Dioksidin instructions for use: a solution in ampoules, ear, nose, throat for washing, inhalation, compress, adults and children. How to breed, analogs, reviews, price

Dioxidine - a drug of domestic production, which was widespread in the Soviet Union. Due to its strong toxicity, and side effects as described in the instructions, use recommended in extreme cases.

Description dioksidina

Dioksidin (Gidroksimetilhinoksilindioksid) - drug with antibacterial action. The chemical formula C10H10N2O4. It refers to topical antibiotics. It has high bactericidal properties and resistance to other types of antibiotics.

It is active against various types of bacteria, pathogenic anaerobes. Able to influence the types of bacteria that are resistant to other drugs.

Release form and composition

It is produced in the form of:

• Ointment for external use 5%, which is presented for sale in the box 30 and the weight 40 g;
• 1% solution for infusions and outdoor use. It occurs in ampoules made of glass with a high chemical resistance, which are packed in a special foil material or paper. If no breakpoint in a glass jar, a knife attached to the opening;

• 1% solution for internal use, which is also applicable to the treatment of superficial damage. Packed into glass vessels 5, 10 ml. It comes in a cardboard box.

pharmachologic effect

The instructions for use is specified: Dioksidin - antibacterial medication orientation. It causes strong structural changes in the cytoplasm of microorganisms. It has chemotherapeutic activity to a variety of infections.

The drug is used with various body injuries. Its use in this case causes rapid cleaning wounds and accelerates their regeneration. All this has a positive effect on the general course of healing.

Pharmacodynamics and Pharmacokinetics

The drug is used for infections caused by:

• Klebsiella (Klebsiella pneumonia, Klebsiella oxytoca et al.);
• coliform bacteria;
• Salmonella;
• staphylococci and streptococci;
• pathogenic anaerobes.

The pharmacokinetics of this facility is poorly studied. For internal administration it is well into the various tissues of the body. Also well absorbed when applied externally and introduced into the cavity. Dioksidin displayed via the kidney, the accumulation in the body when it is absent.

Indications for use dioksidina

In external use Dioksidin effective in:

• lesions of body tissues of different kinds of gravity;
• injuries are difficult to treat;
• acute purulent inflammation of tissues;
• infected burns;
• osteomyelitis.

Internal application is effective in:

• intracavitary purulent diseases;
• inflammation of the pleural empyema and sheets, suppurative destructive formations in the lungs, cystitis and peritonitis;
• a bad cold in the form of prolonged after failure of other therapies.

Contraindications

Using dioksidina possible in such cases:

• during pregnancy;
• period of breast-feeding;
  
• enhanced susceptibility to components of the drug;
• adrenal insufficiency;
• renal failure (decrease drug administration);
• the use of children.

Side effects

When applying dioksidina may experience side effects such:

• okoloranevoe inflammation;
• headache;
• chills;
• temperature rise;
• allergy;
• involuntary muscle contractions;
• nausea and vomiting;
• itching.

Application dioksidina ampoules

Nasal drops:

1. long runny nose;
2. ineffectiveness of other therapies;
3. occurrence of secretions in odor and color.

The liquid for inhalation nebulizer:

1. lung abscess;
2. inflammation of the bronchi in severe;
3. sinusitis and sinusitis;
4. empyema.

Form direct use locus:

1. pneumonia;
2. cystitis;
3. inflammation of the tissues;
4. infectious diseases in the chest and abdominal cavities.

Application in solution Dioxydinum

• Sophisticated drop;
• Intravenous drip:

1. meningitis;
2. purulent infection with rapid spread;
3. prevention of postoperative complications;

• Compresses and applications:

1. therapy healing long period of wounds and ulcers;
2. severe effects of varicose veins;
3. angiopathy, diabetic complications.

Use as an ointment Dioxydinum

Trituration:

1. superficial wounds moderate and severe forms;
2. bedsores.

plugging:

1. severe gashes;
2. high severity burns.

Application dioksidina topically

According to the instructions, it is recommended to apply Dioksidin skin thermal injury (burns), and wounds of varying severity:

• in the treatment of infected wounds with purulent formations applied gauze soaked in Dioksidin (0.5-1%);
• deep body damage tamponiruyut means 1%;
• osteomyelitis bath made from medicinal preparation (0.5-1%), or inject it inside injury for up to 20 minutes, with further overlaying Dioxydinum napkin with 1%;
• after surgery in order to prevent infections. With this means copes with Gidroksimetilhinoksilindioksida content of 0.1-0.5%.

Application dioksidina vnutripolosto

The drug used in the treatment of intracavitary purulent formations. For this administered daily Dioxydinum 10-50 ml of 1% in the requested area (based on the size of the lesion).

Is performed with a syringe or catheter, drain tube also applicable. Daily share patient receives 1, at least 2 times. The absence of side effects makes it possible to use Dioksidin up to 3 weeks.

Maximum daily administration should not be higher than 70 ml. Repeated courses of administration, may be appointed after 1 or 1.5 months.

The use of intravenous dioksidina

Intravenous agent used in inflammatory conditions, severe, purulent meningitis and severe chronic inflammatory reactions in the body.

The drug is slowly introduced dropwise by 3 or 4 treatments. The daily dose should not exceed 900 mg (prescribed by a doctor in extreme cases increases of up to 1200 mg) of the drug. Preparing a solution by mixing the drug with 0.5% glucose, 5%. The concentration of active ingredient in the resulting solution should be between 0.1-0.2%.

Application dioksidina children

Using Dioksidin child, instructions for use should be studied thoroughly. The drug is administered to children only in severe cases when other drugs do not have the desired effect.

It is used in chronic purulent processes, prolonged fever, severe infections, otitis media:

• Dioxidine used as nasal drops. For this preparation was injected into the nasal passage 2 drops of 2 times a day;

• Perhaps the use of the drug as an inhalation. It is used to remove heavy wet cough. For this Dioksidin 0.5% were mixed in a ratio of 1: 2 with saline. Preparation 1% diluted 1: 4.

Application dioksidina during pregnancy and lactation

Because of its strong toxicity and adverse effects on the fetus, the drug is not recommended for pregnant women to receive. Exceptional cases may be serious consequences of rhinitis, sinusitis.

In these situations, the drug is prescribed topical (drops, inhalation) in low concentrations:

• Buried in the nose 5 drops 3 times a day;
• The ear is recommended at a dosage of 0.5 g per day, 2 times;
• As used inhalation Dioksidin 0.5% saline in the ratio 1: 2.

More than 8 mg of the drug per day smoking.

Use in a nebulizer

Inhalation nebulizer using Dioxydinum used for sinusitis, tonsillitis, pharyngitis and laryngitis. A solution is prepared as follows: 2 ml of the preparation of 0.5% to 4 ml saline. The procedure is carried out for 2-3 minutes followed by an increase up to 5-7 min. Inhalation is repeated every day for 7 days.

Instructions for treatment of ear

It is used for purulent otitis, when other drugs do not give the desired effect. Drip necessary in completely purified auditory meatus. Means for children is taken 0.5% hypertonic solution which is diluted to a concentration of 0.2%. Instill 1-2 drops 2 times a day.

The adult dosage is increased to 3 drops. Treatment should not exceed 7 days.

Instructions for treatment of throat

Instructions for use describes the use of the drug dioksidina with pharyngitis, tonsillitis, severe purulent and inflammatory processes of the throat. Drug concentration in the solution should be chosen based on the severity of the disease. Thus, when the ampoule 1 purulent angina drug is diluted with 0.1% miramistinom heated in a glass of water. Washing the throat held up to 4 times per day.

For the treatment of the throat there is another way: to Dioxydinum miramistinom with added hydrogen peroxide (2 tbsp. spoons), which is separately diluted with warm water. The procedure in this case is done by pairwise gargling with these solutions (1 pharynx each) in an amount of 3 times per day.

Instructions for the treatment of nasal

The drug is only indicated for such diseases and symptoms as acute inflammation, chronic rhinitis, mucus odorous and color, heavy sinusitis.

For droplets used Dioksidin 0.5% diluted with hydrocortisone, epinephrine or sodium chloride with water. As a result Dioxydinum concentration should be 0.1-0.2%. In this form, the drug is administered 2-3 drops into each sinus 3-5 times a day. During normal periods tolerability of drug treatment is achieved 4-5 weeks.

For children the drug is rarely used, since the age of 12 years. Its use is justified only in severe forms of the disease. Thus Dioksidin diluted at 1: 2.

Instructions for the treatment of bronchial tubes

The drug administered with inflammatory pathologies of the airways (bronchitis, tracheitis). To relieve the symptoms of it is used in the form of inhalation.

For this purpose Dioksidin 0.5-1% in ampoules. It is diluted with saline 1: 2 (at 0.5%) or 1: 4 (at 1%). Adults Inhalation spend, starting with 3 minutes with an increase up to 5-7 minutes. Use the intensity of 1 time per day. the duration of treatment should not exceed 7 days.

Children's inhalation is only possible with a weak effectiveness of other less toxic agents. For this drug is taken, and 0.5% is mixed with saline 1: 4. Displacement of the active substance must not be higher than 2 ml for 1 procedure, the dosage depends on the age and weight.

Instructions for the treatment of wound surfaces

The external agent applicable in the presence of different concentration of surface wounds, trophic ulcers, burns, wounds osteomyelitis.

It is used as an ointment and liquid:

• When the napkin is applied superficial wounds with Dioxydinum 1%;

• In deep wounds additional plugging is performed using the desired location Dioxydinum 1%;
• In severe cases, osteomyelitis appointed bath with the drug solution (for 20 minutes) with subsequent overlaying napkins to the affected area.

Overdose

Overdose (low tolerance) is the source of the drug:

• Acute adrenal insufficiency. If you experience this symptom requires immediate cancellation dioksidina and hormone therapy;
• Okoloranevogo dermatitis. This feature requires a reduction in the number of received drug or substituted for a portable similar means;
• Anaphylactic shock. This requires immediate discontinuation of the drug, a set of measures for patient treatment;
• Photosensitizing effect. This feature requires reducing the dosage of the drug, or a similar replacement;
• Nausea and vomiting. If you experience this symptom need to discontinuation of the drug, a set of measures aimed at removing dioksidina.

Compatibility with other drugs:

While admission Streptomycin, monomitsin, Gentamicin has been increasing effect of both drugs.

Antihistamines paired with dioksidina have good compatibility, but are not recommended for use both in acute maxillary sinusitis.

Naphazoline, together with Dexamethasone Dioxydinum lead to increased drug effect.

Saline Gidroksimetilhinoksilindioksida serves to reduce the concentration of, without changing the properties of the drug.

Conditions and terms

Dioxidine should be kept in their original packaging in a dark, out of reach of children. Open ampoule is used for one day. The appearance of sediment is normal, For its removal to be heated solution. use period is 2 years.

analogs

By analogues dioksidina include all drugs with the active ingredient Gidroksimetilhinoksilindioksid. These include: Dioksisept, Dihinoksid, Urotravenol.

opinions of doctors

• For a child it is preferable to assign a different, less toxic drug;
• Dioxidine not highly addictive. It is a drug that has no vasoconstrictor effect and antibacterial effect;
• The paper is often discharged with otitis, after the operation in the middle ear;
• In practice, the drug is used for a long time. In the experience of the use of drugs, markedly superior to levomekol, copes with infected wounds. I wash out solution Dioxydinum cavity wounds. The preparation has a high efficiency.

Price dioksidina

Examples of the drug prices in Russia:

The minimum cost	Maximum price	average cost
A solution of 1 ml of 10%	49	432	240
Ointment 5% 30g	240	449	345
Ampoules 5ml 0.5%	41	396	219

Use Dioksidin means you only need a doctor's permission, clearly following its instructions for use. Self-medication because of severe toxicity of the active substance is extremely dangerous for the body to harmful effects.

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