Azitrox (Azitrox) suspension for children. Instructions for use, analogues, price, reviews

Azitrox is a drug new generation from the group of antibiotics. The tool destroys a wide range of pathogenic microorganisms and at the same time (when compared with other medicines from this group) Azitrox contains a small list of contraindications and complications.

In this regard, the drug is popular for the treatment of children. When prescribing an antibiotic, it is important to strictly adhere to the rules that are indicated in the instructions. For the convenience of dosing and using the medication, Azitrox is prescribed in the form of a suspension in pediatrics.

Indications for use

Azitrox is presented in the form of a powder for subsequent preparation of a suspension, which, due to the main element, has a detrimental effect on pathogenic microflora.

Despite the fact that the drug contains a small list of side effects, the drug should be taken strictly in the presence of indications, which include:

• diagnosing an infection in the upper respiratory tract. For example, sinusitis, tonsillitis, rhinitis;
• infection of tissues of the hearing organs (otitis media of various forms);
• the presence of an infection in the lower respiratory tract. These include: pneumonia, bronchitis, tracheitis and other pathologies;
• detection of infection in the genitourinary system (urethritis, adnexitis, vesiculitis and others);
• violation of the integrity of the skin by infection. For example, acne, impetigo, folliculitis and other pathologies;
• infectious pathologies of the digestive tract (stomach and duodenal ulcer);
• borreliosis or lyme disease. The infection enters the body through a tick bite. The antibiotic allows you to destroy the pathogen only at an early stage of infection.

Before prescribing Azitrox, tests are required to determine the sensitivity of the infection to an antibiotic.

Compound

Suspension Azitrox consists of an active substance (azithromycin) and auxiliary components. The active element is a semi-synthetic antibiotic that has a depressing effect on bacteria (inhibits protein synthesis in microorganisms) as a result, they stop growing and lose the ability to reproduction. The course administration of the drug ensures the complete death of the infection.

Auxiliary components allow you to give the antibiotic the desired appearance and extend its shelf life.

These elements include:

List of auxiliary components	Description of the action of the components
Sucrose	The element gives the suspension a sweet taste and also prolongs the shelf life of the antibiotic
Sodium carbonate anhydrous	The substance prevents clumping and sticking of powder particles
Xanthan gum	The component is a stabilizer and thickener. Xanthan gum allows you to keep the prepared suspension of the required consistency
Hyprolosis	The substance facilitates the dissolution of the elements used, in addition, hyprolose is a thickener
Flavors (vanilla, banana and cherry)	Flavors give the suspension a pleasant aroma, as a result, the child does not refuse to take the product

All of these elements are contained in the drug in strictly selected proportions, ensuring the effectiveness of antibiotic treatment.

In what form is it produced

Azitrox is a suspension for children, produced in powder form in two versions. The difference between these forms is only the different content of the active substance. One form contains 100 mg of azithromycin per 5 ml of the finished suspension. In the second form, the concentration of the active element is 200 mg per 5 ml of the finished suspension.

The powder is placed in a 50 ml container made of dark glass. Due to the different concentration of the antibiotic, one bottle can contain 400 and 800 mg of azithromycin. Azitrox in dry form (powder) is presented in the form of small granules of white color (yellow or creamy shade is possible) with a slight smell of the used flavors.

After preparation, the suspension is pale yellow or light cream in color. Azitrox is similar in consistency and sweet taste to syrup. For the convenience of dosing the antibiotic, an instruction, a measuring spoon and a syringe are in the carton along with the bottle.

The price of an antibiotic depends on the type of pharmacy, the region of sale and the concentration of the active substance. The average cost for Azitrox 100 mg / 5 ml is 200 rubles. And for a medication with a dosage of 200 mg / 5 ml, you can purchase for 330 rubles.

Pharmacodynamics

The main element of the antibiotic entering the body begins to affect the pathogenic microflora. It penetrates into bacterial cells, and slows down the process of protein synthesis in them. As a result, bacteria stop growing and gradually die, since protein is necessary for their life.

Also, due to protein deficiency, bacteria lose their ability to reproduce. As a result (but only subject to the rules for taking the suspension and undergoing a full course of treatment), the drug completely destroys the pathogenic microflora, which is sensitive to this antibiotic.

Due to the above action, the antibiotic has the following effect on the body:

• in the area affected by the activity of bacteria, the cessation of the development of the inflammatory process is noted. As a result, the temperature and swelling of the affected tissues decreases;
• due to the death of bacteria, the intoxication of the body stops (bacteria in the process of life release toxins). Intoxication also causes an increase in temperature and a sharp deterioration in the patient's condition.

After eliminating bacteria, the child's immunity is gradually restored. It should be borne in mind that an antibiotic can destroy not only pathogenic microflora, but also beneficial microorganisms, therefore, drug abuse can lead to a deterioration in well-being.

It is important that the exact list of antibiotic-sensitive bacteria is listed in the instructions for the drug.

Pharmacokinetics

Azitrox is a suspension for children, after taking it initially it enters the digestive tract, from where the antibiotic gradually enters the bloodstream. The maximum amount of the drug in the blood is noted 2.5-3 hours later, after taking the medication. It should be borne in mind that if the antibiotic was taken with food, then the absorption time of Azitrox increases.

Further, through the bloodstream, the main component enters the focus of infection. The drug can easily penetrate tissue barriers and cell membranes, having a 100% destructive effect on pathogenic microflora. But, after the passage of blood with an antibiotic through the liver, the main element breaks down into substances that no longer have a bactericidal effect.

Since Azithromycin is found not only in the blood, but also penetrates into the tissues of cells, it is excreted from the body for a long time (all this time the drug has a therapeutic effect), approximately 5-7 days. In this regard, the duration of antibiotic intake should not exceed 5 days.

The main element is excreted from the body mainly with feces and about 6% of the drug is excreted in the urine.

Application for children under 18 years of age

Azitrox in the form of a suspension can be used in pediatrics after the child reaches 6 months. It should be borne in mind that the dosage of the drug varies according to the type of pathology and the weight of children.

Before starting to use an antibiotic, it is important to properly prepare the suspension, for this you need to observe the following points:

1. First, you need to boil filtered water and cool it to a temperature of 20-25 degrees.
2. Measure with a syringe (included in the package with the antibiotic) 9.5 ml of water is required.
3. Open the bottle and pour water from the syringe into it.
4. Close the bottle with a lid and shake the contents thoroughly. You should get a lump-free suspension. The volume should be equal to 20 ml.

   

After that, the suspension can be used or put away for storage in a package.

Further, to achieve a result, you should follow the rules for taking an antibiotic:

• the suspension must be consumed once a day at the same time;
• before use, the antibiotic bottle must be shaken so that the suspension becomes homogeneous again (during storage, the powder may settle to the bottom);
• rinse the syringe (or measuring spoon) and dry (during the first administration of the drug);
• accurately measure the prescribed dose of the medication;
• after taking, the child needs to be given a drink of water. Enough 20 ml. The water will rinse the antibiotic residues from the mouth;
• wash the syringe or spoon after taking the drug;
• keep the bottle closed;
• you need to store the syringe / measuring spoon in a cardboard box along with the bottle;
• after the end of antibiotic therapy, the child should drink a course of probiotics to restore the intestinal microflora.

Azitrox should be taken by the baby about 1 hour before eating or 2 hours after feeding.

It is important that if an antibiotic is accidentally missed, it should be given to the child immediately (that is, immediately after finding the gap, do not wait until the next dose is taken). Further, Azitrox will need to be taken after 24 hours.

Next, the dosages of the antibiotic are considered, depending on the weight and type of pathology:

Child weight (kg)	Suspension with azithromycin concentration 100mg / 5 ml (dosage in ml)	Suspension with a concentration of azithromycin 200 mg / 5 ml (dosage in ml)	Azithromycin dosage in mg
With infectious pathologies of the ENT organs, respiratory tract, genitourinary system, as well as the gastrointestinal tract. The duration of the course is 3 days.
5	2,5	—	50
6	3	1,5	60
7	3,5	—	70
8	4	2	80
9	4,5	—	90
10	5	2,5	100

Further, the weight can be calculated independently, this requires 1 kg of the child's weight multiplied by 10 mg of azithromycin.

Note. The sign "-" means the inconvenience of dosing at a given concentration of the medication.

When diagnosing borreliosis, the dosage and course of taking the drug are as follows:

• on the first day, it is required to give an antibiotic at the rate of 20 mg per 1 kg of body weight 1 time during the day. That is, the values ​​in the above table must be doubled;
• from 2 to 5 days, the child should take the drug at a standard dosage once a day. That is, 10 mg per 1 kg of body weight.

To eliminate infectious pathologies on the skin, the following dosage must be observed:

• the first 3 days you need to take a standard dosage once a day (10 mg per 1 kg of body weight);
• this is followed by a break of 4 days;
• on the 8th day (from the start of treatment) it is necessary to take a standard dose;
• further Azitrox is required to be taken for 9 weeks, 1 time per week.

With pathologies of the genitourinary system in severe form, the antibiotic should be taken once with a dosage of 20 mg per 1 kg of body weight.

Contraindications

Azitrox is allowed to be used in pediatrics only after excluding the presence of the following contraindications in the child:

• hypersensitivity to the components of the drug, including allergy to the components. The use of the drug can cause the development of anaphylactic shock;
• diseases of the liver and kidneys in severe form. The drug affects the activity of these organs, as a result, there is a high probability of a sharp deterioration in well-being, up to the failure of the organs;
• age up to 6 months. The antibiotic can interfere with liver and kidney function.

It is also required to adjust the dosage of the medication if the child has the following pathologies:

• diabetes. The antibiotic contains sucrose, so the pediatrician must choose a gentle but effective dosage;
• diseases of the cardiovascular system (especially with arrhythmias and bradycardia);
• myasthenia gravis. It is an autoimmune disease characterized by rapid muscle fatigue. The antibiotic penetrates the muscles, and due to the presence of this pathology, it can be excreted from the body for a longer time;
• in case of violation of the water-electrolyte balance (in particular, hypokalemia and hypomagnesemia).

Azitrox should be taken with caution in the presence of a fungal infection. The antibiotic destroys not only pathogenic microflora, but also useful, as a result, for a fungal infection there are "ideal" conditions for growth and reproduction.

Overdose

Azitrox - suspension for children, should not be taken longer than the specified course or with an increase in dosage.

Ignoring these recommendations can cause the development of the following deviations:

• severe nausea, vomiting is possible;
• diarrhea (or lack of bowel movement). The antibiotic has a detrimental effect on the intestinal microflora, as a result, the organ ceases to function normally;
• hearing impairment or loss;
• yellowing of the sclera of the eyes and skin due to impaired liver function;
• manifestation of nervousness, aggression;
• violation of the heartbeat, may be accompanied by a blue discoloration of the nasolabial triangle;
• severe dizziness and disorientation;
• deterioration in the quality of vision;
• voluntary muscle contractions in the limbs;
• if the child is allergic, then there is a high probability of developing Quincke's edema.

If an overdose occurred one-time, then it is required to rinse the child's stomach and give sorbents in the near future. If a child is younger than 3 years old or poisoning has occurred due to prolonged use of the drug, then an examination of the victim in the hospital is necessary, followed by the appointment of symptomatic treatment.

Side effects

The course of antibiotic treatment can be accompanied by the following side effects:

• thrush in the mouth and genitals (especially in girls);
• inflammation of the mucous membrane of the pharynx and bronchi;
• exacerbation of gastrointestinal diseases;
• rhinitis and other colds;
• inflammation of the mucous membrane in the intestine;
• violation of the composition of the blood (including a decrease in the level of leukocytes, platelets, erythrocytes);
• sharp weight loss;
• dizziness or headache complaints;
• change in taste and lack of appetite;
• violation of sensitivity, feeling of goose bumps on the skin;
• fatigue, drowsiness, or vice versa, lack of sleep;
• increased anxiety, severe overexcitement or aggression;
• loss of consciousness, hallucinations;
• spontaneous convulsions;
• change or impairment of smell;
• deterioration in the quality of vision;
• tinnitus or hearing impairment, up to complete deafness;
• palpitations, facial flushing due to rush of blood;
• lowering the pressure indicator;
• arrhythmia or bradycardia;
• violation of the breathing process (shortness of breath, sleep apnea);
• diarrhea or constipation;
• nausea, vomiting;
• increased gas production and abdominal pain;
• dryness of the mucous membrane in the mouth;
• violation of the activity of the kidneys and liver (the development of hepatitis is possible).

If an allergic reaction has not been ruled out, then skin rashes, itching and Quincke's edema are possible. When diagnosing these symptoms, you must stop taking Azitrox and contact your pediatrician to adjust the treatment.

Drug interactions

Azitrox - suspension for children, can be used in complex treatment only after consultation with a pediatrician, since it is necessary to take into account with which drugs it is forbidden to combine the antibiotic, and when it should only be adjusted dosage.

The antibiotic must be combined with caution with the following medicines:

• preparations containing an antacid (a means to reduce acidity in the stomach) or ethanol reduce the absorption of the antibiotic;
• you can not take Azitrox and other types of antibiotics at the same time. Shared use will provoke an increase in side effects;
• the simultaneous use of an antibiotic and warfarin (the drug is used to prevent blood clotting) enhances the effect of the last medication;
• the antihistamine terfenadine and Azitrox can provoke the development of arrhythmias;
• aluminum and magnesium containing medications impair the absorption of the antibiotic. Therefore, medications must be taken at intervals of at least an hour;
• Azitrox can enhance the action of the immunosuppressant cyclosporine and the heart drug Digoxin;
• Antibiotic and ergot alkaloids (used to strengthen the tone of the uterus) can cause severe poisoning of the body.

It is categorically impossible to combine the use of Azitrox and Heparin (the agent inhibits blood clotting). Internal bleeding may develop.

Storage conditions and periods

An unopened vial of powder can be stored for 2 years from the date of manufacture. In this case, the antibiotic should be in the box, and the room temperature should not exceed 25 degrees.

After preparation of the suspension, the shelf life of the medication is reduced to 5 days. The product should also be in a box, at a temperature of 2 to 25 degrees above zero.

It is important to freeze the finished suspension in order to extend the shelf life, it is strictly forbidden. The drug immediately loses its therapeutic properties.

Conditions of dispensing from pharmacies

To purchase Azitrox in a pharmacy, a prescription from a doctor is required. In this case, the prescription should indicate not only the name of the medicine, but also the prescribed course with a dosage.

Analogs

If a child has a medication, a severe allergic reaction or other side effects, it is necessary to replace Azitrox with other types of antibiotics.

The following types of drugs have similar therapeutic properties:

List of antibiotics	Age restrictions	Nuances of treatment
Azithromycin. Tablets and powder for suspensions.	The powder is prescribed for children weighing more than 5 kg, and tablets weighing more than 45 kg.	Powder dosage and duration of treatment are similar to Azitrox
Sumamed. Capsules, powder and tablets with different concentrations of the active substance.	The powder is prescribed after 6 months. Tablets with a dosage of 125 mg are approved from 3 years old. Capsules and tablets with a dosage of 500 mg can be used in treatment from the age of 12.	A single dosage of tablets, powder and capsules is calculated based on the weight of the child. The duration of the antibiotic intake is 3 days.
Azitrus. Capsules with a dosage of active substance 250 mg and 500 mg	Capsules are prescribed for children weighing more than 25 kg.	The dosage of the drug is 500 mg once a day for 3 days.
Hemomycin. Capsules, powder, tablets and injection.	The powder can be used from 6 months. Other types of the drug, only if the child weighs more than 45 kg	Antibiotic dosage and course are similar to Azitrox
Azicide. Tablets with an active ingredient concentration of 250 and 500 mg	An antibiotic in pediatrics is prescribed when a child weighs more than 25 kg	The dose of the drug is calculated by weight. The duration of treatment is 2-5 days.
Zitrolide. Capsules	The drug is prescribed if the child weighs more than 45 kg.	Capsules must be taken once a day for 3 days. In severe pathologies, the course of treatment is adjusted.
Azitral. Capsules with an active ingredient concentration of 250 and 500 mg.	Until the child reaches 12 years of age, no medication is prescribed	For treatment, it is necessary to take 500 mg of the active substance once a day for 3 days

The closest, in terms of characteristics, analogue are Azitrox capsules. You can take an antibiotic in this form only after the child reaches 12 years of age.

Azitrox is popular in pediatrics (data taken from reviews), since the antibiotic only needs to be taken once a day, and the duration of treatment is on average 3 days.

At the same time, due to the sweet taste and fruity aroma, children can easily swallow the product. Also, of the listed side effects, only the development of diarrhea, mild abdominal pain, less often a rash were recorded. Moreover, these complications manifested themselves at the end of the use of the suspension.

Author: Kotlyachkova Svetlana

Video about the active substance Azitrox

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