No-spa (No-Spa) in ampoules. Price, instructions for use, where to buy, dosage, reviews

Considered the most popular a remedy from the group of antispasmodics, which is available in ampoules for parenteral use, is No-shpa.

The price of the medication is affordable, and the reviews on its use are mostly positive, which proves the effectiveness and relative safety. Despite this, the drug should be used only as directed by a doctor and after identifying the cause of the violation.

Selling features

The drug in ampoules is a clear yellow solution that does not have sediment or impurities. The solution is packaged in 2 ml dark glass ampoules, which are placed in contour cells, 5 pieces each. An individual cardboard box can contain 10 ampoules, as well as instructions that describe in detail the features of using the medicinal solution.

You can buy a medication in pharmacies in different regions with a prescription from a doctor. Only tablets can be bought in pharmacies without a doctor's prescription. The cost of the medication starts at 120 rubles. per packing.

Composition and active ingredients

No-spa in ampoules (the price of the product is quite affordable) contains drotaverin as the main active ingredient that has a therapeutic effect. It is due to this ingredient that the antispasmodic effect is carried out.

The solution also contains auxiliary components that do not have therapeutic properties, but are necessary to preserve the chemical formula. Among such substances are ethanol, water for injection and sodium metabisulfite.

The tablets also contain drotaverine as the main active substance and auxiliary ingredients that do not have therapeutic properties.

Mechanism of action

The principle of action of the drug is based on the ability of the drug to reduce the activity of muscle fibers of internal organs. As a result, they relax and the spasm is eliminated, which provokes acute manifestations in various diseases.

Drotaverine affects not only the internal organs in the abdominal cavity, but also the nervous system, as well as the heart and coronary vessels. As a result, spasms are eliminated not only of muscle origin, but also neurogenic, which is considered an advantage of the drug over other antispasmodics.

With spasms against the background of a disorder of the central or autonomic nervous system, a significant improvement in the patient's condition is noted, even in the absence of other medications in therapy. The advantage of the drug is considered to be a positive effect on organs, for pathologies of which it is impossible to use drugs from the group of anticholinergics.

Another advantage of the drug is the lack of effect on the blood pressure of patients. This is especially important for patients who suffer from chronic hypotension, but with hypertension like an advantage is also considered necessary, since a critical decrease in performance can provoke deterioration.

When using tablets, the active ingredient of the composition is quickly and almost completely absorbed in the digestive tract, namely in the small intestine. Its bioavailability reaches 95%, which explains its high efficiency.

During the initial passage of the ingredient through the liver, about 65% of the active substance circulates in the blood. The drug does not accumulate in tissues and blood, which is considered an advantage and significantly reduces the risk of complications.

The ability of the drug to penetrate the placental barrier is noted, but its concentration in it is insignificant. Drotaverine is not found in breast milk.

The processing of the active substance is carried out in the liver, where it breaks down into metabolites. The processing and withdrawal period takes up to 2 days. There is a long-term preservation of the therapeutic result if the medicine is compared with other drugs from the group of antispasmodics.

The main amount of the active substance is excreted by the kidneys in a modified form. A small part is evacuated with feces. The withdrawal period may differ in different patients, depending on age, duration of use and dosage, the presence of concomitant abnormalities in the internal organs.

Experts draw the attention of patients to the fact that the agent can be slowly processed and excreted in those who suffer from pathologies of the digestive tract and urinary system.

Despite this, the drug is effective. When using the solution, the state of the digestive tract does not matter, but with liver damage, the effect of the solution is also weakened.

When using the parenteral form, a rapid onset of the therapeutic effect is noted, since it bypasses the digestive organs. However, in severe kidney disease, the evacuation period is slowed down, which can lead to the accumulation of the ingredient in the blood. In this case, the therapeutic effect is not weakened, but the risk of complications increases.

What is No-shpa in injectable form for?

No-spa in ampoules (the price of the product allows it to be used in different cases) is used for patients who, for one reason or another, cannot use pills.

In addition, the solution helps to achieve a therapeutic effect much faster than with oral dosage forms. In case of a critical deterioration of the condition, such a speed is necessary, since it helps to significantly alleviate the course of the pathology.

Indications for use

The drug in the form of a solution can be used for various disorders with the aim of providing short-term or long-term action.

The main indications for prescribing a medication:

• Spasms of smooth muscles of the abdominal organs, provoking discomfort or severe pain.
• Chronic and acute cholecystitis with the formation of calculi or the absence of such complications.
• Pancreatitis in the acute stage, when severe pain significantly worsens the patient's condition. At the same time, the medicine cannot be used as the only method of treatment, since it does not has analgesic properties, but in combination with other drugs has a high efficiency.
• Pathologies of the stomach, small and large intestines, accompanied by severe pain as a result of spasm of smooth muscles.
• Spastic colitis and enteritis of various forms and severity, accompanied by severe pain and disruption of the digestive tract.
• Constipation against the background of spastic disorders of the digestive tract. The remedy is always included in the complex treatment.
• Headache against the background of cerebral vasospasm.
• Painful menstruation in women of different ages. The tool can also be used as part of the complex treatment of menstrual disorders.
• Liver pathologies in acute form, accompanied by spasms of the biliary tract and gallbladder.
• Vomiting of various origins, worsening the patient's condition.

The drug can also be prescribed for pathologies of the urinary system, for example, with damage to the bladder and spasms of the muscle fibers of the organ.

Contraindications and side effects

No-shpa is not prescribed in tablets and in ampoules when an intolerance to the components of the composition and a tendency to such violations are detected. The price of the drug is affordable, so it can be used without prior consultation, which is unsafe for patients.

There are other contraindications:

• Severe hepatic and renal failure, accompanied by a significant violation of the functioning of organs.
• Internal bleeding of severe form, accompanied by a critical decrease in blood pressure and other disorders.
• Low cardiac output syndrome, in which myocardial function is impaired.
• Arterial hypotension of a chronic form, accompanied by a deterioration in the general condition.
• Diseases of internal organs of malignant origin.

With caution, the drug is prescribed for children and pregnant women, it is associated with the presence of a risk of complications. In addition, a preliminary examination and consultation with a doctor is required when patients suffer from chronic pathologies of the cardiovascular system. Usually such disorders are observed in elderly patients.

The drug often provokes negative reactions if the instructions for use are violated. Compliance with all the rules does not guarantee the absence of complications, but it significantly reduces this risk.

Organs and systems	Common complications
Nervous system	Dizziness is considered a common complication when used at higher doses. Patients may also report drowsiness, weakness, and decreased performance. In some cases, there is apathy and depression. Symptoms usually do not worsen, disappear after the end of the course of therapy, but may require special treatment.
Digestive organs	Diarrhea and indigestion is observed with frequent and prolonged use of the drug. The condition is accompanied by abdominal pain, loss of appetite and thirst, dryness of the mucous membranes of the oral cavity.
Vessels and heart	When using the drug, disorders of the heart and blood vessels occur in patients who have chronic diseases of this system. In this case, bradycardia, pain in the region of the heart and deterioration of the myocardium associated with the weakening of muscle fibers are observed.
Skin	Allergy to the drug manifests itself in the form of a rash, itching and burning in the affected area. The severity of negative reactions depends on the individual patient and the dosage of the drug. In addition, scratching the affected areas provokes additional negative reactions that worsen the condition.
Local manifestations in the area of ​​administration	With intramuscular injection of the solution, complications may occur at the injection site. In the area of ​​the injection, induration, redness and pain appear. If untreated, the condition may worsen.

The severity of adverse reactions depends on the duration of use of the solution, general condition and dosage.

In case of an overdose, the disorder mainly affects the heart and blood vessels. Patients develop severe arrhythmias, which can result in cardiac arrest.

Experts note that there is a lethal dosage of a drug, in which no medication helps to eliminate manifestations and prevent death. That is why the medicine is used only for its intended purpose and in the indicated dosage.

With prolonged administration of the solution intramuscularly in the same place, the formation of an abscess, blood poisoning is possible. To prevent such violations, it is worth alternating the areas of introduction, as well as observing all the rules during the manipulation. If an overdose develops, you should immediately stop using the solution.

The patient receives help in a hospital, where he is constantly under the supervision of a doctor. It is imperative to monitor the indicators of body temperature and blood pressure.

How long does the medicine last?

No-spa in ampoules (the price is considered affordable for patients) acts for 5 minutes after parenteral administration, which is considered the main advantage of the drug.

When taking tablets, the therapeutic effect occurs within 20 minutes. In a critical situation, it is preferable to use a solution.

Instructions and dosage

The drug in the form of a solution for injection is administered intravenously or intramuscularly. The duration of therapy is determined individually, depending on the condition. A single dose for an adult is 2-4 ml. Intramuscularly, more than 2 ml is usually not administered. The manipulation is repeated 2-3 times a day, depending on the degree of neglect of the condition.

The average course duration is 7 days. If necessary, immediately eliminate discomfort and other disorders, inject 4 ml of the drug intramuscularly. Intravenous administration is prescribed in most cases, if necessary, to immediately eliminate acute manifestations in calculous cholecystitis and pancreatitis.

In this case, the solution in the amount of 2-4 ml is injected intravenously by jet or drip. In the first case, the solution is mixed with 10 ml of sodium chloride, in the second, it is added to 100-200 ml of sodium chloride and poured using a dropper. The course of therapy lasts from 3 to 10 days. Sometimes prolongation of treatment is required if the effect of the application is absent or weak.

When using a medicine, a specialist usually prescribes other medicines that enhance the effect of the solution. The dosage and duration of use is determined individually.

Application for children

Children's age is not considered a contraindication for prescribing a medicinal solution, but the dosage is determined only by a specialist and only after examination. Adolescents from the age of 14 are prescribed an adult dosage depending on the disease.

Patients from 1 year to 6 years old are prescribed 1 ml of solution per day. Children from 6 to 14 years old are prescribed 2 ml of solution per day. The agent is administered only intramuscularly, very slowly. Intravenous infusion is not recommended due to severe exposure. The duration of treatment for children depends on the specific disease and the presence of concomitant disorders.

Application during pregnancy and lactation

No-spa in ampoules (the price depends on the amount of the product in the package) is not contraindicated during the period of childbearing and breastfeeding. However, the dosage is prescribed with caution and only when indicated. The daily rate during pregnancy does not exceed 4 ml. The solution is injected intramuscularly 2 times a day, dividing the rate by 2 times.

The duration of therapy depends on the condition of the woman. The course can be 2-4 weeks or more. With lactation, it is worth limiting the duration of treatment to 2 weeks, and the daily rate for a woman is 4 ml.

It is not allowed to use the medicine during lactation and pregnancy without a doctor's prescription.

Drug interactions

Do not use the product in combination with other antispasmodics in high doses. It is important to remember that antiparkinsonian drugs become less effective when used simultaneously with a solution.

Do not prescribe a medicine when using a centrally acting muscle relaxant, since the risk of complications increases significantly. When using No-shpy in combination with potent analgesics, adverse reactions may worsen. However, this is considered a reason for canceling such treatment, it only requires the strict supervision of a specialist.

If the patient is taking any medications on an ongoing basis, it is worth consulting a doctor beforehand when the appointment of No-shpy solution is required.

Storage conditions and periods

When storing the solution, it is important to limit access to children, moisture, direct sunlight. Do not store the medicine in the refrigerator.

The maximum shelf life is 3 years. The production date is indicated on the packaging, use after the expiration date is strictly prohibited.

An effective antispasmodic solution in ampoules of 2 ml, No-shpa, has pronounced properties and is used for acute, chronic pathologies of internal organs. The price of the product is affordable, which allows it to be used to treat different patients. It is worth remembering that uncontrolled intake of medication is not allowed without preliminary examination and identification of the cause of the violation.

Video about the drug

Review and recall of No-shpy injections: