Menopur. Reviews for IVF stimulation, ovulation, instructions for use, price

Menopur is drug used as an ovulation stimulatorand for problems with conceiving a child. The drug has many positive reviews and is recommended for both men and women.

Indications for use

Menopur is used as an adjunct treatment for various disorders of the reproductive system.

Indications for women:

• infertility caused by malfunctions of the hypothalamic-pituitary system;
• auxiliary therapy when performing reproductive techniques aimed at eliminating problems with conception.

For men, the remedy is prescribed for insufficient production of seminal fluid, provoked by a decrease in testicular function and a decrease in the production of androgens. In this case, the drug is used as an adjuvant in combination hormone therapy.

Chemical composition

The drug contains 2 active ingredients - follicle-stimulating and luteinizing hormones.

Additional substances:

• milk sugar;
• additive E432;
• caustic sodium;
• hydrochloric acid.

Also, the product contains a solvent - isotonic sodium chloride solution.

Release form

Menopur (Menopur) is produced in the form of a lyophilisate intended for the preparation of an injection solution for intravenous or subcutaneous administration.

The preparation has the form of a pressed briquette of white or almost white color. Isotonic solution has a white transparent color.

The cost of lypholysate varies depending on the area of ​​sale, the distribution network of pharmacies, as well as the volume produced.

Region / region	Dosage / volume	Price
Moscow, Moscow region	Lyophilisate, 75ME	RUB 1050-17350
St. Petersburg	Lyophilisate, 1200 IU + 1200 IU	23300-26900 rub.
Leningrad region	Lyophilisate, 600ME + 600ME	RUB 10,000-25300
Novgorod region	Lyophilisate, 75ME	RUB 1100-15600

The agent is contained in vials, the solvent is in glass ampoules. Everything is packed in cardboard boxes.

Pharmacodynamics

Menopur (reviews during stimulation report the high effectiveness of the drug) is prescribed as an auxiliary treatment.

The drug belongs to the group of menopausal drugs made on the basis of human gonadotropin (class of menotoropins).

The components of the product are extracted from the urine of women who have gone through menopause.

The use of the drug in women leads to an increase in the production of estrogen. It has a stimulating effect and causes accelerated growth and maturation of follicles in the ovaries, and also enhances the growth of the endometrial layer.

The use of injections in men leads to an increase in testosterone levels and the development of male germ cells.

Pharmacokinetics

The maximum concentration of follicle-stimulating hormone in the blood is observed after 6-24 hours after its intravenous administration.

Then the FSH level gradually decreases.

The time for elimination of components from the body is from 4 to 12 hours.

Application

The medicine is intended for intravenous or subcutaneous administration. Dosages are calculated based on the gender of the patient and the underlying disorder.

For women

Dosages for women are determined individually based on the ultrasound examination of the ovaries. The starting daily allowance is 75 to 150 IU. If necessary, the dosage can be increased until the concentration of estrogen in the blood is within the normal range.

With a high therapeutic effect of the drug, the daily rate should be lowered. For the induction of ovulation after 1-2 days after the last use of the medication, 5-10 thousand IU.

For men

The initial dosage for men is from 1 to 3 thousand. IU 3 times a day. Apply the drug in this way until the level of testosterone in the blood is normalized. Then they switch to a different dosage regimen: 1-2 bottles are used 3 times a week. They adhere to this scheme for several months.

Contraindications

Menopur (reviews for stimulating ovulation indicate strict adherence to the prescribed dosages drug) has numerous restrictions on the use associated with physiological characteristics the patient.

Contraindications:

• disorders in the thyroid gland;
• damage to the adrenal glands;
• the presence of neoplasms in the pituitary gland or hypothalamus;
• increased content of prolactin in the blood;
• the presence of fibroids in the uterus;
• excessive development of the genitals, which is incompatible with bearing a child;
• increased size of the ovaries;
• the presence of cystic formations;
• cancer of the ovaries, mammary glands, or uterus;
• the period of bearing or feeding the child;
• the occurrence of bleeding in the genital area in women of unknown origin;
• ovarian failure (the primary form of pathology);
• the presence of androgen-dependent neoplasms in men;
• intolerance to one or another component.

During the carrying of a child, the agent is not used, since it can provoke ovarian hyperstimulation, which, in turn, is dangerous to the patient's health.

Overdose

During the application of the solution, the established dosages should be strictly adhered to, since otherwise negative symptoms may develop and the patient's (patient's) condition may worsen.

At the moment, no cases of drug overdose have been registered. However, with a significant excess of daily norms and the development of any negative signs, it is recommended to immediately contact your doctor.

Side effects

When used correctly, the drug does not cause negative effects. However, in some cases, adverse reactions can develop against the background of the physiological characteristics of the patient's body.

Side effects:

• Endocrine disorders: increased excretion of estrogens along with urine, pain in the area of ​​the mammary glands, increased size of the ovaries; the occurrence of cystic formations in the ovarian region. In men, it is possible to enlarge the mammary glands in the female pattern (gynecomastia).
• Ovarian hyperstimulation: development of nausea and vomiting, soreness in the lower abdomen, weight gain. There is also a decrease in blood volume and an increase in the level of red blood cells, an electrolyte imbalance occurs, and blood is formed in the peritoneal region. In some cases, thromboembolic syndrome develops, signs of ascites are observed, and excess fluid accumulates in the pleural region.
• Digestive system disorders: vomiting and nausea. In rare cases, colic and soreness occur.
• Local manifestations: hyperemic reactions, swelling, itching at the injection sites.
• Allergy symptoms: increased sensitivity to the drug. Long-term use of the drug can provoke the development of antibodies, which can significantly affect the effectiveness of the treatment.
• Other signs: the development of multiple pregnancies, a decrease in blood pressure, an increase in the patient's weight.

In the event of the occurrence of these signs, including unremarked symptoms, further therapy should be discontinued and the attending specialist should be consulted.

Special recommendations

Menopur must be used with extreme caution, since the drug has a stimulating effect on the human hormonal system. According to patient reviews, the remedy is very effective and in some cases can lead to hyperstimulation syndrome, which should be taken into account when using it.

If it is necessary to use the agent, it is recommended to first eliminate the existing violations that may affect the effectiveness of therapy.

Thus, it is necessary to carry out preliminary treatment of the following disorders:

• insufficient production of thyroid hormones (hypothyroidism);
• the presence of neoplasms in the pituitary gland or hypothalamus;
• increased concentration of prolactin in the blood;
• insufficiency of the adrenal cortex;
• increased blood viscosity (lack of water in the blood).

Before starting therapy, it is necessary to undergo additional diagnostics - an ultrasound of the ovaries and an assessment of the level of estradiol in the blood. During therapy, these studies should be performed daily or every other day.

It should be borne in mind that such a group of drugs can lead to ovarian hyperstimulation, which, in turn, can lead to the appearance of cystic formations in the ovarian region. In this case, concomitant symptoms and accompanying disorders may develop.

With the development of enhanced ovarian function, therapy must be discontinued, since this can lead to additional complications and provoke conditions that are difficult for the patient's health.

Also, if negative symptoms occur, further treatment with similar drugs is not carried out. With a high content of follicle-stimulating hormone in the blood of men, in most cases, the drug does not show a therapeutic effect. Great care should be taken during the period of using the solution when driving a car or carrying out other work requiring high psychomotor functions.

Drug interactions

It should be borne in mind that this solution may react with other drugs.

The drug is prohibited for joint use with human chorionic gonadotropin (Choragon). A woman is prohibited from using this combination of funds to stimulate follicular growth and to enhance ovulation. Men should not be prescribed this bunch of drugs to increase the production of male germ cells.

Storage conditions and periods

• The medication should be stored in a darkened room at a temperature not exceeding 25⁰C.
• Shelf life - 2 years from the date of manufacture.
• Do not use the solution after the expiration date printed on the package.

Conditions of dispensing from pharmacies

Implementation rules - according to the recipe.

Analogs

Menopur (reviews during stimulation report the possible development of intolerance reactions) can be replaced with other drugs similar in purpose and action.

It is not recommended to independently select and take analogs, since the wrongly chosen remedy can aggravate the situation.

Before taking this or that medication, you should consult your doctor.

Merional

This analogue is produced in the form of a lyophilisate necessary for the preparation of an injection solution for intravenous or subcutaneous administration. The main ingredient in the medication is human gonadotropin.

Recommendations for the appointment:

• anovulation, including that caused by the presence of cystic formations;
• decreased ovarian function (as an adjunct treatment for controlled hyperstimulation);
• insignificant production of male germ cells (sperm).

There are many limitations to the tool, which you must be familiar with in advance. The age at which the use of the product is allowed is 18 years and older.

Application scheme: therapy is carried out starting from the 7th day of the menstrual cycle. The daily dosage can vary from 70 to 150 IU. Duration of use - at least 1 week. The maximum duration of therapy is no more than 1 month. In the absence of a therapeutic effect within 4 weeks, treatment should be discontinued.

The drug is prohibited for use during childbearing, as well as during breastfeeding.

Men are prescribed 75-150 IU 3 times a day. The duration of therapy is about 4 months. The way of implementation is prescription. The cost of the solution in state and commercial pharmacies of the country starts from 1200 rubles.

Pergonal

Menopur (reviews during stimulation indicate the need for constant monitoring by a doctor while taking funds) can be replaced by a similar drug released by a Swiss medical manufacturer drugs. One such tool is Pergonal.

This medication is produced in the form of a lyophilized powder, which is used to prepare an injection solution. The active substances are follicle-stimulating and luteinizing hormones.

For women, the drug is prescribed as a means of stimulating the growth and maturation of follicles. For men, a medication is prescribed when there is insufficient production of male germ cells (sperm).

Age restrictions - at least 18 years old. The medicine has many limitations, including the period of gestation and breastfeeding. Also, a contraindication is the presence of neoplasms dependent on the production of male sex hormones (androgens).

Method of application: intravenously, 75 IU in the first 7 days of the menstrual cycle. Also, the drug can be used every other day at a dosage of 75 IU. The duration of treatment is 1 week. The daily rate may vary according to the indications of the attending specialist.

Men are prescribed 75-150 IU of solution intravenously 3 times a day. The duration of therapy is individual or 3-4 months. Sales mode - prescription. Prices for medicines in regional and regional pharmacies of the country start from 400 rubles.

Menogon

This medicinal product is made in the form of a lyophilized powder, from which a solution must be prepared.

The active ingredients are FSH and LH.

Indications:

• absence of pregnancy caused by the impossibility of follicle maturation;
• decreased ovulatory function (together with other drugs containing chorionic gonadotropin);
• male infertility, provoked by insufficient production of male germ cells (sperm).

The medication is intended only for patients who have reached the age of majority.

The drug has multiple contraindications that must be consulted in advance (including pregnancy and breastfeeding).

Dosing regimen: for women - 75-150 IU per day, men are prescribed 1-3 thousand. IU 3 times a week. After normalizing the level of testosterone in the blood, they switch to a different dosage regimen: 1-2 ampoules of solution 3 times a day. The duration of treatment is several months.

The method of sale is by prescription.

The cost of a medicinal solution in Moscow and regional pharmacies in Russia ranges from 1,090 to 13,400 rubles.

Before using Menopur or its analogues, you should first read the instructions for their use and consult your doctor. Additionally, it is recommended to study the reviews of patients who used the drug to stimulate ovulation.

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