Combilipen tablets. Price, instructions for use, what is it for, analogues, composition, reviews

B vitamins are vital compounds that are involved in all cellular processes. Combilipen drug contains most of the B vitamins needed for health. You can buy tablets at an affordable price in pharmacies.

Forms of release and composition of the drug Combilipen

Kombilipen multivitamin - film-coated tablets. The contour cell contains 15 pcs. white biconvex tablets. The product is packed in cardboard boxes containing 1–4 cells.

Tablet composition:

• Benfotiamine (vitamin B1), 100 mg;
• Cyanocobalamin (vitamin B12), 0.002 mg;
• pyridoxine hydrochloride (vitamin B6), 100 mg.

Additional components:

• povidone K30, added to bind the components;
• thickener - sodium carmelose;
• a filler that improves the sliding properties of the preparation - microcrystalline cellulose;
• calcium stearate to homogenize the drug substance;
• drying and antibacterial substance - talc;
• the binder for all components is Polysorbate 80.

The film coat covering the tablets contains:

• macrogol;
• white food coloring, titanium dioxide;
• film-forming agent for the protection of tablets, povidone K17.

Pharmacological properties

Combilipen tablets (their price is quite affordable) is a multivitamin complex. The active substances contained in the preparation determine its pharmacological properties.

1. Benfotiamine. A substance derived from thiamine, used in diabetic neuropathy, Alzheimer's disease.
2. Pyridoxine hydrochloride. The acidic form of vitamin B6 significantly affects the functioning of the central nervous system, the metabolism of nutrients. Vitamin helps linoleic and other essential fatty acids to be digested and absorbed, and glycogen is released from the liver with the help of vitamin B6. Plays a role in the production of red blood cells. Its deficiency affects the decrease in immunity, the development of atherosclerosis.
3. Cyanocobalamin. This substance is a derivative form of vitamin B12, it is necessary for the proper functioning of vitamin B9. Promotes the synthesis of myelin, the metabolism of folic acid, is one of the components of the process of hematopoiesis, the development and growth of epithelial tissue, promotes the production of red blood cells.

Pharmacodynamics and pharmacokinetics

Combilipen tablets (the price corresponds to the effectiveness of the drug), as a combined drug, contains 3 main components. Each of them plays an important role in the human life support system.

Cyanocobalamin belongs to the group of cobalamins, natural biologically active compounds. The structural basis of the substances is the corrine ring, the atoms of which are linked to the cobalt atoms. The most famous substance from this group is vitamin B12. If, for any reason, a person's absorption of this vitamin is disturbed, then vitamin deficiency develops.

The chemical synthesis of vitamin B12 is complex. For this reason, as a dietary supplement for human consumption, it is produced using genetically modified microorganisms, and only purified final product.

Daily Needs:

• Infants (up to 12 months): 0.5-1.4 mcg / day.
• Children (1-15 years): 1.5-4.0 mcg / day.
• Women: 4.0 mcg / day.
• Pregnant women: 4.5 mcg / day.
• Breastfeeding: 5.5 mcg / day.
• Men 4.0 mcg / day.

The biological half-life of vitamin B 12 is 450-750 days. The vitamin is continuously released into the small intestine with bile acids and then restored in the ileum by intrinsic factor.

Thus, the need is due to quantities that cannot be reabsorbed in the ileum. Most cases of vitamin B 12 deficiency are caused by abnormalities in the formation of intrinsic factors. Healthy adults store 2,000–5,000 mcg of vitamin B12 in the liver.

Benfotiamine:

The second constituent substance of Combilipen is a molecule with its own name S-benzoylthiamine O-monophosphate. Once ingested, it can be converted to thiamine and is thus considered a prodrug for thiamine.

Benfotiamine is a fat-soluble and structurally stable substance. The bioavailability of benfotiamine is about 5 times higher than that of thiamine. The need for thiamine is associated with energy metabolism; in particular, for every 4400 kJ of energy, 0.33 mg of thiamine is required. For adults, the required amount of thiamine is 1.1 to 1.4 mg per day.

Thiamin, a B1 vitamin, is not synthesized by humans and stored in large quantities in the body.

Thiamine is used to treat various genetic disorders associated with metabolism, thiamine deficiency syndromes (vitamin deficiency syndrome and Wernicke-Korsakoff syndrome).

Benfotiamine may help restore thiamine levels and prevent the effects in the treatment of certain pathophysiological conditions associated with diabetes, heart failure and metabolic disorders: muscle pain, neuropathic pain, pain in joints.

Free thiamine is absorbed by the body in the proximal small intestine, which severely limits the amount of thiamine absorbed orally. For this reason, alternative forms of the substance, such as vitamin supplements, have been developed that are better absorbed by the body.

Pyridoxine hydrochloride or vitamin B6:

The substance is an acidic form of vitamin B6, soluble in water and slightly soluble in alcohol, it is slowly exposed to sunlight and is quite stable in air. Plays an important role in the metabolism of amino acids.

Vitamin B6 is a general term for three chemically related compounds, pyridoxine, pyridoxal, and pyridoxamine. The vitamin acts as an auxiliary enzyme in the body, essential for the creation and conversion of individual amino acids.

Vitamin B6 supplements are commonly referred to in vitamin formulations as pyridoxine hydrochloride. All B vitamins are absorbed from part of the small intestine. Vitamin B6 is important for the formation of the immune system and antibodies, plays an important role in the metabolism of amino acids. Therefore, the need for it increases in adolescents and during pregnancy.

Blood and nerve cells also need vitamin B6. It improves signal transmission through messenger substances (adrenaline and choline) in the nervous system, stimulates the production of antibodies and supports the formation of red blood cells.

Vitamin B6 deficiency can be caused by high alcohol consumption, unhealthy or one-sided diets such as vegetarian and vegan diets.

The RDA is 1.2 milligrams per day for women and 1.5 milligrams per day for men. The need for it increases with illness, stress and hard work. Vitamin deficiency is rare and occurs only with a lack of other B vitamins.

Deficiency symptoms can include:

• Convulsions of the same type as in epileptic seizures.
• Numbness in the arms and legs.
• Skin changes.
• Microcytic anemia, in which the volume of red blood cells decreases.

Indications for use

The price of a multivitamin preparation is low and is an indicator of the availability of Combilipen tablets for rational use.

Due to the triple effect of the substances contained in it, the drug has an effect on the body:

• relieves symptoms associated with neurological disorders;
• increases the process of hematopoiesis or hematopoiesis;
• normalizes the metabolism of carbohydrates in the body;
• has a tonic effect, stimulating the immune system, reducing the risk of disease;
• improves the synthesis of substances involved in the transmission of nervous excitement, regulates muscle excitability, improves blood circulation;
• affects the contractions of smooth muscles, increasing their tone;
• increases the contractility of the myocardium by restoring metabolic processes in the heart muscle;
• eliminates the imbalance of the immune system, increasing its activity;
• helps to restore blood pressure;
• increases the stability of the body and its tissues in the event of a lack of oxygen in some diseases;
• participates in the processes of lowering the level of bad cholesterol.

According to the instructions, the drug is indicated for use:

• Intercostal, trigeminal neuralgia.
• Osteocondritis of the spine.
• Inflammation of the facial nerve.
• Arthrosis.
• Convulsive information of muscles in case of impaired metabolism or diseases of the nervous system.
• Disorders caused by infringement of the vertebral nerves: lumbago, cervical syndrome, radiculopathy.
• Neuritis of the facial nerve.
• Nerve root lesions.

Contraindications

The drug contains a large percentage of bioactive substances that have increased activity and are able to penetrate the placenta. Therefore, the vitamin supplement is not recommended for use by pregnant women, women during lactation.

It is also not recommended to take the supplement:

• children;
• people with a syndrome caused by decompensated dysfunction of the heart muscle, myocardium;
• patients prone to thrombosis, thromboembolism;
• in case of individual intolerance to the components of the vitamin supplement.

At what age can the drug be used in tablets?

Kombilipen should not be taken by children and adolescents under 18 years of age. The reason lies in the fact that the effects of active ingredients on a young body are not well understood.

Instructions for use, dosage

Despite the fact that the vitamin complex corresponds to the category of supplements, it is not recommended to take it without a doctor's prescription.

Tablets are prescribed 1-3 times / day, 1 pc. after meal. The course, frequency of admission is determined by a medical professional in accordance with the disease. More than 1 month the drug is not used, the usual course is from 1 to 3 weeks. Cases of neuropathy appeared after prolonged (more than six months) use of the drug.

Vitamins are taken after meals, should be washed down with a small amount of water. The tablets are used outside the period of exacerbation of the disease and it is desirable that medical supervision be carried out during the intake.

Side effects

The vitamin agent is well tolerated by the body and has sufficient safety.

But, like any medication, it can cause side reactions in the form of:

• increased sweating;
• acne;
• heart palpitations;
• allergic reactions: Quincke's edema, shortness of breath.

Overdose

Symptoms indicating increased doses are increased allergic reactions. In this case, activated carbon, antiallergic drugs are used. Gastric lavage is done in case of poisoning with large doses of the drug.

special instructions

It is not recommended during the period of taking the vitamin complex to participate in labor processes associated with increased attention, electrical appliances. Driving while taking Kombilipen is undesirable.

The drug is incompatible with drinks containing ethanol.

Drug interactions

Before starting the use of vitamins, you should inform your doctor about the drugs that are being taken at this time.

The active ingredients contained in Kombilipene are incompatible with some drugs:

• Vitamin B12 mutually excludes the use of heavy metal compounds, which are part of many antiseptic disinfectants. And also the vitamin is incompatible with ascorbic acid.
• Levodop, prescribed for Parkinson's disease, neutralizes the effect of Combilipen.
• Benfotiamine should not be mixed with preparations containing sulfites, as it completely decomposes in them. Other B vitamins, in particular cyanocobalamin, can be inactivated.
• Thiamine present in the drug is not combined with: riboflavin, benzylpeniplin, sodium phenobarbital, metabisulfate, dextrose. Under the influence of copper, it quickly breaks down, and also partially or completely loses its properties when the pH in the body exceeds 3 units.
• Cyanocobalamin sharply decreases its absorption under the influence of ethanol.
• The simultaneous use of Kombilipen and multivitamins, which contain B vitamins, should be avoided.

Analogs

Combilipen tablets (the price of similar vitamins varies widely) can be replaced with some pre-drugs. When choosing an analogue, one should take into account what substances are in Kombilipen and its therapeutic effect.

Name	Active substance Release form	Application	Price in rub.
Unigamma Vitagamma Trigamma	Structural multivitamin analogs of Kombilipen containing the same active substances. Available in the form of solutions for intramuscular injection, tablets.	Various types of neuralgia, diabetic or alcoholic neuropathy, facial nerve cuts, polyneuritis, neuritis.	150
80
117
Milgamma compositum	A complex of neurotropic vitamins of group B. Active substances of the solution: thiamine hydrochloride, pyridoxine, cyanocobalamin, lidocaine, active substances contained in the pills: banfotiamine, pyridoxine.	Various types of neuritis, neuralgia, ganglionitis, facial nerve paresis, alcoholic, diabetic polyneuropathy, spinal osteochondrosis of neurological properties.	268
Pentovit	A complex containing vitamins of group B, PP	It is used as a prophylactic agent for a lack of B vitamins, in the treatment of asthenia, sciatica, neuralgia, neuritis.	150
Neuromultivitis,	Contains vitamins B1, B6, B12, available in the form of tablets.	Stimulates the metabolism of the nervous system, regeneration of nervous tissue, has a slight analgesic effect. It is used in complex treatment for various types of polyneuropathies, plexitis, neuralgia, degenerative diseases of the spine.	237
Neurobion	Contains Pyridoxine + Thiamine + Cyanocobalamin, available in tablets.	It is used for various types of neuralgia, reduces pain syndromes caused by diseases of the spine.	369

Combilipen is produced by a domestic manufacturer, so its price is acceptable for the consumer.

Terms, conditions of sale and storage

The drug is stored for 2 years, at a temperature not higher than + 25˚С, out of the reach of children. Pharmacies are dispensed with a prescription.

Price in pharmacies in Moscow, St. Petersburg, regions

Kombilipen in tablets (the price varies slightly by region), like its counterparts, can be purchased not only in central, but also in all regional pharmacy chains.

• Moscow: 30 tab. cost from 235 to 400 rubles, the price is 60 tab. - from 400 to 765 rubles.
• St. Petersburg: price 30 tab. 250 rubles, 60 tablets cost from 450 to 570 rubles.
• Chita: price 30 tab. 259 rub., For 60 pcs. you will have to pay 423 rubles.
• Tyumen: 30 pcs. tab. cost from 210 to 426 rubles, 60 tab. - from 360 to 642 rubles.
• Voronezh: the price of a package of 30 tab. from 228 to 400 rubles, packaging of 60 tab. - from 400 to 610 rubles.
• Vladimir: 30 tab. - from 220 to 450 rubles, 60 tab. - from 400 to 690 rubles.
• Kaliningrad: 30 tab. cost 232-475 rubles., 60 tab. - from 425 to 635 rubles.
• Ulan-Ude: cost 30 tab. from 259 to 423 rubles.
• Chelyabinsk: 30 tab. - from 217 to 580 rubles, 60 tab. cost from 368 to 710 rubles.
• Arkhangelsk: 30 tab. cost from 233 to 400 rubles., 60 tab. - from 419 to 435 rubles.
• Nizhny Novgorod: cost 30 tab. ranges from 229 to 411 rubles. for 60 tab. you need to pay from 410 to 792 rubles.

A wide range of prices depends on the pharmacy chains; the larger the chain, the lower the price, and vice versa.

On the pharmaceutical market, you can find a sufficient number of similar drugs, the price of which may be lower or higher. But not every vitamin complex can replace Kombilipen tablets, because it belongs to categories of products containing B vitamins necessary for the body in the treatment of neurological diseases.

Video about the drug Combilipen

Instructions for use of Kombilipen: