Lincomycin (Lyncomycin) in ampoules. Price, instructions for use, where to buy, dosage, reviews

Lincomycin - one of the popular antibiotics in ampoules, which is prescribed to patients of different ages in order to suppress the vital activity of pathogens. The price of the product is quite affordable, so everyone can undergo a full course of therapy. Despite the prevalence of the drug, its use must be agreed with the doctor, which will avoid complications.

Forms of release and composition of the drug

The medication is available in 3 dosage forms. Most often, in a hospital setting, a solution for intramuscular injection is used. It is transparent, packaged in 1 and 2 ml glass ampoules, which are placed in a cardboard box of 10 pieces. The ampoules are accompanied by instructions for using the medication; there is no sediment at the bottom of each ampoule.

In addition, on pharmacy shelves you can find capsules for oral use, which are packaged in blisters of 10 pieces. In an individual cardboard package there can be 2 such blisters, as well as instructions for use. There is also Lincomycin ointment, packaged in tubes of 10 or 15 g, but it is not used so often.

In any form of the drug, lincomycin hydrochloride is present as the main active ingredient. The solution also contains a small amount of water for injection. Other dosage forms also contain auxiliary ingredients that do not have therapeutic properties, but are necessary to preserve the chemical composition.

The medication is produced by various pharmaceutical companies in China, Belarus, Russia.

Pharmacological properties

Lincomycin in ampoules, the price of which is quite affordable, has pronounced anti-inflammatory, antibacterial and antiseptic properties, since it belongs to the group of antibacterial medicines. The active substance belongs to lincosamides, therefore it has a pronounced antimicrobial effect.

The anti-inflammatory properties of the agent are explained by the ability to destroy microbes that lead to the development of an inflammatory process in the tissues. The activity of the active ingredient is noted against gram-positive aerobic and anaerobic bacteria, which often affect the heart, pelvic organs, and bone tissue.

When exposed to the main substance, their gradual destruction and tissue restoration occurs. By eliminating the signs of inflammation, a local and general decrease in body temperature occurs, which also improves the patient's condition. With course use, there is a significant reduction in the risk of complications, as well as stimulation of the restoration of tissues affected by microbes.

Pharmacodynamics and pharmacokinetics

When the drug is administered parenterally, there is a rapid penetration of active components into the systemic circulation. The active substance is concentrated in the area of ​​inflammation and acts on pathogenic microorganisms.

Antimicrobial action is carried out due to the ability of lincomycin hydrochloride to disrupt the synthesis and exchange of proteins in pathogenic bacteria. As a result, metabolic processes are disturbed, followed by the death of microorganisms and a gradual recovery.

It is worth noting that many strains and various bacteria have been identified that are not sensitive to lincomycin hydrochloride. Among them are enterococci, as well as some fungi and other microbes. That is why the agent has a rather narrow spectrum of antimicrobial activity. Today, it is rarely prescribed, with strict indications indicating the development of a specific strain of microorganisms.

With parenteral administration, the maximum concentration of the component in the blood is detected after 30 minutes. The main amount of the active substance is concentrated in the tissues of the heart, bones and pelvic organs. Quite large doses are found in bronchial secretions, kidneys and liver.

The main amount of the substance is processed in the liver, where it breaks down into metabolites. The therapeutic effect during treatment is noted no earlier than after a few days. Removal of components from the body is carried out for 10-15 hours. The main part comes out with feces, a small amount of processed substances - with urine.

Despite the fact that a large dose of lincomycin is concentrated in the kidneys and pelvic organs, the organ is almost not involved in the elimination of processed ingredients. In patients who suffer from liver pathologies, there is a significant slowdown in the evacuation of ingredients from the body, which is associated with a dysfunction of the organ.

Despite this, with a mild form of pathology, the effectiveness of the drug is almost not reduced. Only with severe lesions with a significant deterioration in liver function is a decrease in the effectiveness of the drug noted.

In elderly patients, there is a slight slowdown in the period of assimilation and excretion. active components from the body, which is explained by natural processes that inhibit metabolism. It is worth remembering that the drug crosses the placental barrier and passes into breast milk.

Indications for use

Lincomycin is prescribed for various pathological conditions of microbial origin. The drug in ampoules is considered more effective, and its price does not differ much from oral or external forms.

The main indications for the use of the medication are as follows:

• Bone pathologies that are provoked by microorganisms that are sensitive to lincomycin. With osteomyelitis, septic arthritis, the appointment of the drug is considered the most appropriate, since it helps to stop the inflammatory process.
• Diseases of the upper and lower respiratory tract. The tool effectively copes with the signs of bronchitis, laryngitis and tracheobronchitis. It can be prescribed for pneumonia, as well as sore throat or sinusitis. With the latter disease, the remedy is considered effective as part of a comprehensive treatment.
• Hearing system pathologies, for example, otitis media, are treated quite well with the aid, but only at the initial stage and in the absence of complications.
• Diseases of soft tissues, which are provoked by microbes sensitive to lincomycin. With furunculosis, abscesses, erysipelas and purulent wounds, the drug is prescribed in combination with external drugs in order to accelerate recovery and prevent microbes from entering the blood.
• Purulent processes in the area of ​​the roots of the teeth, which can lead to complications.
• Inflammatory pathologies of the oral cavity, for example, periodontitis, periodontitis, gingivitis. These diseases are often caused by microorganisms sensitive to lincomycin, so the use of the drug helps to eliminate symptoms and prevent complications.

Sometimes the medicine is used as part of the complex therapy of chronic bronchitis, when it is necessary to enhance the effectiveness of mucolytics and other drugs.

Contraindications

An effective remedy cannot be used when detecting intolerance to its components or a tendency to allergic manifestations, since the risk of complications increases. Antibiotics are not prescribed for severe hepatic failure, as well as cirrhosis of the liver, acute hepatitis of various origins.

In case of renal failure, the agent is used in rare cases, according to strict indications and under the supervision of a physician. In addition, contraindications include internal bleeding of various origins, exacerbation of gastric ulcer and duodenal ulcer. Fungal and viral diseases are also an obstacle to the appointment of a medicinal solution.

Do not use an antibiotic when a persistent allergy to drugs from the lincosamide group is detected. In acute heart attack and stroke, the medication is also contraindicated. Do not prescribe the drug during pregnancy and breastfeeding. In exceptional cases, it is allowed to use it in the 2nd and 3rd trimester, but only in the case when the potential harm to the child is much lower than the intended benefit to the mother.

Elderly patients suffering from chronic heart or neurological diseases, the drug is prescribed with caution.

At what age can the drug be used?

Lincomycin in ampoules (the price may differ in different pharmacies) and other dosage forms are prescribed to patients over 6 years old.

In pediatric practice, the ointment can be used in the treatment of children under 6 years of age, but the appointment is made only by a doctor.

Instructions for use, dosage

The solution for injection is administered intramuscularly or intravenously, depending on the patient's condition and some characteristics. The treatment regimen may differ for each disease.

However, the standard method involves the introduction of intramuscularly 2 ml of the drug 3 times a day for 10 days.

In each case, the dosage is determined individually, sometimes it is required to administer 2 ml of the drug 4 times a day and extend the course up to 2 weeks.

As a rule, an increase in the dose is required in case of extensive lesions of soft tissues, when several agents are used at once in order to increase the effectiveness.

It should be noted that the maximum dose for an adult per day is 8 ml of the drug. It is not recommended to exceed it not only at home, but also in the hospital, since the risk of complications increases.

The drug can also be administered intravenously using a dropper when it is not possible to do intramuscular injections or the introduction of 2 ampoules of the agent at once is required to achieve a quick therapeutic result. The procedure is carried out in a hospital 1 to 2 times a day. In a bottle with 200 ml of sodium chloride 0.9%, 2 or 4 ml of a medicinal solution is injected, after which it is poured into the patient slowly.

The course of treatment with this application does not exceed 10 days. In most cases, this is sufficient to obtain the maximum therapeutic result. During the infusion, the patient's condition is monitored by medical personnel.

Children are always prescribed an antibiotic intramuscularly. For patients from 6 to 14 years old, the daily dosage is determined depending on the weight. For 1 kg, there is 20 mg of the drug. 1 ml of solution contains 300 mg of the active ingredient. This means that for 15 kg of the product there is 1 ml of the product.

In each case, the dose is determined by the pediatrician, taking into account the characteristics of each patient and the severity of the course of the disease. Children whose body weight exceeds 25 kg are prescribed 30 mg of medication per 1 kg of body weight, that is, a patient weighing 30 kg is injected with 1 ml of medication.

Patients over 14 years old can be prescribed an adult dosage, but intramuscular injections are given no more than 2 times a day for 10-14 days. If necessary, adjust the dose or duration of use, you should consult your doctor.

Side effects

Lincomycin in ampoules (the price depends on the amount of the product in the package) does not often provoke side effects reactions, but doctors do not exclude such a possibility, which is associated with the individual characteristics of each sick.

Organs and systems	Most common complications
Nervous system	Headache, drowsiness and weakness are common with treatment. Symptoms often occur in children who have not previously received parenteral antibiotics. Sometimes there is sleep disturbance, depression and deterioration in mental performance.
Heart and blood vessels	An increase in blood pressure indicators is observed in elderly patients. In addition, there may be severe dizziness that occurs against the background of hypertension, as well as other disorders, for example, tachycardia, arrhythmia.
Hematopoietic system	Low platelet counts are a common complication. Possible violation of the formation of neutrophils and granulocytes. Such violations are detected only during the study of blood, when the patient addresses other complaints.
Musculoskeletal system	Muscle weakness and pain occurs more often in adults, which leads to a decrease in mobility and performance. Often the condition is accompanied by general weakness.
Skin	Allergy to a drug is often manifested, especially if you ignore the rules that imply a preliminary test for antibiotic sensitivity. Allergy manifests itself in the form of a rash, itching and burning of the skin, areas of irritation and peeling may appear.

The severity of negative reactions depends on the organism of a particular patient. If such violations appear, it is necessary to stop medication treatment and visit a doctor.

Overdose

When using the product in accordance with all the rules, the probability of an overdose is very low. However, with the use of large doses over a long period, the development of complications from the mucous membranes and intestines is noted. Signs of colitis or enteritis may appear.

The condition is accompanied by nausea, poor appetite and vomiting. In addition, patients talk about colic and pain in the intestines, upset stools.

Most people have frequent loose stools, pain during bowel movements, and signs of dehydration. Such disorders can persist for several days. Sometimes taking large doses of the drug leads to the development of a neglected candidal infection, which is associated with a violation of the microflora of the mucous membranes.

In women, candidiasis is more pronounced, provokes itching of the genitals, burning sensation during urination and other disorders. If symptoms of an overdose appear, it is important to stop using the medication. If they do not disappear, it is better to consult a doctor who will prescribe remedies for stopping manifestations.

special instructions

Before starting antibiotic treatment, it is important to conduct a sensitivity test, which will exclude the risk of developing adverse reactions or severe allergies. For the sample, you will need 1 ampoule of the drug and a saline solution of 0.9%.

The nurse draws 0.1 ml of the medicinal solution into a 10 ml syringe, and then fills it up to the 10 ml mark with sodium chloride. After that, the patient makes a subcutaneous test in the area of ​​the inner side of the forearm. The needle is inserted a few millimeters, a small amount of the agent enters the skin, which can be seen from the formed eminence.

For 15-30 minutes, the patient's condition is monitored, who does not leave the manipulation room. The area of ​​introduction should not be treated with any solution and rubbed by hand during this period. In addition, the patient should be warned to keep his hand away from clothing. A small drop of blood may appear at the injection site, which is normal.

After the allotted time has elapsed, the doctor assesses the body's response to the antibiotic. A negative test is considered in the absence of edema, severe redness, rash and itching at the injection site. If such manifestations are present or there is at least one of them, the test is considered positive and the antibiotic is not used for a particular patient.

Drug interactions

Lincomycin in ampoules (the price of different forms of the drug may differ) is not prescribed in combination with other antibacterial medicines. When used in combination with non-steroidal anti-inflammatory drugs, the risk of developing respiratory failure is increased, so this combination should be avoided.

You can not combine the drug with antidiarrheal drugs, muscle relaxants and adsorbents. This reduces its effectiveness and increases the negative impact on the body. It is especially dangerous to prescribe the drug in combination with Kanamycin and Ampicillin.

Negative reactions do not develop when the drug is combined with multivitamins, vascular and nootropic medicines. However, in each case, a doctor's consultation is required if the patient takes any drug on an ongoing basis.

Analogs

If it is impossible to use the original medication, it should be replaced with a remedy with similar therapeutic properties.

The most popular analogues:

• Dalatsin - an analogue of the agent, which belongs to the same pharmacological group, but contains another active ingredient in its composition. It has pronounced properties, it is prescribed for inflammatory and other diseases provoked by the activity of gram-positive microorganisms. It is available in several dosage forms, which facilitates the therapy of patients of different ages.
• Clindamycin - an agent based on the active ingredient of the same name, which has the same therapeutic properties. Available in several forms, including in the form of a solution. Helps to cope with various inflammatory diseases and prevents their progression, the development of complications.

Drug analogues are prescribed only by a doctor after examination. Self-application is strongly discouraged.

Terms, conditions of sale and storage

You can store the medication for 4 years. It is prohibited to use after the expiration date.

During storage, it is important to limit access to sunlight, children and low temperatures. The drug is not frozen. In the pharmacy, the medicine is dispensed with a prescription from a doctor, which is considered an advantage, since it excludes the possibility of self-medication.

Price

The cost of the product may differ in different pharmacies and regions. Its average price is 50-70 rubles. for 10 ampoules.

Lincomycin is a popular and effective drug in ampoules that helps to cope with many pathological conditions of microbial origin. Affordable price and ease of use makes the medication in demand among patients of different ages. Despite this, it is important to visit a doctor beforehand and make sure that there are no contraindications.

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