Terzhinan - complex drug for the treatment of infections of the female reproductive system. It is produced in the form of suppositories for topical application. There are limitations in terms of its use, in particular, Terzhinan pregnancy in 1 trimester is contraindicated. Despite this, your doctor may prescribe Terzhinan, in the case when this drug replace other inappropriate.
testimony
Terzhinan consists of several active ingredients, which causes a wide range of indications for its application:
- Fungal infections caused by pyogenic flora banal;
- anaerobic infections (gradnerellez, bacterial vaginosis);
- chronic forms of nonspecific colpitis;
- fungal infections (thrush);
- toxoplasmosis;
- ureaplasmosis.
Structure
In its composition Terzhinan contains 4 active ingredients:
- Drug imidazole (0.2 g trenidazol) - is indicated for treatment of anaerobic infections.
- Antifungal (Nystatin 100,000 IU) - helps in the treatment of candidiasis.
- Aminoglycoside (neomycin sulfate 0.1 g) - has a bactericidal effect in terms pyogenic flora.
- Glucocorticosteroids (prednisolone 0.003 g) - has an anti-inflammatory effect.
Properties of these substances cause Terzhinan range of applications in the treatment of various diseases of the urogenital sphere in women, as well - some contraindications to its use.
Terzhinan and pregnancy
Terzhinan pregnancy in 1 trimester is contraindicatedSo instead use other drugs. This is due to the fact that the structure includes Ternidazol which has the ability to penetrate through the mucous membrane of the vagina into the bloodstream, and actively accumulates in the body of the fetus, and neomycin, which is partly absorbed through mucous membranes and penetrate through the blood-placental barrier.
Studies have revealed that Ternidazol has a strong mutagenic and kanntserogennym action, and neomycin can penetrate through the mucous membrane, causing ototoxicity (effect on the hearing aid) and nefrotonksichnoe (affecting the kidneys) effect against fetus but only at high doses medications. But in the instructions it indicated that these side effects occur when using the drug in very high doses and mucosal damage.
Mutagenic and carcinogenic effects Ternidazola can provoke malformations in the fetus, so Terzhinan is not recommended during the first trimester. But the likelihood of such side effects is extremely low because the amount of drug that gets into the blood, usually very small and not harmful to any expectant mother or the fetus. It should also be noted that in the early stages of gestation the placenta has not yet formed, so all substances from the mother's blood fall to the fetus without any filtering.
Another danger that arises if you use in the first trimester of pregnancy Terzhinan - what mutagenic influence particularly pronounced in respect of actively dividing cells, and it is in the early stages of gestation fetal cells divide most active, which increases its susceptibility to the drug.
special instructions
Despite contraindications for use during pregnancy Terzhinan, in exceptional cases, medication may be given in early pregnancy. But at the same dosage Terzhinan 1 trimester only chosen doctor, and may differ from that in the treatment of non-pregnant women. Generally, the purpose of the drugs is strictly necessary for the treatment of diseases which are mixed flora, or in case, when the previously untreated coleitis complicated joining another infection (fungus + bacteria, aerobic + anaerobic bacteria, and etc.).
In most cases it is recommended to avoid the use Terzhinan 1 trimester. For the treatment of inflammation caused by a single species of the pathogen, we can choose monopreparations that are not soaked with mucosal surface, but before it must pass from the vaginal smear for bacteriological research.
sources:
Vidal: https://www.vidal.ru/drugs/tergynan__817
GRLS: https://grls.rosminzdrav.ru/Grls_View_v2.aspx? routingGuid = 60587723-2d73-4969-bb91-a65bff6c47a4 & t =
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