Wilprafen suspension for children. Instructions for use, price, reviews

Wilprafen - a drug for the treatment of infectious diseasescaused by microorganisms sensitive to josamycin. The suspension for children is available in 3 dosages. The form recommended in a particular case depends on the child's age, body weight and type of infection.

Indications for use

Wilprafen is a suspension for children that can be used for the following indications:

• infectious diseases of the throat, nose and nasopharyngeal zone;
• diseases of the gastrointestinal tract associated with Helicobacter pylori;
• infectious lesions of the oral cavity, eyes and reproductive system;
• infections in the lungs, trachea, skin and mucous membranes.

In particular, they include many pathologies:

• tonsillitis, otitis media, pharyngitis, sinusitis, scarlet fever;
• bronchitis in the acute stage, pneumonia, whooping cough, psittacosis;
• furunculosis, abscess, anthrax, erysipelas;
• blepharitis, syphilis, cervicitis, lymphogranuloma, urethritis, stomach ulcer.

When combined with topical application of drugs, the duration of treatment is significantly reduced without a recurrence of the infection.

Compound

The preparation contains the main active ingredient in various dosages in combination with auxiliary components.

Active substance	Dosage, mg / ml of the finished suspension
125/5	250/5	500/5
Contents in 1 bottle
Josamycin	15 g	15 g	20 g
Excipients, mg
Citrate Na	112,5
Methylparaben	79,5
Propylparaben	10,5
Simethicone	75
Hypromelose	180	225	300
Perfume	37,5	50
Carmellose Na	570	1200	600
Sugar 3%	10108	7848	10200,5
Mannitol	2250

Josamycin is a natural macrolide antibiotic produced by the actinomycete Streptomyces narbonensis. Since 2012, it has been included in the list of vital and essential medicines.

Excipients increase the pharmacological activity of the active ingredient, increase the shelf life of the diluted suspension and provide the required consistency of the finished product.

In what form is it produced

The drug is available in powder form for self-preparation of a homogeneous suspension. The sizes of individual particles of the active substance provide a long-term therapeutic effect, which makes it possible to reduce the frequency of administration during the day.

Separate dosages provide convenient dosing for children of various ages and should be used as recommended in the instructions.

Average prices for Wilprafen granules:

• 125 mg / 5 ml - from 400 rubles;
• 250 mg / 5 ml - from 430 rubles;
• 500 mg / 5 ml - from 500 rubles.

The cost depends on the type of pharmacy network and the distance of the pharmacy from the central districts of the city. If necessary, the drug can be ordered from online services for delivery to a specific pharmacy at a lower cost.

Pharmacodynamics

Wilprafen is a suspension for children that acts bacteriostatically:

• inhibits protein formation;
• prevents DNA dynamics;
• inhibits the metabolism of bacteria.

As a result, the processes of their vital activity, development and reproduction stop. In combination with a person's own immunity, it is possible to completely suppress the infection in a relatively short time.

When a high concentration is created in the focus, a bactericidal effect is manifested. In this case, josamycin begins to kill bacteria directly. By binding to the 50S-subunit of the ribosomal membrane, it prevents the attachment of transport RNA and the transfer of peptides from the A-center, thereby suppressing protein synthesis in the cell walls of bacteria.

The spectrum of pharmacological activity includes several types of bacteria:

• coccobacilli of the genus Bordetellus;
• anthrax pathogens;
• anaerobic actinomycetes;
• hemophilic sticks;
• corynebacteria;
• streptococci;
• mycoplasma;
• legionella;
• treponema;
• gonococci;
• rickettsia;
• chlamydia.

Also, the drug is active against some fungi and anaerobes of other classes. The effectiveness may decrease slightly due to the development of resistance in microorganisms.

Pharmacokinetics

Josamycin after internal administration in a short time and in full is absorbed in the intestine. The maximum concentration in blood serum is reached after 1-4 hours. About 10% of the dose taken binds to plasma proteins. The highest amounts are found in lung tissue, tonsils, sweat, tears, and salivary fluid.

The substance undergoes biological transformation in the liver tissues to less active forms, which are then excreted from the body in the bile. Excretion of the drug in the urine does not exceed 20%.

Application for children under 18 years of age

Together with the bottle, the kit includes a special measuring syringe for accurate dosing of the finished suspension. Before dialing the required dose, you should always shake the drug thoroughly to evenly distribute the active particles of the drug substance throughout the volume.

After that, you need to draw a single dose with a syringe and carefully inject the drug between the cheek and tongue, not too close to the throat. Then offer the child water or another neutral drink.

The recommended amount of josamycin is 50 mg / kg body weight.

It should be divided into 2 equal receptions:

• 25 mg / kg in the morning;
• 25 mg / kg after 12 hours.

The maximum single dose should not exceed 1 kg, despite the greater weight of the patient than suggested by the given proportion. The duration of therapy is determined by the observing specialist, depending on the symptoms, the severity of the course of the disease and the response of the child's body to the antibiotic. The average duration of treatment can be up to 5-7 days.

If you accidentally skip the next dose, you should not double the amount of suspension.

Contraindications

Wilprafen is a suspension for children, which should not be used for therapeutic purposes if the following contraindications are present:

• hypersensitivity to the action of josamycin or other macrolide antibiotics;
• combination with taking ergotamine, cisapride, pimozide, ivabradine, colchicine;
• with significant pathologies of the functioning of the liver;
• lack of sucrase or isomaltase.

In patients with insufficient renal function, treatment should be prescribed based on the results of examinations for an indicator of creatinine clearance.

Overdose

If the dose is incorrectly calculated, a significant overdose with Wilprafen is possible, in particular in small children with low weight.

Symptoms:

• stool disorders;
• severe nausea;
• vomiting;
• hearing loss.

There are few reports of overdose cases in medicine. Wilprafen, despite the sweeteners, has a rather unpleasant taste, so the risk of significantly exceeding the dose is unlikely.

Otherwise, it is recommended to immediately take adsorbents such as Polisorb or Enterosgel in maximum quantities for quick binding and removal of the drug from the body. Severe conditions require urgent medical attention.

Side effects

Even treatment in recommended doses in most cases is accompanied by side effects:

• on the part of the skin - rashes, erythema, skin pathologies, acute or toxic epidermal necrolysis;
• from the gastrointestinal tract - nausea, vomiting, stool dilution, stool fixation;
• from the liver - an increase in the activity of hepatic transaminases, hepatitis;
• on the part of immunity - allergies by the type of rashes, Quincke's edema;
• others - purpura, vasculitis, metabolic disorders, anorexia.

If any symptoms are found, seek medical attention.

Drug interactions

Vilprafen is a suspension for children, the combined use of which with some drugs can lead to serious consequences:

• ergotamine, dihydroergotamine - the likelihood of sudden tension of the vascular walls with the possibility of necrotic changes in the limbs;
• cisapride, pimozide - the risk of heart rhythm interruptions, endangering the life of the affected person;
• ivabradine - after interaction with josamycin, the content of ivabradine and the risk of side effects increase;
• colchicine - the likelihood of the development of side effects that endanger the life of a sick person increases.

Less dangerous, but also undesirable, include interactions with the following drugs:

• amitriptyline;
• bromocriptine;
• carbamazepine;
• cyclosporine;
• disopyramide;
• halofantrine;
• sildenafil;
• caberboline;
• terfenadine;
• tacrolimus;
• theophylline;
• triazolam;
• astemizole;
• digoxin;
• ebastine.

The simultaneous combination with anticoagulants of indirect influence increases the risk of serious bleeding.

Storage conditions and periods

Wilprafen is a powder mixture for preparing a suspension, which should be stored in a place protected from sunlight, closed for children. The temperature should be no higher than 25 ° С and not lower than 2 ° С. Shelf life is 4 years. After the initial opening and adding the recommended amount of water, the finished suspension can be stored for no more than 1 week.

Conditions of dispensing from pharmacies

The product is dispensed from pharmacies without a prescription. But at the same time, it is impossible to uncontrollably be treated with the drug without a pronounced need. Too frequent use without specific indications can lead to the development of resistance in some microorganisms, and, if necessary, the drug will no longer be able to provide a sufficient effect.

Analogs

The main analogues of Vilprafen include Sumamed, Azitrox, Zitrolide and other drugs that are active the substance in the composition of which is azithromycin - a macrolide antibiotic, the first representative of the subclass azalids.

Another common analogue is clarithromycin. On its basis, preparations in the form of suspensions are also created. One of the most common in pharmacies is Klacid. Its effect on pathogens is somewhat weaker and the therapeutic effect develops more slowly. Therefore, only a specialist should recommend a suitable remedy.

Azithromycin

Pharmacodynamics - the substance has a wide spectrum of antibacterial activity. Azithromycin stops the processes of vital activity and reproduction of bacteria, inhibiting peptide translocase at the stage of transmission to other cells and suppressing the processes of protein synthesis. In high doses, it destroys extracellular and intracellular bacteria.

After internal administration, azithromycin is rapidly absorbed and distributed to all tissues of the body. Bioavailability reaches 37%. The indicator is associated with the effect of primary passage through the liver. The highest concentration in blood serum is reached after 2-3 hours and is about 0.4 mg / l.

Pharmacokinetics - azithromycin penetrates well through cell membranes, and therefore the drug is highly effective against infections localized in their internal cavities. Transport is carried out by phagocytes to the places where microorganisms are spread.

Concentration in soft tissues reaches 10-50 times higher than in blood plasma, and 24-34% more in the focus of infection than in surrounding tissues. In the liver, azithromycin undergoes secondary demethylation, after which the substance loses its pharmacological activity.

The main part of azithromycin is excreted in its original form:

• through the intestines - from 50%;
• kidneys - about 6%.

The half-life reaches 50 hours. Therapeutic concentrations after the last dose taken are maintained at a sufficient level for up to 1 week. Then the process of complete elimination from the body begins. Sumamed and other drugs with azithromycin can be used for infection of all parts of the respiratory tract and many other diseases.

Due to the long elimination time and gradual accumulation in the body, the drug is recommended to be taken no more than 1 time per day.

An important condition for full absorption is not to combine the drug with food:

• you can take funds with azithromycin either 1 hour before meals, or after 2 hours;
• the drug should be taken with a sufficient amount of water, at least 100 ml.

For accurate dosing, the following ratios should be used:

• the calculation must be made based on the child's body weight;
• for 1 kg of weight, it is recommended to take 10 mg 1 time per day for 3 consecutive days.

In severe forms of the disease, the duration of treatment can be increased to 6 days. Longer use is not recommended due to the increased risk of severe side effects.

The following conditions are characterized by the relative frequency:

• candidiasis of the mucous membranes;
• respiratory symptoms;
• bacterial infections;
• appetite disorders;
• exacerbation of gastritis;
• thrombocytopenia;
• leukopenia, etc.

Very common are severe abdominal pain, on average 30 minutes after ingestion. This applies to the variants of the norm. A particular severity of pain is observed after 1-2 receptions. In the future, the symptom weakens. As a rule, azithromycin significantly dilutes the stool, and after the next visit to the toilet, the pain stops.

Clarithromycin

Klacid is a drug containing clarithromycin intended for children, produced in the form of a powder mixture for preparing a suspension. 1 bottle contains 70.7 g of active substance, or 125 mg / 5 ml in a solution ready for treatment. Pharmacologically it is a macrolide. The antibiotic blocks the production of protein in bacteria that are sensitive to it.

Preparation of the suspension - in the bottle you need to carefully add clean water to the risks with occasional shaking. The total volume of the finished product is 100 ml. Room conditions are suitable for storing the suspension. Shelf life - no more than 14 days. Residues of the drug must be disposed of together with household waste.

Dosages:

• the recommended daily dose for children is 7.5 mg / kg of body weight 2 times a day;
• the highest dose should not be more than 0.5 g 2 times a day.

Single dose for taking 2 times a day:

• 8-11 kg - 2.5 ml;
• 12-19 kg - 5 ml;
• 20-29 kg - 7.5 ml;
• 30-40 kg - 10 ml.

For children weighing less than 8 kg, the calculation is made based on the proportion of 7.5 mg / kg. The received volume of the drug should also be taken 2 times a day. The usual duration of treatment is no more than 10 days. It depends on the well-being of the child and the type of infection. When creatinine clearance is less than 30 ml / min, it is recommended to reduce the volume of a single dose by 2 times. The total duration of treatment is up to 2 weeks.

Wilprafen is an effective drug for treating children from a variety of infections and other pathologies. If necessary, it can be replaced with another drug in the form of a suspension from the macrolide group. It is only important to follow the basic recommendations in order to achieve maximum efficiency in the shortest possible time.

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