Procto-Glyvenol candles. Instructions for use, analogues, reviews, price

Procto-Glivenol - popular rectal suppositories, which are used to treat pathologies of the rectum of inflammatory origin. Instructions for use suggest their appointment in order to alleviate the condition and prevent the progression of the disease. In combination with other medications, suppositories have a good effect.

Forms of release and composition

The medicine is sold in pharmacies in the form of rectal suppositories. They have a standard size and shape, white color. Candles are placed in plastic contour cells, 5 pieces each. The cells are in cardboard boxes. Each box contains 2 suppository plates.

In the composition of the agent there is a tribenoside substance, which has the main therapeutic effect. Its effectiveness is enhanced by the presence of lidocaine in the composition. As an auxiliary ingredient, there is a base for candles in the composition.

The amount of tribenoside in the composition is 400 mg, the dosage of lidocaine per 1 suppository is 40 mg. On pharmacy shelves, you can also find Procto-Glivenol cream, which contains the same ingredients and has similar therapeutic properties.

The cream is packaged in 30 g aluminum tubes. Each dosage form is accompanied by detailed instructions describing the features of therapy and possible complications.

Pharmacological properties

Procto-Glivenol - suppositories (instructions for use assume their use only as directed by a doctor), which have analgesic, anti-inflammatory and anti-hemorrhoidal properties.

The remedy eliminates pain in the affected area due to the presence of lidocaine in the composition, and also helps to prevent its recurrence over a short period of time.

The drug also:

• stimulates tissue repair;
• improves their nutrition;
• helps to eliminate the most pronounced symptoms of hemorrhoids and some other diseases of the rectum.

The complex effect of the agent on the affected area leads to an improvement in the condition and prevents the development of complications.

Pharmacodynamics and pharmacokinetics

After the introduction of the suppository, its dissolution and absorption of active components that have a therapeutic effect begin. Tribenoside in the composition of the drug has a positive effect on the walls of blood vessels, reduces their permeability, which has a beneficial effect on microcirculation and prevents the aggravation of edema and other symptoms.

The substance also helps to eliminate congestion in the veins of the rectum, has a beneficial effect on their condition, prevents varicose veins. The drug normalizes microcirculation in the affected area, stimulates tissue regeneration.

Other properties of the drug are also noted:

• Prevents the formation of blood clots in the veins of the rectum, which has a positive effect on the state of blood vessels and prevents thrombosis. The agent affects the ability of platelets to stick together and form a blood clot.
• A decrease in vascular permeability leads not only to the gradual elimination of edema, but also helps to improve the general condition, since the disappearance of tissue edema leads to a decrease in pain. As a result, a significant improvement is noted after the first use.
• Lidocaine in the composition of the drug has pronounced analgesic properties, which are manifested in the field of application. The remedy does not have a systemic effect, therefore it cannot eliminate concomitant manifestations.
• Due to the slowing down of the conduction of the nerve impulse as a result of exposure to the tissues of lidocaine, the analgesic effect persists for a long time.

After the suppository dissolves in the rectum, the components penetrate into the blood through the mucous membranes. The maximum concentration of ingredients in the blood is found 2 hours after the initial use. The bioavailability of the drug is low, reaching 40%, but this does not weaken the therapeutic effect.

The active component of the composition does not accumulate in the blood, which is also considered an advantage, since the risk of developing an overdose with prolonged use is reduced.

Substances are processed in the liver, where they are broken down into metabolites. Only lidocaine is evacuated mainly in an unprocessed form. The evacuation of ingredients is carried out with the help of the kidneys for 6-10 hours. An insignificant amount of substances is excreted with feces.

With prolonged use, the process of excretion of ingredients may deteriorate, as well as their accumulation in the body is insignificant. If the patient does not use higher doses of the drug, the substances are quickly excreted.

Indications for use

Procto-Glivenol - effective suppositories that are prescribed for varying degrees of pathological condition of the rectum.

The instructions for use assumes their use in the following cases:

• Symptomatic external hemorrhoids. The tool can be used in acute and chronic form, as well as as part of a complex treatment in combination with other drugs.
• The internal form of hemorrhoids, accompanied by acute symptoms.
• Chronic hemorrhoids.
• Anal fissures and rectal irritation.

The drug is usually used as part of a complex treatment, but as the main therapy, the drug is prescribed for a mild form of a pathological condition.

Contraindications

The drug is not prescribed for intolerance to the components of the composition or a tendency to similar manifestations in the patient's history.

There are other absolute contraindications for medication treatment:

• Hepatic failure in severe form, accompanied by severe disorders and worsening of the condition.
• Renal failure, in which the process of removing ingredients from the body worsens.
• Bleeding from the rectum, developing against the background of damage to the hemorrhoids. The drug is rarely used in this case.
• Acute internal bleeding with damage to the mucous membranes of the digestive tract. The use of the drug can provoke complications.
• Trophic changes in the skin in the anal area.
• Rectal prolapse, in which it becomes impossible to administer a suppository and the onset of a therapeutic effect.
• Lactation and pregnancy period. In this case, the use of the medication can provoke complications. Experts draw the attention of patients to the fact that the entire period of gestation is not considered an absolute contraindication, but in the 1st trimester, the drug is categorically contraindicated.
• Children and adolescents. Application for the treatment of patients under 18 years of age is usually not required.

For elderly patients, the drug is prescribed with caution, especially if there is a history of cardiovascular pathologies.

Instructions for use, dosage

Procto-Glivenol - suppositories, instructions for use of which require a preliminary examination to determine the optimal therapy regimen depending on the disease.

With thrombosis

When diagnosing venous thrombosis of the rectum, the agent is used with caution and only after examination. Enter 1 piece per day, preferably before bedtime, which will allow you to get the maximum therapeutic effect.

When introduced, it is better to take a position lying on its side with legs bent at the knees. It is preliminarily recommended to empty the intestines, as well as to conduct a toilet of the external genital organs and anus, which will prevent the penetration of pathogenic microorganisms through damaged plots.

It is important to thoroughly wash your hands beforehand, free the candle from the packaging and slightly moisten it with water. The introduction is carried out carefully, trying to move the candle 2-4 cm into the rectum. After that, it is recommended not to take an upright position for 2-3 hours. That is why the introduction is best done before bedtime. Treatment for such a violation lasts 5-10 days, depending on the severity of the manifestations.

With cracks

When cracks are detected, candles are used with extreme caution, as they can lead to an aggravation of the condition. The course of treatment lasts no more than 5 days. Suppositories are administered 1 piece per day.

The route of administration and all precautions do not differ depending on the disease. In the absence of a therapeutic effect, treatment can be extended up to 7 days, but only according to indications. Experts strongly recommend that the suppository be administered only after bowel movement. That is why it is allowed to carry out manipulation at any time of the day, depending on the mode of emptying.

With bleeding hemorrhoids

When diagnosing such a disease, the drug is not used so often, since its effectiveness decreases slightly with constant blood secretion. But often the patient's condition worsens significantly, which is associated with severe pain. Then the patient is prescribed a short course for 3-5 days in order to alleviate the symptoms.

Suppositories are injected at 1-2 pieces per day, depending on the severity of pain. The route of administration and precautions are the same for such a violation as for other diseases.

With bleeding

When diagnosing bleeding, it is important to determine its origin. In the acute period, the drug in any form is not used, since its effectiveness is rather low against the background of rapid leaching of the active components and malabsorption.

After stopping bleeding or reducing the amount of blood secreted to a minimum, it is allowed to enter 1 suppository before bedtime for 7 days. The drug relieves pain, improves microcirculation. Despite this, the treatment is carried out under control. This is due to the drug's ability to slow down the formation of blood clots, which can worsen bleeding.

During pregnancy and hepatitis B

Procto-Glivenol - candles, instructions for use of which are attached to each package, rarely prescribed during pregnancy. In the 1st trimester, they are categorically contraindicated, but in the 2nd and 3rd trimester of gestation, it is allowed to use them after a doctor's prescription.

The route of administration is standard, the daily dosage is 1 suppository. The duration of treatment during gestation usually does not exceed 5 days. During lactation, the use of the medication is not recommended. But if necessary, it is better to refuse feeding during the treatment.

Side effects

The drug often provokes negative reactions if instructions are violated. If all the rules are followed, complications may also develop. In most cases, they affect the mucous membranes and skin in the anal area, but sometimes the appearance of systemic disorders is noted.

Organs and systems	The most common complications
The cardiovascular system	On the side of the vessels and the heart, complications occur quite often, especially in patients who suffer from chronic diseases of this system. The patient may notice a violation of the heart rhythm and tachycardia, some talk about fluctuations in blood pressure indicators. The general condition worsens, pain appears in the region of the heart.
Digestive organs	From the side of the digestive tract, complications do not occur so often. They usually appear in patients who suffer from chronic diseases of the digestive system. Adverse reactions are manifested in the form of nausea, bouts of vomiting and stool disorder. The condition is aggravated by the appearance of pain in the stomach, as well as in the absence of appetite. Such manifestations provoke complications from other internal organs.
Mucous membranes	From the side of the mucous membranes, complications develop quite often, especially in patients who have a tendency to similar manifestations. Disorders are accompanied by tissue swelling, pain and itching. Sometimes the symptoms of the underlying disease are aggravated, which only worsens the condition.
Respiratory system	The respiratory organs are affected by the use of the medicine less often. If the patient's negative reactions from the heart are aggravated, shortness of breath, difficulty in breathing is noted. Such reactions occur against the background of physical exertion or stressful conditions.
Skin	On the part of the skin, itching, burning and flaking is noted, aggravated by irritation. As the condition progresses, the reactions spread not only to the skin in the anal area, but also to other areas of the skin. This leads to a worsening of the condition, and also provokes damage to the outer layer of the skin and increases the risk of infection.

Against the background of negative reactions in the area of ​​exposure to the medication, the appearance of disorders from the nervous system is noted. They are accompanied by irritability, disturbed sleep at night, and depressive disorders. With long-term treatment, such symptoms can provoke severe nervous disorders.

The severity of negative reactions depends on the individual patient and the underlying disease, which is treated with suppositories. If complications appear, you should stop using the medication and visit a doctor.

The patient usually receives help at home, but sometimes long-term treatment in a hospital is required in order to alleviate the condition. In each case, the scheme of application may differ, which depends on the specific symptomatology of the patient.

Overdose

Cases of drug overdose have not been recorded, since it does not accumulate in the body. However, experts warn that you should immediately seek medical help if candles or cream accidentally get inside.

First aid involves immediate gastric lavage and the appointment of special means to prevent complications. The therapy regimen includes enterosorbents and some other medicines to improve the condition. If the patient does not receive timely assistance, the condition may worsen significantly, accompanied by severe headache, repeated vomiting during the day, and impaired coordination.

You cannot ignore the symptoms or self-medicate, as this can provoke complications from other organs.

special instructions

Procto-Glivenol - candles, the instructions for the use of which should be carefully studied before starting the course. During therapy, it is important to strictly follow the rules of personal hygiene, which will prevent the addition of infection.

Do not hold a candle in your hands for a long time without packaging, and also immerse it in water. Light wetting is sufficient to improve dissolution. If the patient is prescribed a cream, but the introduction from the tube is difficult, it is worth using a special nozzle that facilitates the introduction. It should be used with caution, as careless movements can provoke tissue damage.

Many patients note the effectiveness of the remedy, but this is not considered a reason for independent uncontrolled use without preliminary examination. You should not use candles when there is a slight discomfort, as addiction may develop.

Drug interactions

The drug is not used simultaneously with drugs in the same form and similar therapeutic properties.

The drug does not affect the action of systemic medicines, since it does not accumulate in organism, and its active components circulate through the systemic blood flow. Other local medicines in the form of suppositories, gels, ointments are not prescribed in combination with the medicine. If their use is required, it is worth taking a break for at least 2 hours.

Analogs

In the absence of an original drug, it is allowed to use substitutes with similar properties.

The most popular analogs today:

• Proctosedil M - rectal capsules that have antiseptic, anti-inflammatory and antipruritic properties. The product contains benzocaine and hydrocortisone, as well as other components that have anti-edema properties. The drug is considered quite effective, it helps to quickly eliminate the manifestations of hemorrhoids of various forms and severity.
• Relief - a drug in the form of a cream, ointment and rectal suppositories, which are prescribed for hemorrhoids, anal fissures and some other disorders of the rectum. The medication is effective, as evidenced by the reviews of many patients. Despite this, use is only permitted for the intended purpose.
• Proctosan - candles, ointment for external use. The drug has anti-inflammatory, astringent properties, relieves pain at the site of injury, irritation and dryness. The medicine prevents the progression of the disease and various complications. Use the remedy locally, but only according to the prescribed scheme, since self-medication can provoke complications.

Analogs of the remedy contain other active ingredients, but have a similar therapeutic effect. Only a doctor should prescribe a substitute based on examination data.

Terms, conditions of sale and storage

The drug can be stored for 5 years in a dark and cool place, restricting access to children.

Dispensing of medicine in pharmacies is carried out without presentation of a prescription from a doctor. Application after the expiration date is strictly prohibited.

Price

The average cost of a drug in pharmacies is 400 rubles. But it may differ depending on the distribution region.

Procto-Glivenol - effective rectal suppositories, which are actively used to treat hemorrhoids of various forms and degrees of neglect. Instructions for the use of the medication assumes a preliminary examination and identification of the stage of the disease. Otherwise, complications may develop.

Video about the drug

Overview of suppositories Procto-Glivenol: