Ezetimibe 10 mg. Price, instructions for use, reviews

Ezetimibe 10 mg is a prescription drug intended for to significantly reduce total cholesterol levels in blood plasma, as well as to neutralize harmful aromatic hydrocarbons in the intestines. Its price is determined by the form of release, and the dosage varies depending on the patient's disease.

Ezetimibe is produced by Schering-Plow, which is based in America. This is one of the most famous pharmaceutical companies, so their products are popular and considered effective.

Composition and form of release

Ezetimibe 10 mg (the price of the drug is determined by the components that make up the tablets) is discussed in the table below. It contains a description of each of the active and auxiliary substances.

Substance	Amount of substance in 1 tablet	Description
Micronized ezetimibe	10 mg.	The main active ingredient in the preparation. It dissolves well in an alkaline environment. It is a white crystalline powder. When it hits the microscopic villi of the cell surface of the small intestine, it stops the absorption of cholesterol. If it is in the body for a long time, it is able to reduce the amount of cholesterol that enters the liver. insta story viewer
Lactose monohydrate	45.0 mg	Disaccharide derived from whey. Has a weakening effect and also gives the tablets a pure white color.
Microcrystalline cellulose	27.0 mg	A substance with zero calories that is not absorbed by the body. As a result, cellulose is gently excreted from the body, taking with it all the toxins from the intestines. Thus, his work is improved.
Croscarmellose sodium	10.0 mg	It is a thickener, powdery white or slightly grayish substance. Designed to ensure stable and effective disintegration of the tablet in the human body.
Sodium lauryl sulfate	4.0 mg	Active substance with an aggressive effect. It is used as a strong cleaning and wetting agent.
Sodium carboxymethyl starch	10.0 mg	Colorless solution used as thickener and stabilizer. It is tasteless, colorless and odorless.

Ezetimibe 10 mg, the price of which is considered high on the market, is available in several forms, depending on the number of tablets in the package:

• 7 pcs. - contoured cell packaging in a cardboard box;
• 10 pieces. - contour cell packaging in a cardboard box;
• 14 pcs. - cell contour packaging in a cardboard box;
• 20 pcs. - cell contour packaging in a cardboard box;
• 40 pcs. - in a plastic can;
• 50 pcs. - in a plastic can;
• 100 pieces. - in a plastic can.

The package contains round and biconvex tablets of white, less often white-yellowish color. One side is chamfered.

The shelf life of the tablets is 3 years from the date of release. The date of manufacture is indicated on the front of the package. After the expiration date, it is prohibited to take the drug due to the high risk of poisoning.

Terms of sale and prices

Ezetimibe contains aggressive and potent substances, therefore it is a prescription drug. Sold by doctor's prescription only. Ezetimibe 10 mg (the price is determined by how many tablets are in the package) is purchased by the patient depending on the average price tag.

The cost of the drug, depending on the packaging:

• 10 pieces. - 820 rubles;
• 30 pcs. - 1970 rubles;
• 50 pcs. - 2890 rubles.

The larger the package, the cheaper the cost of one tablet in it. Therefore, it is most profitable for people who use the drug on an ongoing basis to buy the drug in large quantities.

Most often, on the shelves of pharmacies you can see ezetimibe in 14 or 30 pieces. packaged.

Action

Ezetimibe is a completely new and unique representative in the class of lipid-lowering drugs that are absorbed into the blood within a few hours. Designed to quickly inhibit the level of cholesterol and the class of styrenes.

The uniqueness of the drug lies in its pharmacodynamic effects and structure. The main molecular constituent of ezetimibe is a transport protein. It is responsible for the absorption of phytosterol by the gastrointestinal tract.

Ezetimibe has a complex effect on humans. Once in the body, the film-coated tablets rapidly dissolve, and the substance is located in the fleecy border of the intestine. This prevents active absorption of cholesterol by the liver. Due to the entire action, the elimination of cholesterol from the blood plasma is accelerated.

Unlike potent sequestrants, the drug does not enhance the excretion of bile acids and metabolic end products from the body, which are needed to maintain vital functions. Compared to statins, it does not induce cholesterol production. This makes the use of the drug more gentle.

Once in the large intestine, ezetimibe binds tightly to blood plasma proteins. The level of its distribution in the cells is more than 90%, which guarantees a quick result and high efficiency of action.

After oral administration, the tablets are actively absorbed, forming an active phenolic glucuronide. Absorption takes 4 to 12 hours. The exact level of bioavailability of the drug cannot be determined, since its compounds are practically insoluble in water. According to the data studied, about 78% of the total dose was excreted from the body within a week. The radioactive substances that make up the drug were not detected in the biochemical composition of the blood after 2 days.

The pharmacokinetics of the drug can be considered in certain groups of patients, since, depending on the age, sex and general condition of the patient, the following changes:

Patient group	Peculiarities
Adults and children	The indicators in the field of pharmacokinetics are the same in both children and adults. There is no data on the effect of the drug on babies under 6 years old. Clinical trials have not been conducted.
Seniors (over 65 years of age)	When compared with a younger category of the population, the concentration of the active substance in the blood plasma is 2-3 times higher when the same dosages are administered. The degree of concentration reduction and the level of safety do not change, therefore, an individual selection of the daily dose is not necessary.
People with liver failure	After a single dose of the drug, the average ezetimibe level was 1.7 times higher than in the group of people without liver dysfunction. Therefore, an individual dose selection and adjustment is not required.
People with kidney failure	In people with severe impairments in the work of the kidneys, after taking the drug, the level of the total active substance in the blood increased by about 1.5 compared with healthy people. These indicators slightly deviate from the norm, therefore, when drawing up a course of treatment, doctors are not taken into account. In patients who underwent a kidney transplant, after taking the drug, an increase in the level of the active substance in the blood was found 12 times.
Female and male representatives	The concentration of the total volume of the active substance is slightly higher in women - no more than 20%. The degree of change in cholesterol level and safety is equal in both sexes.

The pharmacological efficacy of the drug has been proven through clinical trials. For 2 weeks, 18 patients with hypercholesterolemia took ezetimibe on a regular basis. According to research results, the drug reduced the production of cholesterol in the intestine by 54% compared to placebo.

A number of clinical studies have made it possible to find out how ezetimibe and various inhibitors of the absorption of cholesterol are combined. According to the results, the combination of drugs only temporarily suppressed the absorption of cholesterol by the liver. Their effect on the absorption of triglycerides as well as fatty acids has not been proven.

With the help of clinical studies, the effectiveness of the use of the drug together with statins has been proven. The drugs have 2 different mechanisms of action, which allows them to be effectively combined with each other. When used together, they provide a rapid reduction in cholesterol levels. From the additional positive properties of such a combination, an increase in the level of high-density lipoproteins, as well as the release of lipoproteins, low-density triglycerides from the intestine can be distinguished.

Indications and contraindications

Ezetimibe 10 mg, the price of which is quite high on the market, is prescribed to patients due to its effectiveness in the presence of the following diseases:

• Primary hypercholesterolemia - for an active effect on the body, it is used together with inhibitors. Additionally, they can introduce a diet that promotes the rapid absorption of drugs, reduces the production of cholesterol.
• Homozygous familial hypercholesterolemia - in conjunction with a statin, the drug is recommended to reduce high levels of TC and CS in the body. Patients can receive auxiliary procedural treatment on devices.
• Homozygous familial sitosterolemia - the disease is characterized by an increased level of plant styrenes in the blood with a normalized cholesterol level. The drug in small dosages copes well with the treatment, so the introduction of additional drugs is not required.

When choosing a drug for treatment, contraindications must also be taken into account.

You can not take pills to the following categories of citizens:

• Moderate or severe kidney failure.
• Chronic liver disease.
• Patients taking Cyclosporine on a regular basis. The substances are incompatible with each other.
• Diseases of the kidneys and liver, expressed in acute form.
• A persistent increase in the level of hepatic transaminases.

The use of the drug in the presence of the above situations can lead to both the appearance of severe side effects and a general deterioration in a person's condition.

The testing of the drug on animals during pregnancy should be noted separately. When ezetimibe was administered orally to rabbits and rats, the occurrence of defects in the development of the skeleton in the fetus was noted.

According to the study, the active ingredient enters the mother's body, is absorbed into the bloodstream and passes through the placenta. When it gets to a child, it has a destructive effect on the developing organism, destroying cells. At the same time, many doctors still do not note the danger of the drug for a growing fetus.

It is important to note that the safety of using ezetimibe in tandem with fibrates has not been identified. Therefore, many doctors do not risk combining these 2 potent drugs with each other.

Method of administration and dosage

Before starting to take the drug, doctors insist on the introduction of a lipid-lowering diet, which is based on reducing fat intake and increasing the amount of food high in protein, as well as complex carbohydrates.

An unlimited amount is introduced into the human diet:

• Fish.
• Chicken meat.
• Vegetables.
• Fruits.
• All varieties of cereals.
• Game.

It is necessary to follow a diet during the entire course of treatment to maintain the high efficacy of the drug ezetimibe.

Ezetimibe tablets are taken orally with a small amount of warm water for better absorption in the intestines. The recommended dose is 1 tablet once a day. The dosage is not affected by the use of the drug in combination with other drugs, such as statin or fenofibrate.

It should be noted that the preparation of an individual program for the use of the drug for the elderly, patients with mild hepatic or renal failure is not necessary. In some cases, the doctor may increase the consumption of the drug up to 2 times a day, 10 mg each, if the level of cholesterol in the blood is at critical levels.

It is important to know that when taking the drug, side effects may occur, which are the norm, if not expressed in a vivid form.

With monotherapy, it is possible:

• Persistent migraines.
• Disturbance in the work of blood vessels.
• Lack of appetite.
• Disturbance in the respiratory system.
• Violation of the chest.
• Diarrhea.

During the use of the drug in clinical practice, the following side effects and complications were recorded:

• Nausea.
• Skin rash all over the body.
• Descending angioedema.
• Hepatitis.
• Pancreatitis

  

When using the drug with a statin, it was noted:

• Constipation.
• Stomach ache.
• Fast fatiguability.
• Constant tiredness.

When taking the drug with fenofibrate:

• Abdominal pain.
• Disruption of the stomach.
• Back pain, muscle fatigue.

The drug should be taken with caution in children under the age of 18, since laboratory studies have not been carried out.

If the drug is prescribed with a statin, you should first carefully read the recommendations for use.

Information confirmed by doctors is presented below:

Affected area of ​​the body	Explanation
Liver enzymes	In clinical laboratories, when some volunteers were prescribed Ezetimibe and Stanin, a 3-fold increase in the level of liver enzymes was observed at the same time. Therefore, if drugs are prescribed for oral administration together, it is necessary to register liver function even before starting treatment. If the level of AST or ALT in the liver begins to exceed the norm by 3 times, one of the drugs should be abandoned.
Rhabdomyolysis and myopathy	The use of potent drugs within acceptable values ​​did not lead to complications. The risk of toxicity to the skeleton and muscle muscles occurs in 3 cases: exceeding the norm of the bed, the patient's age from 65 years, as well as serious disorders in the renal system. When the first signs of myopathy, rhabdomyolysis appear in a person undergoing treatment, treatment must be suspended. Instead, drugs with a different active ingredient are selected.

It is highly recommended that you follow the dosage prescribed by your doctor. Several cases of drug abuse are known. People have experienced vomiting, persistent nausea, and skin redness.

Ezetimibe was administered to 10 volunteers at a dose of 50 mg per day. The study lasted for 2 weeks. After the experiment, side effects were not recorded. There were no complications either.

Some analogues

The price of the drug Ezetimibe 10 mg is one of the highest on the market, so it would be a wise decision to consider analogues of the medicinal product that are presented by pharmacological companies.

Among them:

• Otrio - the drug is distributed in pharmacy services. Sold in packs of 30, 60 or 90. tablets. Not suitable for people with lactose intolerance, as it contains substances of this class.
• Lipobon - has a mild effect, which largely helps to reduce the possibility of side effects. It is actively used with stannin, like ezetimibe.
• Ezetimibe-C3 - the analog can be used to lower cholesterol levels in children, since its effect on the body has been studied using controlled clinical studies.

Analogs of the drug contain the same active ingredient - ezetimibe.

Despite the price, Ezetimibe 10 mg is an effective and potent drug that has a beneficial effect on the body. It not only normalizes the total level of cholesterol in the blood plasma, but also helps to remove toxins and toxins from the intestines.

But, it is worth considering the high risk of side effects. Therefore, the drug is produced only by prescription and can only be used under the supervision of a specialist.

Video about the drug Ezetimibe

Possibilities of clinical use of ezetimibe: