Zodac (Zodac) tablets for allergies. Instructions for use for children, adults, analogues, price, reviews

Zodak is a medicine produced by Zentiva and prescribed by doctors for allergies. The manufacturer puts in the packaging detailed instructions for the use of the tablets.

What is included, features of sale

The drug on sale comes in several dosage forms, including tablets for oral administration. They are white, oval in shape. The tablets are thin-coated and have a risk of being split in half. There can be 10 or 30 of them in 1 package.

Therapeutic action from the medication is explained by cetirizine, of which 1 tablet contains 10 mg.

In addition to it, the following inactive components are a part of the tablets:

• titanium white;
• maize starch;
• simethicone emulsion;
• polyvinylpyrrolidone;
• milk sugar;
• E 553b;
• E 572;
• E 464;
• PEG 6000.

  

The price of Zodak tablets in rubles is as follows:

City	Zodak 10 mg No. 10	Zodak 10 mg No. 30
Moscow	160	277
St. Petersburg	170	287
Ufa	159	287
Kazan	162	291
Nizhny Novgorod	161	279
Ekaterinburg	165	278
Rostov-on-Don	152	294

Mechanism of action

Zodak (tablets for allergies) belongs to the group of antiallergic medicines. It suppresses H1-histamine receptors, has almost no anticholinergic and antiserotonin effects.

It has a pronounced anti-allergic and anti-exudative effect, relieves itching, prevents the appearance of allergies and relieves its severity. Zodak acts on the initial stage of an allergic reaction, reduces the movement of cells that cause the inflammatory process.

The medication suppresses the formation of mediators that cause a late allergic reaction. It reduces the permeability of small blood vessels, prevents the appearance of tissue edema, and relieves spasms of smooth muscle fibers. The medication stops the skin reaction to cold (with cold urticaria) and to the ingress of histamine and specific allergens into the body.

If Zodak is taken in the dosages indicated in the instructions, then it does not have a sedative effect. After a course of therapy, tolerance does not arise. After oral administration, half of the patients develop the effect of the medication after 20 minutes, and after 1 hour in 95% of patients. The effect of the drug lasts a day.

After using the drug, it is well absorbed from the digestive tract, but does not migrate through the BBB. The highest drug content is reached after 0.5-1 hour. Food intake slightly slows down the rate of absorption of the drug, but does not affect its value.

Up to 93% of the dose taken binds to blood proteins. The drug does not accumulate in the body. Up to 70% of the consumed dose is excreted in the urine. The half-life of Zodak in patients over 12 years old is approximately 10 hours, and in children 2-12 years old, it is reduced to 5-6 hours.

With renal dysfunction, when the glomerular filtration rate varies from 11 to 31 ml per minute. and in people who are on hemodialysis with a renal blood flow rate of less than 7 ml per minute. the half-life is increased by 3 times, and the clearance is reduced by 70%.

In persons of the older age group and patients with chronic pathologies, the half-life increases by 50% and excretion decreases by 40%.

After completion of therapy, the effect of cetirizine persists for 3 days.

Features of appointment

The drug is recommended for the following pathologies:

• angioedema;
• dermatoses of allergic genesis, accompanied by itching;
• nettle fever, including chronic fever, which has arisen for unknown reasons;
• runny nose and inflammation of the conjunctiva of allergic etiology;
• hay fever.

The medicine can be taken by patients over 6 years old.

Contraindications

Zodak (allergy pills are contraindicated for women in position and breastfeeding) does not cause malformations, does not possess embryonic and neonatal toxicity, however, existing clinical practice confirming this fact not enough.

In experiments on animals, it was not revealed that the antihistamine has any undesirable effects. for the developing fetus, as well as for the offspring in the extrauterine period, throughout pregnancy and during childbirth.

But there have been no controlled clinical trials in pregnant patients, so Zodak cannot be used by women who are carrying a child. No negative effects of the antihistamine on fertility were found. Depending on the time of taking the medication, up to 25-90% of the dose taken is excreted in breast milk.

The medication is prohibited if the patient has the following health problems:

• allergy to the composition of the tablets;
• severe renal dysfunction when the renal blood flow rate is less than 10 ml / min;
• hypolactasia;
• problems with the absorption of dextrose and galactose;
• galactosemia.

Zodak should be taken with caution for allergies in the elderly, as well as with liver and kidney dysfunction.

The pills can cause the following health problems:

• decrease in the number of platelets;
• cephalalgia, migraine, drowsiness, dizziness, fatigue;
• violation of sensitivity;
• convulsions, movement disorder;
• memory problems, incl. her loss;
• increased heart rate;
• dry mouth, upset stomach, pain in the abdominal cavity, nausea;
• increased appetite;
• swelling of the limbs;
• excitation;
• weight gain;
• violation of urination, incontinence or urinary retention;
• thoughts of suicide;
• aggressiveness, impaired consciousness, sleep problems, depression, hallucination;
• inflammation of the pharynx, runny nose;
• trembling of the pupils, blurred vision, disorder of accommodation;
• increased activity of liver enzymes;
• malaise, impotence;
• violation of taste;
• trembling of body parts;
• tic, loss of consciousness, dystonia;
• allergy, which is manifested by anaphylaxis, rashes, itching, urticaria, Quincke's edema, persistent erythema, when it appears, taking the pills should be stopped and seek medical help.

The instructions for Zodak are not indicated, but preparations containing cetirizine can cause the following side effects:

• anxiety, nervousness, problems concentrating, thinking disorder, difficulty falling asleep, euphoria, dysphonia, paralysis, depersonalization, ataxia, spinal cord inflammation;
• drooping of the eyelids, eye pain, high intraocular pressure, bleeding in the eyes;
• ototoxicity, ringing in the ears, hearing loss;
• problems with smelling;
• bloating, refusal to eat, stomatitis, an increase in the amount of saliva, swelling of the tongue and discoloration, thirst, inflammation of the mucous membrane stomach, stool retention, vomiting, blood in the stool, bleeding from the anus, hemorrhoids, liver dysfunction, increased cariousness;
• palpitations, increased blood pressure, heart failure;
• runny nose, polyps in the nose, nosebleeds, pharyngitis, cough, narrowing of the lumen of the bronchi, shortness of breath, inflammation of the bronchi, lungs or sinuses, hyperventilation, increased phlegm, upper respiratory tract infections;
• increased daily urine output, the appearance of blood in the urine, urinary tract infections, inflammation of the bladder;
• weakening of sexual desire;
• dehydration;
• painful menstruation, uterine bleeding, colpitis;
• joint and muscle pain, joint inflammation, arthrosis, muscle weakness, back pain;
• dry skin, acne, furunculosis, hair loss, hair growth, photosensitivity, increased sweat, seborrhea, thickening of the stratum corneum of the epidermis, eczema, dermatitis;
• diabetes;
• fever, chills;
• swollen lymph nodes;
• pain in the mammary glands;
• hot flashes.

If you experience any undesirable reactions, you should consult your doctor.

Overdose symptoms

Zodak (tablets for allergies) in cases of exceeding therapeutic doses may become the cause of an overdose, which is manifested by the following symptoms:

• violation of consciousness;
• weakness;
• dizziness;
• increased heart rate;
• headaches;
• loose stools;
• anxiety;
• retention of urination and stool;
• trembling limbs or other parts of the body;
• dilated pupils;
• dry mouth;
• itching;
• stunnedness;
• aggressiveness;
• drowsiness;
• causeless fatigue;
• impotence;
• fast fatiguability;
• lethargy.

In case of poisoning with Zodak, the victim needs to rinse the stomach if he is conscious. Inducing vomiting at home is not recommended for young children and women in position. To reduce the harm from antiallergic agent, you can drink activated charcoal.

The antidote for poisoning with Zodak is unknown, therefore, the victim is prescribed drugs that stop the signs of overdose and support the function of vital organs. Hemodialysis with drug intoxication is ineffective.

Admission rules

You need to take Zodak regardless of food, drinking the medicine with a small amount of liquid.

The regimen depends on the age of the person:

Number of complete years	Dosing schedule
6—12	1 tablet 1 time per day or 0.5 tab. 2 times a day (morning and night).
From 12	1 tablet once a day.

In case of renal dysfunction, the dosage of the medication should be reduced depending on the rate of renal blood flow:

Glomerular filtration rate	Dosing schedule
30-49 ml / min	Drink the medicine 0.5 tablets once a day.
10-29 ml / min	Take the medication ½ tablet every 2 days.

You also need to reduce the dosage in the elderly, depending on the glomerular filtration rate.

It depends on the serum creatinine concentration and is calculated for men using the following formula:

CC (ml / min) = [140 - age in years] x weight in kg / 72 x CC serum (mg / dl).

For women, QC is calculated using the same formula, multiplying the result by 0.85.

For liver dysfunction, the antihistamine is taken as usual.

If you miss a medication, you need to drink the next dosage as soon as possible. When it is time to take the next dosage, it must be drunk on schedule, the dosage cannot be increased.

special instructions

During therapy, the following should be considered:

• While taking Zodak, it is undesirable to prescribe medications that have a depressing effect on the central nervous system.
• If you take more than 10 mg of an antihistamine per day, then it can slow down the speed of the psychomotor reaction.
• During the period of treatment with an antihistamine, it is not recommended to drink alcohol and drugs containing ethanol in order to avoid depression of the central nervous system.
• During therapy, one should refrain from driving a car and working with potentially dangerous mechanisms that require a quick reaction rate.

Compatibility with drugs

The annotation to the drug says that there was no clinically significant interaction of the antiallergic agent with other medicines. But there is evidence that myelotoxic drugs increase the manifestations of hemotoxicity from cetirizine.

When taken in combination with theophylline in a daily dosage of 400 mg, the total clearance of the antiallergic agent decreases, while the pharmacokinetics of theophylline does not change.

Storage rules

Zodak (allergy tablets) should be kept in a dry place where children cannot reach them. It can be stored for 36 months from the date of issue. The storage temperature can vary from +10 to +25 degrees.

Substitutes

The following complete analogues of Zodak are on sale, which contain cetirizine as an active ingredient:

• Zintzet. Price 10 tab. is 114 rubles.
• Zyrtec. This is the original drug containing cetirizine. 1 package can contain 7 tab. (price 215 rubles) or 20 tab. (403 rubles).
• Cetirizine. The drug is produced by several companies, so its cost may vary, it starts from 58 rubles.
• Cetrin. This is an Indian medication that comes in several dosage forms, including tablets. 1 package contains 20 tablets, the price of which is 164 rubles.

In addition, there are Zodak substitutes for the pharmacological group on sale:

• Zodak Express. The drug is produced by Zentiva, which are commercially available in tablets. They contain levocetirizine dihydrochloride as an active ingredient. There are 5 mg of it in each tablet. Levocetirizine has 2 times more affinity for histamine than cetirizine. Price 7 tab. is 279 rubles, and the cost is 28 tab. - 509 rubles.
• Suprastinex. The drug contains levocetirizine as an active ingredient. 1 package contains 7 tablets, the price of which is 254 rubles.
• Elset. The therapeutic effect of the medication is explained by levocetirizine. 1 package contains 14 tablets, the cost of the drug is 220 rubles.
• Allerway. The medication contains levocetirizine as the main component. The cost of 10 tablets of the drug is 247 rubles.
• Ksizal. This is an original medication that contains levocetirizine as its main component. 1 package may contain 7 tablets (price 530 rubles) and 10 tablets (their cost is 671 rubles).
• Erius. The therapeutic effect of the medication is due to desloratadine. The price of 10 tablets is 484 rubles.
• Delorsin. As the main substance, the medication contains desloratadine. The cost of 30 tablets is 273 rubles.
• Blogir-3. The therapeutic effect of the drug is due to desloratadine. On sale, the medicine is in lozenges. 1 package can contain 10 tablets (they cost 211 rubles) or 30 tablets (their price is 316 rubles).
• Suprastin. It contains chloropyramine as the main component. One form of release is tablets. 1 package may contain 10 tablets (price 138 rubles) or 20 tablets (cost 241 rubles).
• Clarisens. This is a domestic antiallergic agent, the therapeutic effect of it is explained by loratadine. The price of 10 tablets of the drug is 75 rubles, and the cost of 30 tablets of the drug is 145 rubles.
• Claridol. This is an Indian drug that contains loratadine as its main component. The cost of 10 tablets is 178 rubles.
• Lomilan. The therapeutic effect of the drug is due to loratadine. The price of 7 tablets of the drug is 132 rubles, the cost of 10 tablets of the drug is 149 rubles.
• Lorahexal. It contains loratadine as the main substance of the drug. The price of 10 tablets is 51 rubles.

Despite the fact that Zodak tablets are dispensed without a prescription, self-medication with them is prohibited, since they have contraindications and can provoke a number of undesirable reactions. Therefore, in case of allergies, the drug is prescribed by a doctor in dosages depending on the severity of the manifestations of the disease.

Video about the drug Zodak

Instructions for the drug Zodak: