Lucetam 400/800/1200 tablets. Indications for use, instructions, reviews

Lucetam is a drug used for various cognitive impairments. According to the indications, the drug can be used as a basic therapy for cognitive dysfunctions.

Release form and composition of tablets Lucetam 400, 800, 1200 mg

The drug is produced in Hungary in the form of tablets for oral use. The active ingredient of the drug is piracetam.

Additional composition:

• magnesium stearate;
• water-soluble polymer PVP;
• dibutyl sebacat;
• suspension of ethyl ether of cellulose;
• opadry white.

Tablets are contained in plastic blisters or glass jars packed in cardboard boxes.

Pharmacological properties

The medication belongs to the group of nootropic drugs. The drug acts on the central nervous system in various ways.

Effects:

• improves and transforms neurotransmission in the region of the brain;
• increases the plasticity of the brain;
• helps to restore microcirculation in the brain;
• does not have a vasodilating effect;
• improves and restores blood counts.

When using capsules in patients with cerebral impairment, the agent is able to restore cognitive functions. Positive dynamics can be tracked using an electroencephalogram.

The medicine helps to eliminate cognitive impairments caused by toxic brain damage, electric shock or lack of oxygen. It also reduces the severity of inflammatory processes occurring in the region of the vestibular nerve.

The drug helps to suppress platelet aggregation, increases their plasticity and restores the ability to filter.

Pharmacodynamics and pharmacokinetics

Lucetam (indications for the use of tablets are identical to the recommendations for the use of the solution) has a good absorbing ability and is completely absorbed from the gastrointestinal tract when taken orally. The biological availability of the drug is 100%.

When using a dosage of 2000 mg, the maximum concentration of the active substance is observed after half an hour. In the cerebrospinal fluid, the level of active components is reached after 2-8 hours.

The drug has a cumulative effect and is deposited mainly in the tissues of the cerebral cortex. The active component does not interact with blood plasma proteins.

The drug is not able to penetrate the blood-brain or placental barrier. The active substance does not participate in metabolic processes and does not break down into additional components.

The half-life from the blood is about 4-5 hours, from the cerebrospinal fluid - about 8.5 hours. The drug is excreted from the body mainly by the renal system within 30 hours. The drug excretion rate is approximately 95%. With kidney failure, the elimination half-life increases.

Indications for use

The drug is prescribed as the main or auxiliary means of treatment of dysfunctions in the brain.

Indications:

• intellectual and mnestic disorders not associated with the development of dementia (as symptomatic therapy);
• reduction of clinical manifestations in the presence of cortical myoclonus in patients with high sensitivity to the active ingredient.

The medication is used only in the presence of these disorders under the supervision of a physician.

Contraindications

The medication has some restrictions on admission associated with the action of the active substance in patients with various disorders.

Contraindications:

• Huntington's syndrome;
• stroke (hemorrhagic form of the disorder);
• chronic and severe kidney failure;
• period of bearing a child, lactation;
• intolerance to the active substance.

With extreme caution, pills can be prescribed in the following cases:

• transferred (extensive) surgical operations;
• hemostatic disorders, especially in patients taking anticoagulants and antiplatelet agents, including aspirin;
• severe bleeding;
• chronic kidney failure.

Before using the drug, additional studies are required to confirm the absence of contraindications.

At what age can the drug be used

The drug has no strict age restrictions. However, it is still recommended to refrain from using it in children under 18 years of age.

The product can be used in childhood only with the permission of the attending specialist, taking into account the potential risks and benefits for the child. Therapy should be carried out under the constant supervision of a physician.

Instructions for use, dosage

Lucetam (indications for the use of tablets are recommended to be further clarified with the attending physician) is intended for oral administration. It is consumed on an empty stomach or with food.

In this case, the daily rate should be divided into 2-4 doses. The last application of the product should be carried out no later than 17 hours before bedtime. The dosage is calculated based on the identified form of the disease.

With depression

The daily dosage for depressive conditions is 2.4 g, divided into 3 equal doses. The duration of treatment is according to the testimony of a specialist.

With VSD and dizziness

With vegetative-vascular dystonia and dizziness, the recommended daily dosage is 2.4 to 4.8 g. The duration of the course is determined individually.

For migraines and headaches

For migraines and headaches, it is recommended to take 800 mg of the drug 3 times a day.

The duration of treatment is 1.5 months or as recommended by the attending physician.

With osteochondrosis

With the development of osteochondrosis, 2.4-4.8 g of the drug are prescribed per day. In this case, the dosage should be divided into 3 doses. The duration of therapy is according to the recommendations of the attending physician.

With alcoholism

With alcoholism, 12 g of the drug is prescribed per day. As a maintenance treatment, 4.8 g is prescribed per knock. The duration of treatment is determined individually.

With a concussion

In case of concussions or other traumatic brain injuries, 9-12 g of the drug per day are prescribed.

Then the daily dosage is gradually reduced until it is 2.4 g per day. The duration of treatment is set individually.

Side effects

The agent can cause various negative reactions associated with the physiological characteristics of the patient or the action of the active component.

Adverse reactions:

• Disturbances in the central nervous system: the development of dizziness and drowsiness; depressive conditions; asthenic syndrome; increased irritation; migraine pain; hyperkinetic syndrome; sleep disorder (insomnia).

Ataxic conditions, tremors, loss of balance, hyperexcitability, anxiety, or restlessness may also develop. In patients with epilepsy, the course of epileptic seizures may worsen. In some cases, hallucinations, confusion, and increased sex drive may develop.

• Cardiovascular disorders: a decrease or increase in blood pressure.
• Digestive disorders: symptoms of dyspepsia, diarrhea. Soreness in the abdomen.
• Metabolic disorders: an increase in body weight.
• Skin manifestations: itching, urticaria, dermatitis.
• Immunity malfunctions: hypersensitivity reactions, anaphylaxis, angioedema.

If these signs occur, including other unremarked symptoms, you should stop taking further pills and consult a specialist.

Overdose

Lucetam has no toxic effect even with high doses (according to the indications, the maximum daily dosage can be up to 12 g). At the moment, one case of the development of dyspepsia is known when a daily dosage of more than 75 g is used.

If there are signs of overdose, it is necessary to artificially induce vomiting and gastric lavage. The specialist should prescribe symptomatic therapy. Hemodialysis is only 50-60% effective. There is no specific antidote.

special instructions

During therapy aimed at eliminating the signs of cortical myoclonus, it is required to avoid abrupt rejection of the pills, since this can provoke an exacerbation of the disease.

Elderly patients need to undergo systematic studies of indicators of renal function. The dosage should be adjusted if necessary. The drug is able to penetrate the filters of devices intended for hemodialysis.

No dosage adjustment is required in patients with functional liver disorders. A high degree of care must be taken when driving. or carrying out other work requiring high psychomotor functions.

Drug interactions

With a combination of the main medication and extracts of the thyroid gland, irritation, disorientation in space and insomnia are possible. At higher dosages, the agent can react with acenocoumarol. In this case, negative reactions are observed in patients with venous thrombosis.

In most cases, the pharmacokinetic and pharmacodynamic properties of the drug do not change when it simultaneous use with other medicines, since the main substance of the tablets leaves the body in unchanged form.

The drug does not enter into metabolic reactions with other groups of drugs. However, there was a slight change in some isozymes when the drug was taken at a dosage of 1422 μg / ml.

When using the drug in a dosage of 20 mg / day, there were no changes in the pharmacokinetic parameters of antiepileptic drugs in patients with epilepsy. The drug does not interact with ethanol and does not cause negative effects. It can be used for chronic alcoholism.

Analogs

Lucetam (indications for the use of the drug indicate the possibility of its use as part of a combination treatment) with the development of intolerance reactions should be replaced with another similar drug. The selection of a generic drug is based on the indications and mechanism of action of the active ingredients.

Analogs:

• Piracetam. This drug is available as a tablet for oral use or as an intravenous / intramuscular solution. Generic is a complete analogue of the main drug and contains an identical active ingredient - piracetam.

The drug belongs to the group of nootropics and has the following indications for prescription: impairment of cognitive functions; dementia; brain damage; Alzheimer's; coma; ischemic stroke; withdrawal or psychoorganic syndrome caused by chronic alcoholism; poor learning ability in children; asthenic syndrome (sickle-cell form of pathology).

The dosage and duration of therapy is calculated individually based on the disorder and the dosage form used.

Contraindications: impaired cerebral circulation, proceeding in an acute form (hemorrhagic type of stroke); Huntington's syndrome; kidney failure (chronic type of disorder); children's age - based on the prescribed dosage form.

During gestation, a substitute can only be used with the permission of a doctor, taking into account the potential threat and benefits, both for the mother and the fetus. Terms of sale - according to the recipe. The cost of a medicine in regional and regional pharmacies in Russia ranges from 20 to 215 rubles.

• Memotropil. This substitute is available as an oral tablet. The main ingredient of the product is piracetam, a component with a pronounced nootropic effect.

Recommendations for use: psychoorganic syndrome; a condition associated with a previous ischemic stroke; decreased learning in children; withdrawal syndrome associated with chronic alcoholism; rehabilitation after traumatic brain injury.

Also, the recovery period after suffering a toxic brain injury; cortical myoclonus; dizziness and sickle cell anemia (as part of complex treatment).

Dosing regimen: 30-160 mg / kg from 2 to 4 times a day. The dosage may vary depending on the underlying disease. In childhood, the daily rate is selected individually. The duration of the therapeutic effect is according to the recommendations of the attending physician.

Restrictions on admission: hemorrhagic stroke; children's age up to 12 months; period of gestation and breastfeeding; renal failure; hypersensitivity to components. The way of implementation is according to the recipe. Prices for medicines in pharmacies in Moscow and the Moscow region vary between 100-150 rubles.

• Nootropil. This analogue is manufactured in several dosage forms - capsules / tablets for oral use and solution for intramuscular or intravenous administration. The active component of the drug is piracetam - a substance belonging to the class of nootropic components.

The list of recommendations for appointment: the presence of a psychoorganic syndrome; dizziness and related conditions; myoclonus (cortical form of pathology); vaso-occlusive crisis (sickle-cell form of anemia). In childhood, the drug is prescribed as an adjunct treatment for sickle cell anemia.

Application regimen (for solution): 2-4 g per day. Dosing regimen (for tablets / capsules): 2.4-4.8 g per day, divided into several equal doses.

List of contraindications: high excitability at the time of prescribing the medication; Huntington's syndrome; intolerance to the components; children under 3 years old; chronic renal failure; hemorrhagic stroke.

It is also recommended to refrain from using the medication during the period of gestation and feeding of the child. Terms of sale - prescription. The cost of the drug in state or commercial pharmacies in Russia ranges from 80 to 470 rubles. depending on the purchased dosage form.

Lucetam (indications for the use of the drug can be supplemented by the attending specialist) should be replaced with generics only with the permission of the attending specialist.

You should not choose and take similar drugs on your own, since the wrongly chosen the medication can provoke an aggravation of the condition and lead to the development of complications or side effects.

Terms, conditions of sale and storage

The drug should be stored in a dry and dark place at a temperature of 15 to 30 ⁰C. The shelf life of the tablets is 5 years from the date of manufacture. Do not use the medication after the expiry date of the expiration date on the package. The method of sale is by prescription.

Price

Prices for a medicine may differ depending on the region or region of their sale, as well as on the basis of the dispensed dosage. You can find out the exact cost of the drug at any pharmacy located in your place of residence.

Region / region	Dosage form / dosage	Price
Moscow, Moscow region	Tablets, 800 mg	RUB 60-85
St. Petersburg	Solution for injection, 1 g, 5 ml	RUB 175-265
Saint Petersburg (suburbs)	Tablets, 1200 mg	RUB 85-120
Novgorod region	Tablets, 800 mg	RUB 65-80
Leningrad region	Solution for injection, 1 g, 5 ml	90-110 rub.

Before using Lucetam, you should consult with a specialist to carefully study the indications for the use of tablets indicated in the instructions. Additionally, it is recommended to familiarize yourself with the reviews of patients who have used the drug in the treatment of various disorders of a vascular origin.

Video about the drug

Lucetam 400/800/1200: