Reaferon-Lipint for children. Instructions for use, reviews, price

Reaferon-Lipint is a drug, prescribed to children as a treatment for various viral diseases. The product has high clinically proven efficacy and many positive reviews.

Indications for use

The drug is prescribed as an auxiliary or main therapy for infectious and viral diseases, including seasonal respiratory diseases.

Recommendations for use:

• complex treatment of influenza and respiratory viral diseases;
• hepatitis B (acute course of the disease);
• prevention of influenza and other seasonal (respiratory) viral diseases;
• immunotherapy prescribed for various atopic pathologies - an allergic form of rhinoconjunctivitis, bronchial asthma;
• a chronic form of hepatitis, accompanied by the development of glomerulonephritis.

The remedy can be prescribed both in childhood and in adulthood.

Compound

The main component of the drug is human recombinant interferon alpha-2b.

Additional ingredients:

• sodium hydrogen phosphate;
• sodium chloride;
• sodium dihydrogen phosphate dihydrate;
• milk sugar;
• lipoid C100;
• LDL (cholesterol);
• vitamin A.

The product is contained in glass bottles and packed in cardboard boxes.

In what form is it produced

The drug is produced in the form of a lyophilisate, which is intended for the preparation of an oral suspension.

Description of the product - a dense powdery mass of white or almost white color with a yellow tint. The mass can flake off and resemble a tablet form.

The cost of a medication may differ based on the area of ​​sale, the retail pharmacy network and the dosage dispensed. You can find out the exact price and purchase the powder at any state or commercial pharmacy located in your place of residence.

Region / region	Dosage form / dosage	Price
Moscow, Moscow region	Suspension powder, 1 mln. IU	RUB 550-1275
St. Petersburg	Powder for injection, 3 mln. IU	RUB 935-1650
Leningrad region	Suspension powder, 1 mln. IU	RUB 520-1260
Novgorod region	Suspension powder, 1 mln. IU	RUB 650-1100
Volgograd region	Powder for injection, 1 mln. IU	RUB 310-1215

Pharmacodynamics

Reaferon-Lipint (only one dosage form of the drug is produced for children) belongs to the group of antiviral drugs with a high immunomodulatory effect.

The main active substance is synthesized in the cells of pathogenic microorganisms. It is located in the genetic structure of Escherichea and is a protein of 165 different amino acids and has the same structure and function as human interferon.

The main properties of the active component occur during the reproduction period of microorganisms, when the substance begins to integrate into the cells of the bacteria and is involved in its metabolic processes. In this case, the ingredient promotes the development of various reactions that lead to the production of protein and RNA in the pathogen.

The immunomodulatory effect of the drug is achieved by increasing the phagocytic action of macrophages. At the same time, an increase in the activity of lymphocytes in relation to target cells is noted, as well as a change in the composition of cytokines. The cells responsible for immunity change their functional action. The proteins located inside the cells change their secretory function and the amount produced.

Pharmacokinetics

There are no data on the pharmacokinetic properties of the drug.

Application for children under 18 years of age

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The product is intended for oral use.
Immediately before use, a little boiled (room temperature) water should be added to the suspension bottle. Shake the bottle with the product before use.

Dosage regimen (for hepatitis B):

• For children from 3 to 7 years old - half an hour before eating, 500 thousand. IU once a day. The duration of treatment is no more than 1.5 weeks. Based on the studies carried out, therapy can be extended.
• Children from 7 to 18 years old are assigned 1 million. IU 2 times a day. The course of therapy is 1.5 weeks.

Dosing regimen (for hepatitis B, including chronic course of the disease):

• Preschool children - 500 thousand IU 2 times a day for 1.5 weeks. Then they use the remedy for 500 thousand. IU for 30 days. Take every other day, preferably before bedtime.
• For children from 7 to 18 years old, the daily rate is 1 million. IU 2 times a day. The course of treatment is 1.5 weeks. Then they switch to a different scheme: 1 mln. IU once a day every other day (before bedtime) for 30 days.

As a treatment and prevention of influenza and respiratory infections, it can be used in childhood, starting from 3 years.

Dosing scheme:

• For prevention (for children aged 15 and over) - 500 thousand. IU once a day, no more than 2 times a week. It is taken for 1 month during the season of increasing incidence. Children from 3 to 15 years old are assigned 250 thousand. IU once a day, 2 times a week. Use the remedy for 1 month.
• Treatment: children from 3 to 15 years old are prescribed 250 thousand. IU every day, 2 times a day. The course is 3 days. Children from 15 years old are recommended to take 500 thousand. IU 2 times in knocks for 3 days.

Preventive treatment of encephalism caused by a tick-borne pathogen: half an hour before eating, 500 thousand. IU 2 times a day. The course of treatment is 5 days. As a supplement, an injection solution of immunoglobulin is used.

Contraindications

Reaferon-Lipint (identical contraindications are indicated for children and adults) has some restrictions on the appointment associated with the special condition of the patient or his other physiological features.

Contraindications:

• intolerance to the components of the suspension;
• severe allergic diseases;
• the period of pregnancy and breastfeeding;
• lack of lactase, allergy to lactose, glucose-galactose malabsorption syndrome.

With extreme caution and only under the supervision of a physician, the medication can be used for renal and hepatic insufficiency, thyroid pathologies, as well as with a pronounced course of myelosuppression.

Overdose

At the moment, no cases of drug overdose have been registered. However, with a significant excess of the prescribed daily norms, an increase in adverse reactions is possible. In the event of such conditions, it is recommended to contact your doctor for symptomatic therapy.

Side effects

According to the conducted clinical studies, there were no adverse reactions in patients. However, taking into account the incoming main component (interferon) side effects may develop in the form of the following symptoms:

• febrile state:
• chills;
• asthenic syndrome;
• migraine;
• allergic reactions;
• muscle or joint pain.

These signs can be eliminated independently with paracetamol or indomethacin.

Other side effects:

• Digestive disorders: dry mouth, nausea, dyspeptic disorders, lack of appetite.
• Central nervous system reactions: increased irritability, anxiety, sleep disturbances, apathy, depressive states. These symptoms usually occur with prolonged use of the medicine.
• Endocrine disorders: malfunction of the thyroid organ.
• Changes in laboratory parameters: a decrease in the level of leukocytes, platelets and lymphocytes. These signs develop with prolonged use of the lyophilisate.

If the listed symptoms occur, as well as other signs that are not noted in the instructions, you should stop further taking the suspension and consult your doctor for advice.

Special recommendations

For children, this medicine is prescribed very carefully, since the child's body can react differently to the active substance. Reaferon-Lipint is an immunomodulatory drug and requires careful use and strict adherence to dosages and recommendations prescribed by the attending physician.

Thus, if any allergic manifestations occur while taking the lyophilisate, you should consult a doctor for advice.

In the presence of pathologies of the thyroid gland, the agent should be used only under the supervision of an endocrinologist. In this case, it is necessary to undergo systematic studies of the level of TSH in the blood.

The medication does not affect the psychomotor functions of a person. However, in some cases, fatigue and drowsiness may develop, therefore it is required to exercise high caution when driving or performing work that requires high cognitive or visual functions.

Drug interactions

It should be borne in mind that the medication can react with other drugs.

Thus, the drug contributes to a decrease in the effectiveness of cytochromes P450, which, in turn, leads to a violation of the metabolic activity of the following components and substances:

• diazepam;
• theophylline;
• warfarin;
• cimetidine;
• chime;
• propanolol;
• fepitoip.

Also, this trend is observed with the combined use of a lyophilisate and some types of cytostatic drugs.

The simultaneous use of a medication with drugs can lead to an increase in myelo-, cardio- and neurotoxic effects.

It is forbidden to use the medicine in conjunction with immunosuppressants, as well as drugs that depress the work of the central nervous system, including with various dosage forms of corticosteroid funds.

It is recommended to refrain from drinking alcohol for the entire period of treatment.

When taking other drugs, you should first inform the attending specialist about this, which will eliminate any risks of developing drug incompatibility.

Storage conditions and periods

The pharmaceutical product must be stored in a dark and cool place at temperatures up to 8 ⁰C.

The term of use of the lyophilisate is 2 years from the date of production.

Do not use the medicine after the expiry date of the expiration date on the package.

After preparing the suspension, it must be consumed immediately. It is not allowed to store the agent prepared in advance, as this can lead to a decrease in its therapeutic effect.

Conditions of dispensing from pharmacies

The way of implementation is prescription.

Analogs

Reaferon-Lipint for children is prescribed only if all the components that make up it are well tolerated. If any signs of allergy occur, the drug should be replaced with another drug that is similar in indications and action.

Similar means are recommended to be used only with the agreement of the attending physician, since independent and uncontrolled intake of medications can provoke an aggravation of the condition the patient.

Altevir

This pharmacological agent is produced in Russia in the form of an injection solution intended for intravenous or subcutaneous administration.

The main ingredient of the substitute is interferon alpha-2b.

The drug has a pronounced antiviral, immunomodulatory and antitumor effect.

Scope (disease):

• chronic course of hepatitis B (in the absence of symptoms of liver cirrhosis);
• chronic form of hepatitis C (without complications in the form of liver failure);
• the presence of papillomas in the throat;
• tumor processes (cancer);
• genital warts.

The scheme of application and the duration of the course are calculated individually, based on the form of the disease, as well as the degree of its severity and progression. In this case, dosages can vary from 500 thousand. up to 15 million IU per day. The duration of therapy in some cases can be up to 1 year.

Contraindications:

• severe cardiovascular pathologies;
• failure of the kidneys or liver (severe disease);
• functional disorders of the central nervous system, including epileptic seizures;
• chronic forms of hepatitis, complicated by cirrhosis of the liver;
• various autoimmune diseases;
• diabetes mellitus (decompensated form);
• COPD (in the stage of decompensation);
• pathology of the thyroid gland;
• intolerance to the drug;
• the period of pregnancy and breastfeeding;
• hypercoagulation;
• rehabilitation period (transplantation);
• myelodepression (severe form of the disorder).

In childhood, the medication can be used only with the permission of a doctor.

The method of sale is prescription.

Prices for medicines in Moscow pharmacies vary between 700-1900 rubles.

Binnoferon Alpha

Reaferon-Lipint for children, as well as its substitutes, should be taken only on the recommendations of the attending physician. Binnoferon Alpha is also an analogue of Reaferon-Lipint and has similar indications and principle of action.

This medicine is made as a solution for intravenous or subcutaneous injection. The main ingredient is interferon alpha-2b. The drug exhibits pronounced immunomodulatory, antiviral and antitumor activity.

Indications:

• chronic course of hepatitis B, C and D;
• the presence of cancer cells;
• keratitis and conjunctivitis, which is of a viral nature of origin;
• prevention and treatment of influenza and respiratory infections;
• tick-borne encephalitis (as an emergency treatment);
• multiple sclerosis;
• the presence of papillomavirus infection in the larynx in children.

The scheme of application depends on the age of the patient, the detected disorder, the severity and progression of the pathology. In this connection, it is developed individually by the attending physician.

The duration of therapy is also determined taking into account the nature of the pathological process. The drug has numerous restrictions on its prescription, including chronic forms of hepatitis complicated by cirrhosis of the liver, as well as the period of pregnancy and breastfeeding.

Age restrictions - children at least 3 years old. In childhood, treatment is carried out under the strict supervision of a specialist.

Dispensing mode - prescription.

The cost of a generic drug in public and private pharmacies in the country starts from 70 rubles.

Lipoferon

This substitute is a complete structural analog of the main drug and has similar indications. An interferon-based agent is produced and has antiviral, immunomodulatory, antiproliferative and antitumor effects.

The dosage form is a lyophilisate for the preparation of an oral suspension.

Recommendations for use:

• hepatitis B, including acute forms of pathology;
• atopic disorders - an allergic form of rhinoconjunctivitis;
• prevention and treatment of influenza and acute respiratory viral infections.

The dosage is calculated individually, based on the patient's age and the identified form of the disease.

The standard regimen for hepatitis B: 250 thousand - 1 million are consumed. IU 1-2 times a day for 1.5 weeks. If necessary, treatment can be continued after additional laboratory tests.

For respiratory diseases, the drug is taken within 3 days. The dosage in this case varies from 250 thousand. up to 1 million IU.

Restrictions on the use of the medication are reactions of intolerance to the components, as well as children under 3 years of age. In preschool children, treatment should be carried out only under the supervision of a physician.

The medicine is prohibited for use during pregnancy and breastfeeding.

The way of implementation is prescription.

The cost of a medicine in regional and regional pharmacies of the country ranges from 300 to 500 rubles.

Before using Reaferon-Lipint, you must first consult with a specialist and read the instructions for its use. Additionally, it is recommended to study the reviews of parents who used lyophilisate for children.

Video about the drug Reaferon-Lipint

How to breed Reaferon-Lipint: