AMG rate for IVF is 2,1-7,3 ng / ml. Low serum concentration antimyullerova hormone indicates insufficient follicles or ovarian dysfunction. The risk group includes women over 40 years who require ovulation hormones stimulation. With insufficient levels of the hormone compounds have a low probability of conception.
Effect of AMH levels of conceiving
Anti-Müllerian hormone, or AMH, necessary for normal functioning of the ovaries, ovulation and the egg output in the uterine cavity. With age, the amount of the substance is reduced, and therefore stops the growth and maturation of follicles. With a lack of observed infertility, IVF is not possible transplantation of fetal eggs. To eliminate the risk of rejection of the embryo prior to artificial insemination, a woman should have a blood test to determine the level of AMH.
In fertile age concentration of the active substance remains stable regardless of the phase of the menstrual cycle. Blood hormone decreases after age 40, when there is a death of antral follicles. The latter are the cells, which mature and become ready to fertilize the egg.
Due AMG can predict the body's response to therapy with hormonal agents. With normal hormone patient can get pregnant on their own during artificial conception are high chances of successful implantation of the ovum. Low AMH and IVF are almost incompatible, because the decrease in the hormone indicates the ovary dysfunction.
At low rate antimyullerova hormone women often do not take on IVF CHI. This is due to the fact that the hormonal stimulation of ovulation drugs organs of the reproductive system can not respond to the therapy.
How to get tested
Screening for IVF AMH carried out for 3-5 hours after the onset of menstruation. During this period of the menstrual cycle Anti-Müllerian hormone in women remains unchanged. This is due to high activity of ovarian follicle maturation beginning.
By carrying out laboratory tests required necessarily to prepare. Otherwise, often seen as external factors decreased AMH in the female body. To obtain accurate results, you must adhere to the following rules:
- at least 48 hours prior to sampling biomaterial to reduce physical activity;
- sleep well;
- Avoid contamination by bacteria and viruses (in infectious disease is required to fully recover and then be screened);
- do not eat food for at least 12 hours prior to the study;
- stop smoking and drinking alcohol;
- for 3 hours before the manipulations do not drink water;
- 2 days did not take tonics and beverages;
- 48 hours, stop taking antibiotics, anticonvulsants and hormonal preparations.
Decrease the level of the hormone is able to stress, emotional stress. T. a. IVF with a low AMH is not carried out before the delivery of the venous blood a woman should not be subjected to mental and physical loads that can distort the accuracy of the results and show low values of hormonal connection.
For research laboratory is taking venous blood from the cubital vein. Test results are obtained after 1-2 days. If necessary, a second study, in order to avoid mistakes. It is advisable to take blood in laboratory conditions at one and the same time, in the morning until 11:00.
The indications for the analysis of AMH at IVF are:
- elevated levels of follicle stimulating hormone;
- lack of adequate response to hormonal therapy in ovarian stimulation;
- determination of ovarian reserve in women who have a long time can not conceive a child.
Norma AMG for IVF
Normally, a number of women of childbearing age hormonal substance varies within 2-4 ng / ml. This suggests a large follicles stock, ready for ovulation, and the good work of the ovaries. Reduction of AMG to 1 ng / ml is observed in the following pathological conditions:
- the depletion of the glands of the reproductive system;
- insufficient follicular reserve, which is typical for women older than 40 years;
- low functional ovaries.
IVF with a low AMH try not to carry out, t. To. There is a high probability that ovulation does not occur, or the embryo will not be able to infiltrate the endometrial layer of the uterus for further development. High plasma levels of the hormone adversely affects the artificial insemination. In this case, there is a hyperfunction of the ovaries, which results in menorrhagia, irregular cycles.
According gynecologists, normally for Eco indicator AMG must not be below 0.8 ng / ml. When good condition reproductive system hormone concentration is from 2.1 to 7.3 ng / ml.
Whether it is possible to carry out low level IVF
IVF with a low AMH provides minimal chances of normal fertilization. But the deviation from the norm analysis is not an absolute contraindication for the procedure. To increase the likelihood of conception, by means of intensive therapy of hormone group.
When the therapeutic effect of medicines increase the ovarian activity, stimulate oocyte yield of mature follicles.
If the treatment has not brought the desired results, IVF program is adjusted depending on the patient's age. Replacement of hormonal drugs, the daily dosage is increased. In the event of ovulation gynecologists transferred to the next stage: the ovarian puncture is performed, and then artificially fertilized female gametes. At the end of 3-5 days, the cells begin to actively share, which means a high viability of the embryo and its readiness to introduce the mother in the endometrium.
Is it possible to increase the rate AMG
IVF is not recommended for low-AMG, so first try to increase the concentration of the hormone compounds. agent level rises naturally in the summer and spring 20%.
To increase the content of antimyullerova hormone artificially held dehydroepiandrosterone therapy. Treatment is prescribed for AMG below 0.8 ng / ml for 12-16 weeks before planned IVF. Therapy based on hormonal drugs for ovarian stimulation, injectable vitamin D. Ergocalciferol regulates the production of AMH in the reproductive organs.
To increase the amount of hormone administered diet therapy:
- in the diet increase the amount of dairy fat with a level above 3.2%;
- use fresh fruits and vegetables;
- They include sea fish;
- of meat products, preference is given boiled or smoked beef, turkey or chicken, mutton;
- further comprising receiving multivitamin complexes;
- exclude reception offal;
- amount of confectionery and bakery products limit.
During the period of hormone replacement therapy should be abandoned by intense exercise, heavy physical exertion. It is recommended to replace the strength training and cardio classes on a bicycle, swimming, water aerobics. It needs to give up smoking and drinking. It is strictly forbidden to use the products, leading to a sharp increase in weight. Obesity leads to serum AMH fall.
Losing weight by 5 kg increases the likelihood of conception, by 4%, but this does not mean that you must sit on an extreme diet to quickly get rid of excess weight. Exhaustion will lead to hormonal imbalances, menstrual disorders.
