Augmentin. Instructions for use (suspension, tablet). Price, reviews, analogues

Augmentin belongs to the penicillin group of antibiotics. The spectrum of action of the drug is extended relative to the main number of drugs due to entering into its composition of clavulanic acid. Means permitted use in the treatment of prescription-only specialist in compliance with the instructions.

Shape and composition of the drug release

Augmentin is made in 4 types (for the convenience of dosing and drug administration):

• the powder mixture for administration by injection (solution) with 500/100 or 1000/200 numbering;
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• the powder mixture for oral administration in the form of a slurry with numerovkoy 400/57, or 200 / 28.5, or 125 / 31.25;
• pelletized form with an engraving producer and dosage main components numerovkoy 250 + 125 or 500 + 125 + 125 or 857;
• tablet formulation of long-acting drug. This effect is due to the gradual release of basic substances numerovkoy 1000 / 62.5.

The figures on the packaging characterize how much of the active elements is available in 1 dose. The first number - the content of amoxicillin, the second - clavulanic acid.

The constituent elements of the product:

List of active components for all types of drug	Brief description components
1	amoxicillin	The antibiotic of the penicillin group, semi-synthetic. It destroys most of the pathogenic bacteria.
2	clavulanic acid	It protects amoxicillin from the rapid destruction and accelerates the destruction of bacteria.
Additional tablet components
1	Colloidal silicon dioxide	It stimulates the removal of bacteria killed organism and harmful substances produced as a result of agent activity.
2	magnesium stearate	To make the drug desired shape.
3	Microcrystalline cellulose	It gives the desired tablet strength and accelerates the absorption of the drug.
4	sodium carboxymethyl starch	Adjusts the gradual release of active substances.
Composition of tablets shell
1	Titanium dioxide	To make the tablets white hue and increase the shelf life of the medicament.
2	hypromellose	It preserves the structure of the tablets, readily soluble in the digestive tract.
3	macrogol	Output contributes to the acceleration from the body of dead bacteria.
4	Dimethicone (silicone oil)	It creates the desired film on the tablets.
Additional components of the powder mixture
1	aspartame	It gives medicines sweetness.
2	xanthan gum	Impart cooked slurry homogeneous state.
3	hypromellose
4	succinic acid	It removes harmful substances and protects the cells against infection.
5	Colloidal silicon dioxide	It accelerates bacteria from the body.
7	flavors	To give the medicament a pleasant aroma and taste.

For children it is recommended to use a powder mixture. They are convenient to dose, and they have a pleasant smell. Injections are assigned to patients in critical condition, in this form of medication effect is faster oral agents.

pharmacological properties

The drug is prescribed for bacterial infections with nature. It has an extended operating range.

Pharmacodynamics and Pharmacokinetics

Augmentin (instruction manual comprises the information of active elements act on the body and pathogen) is a multi-component preparation, which functions due amoxicillin and clavulanic acid. This combination makes it possible to destroy bacteria that are resistant to penicillin classical means.

Amoxicillin gives metabolism in bacteria, reduces the strength of their cell envelope. Consequently, the process of development and growth of the pathogen becomes impossible. There is a gradual destruction of the bacteria. However, amoxicillin can be destroyed by the action of enzymes produced by infection protection.

Clavulanic acid blocks production of these enzymes from the pathogen, penetrating into its cells. This protects amoxicillin from being destroyed, thereby increases the effects of an antibiotic.

With proper oral agents (before food intake), both the active element once absorbed by the digestive tract. Next, enter the bloodstream and in all bodies, and also in the sputum of bronchial tubes and the joint fluid. Such an extension enables destroy pathogens anywhere in its localization.

Active elements mostly (70%) in the blood plasma in the free state. They are able to get into the milk, breastfeeding, and to penetrate to the fetus through the placenta.

Augmentin leaves the body with stool and urine through 6 hours after consumption of the drug.

Indications

Augmentin is indicated for the removal of the following pathologies:

• disease bacteriological nature ENT (ear inflammation in the passages, nasal cavity and throat);
• infectious diseases of the bronchi (pneumonia, bronchitis and other pulmonary inflammatory processes of the system);
• infectious processes in the oral cavity (erosive disease, scarlet fever, periodontitis);
• inflammatory processes of infectious nature of the bladder, kidney and urinary tract (chlamydia, cystitis, pyelonephritis);
• cutaneous diseases of bacterial origin tissue (furunculosis, folliculosis, carbunculosis);
• inflammatory and infectious diseases in bone and joints (arthritis, synovitis, osteomyelitis);
• inflammation caused by bacteria in the digestive tract (salmonellosis, typhoid, dysentery);
• reproductive system disease caused by hit bacteria (vulvitis, adnexitis, colpitis);
• as a preventive measure during an operation for implantation of implants and other surgical procedures.

Before the appointment, a test antibiotic sensitivity of pathogens to the effect of this drug.

Contraindications

Augmentin (instruction on the need to review the list of contraindications to the drug) may not be used in the following cases:

• intolerance or allergic reaction to components of the formulation;
• malfunction organs liver and kidney;
• Mononucleosis infectious nature. Using the tracking deteriorates the dynamics of treatment;
• the age limit for receiving the drug.

During the period of gestation or feeding a child breast milk medication therapy is conducted with the permission of the treating specialist under strict control.

Instructions for use, dosage of Augmentin drug in the various forms of release

Augmentin is used in the treatment of prescription-only physician or pediatrician. The course of therapy and the use of the drug selected by individual parameters (weight, age and the character of pathology parameter percolation).

Also a specialist takes into account individual characteristics (changes functioning kidney and liver). In addition, it should be excluded contraindications specified in the instructions.

Antibiotics need to guzzle strictly on time, at regular intervals and a full course. Self cancellation means (in improving the general condition) can lead to reinfection. In this case, the bacteria are no longer susceptible to the drug used.

Therefore, to eliminate the disease, the treating specialist will be forced to appoint a stronger medicament which can cause the development of side reactions such as degradation of the liver, intestine and kidney.

Common features of Augmentin therapy:

• use of oral antibiotics is recommended before eating. Then the action of the elements reaches a maximum effect;
• Augmentin, for any disease, you need to take at least 5 days;
• prolonged therapy, after 10 days of treatment, the blood gives up for tracking changes in its composition;
• the use of the drug for more than 14 days, is prohibited without the re-examination. You may need a replacement product;
• to correct abnormalities in severe initially prescribe antibiotics injection. While improving reception means being permitted in oral form. Therapy is adjusted by the doctor;
• when using the tablet form for the treatment, it can not be chewed or violate its integrity. It is used only as a whole and washed down with water;
• powder mixture for oral administration, dilute completely, divided into portions. Otherwise there would be compliance with the concentration of active substances. Before use, mix thoroughly the composition;
• when receiving oral means, in particular a suspension, it is necessary, after the procedure, rinse the mouth with water to prevent browning from the enamel of teeth. Taking the drug through a tube as possible;
• Augmentin injection may be administered with a dropper or syringe only intravenously. The solution is made prior to the procedure. Means for breeding antibiotic is chosen by the attending specialist, depending on the existing contraindications.

Features of the use of antibiotics, depending on the type of drug and age indicators:

Age of the patient	A single dose (mg)	Daily dose (mg)	Full chickens reception (days)	Individual characteristics
Mild to moderate Zabol, Evan	Severe form of patho-ogy	Mild to moderate Zabol, Evan	Severe form of disease	Mild to moderate Zabol, Evan	Severe form of disease
Pills
Up to 12 years and children weighing less than 40 kg pills are contraindicated.
Children older than 12 years (with a weight of over 40 kg) and adults	1 tablet of 250/125	1 tablet of 500/125 or 875/125	3	At treatment with dose 500/125 multiplicity 3 times a day. When receiving the tablets 875/125 multiplicity use 2 times in 24 hours.	7 to 14	Objectified elyaetsya spe-Aliste on the dynamics of treatment	If spe-Aliste assigned tablets numbered 250/125, then produce self-replacing yours elf on 500/125 or 875/125 prohibited. Ntratsiya end-product varies.
Suspension
Infants under 3 months (ispol'uet-zuetsya suspension only with active substances parameters 125 / 31.5)	The daily dosage divided into 2 doses that need to implement every 12 hours.	30 mg per 1 kg weight grudnichka.	Duration of treatment is assigned a pediatrician on the severity of the pathology and tolerability.	When cald-tyvanii dosage should take into account the maxi-mal volume of the vial. Exceed the specified label is prohibited.
Children with weight categories of less than 40 kg or aged 3 months to 12 years (the suspension 125 / 31.5)	Calc'd daily dosage divided into 3 doses. Consumed every 8 hours.	From 20 to 40 mg per 1 kg of weight of the child. Depending on the severity of the disease.	Treatment lasts from 5 to 14 days. Adjusted dynamics of treatment.
Children with weight categories of less than 40 kg or aged 3 months to 12 years (for suspensions 200/400/57 and 25.8)	Intended daily dosage divided into 2 doses per day.	From 25 to 45 mg per 1 kg of weight of the child. The dosage is determined by the diagnosis	5	14	Self-oyatelno choose the type of drug (concentrations of active elements is recombination-enduetsya) determined by a specialist-sheet. When qs-gence substitution of one agent to another, it is necessary to negotiate with the doctor-correlator ktirovku course.
Children older than 12 years (with a weight of over 40 kg) and adults Execu-zuetsya only suspension 400/57	The daily dosage assigned therapist divided into 2 doses.	45 mg of the drug required for 1 kg body weight	5	14 possible to continue therapy until complete vyzdor-copulating, but not more than 28 days
injections
Infants up to 3 months	To prepare the solution needed 25-50 mg (taken into account the indicator amoxicillin) per 1 kg of weight.	2-3 depending on the diagnosis and the child's general condition.	Duration of Injection assigned pediatrician. While improving the state of health can translate to oral agents.	It is important to stir the mixture well before administration, until complete dissolution of the drug in the infusion fluid.
Children with weight category below 40 kg, or between the ages of 3 months to 12 years	3-4 dosing frequency is assigned a pediatrician
Children older than 12 years (with a weight of over 40 kg) and adults	Used drug 1000/200	Were injected with the drug 1000/200	3	4-6

For convenience of dosing are assigned specialist suspensions and tablets with the desired content of active substances. Prior to the appointment of medication is recommended to carry out the sensitivity of bacteria to Augmentin.

Side effects

The antibiotic can be administered orally or intravenously accompanied by side acts on the elements of the drug (generally mild)

• an allergic reaction to different types of (the rash is accompanied by itching, throat swelling, redness of the skin);
• disruption of the functioning of the digestive tract (abdominal pain, stool consistency violation, retching). Perhaps they gain on the duration of the reception means. Including deterioration state of the liver accompanied yellowness integuments;
• change of state oral mucosa with a probability of development of yeast as well as discoloration of the teeth enamel and darkening of the tongue;
• changes in blood composition with a decrease in the platelet count (dangerous bleeding stop bad), destruction of red blood cells and reduction in the number of leukocytes from the norm;
• twitching of muscles. Often caused by the deterioration of renal function;
• behavior change in children is characterized by hyperactivity, anxiety and poor sleep quality;
• disrupting the functioning of the renal system from deteriorating composition of urine;
• formation of lumps and veins change state at the site of injection;
• dizziness or headache develops extremely rare;
• strong decline in immunity, resulting in bacterial diseases can join viral or fungal disease.

When the manifestation of these complications requires adjustment or replacement therapy drug.

Overdose

Augmentin (instruction manual comprises the information about the maximum permitted daily dosages) can cause development of severe complications in excess of its concentration in the body due to non-compliance appointments specialist. To derive the excess drug from the body need care physicians.

In overdose or exceeded, the course of treatment the medicament develop following variations:

• profuse vomiting, loose stools;
• large concentration of salts in the urine, thereby disturbed water-salt balance, and functioning of the urinary system, including renal failure;
• strong spasmodic muscle contractions with the probability of injury;

Augmentin can deduce by dialysis (blood purification hardware).

special instructions

Individual instructions for receiving Augmentin:

• antibiotics can not be used in the treatment of intolerance to penicillin. The development of side effects can be fatal. If data is not available, it is necessary monitoring of the patient on the first day dosing;
• in the presence of the antibiotic is contraindicated mononucleosis. Its use in the treatment may cause a rash on the skin that will make it difficult to diagnose the dynamics of therapy;
• a long course of treatment may provoke proliferation of pathogens, which are insensitive to the drug, thereby will worsen the patient's condition;
• in the presence of liver function impairment or kidney disease, antibiotic treatment occurs under strict control. Individual selection of single and daily dose and therapy;
• if assigned a long course of administration of the antibiotic is monitored blood composition after 10 days, the state of the kidneys and liver. When a change is detected are replaced with the drug;
• to reduce the likelihood of complications in the digestive tract, oral agents should be taken before eating the food;
• after receiving the slurry must purification residues from the oral preparation for preventing browning of tooth enamel;
• during reception of the medicament is not recommended to transport;
• at higher doses of medicament (treatment of severe pathology) the quantity of salt consumed in the food should be reduced, and the fluid intake is increased, to prevent violations of water-salt balance.

The medicine can not be combined with alcoholic beverages as it increases the burden on the liver, which can lead to severe intoxication.

drug interactions

Augmentin (instruction manual contains information on the joint use of an antibiotic with other medicine) can not be combined with allopurinol (drug is given at an elevated uric acid content in blood). Simultaneous use of funds increases the risk of allergic reactions.

Augmentin reduces the effect of oral hormonal contraception use. For the period of treatment is necessary to comply with a different method of contraception. Simultaneous treatment with antibiotics and medications to reduce the activity of the immune system increases the risk of side effects from the second medicament.

When assigning two types of antibiotics in the form of injection, they can not be confused for a single administration. Injections are placed at intervals specified in the instructions. A powder mixture for intravenous administration can only be diluted with the infusion fluids (diluted in protein solutions is prohibited since last activity is neutralized).

analogs

If the use of Augmentin accompanied by side reactions or a composition contains the component causing an allergic reaction, the produced replacement the following medications:

• Amoxiclav.
• Artlet.
• Amovikomb.
• Baktoklav.
• Verklan.
• Klamosar.
• Liklav.
• Medoklav.
• Panklav.
• Rapiklav.
• Taromentin.
• Ekoklav.

Replacement is done by the attending specialist with the new appointment and a single daily dosage and course of treatment.

Terms, conditions of sale and storage

Augmentin can only be purchased on an existing recipe in Latin with an exact dosage of the drug and the course of treatment. Formulations retain therapeutic effect when stored in a cool and dark places (preferably the fridge). Packaged tablets were stored up to 3 years, the powder mixture up to 2 years.

Shelf-life of ready resources:

• A suspension for oral administration require refrigeration to 7 days. At 8 the drug loses effectiveness;
• Tablets in printed form can be stored 30 days;
• the powder mixture to be administered intravenously, via syringe kept for 20 minutes. For administration via IV can store 3 h.

Do not use the drug after the expiry date or if not properly stored. It does not contain a therapeutic effect, but will cause an adverse reaction.

Price Augmentin in different dosage forms in pharmacies of Moscow, St. Petersburg, regions

Price range varies from manufacturer, type of preparation and quantitative content in the active elements.

Average price indices by region (rub.):

View Augmentin	Moscow	St. Petersburg	Yekaterinburg	Permian	Volgograd	Khabarovsk	Sochi
Pills	250/125	264	274	259	238	240	265	257
500/125	373	378	270	357	259	274	263
857/125	252	259	248	241	243	253	246
1000/62,5	706	721	701	689	291	707	698
Powder mixture for injection	500/100	57	61	54	52	54	58	55
1000/200	138	143	134	124	126	139	134
the powder mixture for oral use	125/31,25	142	149	139	129	131	143	135
200/28,5	146	151	141	131	133	147	140
400/57	251	258	248	244	247	252	247

Augmentin, thanks to the combined composition, capable of destroying a large part of the diversity of bacteria. The drug is allowed to destination the attending specialist, after the determination of single and daily dosage (according to instructions), as well as the full course of therapy.

The drug is available with different concentrations of active elements, making it comfortable to use for all ages.

Author: Svetlana Kotlyachkova

Registration of the article: Mila Friedan

Video of Augmentin

Indications for use of Augmentin: