Tobradex eye drops. Reviews, instructions for use, analogues, price

Drops Tobradex - it is an effective drug local spectrum of action, which is used to treat eye diseases with signs of an inflammatory process.

This drug is distinguished by a complex chemical composition, the action of which is aimed at suppressing the bacterial microflora parasitizing on the surface of the mucous membrane of the organ of vision. Most of the reviews of patients using Tobradex for therapeutic purposes are positive.

Indications for use

Eye drops Tobradex is a combined drug that can be used as an independent drug, or is included in complex therapy.

This medication is indicated for use in patients who are diagnosed with

the following types of diseases and pathological conditions of the body:

• keratitis without signs of damage to the epithelial layer;
• blepharitis of an infectious nature of origin;
• conjunctivitis caused by bacterial microorganisms (the constituent components of this drug are not effective against viral microorganisms);
• an urgent need for preventive treatment of postoperative complications associated with infection of the eyeball.

Drops for eyes Tobradex, reviews of which are mostly positive, can be included in the complex therapy of patients suffering from ophthalmic diseases of other types.

In this case, the ophthalmologist independently determines the appropriateness of using this medication in the treatment of one or another eye pathology, which has an infectious nature of origin. A prerequisite for successful therapy is the use of drops against microorganisms that are sensitive to the antibacterial components of the drug.

Compound

Ophthalmic drug Tobradex is a drop with a complex chemical composition that contains several active substances. The table below shows the main components of this product, as well as their therapeutic dosage.

Compound	Dosage and characteristics of the active substance
Dexamethasone	Dexamethasone is a chemical component from the pharmacological group of glucocorticosteroids, the dosage of which is 1 mg in 1 ml of eye drops. This substance acts as a potent anti-inflammatory agent. In relation to patients with signs of inflammation of the mucous membrane of the eyes, which is caused by an acute allergic reaction, dexamethasone has a pronounced antiallergic effect. Like most other glucocorticosteroids, dexamethasone requires strict adherence to the dosing regimen. Otherwise, the risk of side effects increases.
Tobramycin	Tobramycin is a broad-spectrum antibacterial substance that belongs to the pharmacological group of aminoglycosides. The mass fraction of this substance is 3 mg in 1 ml of eye drops. The main antibacterial effect of Tobradex is due to the effect of this antimicrobial component.

Tobradex - eye drops (reviews of this medication are 97% positive), which contain the following substances, performing an auxiliary function:

• benzalkonium chloride;
• sodium hydroxide;
• anhydrous sodium sulfate;
• low concentration sulfuric acid, which maintains the stability of the pH balance;
• hydroxyethyl cellulose;
• sterile water that has undergone preliminary chemical treatment;
• disodium edetate;
• tyloxapol.

All constituent components of Tobradex eye drops are completely safe for the sensitive mucous membrane of the eyeball. The active and auxiliary substances of this drug do not have a toxic effect, do not have carcinogenic and mutagenic properties.

In what form is it produced

The drug Tobradex is available in the form of a drop solution, which is used exclusively in ophthalmology. Visually, this medication looks like a white suspension. The filling of the medicinal product is carried out in plastic dropper bottles of the Drop Tainer type with a capacity of 5 ml.

The main packaging of the drug is a cardboard box, complete with detailed instructions for the use of this drug. The average cost of 1 bottle of Tobradex eye drops ranges from 372 to 419 rubles.

Pharmacodynamics

Tobradex - eye drops (reviews of this drug indicate its high therapeutic efficacy), pharmacodynamics which is due to the simultaneous action of an antibacterial agent in the form of tobramycin and a glucocorticosteroid dexamethasone.

After applying the drug to the surface of the mucous membrane of the organ of vision, ophthalmic the solution is evenly distributed over the entire eyeball, the antimicrobial effect is activated tobramycin. This component exhibits therapeutic efficacy against most gram-positive and gram-negative microorganisms.

A distinctive feature of the pharmacodynamics of the drug Tobradex is that its antibacterial the component completely destroys the following types of pathogenic microflora:

• Staphylococcus aureus;
• strains of staphylococcus that cause various kinds of dermatological diseases (for example, simultaneous inflammation the mucous membrane of the eye with the spread of the pathological process to the skin of the eyelids, tissues located in the circumference of the organ vision);
• staphylococcal infection, representatives of which belong to the beta-hemolytic species of group A;
• non-hemolytic species of staphylococcus, including those that have natural immunity to antibacterial drugs based on penicillin;
• Escherichia koli;
• Proteus;
• klibsiella;
• haemophilus influenzae.

The above microorganisms are highly sensitive to the antibacterial component tobramycin. The pharmacodynamic properties of this substance appear immediately after its application to the mucous membrane and tissues of the eyeball.

The pharmacodynamics of dexamethasone is manifested by the development of the following therapeutic effects:

• pronounced anti-inflammatory effect;
• removal of signs of an acute allergic reaction, when an infectious lesion of the mucous membrane of the eyes is simultaneously exposed to allergens;
• anti-edema action;
• elimination of signs of lacrimation.

In combination with the antibacterial effect of tobramycin, the active substance dexamethasone accelerates the process of mucosal recovery membranes and tissues of the eyeball, which for a long period of time have been under the influence of acute or chronic inflammation.

Pharmacokinetics

Pharmacokinetics of the drug Tobradex is characterized by extremely low absorption of its active and auxiliary components. A distinctive feature of this medication is that its constituent substances do not saturate the general blood flow and do not penetrate into the lymphatic fluid.

Tobradex eye drops have an exclusively local effect. In this regard, the metabolic breakdown of active substances in the form of tobramycin and dexamethasone does not occur in the patient's liver tissues. This is especially important for people who have concomitant liver and kidney disease.

Application

Tobradex - eye drops (reviews of this medication are positive from ophthalmologists and patients), which are used to treat patients of the adult age group.

For children under 18

The drug Tobradex can be used to treat patients who have reached the age of 12 years. The dosage regimen for children is 1-2 drops, which are introduced into the sore eye in compliance with the time interval from 4 to 6 hours. More frequent use of this medication is not recommended, since the child's body is more sensitive to the properties of the glucocorticosteroid dexamethasone.

For adults

Patients of the adult age group use Tobradex during a continuous therapeutic course. In the presence of acute inflammation of the mucous membrane and tissues of the eyeball, which has a bacterial nature of origin, in the first 1-2 days the drug is prescribed 1-2 drops every 2 hours.

Ophthalmic solution is introduced directly into the conjunctival sac of the diseased eye. On the 3rd day, as the signs of the pathological process decrease, it is possible to reduce the daily dosage to 1-2 drops, which are buried every 4-6 hours. The total duration of the therapeutic course is determined by the attending physician, depending on the type and severity of the disease.

For pregnant

The manufacturer of drops Tobradex focuses on what is currently missing clinically confirmed data on the effect of the constituent components of the drug on the body of pregnant women women.

The use of this medication is possible only if the potential benefit is higher than the risk of side effects. Tobradex eye drops are strictly prohibited for women who are breastfeeding.

For the elderly

Elderly patients are treated with Tobradex under similar conditions and with the same dosage regimen as all other adults. The limitation to the use of this remedy is the presence of medical contraindications.

Contraindications

Tobradex - eye drops (reviews of this drug confirm its excellent antibacterial properties), which have a number of restrictions on their use for therapeutic purposes.

This medication is contraindicated for use in the following cases:

• damage to the conjunctiva and cornea of ​​the eye by viral microorganisms;
• complications of chickenpox, which provoked an inflammatory process in the structure of the eyeball;
• keratitis caused by the herpes virus;
• all types of fungal diseases of the organ of vision (in this case, the use of Tobradex drops will not bring a positive effect, but will only lead to an aggravation of pathological processes);
• post-traumatic conditions resulting from the removal of a foreign body from the cornea.

Tobradex eye drops are prohibited for use by patients who have individual sensitivity to the constituent components of this drug. Failure to comply with the above contraindications entails the development of side effects.

Overdose

Patients who violate the dosage regimen of Tobradex drops are at risk of encountering with the manifestation of the following symptoms of an overdose with this medication:

• severe itching of the eyes, as well as epithelial tissues located in the circumference of the organ of vision;
• inflammation of the mucous membrane of the eyeball;
• severe swelling and swelling of the eyelids;
• incessant lacrimation;
• hyperemia of the conjunctiva of the eye;
• redness of the mucous membrane of the organ of vision.

If such symptoms appear, it is necessary to immediately stop further therapy with Tobradex drops. Then you should rinse your eyes using clean warm water. After that, the patient should be examined by an ophthalmologist. Depending on the general condition of the organ of vision, the patient is shown symptomatic therapy.

Side effects

The local action of Tobradex eye drops does not reduce the likelihood of developing negative reactions of the body.

In this case, the following side effects may appear, which are caused by the influence of tobramycin and dexamethasone:

• redness of the conjunctival sac;
• severe swelling of the lower and upper eyelids;
• itching of the mucous membrane of the eyes;
• increased intraocular pressure;
• a slower process of regeneration of damaged eye tissue (the manifestation of this side effect occurs in patients undergoing postoperative rehabilitation);
• the appearance of cataracts, which forms in the posterior subcapsular part of the eyeball;
• decreased functions of local immunity, which leads to the development of a secondary bacterial infection;
• ulceration of the surface of the cornea of ​​the eye, indicating infection of the organ of vision with fungal microorganisms.

In most cases, the appearance of the above side effects of the body is associated with long-term treatment with Tobradex drops. The occurrence of such symptoms is the basis for the termination of further therapy with this drug.

Special recommendations

In the course of simultaneous therapy with Tobradex eye drops and antibacterial agents from the aminoglycoside group, it is necessary to constantly monitor the parameters of peripheral blood. In this case, a change in its cellular composition may occur, which negatively affects the general well-being of the patient.

Treatment of the organ of vision with other ophthalmic drugs should be carried out with the obligatory observance of the time interval, which is at least 5 minutes.

For example, after the introduction of Tobradex drops, eye treatment with medicines with a different chemical composition can be carried out after a specified period of time. It is possible that earlier use of other ophthalmic agents will cause negative drug interactions.

During the introduction of drops of Tobradex on the surface of the mucous membrane of the organ of vision, do not touch the tip of the pipette to the eye. After each use of the drug, it is necessary to tightly close the bottle with the medicine in order to exclude its prolonged contact with air.

Otherwise, due to oxidative processes, the chemical composition of the drug may change, its therapeutic properties may deteriorate. Before each use of Tobradex eye drops, it is recommended to thoroughly shake the bottle so that the drug is not separated into fractions.

Drug interactions

Due to the low absorption of active components, Tobradex eye drops are well combined with the simultaneous administration of most drugs of various pharmaco-therapeutic groups. The only exception applies to antibacterial agents from the aminoglycoside category.

In combination with Tobradex drops, antimicrobial medicines of this group increase the likelihood of side effects. In this regard, patients who take these drugs at the same time should control their well-being, and also undergo regular examinations by an ophthalmologist.

Storage conditions and periods

Tobradex eye drops should be stored in a dark and cool place away from children. The bottle with ophthalmic solution must be kept strictly upright at an ambient temperature between +8 and +27 degrees Celsius.

After opening the dropper bottle, its contents should be used within 1 month, or the drug is disposed of in the prescribed manner. The general shelf life of the closed medication is 2 years.

Conditions of dispensing from pharmacies

The ophthalmic drug Tobradex is dispensed on the basis of a doctor's prescription.

Analogs

A small number of drugs for the treatment of bacterial eye diseases are presented on the pharmaceutical market, which are complete analogues of the drug Tobradex.

DexaTobropt

DexaTobropt is an ophthalmic solution produced by the Romanian company Rompharm Company. The active components of this drug are the constituents of the substance tobramycin at a dosage of 3 mg and dexamethasone with a mass fraction of not more than 1 mg in 1 ml of the drug.

DexaTobropt is a white suspension with signs of a flocculent sediment, which quickly disappears after a short shaking of the bottle. This product is available in 5 ml plastic bottles, each of which is equipped with a dropper stopper for more convenient use.

DexaTobropt is intended for topical use. Children with signs of an inflammatory process of the eyes of an infectious nature of origin are instilled with this medication 1-2 drops every 4-6 hours.

The drug is applied directly to the surface of the conjunctival sac. For adults, a similar dosing regimen is established, but the time interval between the next use of eye drops is reduced to 2 hours.

The duration of treatment is determined by an ophthalmologist. It is strictly forbidden to carry out early termination of therapy with DexaTobropt after the first signs of positive dynamics appear. In this case, a relapse of the disease is possible. The average cost of this drug is in the price range from 229 to 304 rubles.

Tobrazon

Tobrazon is an ophthalmic drug manufactured by the Indian pharmaceutical company Kadila Pharmaceuticals. The active components of this agent are the antibiotic tobramycin (produced in the form of sulfate) with a dosage of 3 mg, as well as dexamethasone (based on sodium phosphate) with a concentration of 1 mg.

Tobrazon is indicated for use in the following clinical cases:

• blepharitis;
• prevention of the possible occurrence of infectious processes after an operation on the organ of vision;
• keratitis without signs of damage to the epithelial layer;
• conjunctivitis of a bacterial origin.

Torazon is not effective in the treatment of ophthalmic diseases that are provoked by fungi or viral microorganisms. The dosage regimen with this medication is 1-2 drops, which are introduced into the sore eye every 2 hours, or the time interval is reduced to 6 hours.

The duration of therapy and the dosage regimen can be changed by the doctor depending on the type and severity of the pathology. The average cost of this drug is from 206 to 211 rubles.

Tobradex eye drops are an effective local-spectrum drug that has a large number of positive reviews from patients and specialists in the field ophthalmology. A distinctive feature of this medication is its combined chemical composition.

This drug simultaneously contains a glucocorticosteroid in the form of dexamethasone and the antibacterial substance tobramycin. Tobradex eye drops have a pronounced antimicrobial effect, relieve inflammation, eliminate lacrimation caused by an allergic reaction and the disease-causing activity of pathogenic microorganisms

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