Gentomitsin injections. Indications for use, instruction in gynecology as divorce, put a shot intramuscularly with sinusitis, sore throat, prostate, intestinal infections, cystitis, rotavirus, otitis. Price, reviews

Gentamicin - antibacterial drug with broad spectrum of action. Injections of the drug indicated for many pathologies of the organism, as it is written in the instructions of use.

release Form

Pharmaceutical industry produces Gentamicin in the form of a sterile dosage of liquid to be administered into the muscle or the venous system that bypasses the gastrointestinal system.

The homogeneous mixture for injection - it ampoules main active antibacterial substance dissolved in water for injection. The preparation has the form of transparent or yellow tinge liquid odorless. Hermetically sealed glass jar with the medicine contains 2 cu. ml medication, which contains 0.08 g of the main substance.

Chemical composition

Gentamicin in the form of injections to injections is composed of:

• universal aminoglycoside antibacterial agent series;
• organic compound sodium salt pirosernistokisly pirosernistoy acid;
• ionokoagulyant disodium etilendiamitetrauksusnoy cations and acid anions;
• sterile medical liquid.

pharmachologic effect

Gentamicin is an antibacterial agent from the group of organic compounds that consist of amino sugars linked by a covalent bond with aminotsiklicheskim ring. As a drug with a broad spectrum of activity, it inhibits microbiological multistage process of synthesis and maturation of proteins in living organisms.

The medicament is highly effective against many types of bacteria that are not stained crystal violet, as well as microorganisms, preserving special color after washing solvent.

These domains of living organisms include:

• rod-shaped bacterium Escherichia;
• facultative anaerobic, rod-shaped Proteus;
• Pseudomonas psevdomanad;
• opportunistic bacterium Klebsiella pneumoniae;
• rodlike peritrichous asporogenny gram chemoorganotrophic microorganism Enterobacter;
• rod-Serratia martsestsens;
• Pathogenic bacteria tsitrobakter Freund;
• sporebearing microorganism genus Salmonella;
• highly contagious Shigella Proteus;
• kind of staph bacterium.

By aminoglycoside antibiotic resistant microorganisms are the following:

• fixed lancetshaped diplococcus - Streptococcus pneumoniae;
• ovoid asporogenous bacteria of the genus Streptococcus;
• elongated microorganism Enterococcus;
• pale treponema;
• organisms that are viable in the absence of oxygen;
• Bacteroides rod;
• spore-forming obligate anaerobic clostridia.

The drug gentamicin relates to basic drugs that compete with complex purulent inflammation in the body. Sometimes the remedy should be prescribed if other antibacterial agents do not exhibit sufficient therapeutic effect.

Bacterial resistance to the drug is very slow - it makes Gentamicin is active in a large number of microorganisms.

Intramuscular use the drug concentration in the liquid of the biological part of blood, in which red blood cells are absent, reaches its maximum after ½ hour. At the same therapeutic activity remains about 1/3 days.

Introduction Gentamicin as droppers enables preparation exceed the concentration of the basic substance in liquid connective tissue, as compared with parenteral use.

Indications

Gentamicin injections to be appointed under the following disease states, according to the instructions for use:

• microorganisms infecting organism Streptococcus and Staphylococcus;
• invasive neonatal infections;
• rapidly developing inflammation of the gall bladder;
• angiocholitis;
  
• inflammation of the kidney tubule system lesion pelvis;
• acute process in the urinary system;
• alveolar damage and interstitial pulmonary tissue as a consequence of the introduction of bacteria;
• Complications in the pleura after pneumonia;
• pleural empyema;
• severe general state of the organism in the inflammatory process in the peritoneum;
• complicated purulent process in the body;
• inflammation in the brain ventricle;
• bacterial development process at the wound site;
• infection provoked by the action of high temperatures;
• penetration of microorganisms in the skeletal system;
• inflammation of the prostate gland;
• skin staph infection;
• purulent inflammation of the follicles;
• staphylococcal necrotic lesions of the sebaceous glands;
• introduction into the skin of Staphylococcus aureus;
• paronychia;
• inflammation of the sebaceous glands;
• acne;
• secondary infection of the skin;
• suppuration after insect bites;
• varicose ulcer lesion;
• infections of the upper and lower eyelids;
• inflammation of the conjunctiva of the eye;
• inflammation of the lacrimal sac;
• clouding, corneal ulceration eye;
• bacterial process in the glands that are thicker in the eyelids.

Dosing and Administration

Gentamicin antibacterial agent should be administered in many pathological processes in the body:

1. acute sinusitis (In-patient treatment conditions). In this disease otolaryngologist appointed by intramuscular injection of the drug. The dose of drug to be calculated, based on the weight of the patient. Usually the required amount of the antibacterial agent is 0.170 g per 1000 g of weight of the patient to be administered into the muscle of the morning and evening. Duration of treatment - no more than 7 days to avoid negative manifestations.
   
2. Inflammation of the tonsils sky. With angina should definitely prescribe antibiotics. Otherwise, you may develop complications of the cardiovascular system. Gentamicin with the inflammation of the tonsils should be used by intramuscular injection and only for the purpose of a therapist. The course of treatment for different varieties of the disease is different, but not more than 10 days. The number should be calculated in accordance with the age and weight of the patient. Children up to 12 years - 0,003 g 1,000 g weight. With 12 years and older need to increase the drug dose to 5 mg / kg, which should be divided by the number of times assigned therapist.
3. Infection of the prostate gland. The disease should be treated with Gentamycin both intramuscularly and intravenously. The amount of drug necessary to calculate, based on the variety and complexity of the pathological process. Intramuscular formulation should be administered twice per day. Intravenous use is necessary to restrict the use of drip once a day. means the dose of 0.100 g-0.170 g for a single intramuscular use. When drip amount of drug calculated to 24 hours, to be administered once. Therapy should be continued for 10 days, if there are no other recommendations urologist.
4. Infectious diseases of the digestive system. When intestinal infections, depending on the causative agent of the pathological process, you must use the Gentamicin. This drug is a long time does not appear microbial antibiotic resistance, which is very often the case with intestinal infections. The duration of therapy for pathologies of the digestive system should not exceed five day period. The drug should be administered intramuscularly every 12 hours. The amount of funds to be calculated according to the weight and age of the patient. For adults (patients older than 12 years), the drug should be administered in a daily dose of up to 5 g Children's age - the amount of the drug corresponding to no more than 3 grams per day.
5. reovirus infection. Rotavirus in the body affects not only the mucous membrane of the digestive tract, as well as the respiratory system. To prevent secondary infection to join, for the treatment of this disease should be used antibacterial agents. The drug gentamicin is a universal antibacterial agent. The drug should be used within 7 days, morning and evening. means the dose is calculated on the basis of patient body weight. Patients who are older than 12 years should use the drug in an amount of 1.7 mg per 1 kg of weight - at one time. Children need to use no more than 3 grams of the drug per day, which should be divided into several times (in accordance with the recommendations of an infectious disease physician).
6. Ear infection. When otitis intramuscular antibacterial drugs should be prescribed if local therapy did not produce a positive result. For primary drugs should include Gentamicin. The drug is universal and is struggling with many microorganisms. For the treatment of otitis media should be used only by prescription antibiotic otolaryngologist, because of the large number of negative phenomena. means of treatment should not be longer than 7 days.

To make an intramuscular injection should be aware of certain rules:

1. For subcutaneous injections must be taken 2.5-3 ml syringes to insert the needle and a depth of not more than 2 cm.
2. Antibacterial agents to be administered into the muscle. To do this, take a syringe volume of 5 ml (needle diameter is calculated on muscle density). Location of drug administration, as a rule, top, extreme quarter of the gluteus maximus.
3. Before applying the medication the skin should be wiped with ethanol.
4. Select preparation in the pre-prepared syringe.
5. Slightly lower the liquid drug through the needle by a piston that was not air.
6. It is necessary to introduce the needle at an angle of 45-60 degrees in a relaxed gluteal muscle.

   

7. After manipulation should pull the needle out of the body and flatten the injection site with a cotton swab with an alcohol in order to avoid penetration of infection and hematoma formation.

Pregnancy and lactation

Gentamicin injections should not be used during pregnancy. In the event that demonstrates the use of the drug, should take it seriously and give up breastfeeding.

The use in children

The use of a medicament for the treatment of children up to 3 years is only necessary for health reasons. Up to 5 years should be used a means of calculating 0.015 g - 0.030 g of 6 years to 12 years - 3 mg / kg. The duration of therapy is determined by a pediatrician.

Contraindications

Gentamicin injections (indications for use and contra-indications are described in the instructions) should not be given in the following pathologies:

• allergic reactions to antibacterials;
• lesions in the auditory nerve;
• renal failure;
• intoxication substances which are output affected kidney;
• period of gestation of the child;
• lactation.

Side effects

Negative developments from the use of Gentamicin can be in many systems of the body.

GI:

• vomiting reflex;
• increase in AST and ALT;
• increasing the number of bilirubin.

Blood:

• reduction in red blood cells;
• decrease in white blood cell count;
• granulocyte deficiency;
• low platelet count.

Nervous system:

• migraine;
  
• weakness;
• hearing loss due to the impact of drugs on the nerves;
• unsteadiness of gait.

Immunological disorders:

• urticaria;
• chills;
• anaphylactic shock;
• excessive sensitivity to ultraviolet rays.

special instructions

Gentamicin injections (indications for use should be read in the annotation to the drug) should be used, knowing the specific instructions:

• only for the purpose of a therapist is necessary to use the drug in patients with Parkinson's disease;
• gently use for muscular pain;
• renal parameters must be controlled;
• check the ears;
• control the receptors of the inner ear.

Overdose

When used improperly, the drug Gentamicin overdose symptoms may appear.

These include:

• strengthening the gag reflex;
  
• unsteadiness of gait;
• respiratory insufficiency;
• loss of muscle.

For relief of the manifestations be administered neuromidin, calcium gluconate and calcium chloride (only i.v.).

drug interactions

When using the drug antibiotic should be aware of the need for interaction:

1. Simultaneous use of Gentamicin with means aminoglycoside series, glycopeptides and tricyclic lactam antibiotics is the risk of auditory nerves.
2. Use of drugs with NSAIDs reduces the rate of elimination of the antibacterial agent from the body, which is fraught with intoxication.
3. The use of Gentamicin with medications that contain opiates, can create a blockade of peripheral nerves.
4. Possible increases intoxication while using the antibacterial agent with diuretic drugs.

analogs

Pharmaceutical industry produces drugs, similar drugs Gentamicin:

drug Name	The composition of the drug	Application area	Cost, rub.
Amibiotik	Semisynthetic antibiotic imikatsin	Inflammatory pathology in the body provoked by introduction of Gram-negative bacteria	Rub.- 240 300 rubles.
Brakson	Antibacterial substance amiglikozidnogo number of tobramycin	Severe infectious disease pathogens which have resistance to penicillins	720 rubles. - 810 rubles.
Kanamycin powder for injection	1 kanamycin antibiotic generation	Purulent pathological processes in the body	37 rubles. - 50 rubles.

Conditions and terms

Gentamicin formulation must be stored under specific conditions of a temperature no higher than 20 degrees, to make sure that no We caught the sun's rays, without the need to open the ampoule not (they become unsuitable for further use). Time application since manufacture - 60 months.

Where can I buy

Injecting the drug can be bought in pharmacies network. To purchase the product does not need a prescription. The cost of funds varies from 25 rubles. to 54 rubles. Gentamicin injections should be used, as indicated by a specialist. The instructions for use of the drug described the universal effect of the agent, which is struggling with a number of microorganisms.

Registration of the article: Lozinski Oleg

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