxone with blood enters the tissues where begins to destroy the bacterial flora;
- a day number of active metabolites is reduced and the effect required to maintain a second drug.
Instructions for use indicates that the body is excreted in the urine Ceftriaxone and partly the bile. At the time in which the drug will indicate completely from the body, affected by the state of the liver and kidneys. In diseases and pathological conditions of organs during the removal of active substances from the body increases - it should be considered when planning treatment with other drugs or consuming alcohol beverages.
Can I store the diluted
Features of ceftriaxone and other antibacterial drugs cephalosporin and penicillin are, that before the introduction means, they should be mixed with a physiological sodium chloride solution or anesthetic.
After dilution of the preparation is as follows:
- By reacting with a solution of active ingredients are in powder, pass into an active form;
- Maximum activity is maintained for about an hour, and then the active ingredients in solution begin to disintegrate into inactive components.
At room temperature already after 6 hours of storage solution efficiency decreases almost twice diluted powder.
Sometimes patients who are being treated at home, are interested in - whether the drug will save efficiency, if stored in diluted form in a refrigerator at a multiplicity of injection twice Ceftriaxone day.
Indeed, a decrease in temperature slows down the disintegration of the active ingredients, but the injections are set at intervals of 12 hours and during prolonged storage Ceftriaxone still reduce its effectiveness. If the doctor prescribes conduct Ceftriaxone injection twice a day, and should do, throwing up the next batch of the drug immediately prior to administration.
When it is possible to store long preparation
Ceftriaxone administered in solution not only for the injection administration, it is also used for the treatment of skin and mucous membranes in the following cases:
- irrigation oropharynx ENT infections and diseases of the gums caused by bacterial microflora;
- skin wound treatment or when a suppuration.
In these cases, use up the prepared solution immediately impossible, therefore, allowed to store Ceftriaxone in diluted form during the day. A slight degradation of active substances drugs do not affect the effectiveness of the drug.
Ceftriaxone term storage in diluted form for injections should not exceed 6 hours at room temperature and 12 - in the refrigerator. Prepared for treatment of the skin or mucous solution is allowed to store hours and change color (become yellow-orange) does not indicate that the drug has lost effectiveness. But it should be remembered that Ceftriaxone has a maximal therapeutic effect for one hour, and then, during storage, Activity of the active ingredients is reduced: it is recommended not to store the prepared solution is long, and to prepare using.
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