Tempalgin tablets. Instructions for use, price, reviews

Clinical and pharmacological group of non-steroidal anti-inflammatory medications include Tempalgin tablets. The drug has a combined effect, since if the recommended dosage is observed, normalization can be achieved body temperature with fever, eliminate painful symptoms (algosyndrome) in the presence of inflammatory process.

To reduce the likelihood of adverse reactions, it is recommended to take Tempalgin no more than 3-5 days. Before buying the drug, you need to consult with your doctor and study the instructions for use to make sure there are no contraindications.

Form of release of Tempalgin tablets

The drug Tempalgin is produced in the form of rounded biconvex tablets, which are covered with a green shell. The drug is sold in blisters, each of which contains 10 tablets. 1 cardboard box can contain 2, 10 or 30 blisters. The drug has a pronounced anti-inflammatory and analgesic principle of action. Tempalgin helps to cope with algosyndrome. The drug eliminates discomfort after 20 minutes. after application. The positive therapeutic effect lasts for 4 hours.

Composition of the preparation

Tempalgin - tablets (instructions for the use of a pharmacological agent confirm that the drug helps to cope with pain syndrome in inflammatory disease of peripheral nerves, when the patient can additionally be diagnosed with paresis) of a wide spectrum of action, intended for oral administration application. As the main active ingredients, the preparation contains 2 substances at once: triacetonamine-4-toluenesulfonate (tempidone), sodium metamizole.

Additional components of Tempalgin:

• E572.
• Wheat starch.
• Dye.
• Povidone.
• PEG.
• Glycerol.
• E171.
• Methacrylic acid.
• Dibutyl ester of phthalic acid.
• Copolymer MC.
• Talc.
• Castor oil.

Metamizole sodium refers to non-steroidal anti-inflammatory drugs (pyrazolone derivatives). The action of this substance is based on the suppression of the activity of cyclooxygenase. This group of enzymes is responsible for the production of prostaglandins.

Metamizole sodium has the following properties:

• Anti-inflammatory.
• Analgesic.
• Antipyretic.
• Membrane stabilizing.

The second active component of the drug is tempidone, which belongs to the category of psycholeptics. This substance affects the central nervous system by blocking the natural neurotransmitter acetylcholine.

Tempidone is included in medications to achieve the following results:

• Decreased motor arousal.
• Elimination of causeless anxiety, fear, panic.

Tempalgin helps to reduce the synthesis of prostaglandins in peripheral tissues and the central nervous system.

Pharmacological properties

Tempalgin is a combined drug, the action of which is aimed at normalizing body temperature and eliminating algosyndrome. In laboratory conditions, it has also been proven that this drug stops the inflammatory process and improves the general psycho-emotional state of the patient, which is due to the suppression of an unreasonable feeling of anxiety, fear.

The bioavailability indicator of the drug reaches 99%. Tempalgin is an antipyretic analgesic that is in demand in almost all branches of modern medicine. After oral administration, the active and auxiliary components of the drug are rapidly absorbed into the gastrointestinal tract, penetrating into the patient's systemic circulation. The drug is evenly distributed in the tissues, stopping inflammation and eliminating pain.

Pharmacodynamics and pharmacokinetics

Food intake does not affect the effectiveness of metamizole sodium. Tempidone is best absorbed in the esophagus and stomach. The maximum concentration of Tempalgin in blood plasma is possible only after 60 minutes. after using the drug. Metamizole sodium only binds to plasma proteins by 30-40%. This substance also undergoes biotransformation in the liver. The main metabolites AA and MAA are pharmacologically active. An anti-inflammatory agent is excreted along with urine.

Indications for use

Tempalgin - tablets (instructions for the use of a pharmacological agent should be studied by the patient first of all, since only if the recommended scheme is followed treatment, you can achieve a positive therapeutic effect in the fight against algosyndrome) with antipyretic, analgesic effect, which can be taken for 5 days. When undergoing long-term therapy, it is necessary to monitor the state of the liver.

In the annotation to the drug, the manufacturer indicated the following indications for use:

• Pain syndrome that arose after undergoing surgical or diagnostic interventions (Tempalgin is prescribed to the patient as an auxiliary pharmacological agent to normalize state).
• Weak and moderate algosyndrome in the presence of the following diseases and conditions: migraine, pulpitis, sciatica, radicular syndrome, intercostal neuralgia, pain in joints and muscles, algodismenorrhea. Tempalgin is effective for increased neuro-reflex excitability.
• Mild painful symptoms of a visceral nature. The drug is best taken simultaneously with antispasmodics. Tempalgin helps to normalize the patient's condition with colic.
• Increased body temperature in patients with seasonal colds and infectious and inflammatory diseases.

Tempalgin can be used as an analgesic before visiting the dentist's office. Thanks to this, it is possible to reduce the intensity of the manifestation of pain syndrome by 50-80% during invasive procedures and other manipulations. It should be borne in mind that the drug does not have a therapeutic effect, but only for 2-5 hours. eliminates painful symptoms.

Contraindications

Not all patients can take Tempalgin, since in some cases this drug can cause the development of adverse reactions.

The following contraindications are indicated in the annotation to the analgesic:

• Hypersensitivity of the body to the components of the drug.
• Anemia, which has arisen against the background of a deficiency of glucose-6-phosphate dehydrogenase (there is a high probability of hemolysis).
• Disruption of the exchange of bilirubin and porphyrin (pyrolloporphyria).
• Bone marrow dysfunction. Tempalgin is prohibited from taking after treatment of a diagnosed disease with cytostatic drugs.
• The period of bearing a child.
• Lactation.
• Severe hepatic renal failure.
• Pathology of the hematopoietic system. For example, agranulocytosis, inhibition of the function of hematopoiesis of the red bone marrow, a decrease in the concentration of white cells in the blood.
• Hypotension, in which blood pressure indicators are below 95 mm Hg.
• Children's age (up to 15 years old).

The components of the drug can pass into breast milk, which is why Tempalgin is prohibited from taking during lactation. Otherwise, during the treatment, the child should be transferred to artificial feeding.

With caution, the analgesic can be taken in the presence of the following diseases:

• Moderate hepatic or renal impairment.
• Kidney disease (glomerulonephritis, tubulointerstitial nephritis).
• Alcoholism.
• Predisposition to a sharp decrease in blood pressure indicators.
• The presence in the patient's history of records of diagnosed bronchial asthma, recurrent polyposis of the paranasal sinuses.

Only the attending physician can assess the feasibility of using the Tempalgin drug by the patient. Self-drawing up a treatment regimen can provoke a further deterioration in well-being and the development of complications.

At what age can Tempalgin be used?

In laboratory conditions, the necessary studies have not been carried out on how the active and auxiliary components of Tempalgin affect a growing body. That is why, in pediatrics, this analgesic, anti-inflammatory drug can be prescribed to adolescents over 15 years old. The use of Tempalgin at an earlier age is fraught with the development of adverse reactions, which may require long-term symptomatic treatment to combat.

To eliminate pain, patients from 15 to 18 years old are prescribed 1 tablet 1 time per day. The doctor determines the duration of the treatment course depending on the general condition of the patient and the presence of complications.

Instructions for use, dosage

Tempalgin is intended for oral administration. The tablets should be taken with a sufficient amount of still water. The instructions for use indicate that the dosage of the drug depends on the age of the patient, the severity of the algosyndrome and the individual characteristics of the organism. It is recommended to take the medicine after meals.

No dosage adjustment is required to eliminate pain in patients over 65 years of age. It is possible to prescribe Tempalgin to a patient with chronic kidney or liver pathologies only for 2-3 days. In this case, the permissible daily dose of the drug is 2 tablets.

With menstrual pain

Aching pain in the lower abdomen occurs with algodismenorrhea, which is associated with excessive synthesis of prostaglandins, which provoke uterine contraction, and also cause spasm of the pelvic vessels. Due to stagnation of blood, soft tissues lack oxygen, which is the reason for the excitation of pain receptors.

With menstrual pain, Tempalgin eliminates discomfort by regulating the synthesis of prostaglandins and reducing the frequency of contraction of the uterine muscles. Additionally, the drug blocks pain receptors. To achieve the maximum therapeutic effect, it is recommended to take the drug 1-2 times a day, but not more than 4 days in a row.

With a headache

Tempalgin - tablets (instructions for use confirm that this pharmacological agent is effective if there is a history of the patient a chronic neurological disease characterized by recurrent bouts of intense headache and autonomic disturbances) a broad spectrum of action, affecting the expansion of blood vessels, which helps to normalize blood circulation and improve well-being sick.

The maximum effect in the fight against migraines is achieved by blocking pain receptors.

For headaches, Tempalgin should be taken 1-3 times a day. The duration of the therapeutic course should be determined by the attending physician after a comprehensive examination of the patient's body.

For toothache

Thanks to the combined pharmacological principle of action, the drug not only eliminates pain, but also suppresses the inflammatory process that inevitably occurs with pulpitis. It is possible to improve the state of health in 20-40 minutes. after using the drug. Even if there is no positive therapeutic effect, then you should not increase the dosage of the drug yourself. It is possible to completely get rid of a toothache only after contacting a dentist.

To effectively combat toothache, you can take the drug a maximum of 4 times a day. The maximum course of therapy is 5 days.

Side effects

In 99% of cases, the components of the analgesic pharmacological agent are well tolerated by the body of patients over 15 years old. But if, before taking the drug Tempalgin, the patient did not take into account the existing contraindications, then, with a probability of 98%, he will have to face the following adverse reactions:

• Central nervous system: migraine attacks, discoordination, perception disorders.
• Gastrointestinal organs: slowing down or complete cessation of bile secretion, discomfort in the epigastric region, increased activity hepatic transaminase, an increase in bilirubin in the blood, xerostomia, icteric staining of the skin and visible mucous membranes shells.
• Urinary system: anuria, a significant decrease in daily urine production, interstitial nephritis, an increase in the concentration of protein in the urine.
• Vascular system: tachycardia, bluish color of the skin and mucous membranes, a sharp decrease or increase in blood pressure.
• Allergic reactions: Quincke's edema, urticaria, narrowing of the lumen of small bronchi and bronchioles, itching and burning of the skin, erythema multiforme exudative (EEE), Lyell's syndrome, anaphylactic shock.
• Hematopoietic system: a critical decrease in the level of leukocytes, thrombocytopenia.

If any adverse reactions occur, the patient should stop taking Tempalgin. For the safe elimination of pain, it is recommended to seek the advice of your doctor, who will help you choose an effective analogue of the drug.

Overdose

Tempalgin - tablets (instructions for use include information that the use of an antipyretic drug in large doses can lead to the development diseases of the stomach and deterioration of the patient's quality of life), which reduce the sensitivity of nerve endings, and inhibit the transmission of nociceptive impulses at the level structures of the central nervous system. In medical practice, isolated cases of overdose of the described drug have been recorded.

If a patient takes more than 5 tablets in 1 day, then with a probability of 93% he will experience the following overdose symptoms:

• Increased heart rate.
• Nausea, vomiting.
• Arterial hypotension.
• Sleep disturbance.
• Abdominal pain.
• Dyspnea.
• Limb cramps.
• Impaired consciousness.
• Renal or hepatic impairment.
• Stool disorder.
• Increased irritability.

If symptoms of an overdose occur, you need to stop taking the anti-inflammatory drug Tempalgin and rinse the stomach. The patient should take activated charcoal or Enterosgel. In severe cases, it may be necessary to carry out forced diuresis or hemodialysis in order to achieve detoxification of the body.

Additionally, the doctor may prescribe symptomatic treatment. Patients with convulsions of the extremities must be injected intravenously with fast-acting barbiturates and Diazepam to stabilize the general condition.

special instructions

Tempalgin refers to symptomatic medications, which is why it can be taken only in the presence of pain syndrome. To prevent the deterioration of the functioning of the organs of the gastrointestinal tract, it is additionally recommended to use drugs that protect the mucous membrane of the gastrointestinal tract from irritation. It is forbidden to use Tempalgin in cases where the etiology of the algosyndrome is unknown.

For the analgesic drug, anxiolytic effect is characteristic, due to which, during treatment it is recommended to give up driving and complex mechanisms that require increased concentration attention. It is unacceptable to use Tempalgin with alcoholic beverages. Otherwise, it is possible that the effects of ethanol will increase.

Drug interactions

Only the attending physician can prescribe a safe combination drug therapy to the patient.

To draw up an effective treatment regimen, it is imperative to take into account the principle of interaction of Tempalgin with other drugs:

• With cytostatics - the probability of a decrease in the number of leukocytes per unit of blood volume increases by 85% (less than 4000 in 1 μl).
• The use of Tempalgin together with Chlorpromazine and other phenothiazine derivatives can provoke the occurrence of pronounced hypertension.
• When an anti-inflammatory drug is combined with barbiturate acid derivatives, Phenylbutazone and others as inducers of proteins produced by the endoplasmic reticulum, the effect of metamizole sodium is weakened.
• With sedative and psychotropic pharmacological agents, the analgesic effect of Tempalgin is enhanced.
• With Indomethacin, oral hypoglycemic drugs, glucocorticosteroids, anticoagulants indirect principle of action - the effectiveness of all the listed medications increases by 30-40% funds.
• Reducing the intensity of excretion of metamizole sodium and simultaneously enhancing the therapeutic effect of this component occurs with the combined use of Tempalgin and Propranolol, Codeine, as well as histamine blockers H2 receptors.
• Cyclosporine. The active components of Tempalgin reduce the concentration of cyclosporine in the patient's blood plasma.
• Oral contraceptives, tricyclic antidepressants (TCAs), non-opioid analgesics, Allopurinol. When Tempalgin is used, the toxicity of all of these drugs increases.

For the appointment of combined drug therapy, the attending physician should be guided by the patient's history. Otherwise, an incorrectly drawn up treatment regimen can pose a threat to the patient's life.

Analogs

If there are contraindications, Tempalgin should be replaced with a more suitable drug with an identical principle of action. At the same time, commercially available antipyretic, anti-inflammatory, analgesic drugs can differ from each other not only in price, but also in composition, contraindications, as well as possible side effects reactions.

Drug name	Description	Average price (rub.)
Paracetamol	The active ingredient is paracetamol. The tool is intended to eliminate algosyndrome of weak and moderate intensity, post-vaccination hyperthermia, as well as fever that occurs during infectious and inflammatory diseases. The drug is prohibited to use in the following cases: hypersensitivity to the composition, fructose intolerance, pathology of the hematopoietic system, sucrose / maltose deficiency, children's age (up to 12 years). It is recommended to take Paracetamol 1-2 tablets in the morning, at lunchtime and in the evening. The maximum daily dose of the drug is 8 tablets. The standard therapeutic course is designed for 5 days.	35
Tempanginol	The preparation contains 2 active components - triacetonamine-4-toluenesulfonate, sodium metamizole. Tempanginol is intended to eliminate moderate and mild algosyndrome. The medicinal product must not be used in the presence of the following diseases and conditions: porphyria, renal failure, allergic susceptibility to the composition, leukopenia, childhood (up to 14 years old). Take Tempanginol 1 tablet 1-3 times a day. The recommended duration of the therapeutic course is 5 days. Only the attending physician can change the treatment regimen.	180
Ibuklin	The active ingredients of the drug are: paracetamol, ibuprofen. Indications for use: fever, pain, myalgia, neuralgia, inflammatory and degenerative diseases of the musculoskeletal system. Ibuklin is forbidden to use in the following cases: gastric ulcer and duodenal ulcer, increased sensitivity of the body to the components of the drug, pregnancy, inflammatory bowel disease, childhood (up to 14 years old). It is necessary to take the drug 1 tablet a maximum of 3 times a day. The therapeutic course is designed for 5 days. Treatment can be extended only after prior consultation with the attending physician.	145

Before buying an analogue of Tempalgin, you need to study the instructions for use to make sure there are no contraindications, thereby reducing the risk of adverse reactions. Additionally, it is recommended to take into account that taking analgesics to eliminate acute pain in the abdominal area is strictly prohibited, since in such a situation an immediate comprehensive examination is required organism.

Terms, conditions of sale and storage

Tempalgin - tablets (instructions for use contain information that the drug helps to eliminate aching pain during development neurological syndrome caused by irritation of the spinal roots) for oral administration, implemented without doctor's prescription.

Store the drug in a dry, well-ventilated place, out of the reach of children and direct sunlight. The air temperature in the room should be between +12 and +25 C. The shelf life of the drug is 4 years.

Price

You can buy Tempalgin tablets both in a regular pharmacy and on the Internet. The price of the drug varies from 100 to 560 rubles. (it all depends on the number of tablets in the package). For the safe elimination of pain, before using the drug, you need to study the instructions attached to it, which indicates the recommended dosage and the duration of the therapeutic course.

Tempalgin video

Instructions for Tempalgin: