Ceftriaxone and tablet analogs. Price, instructions for use, reviews

Ceftriaxone and its analogues in the form of tablets - these are drugs with an antibacterial spectrum of action, which are used to treat diseases of an infectious etiology. The price of this medication is 14 rubles. per bottle weighing 1 g. Ceftriaxone belongs to the pharmacological group of 3rd generation cephalosporins.

Indications for use

Ceftriaxone exhibits therapeutic efficacy against most bacterial microorganisms that provoke inflammatory processes of varying severity.

This drug is indicated for use in the following cases:

• inflammation of the cerebral cortex caused by meningococcal infection;
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• bacterial blood poisoning;
• osteomyelitis;
• infection of open wounds, tissues that have undergone surgery;
• peritonitis;
• infectious inflammation of the digestive tract and biliary tract;
• Lyme borreliosis;
• bacterial inflammation of the urinary tract and kidneys;
• dermatological diseases caused by infectious microorganisms;
• pneumonia;
• gonorrhea and other infections that affect the organs of the reproductive system;
• inflammatory processes in the nasopharynx and upper respiratory tract;
• bacterial infection of the body in people who have a severely weakened immune system.

Ceftriaxone and its tablet analogs can be used as a prophylactic agent. to prevent the development of an infectious process in patients who have undergone surgical operation. The use of this drug can speed up the wound healing process. The price of Ceftriaxone is affordable for most citizens in need of antibiotic therapy.

The main property of the drug Ceftriaxone is its antibacterial effect, which extends to most pathogens. The active substance of this medication is effective against infections that are resistant to penicillins, aminoglycosides, and some cephalosporins.

Compound

The table below describes the active substance of the drug Ceftriaxone, as well as its therapeutic dosage.

The active substance of the antibiotic Ceftriaxone	Concentration of the constituent component in 1 vial of the drug
Ceftriaxone	Ceftriaxone is a cephalosporin antibacterial agent that is produced in the sodium salt form. The latter component is readily soluble in sterile water for intramuscular and intravenous injections. The concentration of ceftriaxone is 1 g.

This antibacterial agent is a medicine with a wide spectrum of action. Ceftriaxone has a powerful pharmacological formula. At the same time, the drug has passed all clinical studies related to safety for the human body.

In what form is it produced

Ceftriaxone is produced in the form of a white crystalline powder that has a slight yellow tint. On the basis of this drug, solutions are prepared for intravenous and intramuscular administration. The medicine is packaged in a 1 g glass bottle. The main packaging of the antibacterial agent is a cardboard box, inside which contains instructions for using the drug.

Pharmacodynamics

Ceftriaxone and analogs in tablets (the price of the medication is not high) are semi-synthetic antibiotics of the 3rd generation, which belong to the group of cephalosporins. The bactericidal effect of the active substance Ceftriaxone is provided by suppressing the cell membranes of pathogenic microorganisms.

The pharmacodynamic feature of this drug is its resistance to the influence of beta-lactamases of most strains of bacterial infections. The death of pathogens occurs by damage to their cellular structure.

As a result of this process, the pathogenic microflora is deprived of the opportunity to increase its numerical population. In a person taking this antibacterial agent, there is a gradual decrease in the inflammatory process, wound healing and restoration of the functions of internal organs.

Pharmacokinetics

After intramuscular administration, Ceftriaxone is very rapidly absorbed into the systemic circulation. The bioavailability of this drug is 100%. The average concentration of the antibacterial agent in the blood is detected 2-3 hours after the injection.

With repeated administration of Ceftriaxone, the effect of accumulation of the drug in the blood serum develops. The metabolism of the antibacterial agent occurs in the liver tissues. Excretion of 33% to 67% of the active substance of Ceftriaxone is carried out by the kidneys. The rest of the half-life products of the drug enters the intestines along with bile.

Application

Ceftriaxone and analogs in tablets (the price of the drug is slightly different in different pharmacies in the city) are used to treat children, adult men and women, as well as elderly patients. In order to prepare an injection solution for intramuscular administration, it is necessary to dilute 1 g of the drug in 9.6 ml of sterile water. The finished product will contain 100 mg of the active substance ceftriaxone.

For children under 18

Ceftriaxone is approved for use in infants. Babies under 2 weeks old are prescribed 20-50 mg of antibacterial agent per 1 kg of body weight. Intramuscular or intravenous injection is performed once a day. The calculation of the therapeutic dose is the same for full-term and premature babies. For an infant who is older than 15 days, as well as for children under 12 years of age, the drug

Ceftriaxone is prescribed in doses ranging from 20 to 80 mg per kg of body weight. Injection of an antibiotic is carried out no more than once a day. The terms of treatment are determined individually by the pediatrician. Children weighing more than 50 kg receive the same doses of Ceftriaxone as adults.

For adults

Adult patients and children over 12 years of age should be treated with Ceftriaxone at doses from 1 to 2 g no more often than 1 time per day. In especially severe cases, when infectious microorganisms have partial sensitivity to the drug, the daily dose of the antibacterial agent is increased to 4 g.

The duration of treatment depends on the strain of the bacterial infection, the severity of the inflammatory process and the dynamics of the patient's recovery.

For pregnant

Women who are in a state of pregnancy are allowed to use Ceftriaxone, but only in extreme cases, when there is a real threat to the life of the patient and the child. It is necessary to take into account the fact that the active component of the antibiotic is able to cross the placental barrier. This means that Ceftriaxone will have a direct effect on the fetal tissue.

For the elderly

Elderly patients are treated with Ceftriaxone under the same conditions as all other adults. In this case, it is very important that the patient does not have concomitant diseases that exclude therapy with this antibiotic.

Contraindications

Ceftriaxone and analogs in tablets (the price of the medication remains stable) are contraindicated in people who have individual intolerance to antibacterial agents belonging to the group of cephalosporins, carbapenems, and penicillins.

In this case, the development of an acute allergic reaction is possible.

Ceftriaxone is prescribed with extreme caution to patients who have the following diseases and pathological state of the body:

• dysfunctional disorders in the liver and kidneys;
• enteritis and colitis, which develops after taking antibacterial agents (there is a separate category of patients suffering from severe gastrointestinal upset caused by antibiotics);
• newborns and premature babies who have signs of hyperbilirubinemia.

Ceftriaxone is not used to treat patients suffering from viral and fungal diseases. Before using this medication, it is necessary to undergo a comprehensive examination, as well as isolate a strain of bacterial microorganisms that cause the inflammatory process.

Overdose

An overdose of Ceftriaxone is characterized by the manifestation of symptoms that are similar to side effects. Neutralizing the antibacterial agent with peritoneal dialysis or hemodialysis is ineffective. Currently, there is no specific antidote that can deactivate the active substance ceftriaxone.

Overdose therapy with this drug is symptomatic. The main task of the medical staff is to stabilize the general condition of the patient, to maintain the vital functions of his body until the complete disintegration of the antibiotic. Treatment is carried out in the in-patient department of the toxicology department of the hospital.

Side effects

Ceftriaxone and analogs in tablets (the price of the drug is low, and its therapeutic efficacy is at a very high level) are characterized by the presence of a large number of side effects.

In the course of treatment with this antibacterial agent, the following reactions of the body may manifest:

• itching of the skin;
• red rash;
• edema of epithelial tissues;
• hives;
• erythema of the multiforme type with signs of an exudative process;
• bronchial spasm, which is the result of an acute allergic reaction;
• anaphylactic shock;
• eosinophilia;
• nausea;
• discharge of vomit;
• diarrhea;
• complete or partial loss of appetite;
• increased gas production in the intestines;
• dysbiosis caused by the death of beneficial microflora;
• enterocolitis;
• constipation;
• changes in the sensitivity of taste buds;
• ulcerative formations on the oral mucosa;
• inflammation of the tissues of the tongue;
• impaired liver function;
• an increase in bilirubin, as well as hepatic transaminases;
• the appearance of attacks of abdominal pain;
• leukocytosis;
• thrombocytopenia;
• anemia;
• an increase in the level of urea in the blood;
• dysfunctional disorders in the work of the kidneys;
• hematuria;
• painful sensations in the tissues of the upper limb, into the blood vessel of which the intravenous administration of Ceftriaxone was performed;
• phlebitis;
• the development of superinfection, which is caused by a strong weakening of the patient's immune system (in this case, there is a real threat to the patient's life);
• dizziness;
• attacks of severe headache;
• candidiasis, which is a consequence of prolonged therapy with Ceftriaxone;
• opening of nosebleeds;
• granulocytopenia.

The occurrence of side effects is the basis for the immediate termination of further therapy with Ceftriaxone. A patient with signs of negative body reactions should seek medical help from their doctor who prescribed this antibiotic.

Special recommendations

Patients who are being treated with Ceftriaxone, but suffer from renal and hepatic insufficiency, are on hemodialysis, should regularly be tested to determine the level of antibiotic in the plasma blood.

These actions are aimed at preventing overdose. In very rare cases, during an ultrasound scan of the gallbladder, areas of darkening of its walls may be found. Even if this clinical picture is accompanied by periodic pain in the right hypochondrium, it is recommended to continue antibiotic therapy.

Throughout the course of treatment with Ceftriaxone, it is strictly forbidden to drink alcohol.

The simultaneous use of this antibiotic and drinking alcohol is fraught with the following symptoms:

• spasm of the walls of the stomach;
• feeling short of breath;
• decrease in blood pressure indicators;
• nausea;
• Strong headache;
• heart rhythm disturbance;
• vomit;
• redness of the skin of the face.

All antibacterial agents of the cephalosporin series are capable of causing acute allergic reactions in the form of anaphylactic shock. In such a situation, to preserve the life and health of the patient, intravenous administration of Epinephrine is required, and then the use of medications from the group of glucocorticosteroids.

Ceftriaxone has the pharmacological property of displacing bilirubin from the blood serum. In this regard, this drug is used with extreme caution to treat newborns with signs of hyperbilirubinemia. Patients with a severely weakened body may need a concomitant intake of vitamin K.

Drug interactions

During simultaneous treatment with drugs that disrupt the process of platelet aggregation, it is possible to open nasal and internal bleeding. In this case, there is a negative drug interaction with non-steroidal anti-inflammatory drugs, salicylates, as well as medicines containing sulfinpyrazone.

Simultaneous therapy with Ceftriaxone and drugs from the pharmacological group of anticoagulants leads to an increase in the pharmacological properties of the latter.

Loop diuretics increase the risk of renal nephrotoxicity. In the course of treatment with Ceftriaxone, it is not recommended to simultaneously mix this drug with other antibacterial agents.

Even in the case of infusion therapy. Ceftriaxone should not be added to medicinal solutions that contain calcium. It is important to remember that this antibiotic and drugs from the aminoglycoside category are synergistic against most gram-negative bacteria.

Storage conditions and periods

The prepared solution for intravenous or intramuscular administration should be stored at room temperature for no more than 6 hours. Ceftriaxone powder should be left in a dry place, away from children and the sun.

The ambient temperature should not exceed +25 degrees Celsius. Otherwise, the medication will lose its properties. The shelf life of the drug is 3 years.

Conditions of dispensing from pharmacies

The antibacterial agent Ceftriaxone is available by prescription.

Analogs

There are drugs that are analogs of Ceftriaxone, but they are available in the form of tablets.

Zinnat

Zinnat is a broad-spectrum antibacterial agent that belongs to the category of 2nd generation cephalosporins. This drug is available in the form of white oval tablets, covered with a protective layer.

The active substance of this medication is cefuroxime at a concentration of 125 or 250 mg in 1 tablet. The pharmacological properties of the antibacterial agent Zinnat are similar to the therapeutic effect of Ceftriaxone, but only this drug is in the form of tablets.

The cephalosporin antibiotic Zinnat is indicated for use in patients with the following diseases of the body:

• pneumonia;
• acute and chronic bronchitis;
• infectious lesions of the skin and mucous membranes;
• gonorrhea;
• urethritis;
• cystitis;
• chronic tonsillitis and other diseases of the throat, nasopharynx, which are of bacterial origin;
• borreliosis, which is at an early stage of its development.

Zinnat can be used to treat inflammatory diseases of the kidneys, bladder and other organs of the excretory system. The standard course of therapy with this medication is from 5 to 10 days, depending on the strain of the infectious agent.

The dosage regimen for Zinnat is from 125 to 250 mg taken 2 times a day. The tablets should be taken immediately after meals. The average cost of the antibiotic Zinnat is in the range of 109-174 rubles.

Suprax Solutab

Suprax Solutab is a broad-spectrum antibiotic that is analogous to Ceftriaxone. This medication belongs to the category of 3rd generation cephalosporins. Suprax Solutab is available in the form of light orange tablets with a pronounced strawberry aroma. The active substance of this drug is the chemical compound cefixime at a dosage of 400 mg.

This drug is indicated for use for the treatment of the following diseases:

• pharyngitis;
• chronic and acute bronchitis;
• tonsillitis;
• infectious infection of the organs of the genitourinary system without signs of complication;
• sinusitis;
• inflammatory processes in the tissues of the nasopharynx;
• otitis.

Throughout the entire therapeutic course, adults and children over 12 years old, weighing more than 50 kg, should take 1 tablet of Suprax Solutab 1 time per day. It is also possible to divide this dose into 2 doses. The average duration of treatment is 10 days. Prices for this antibiotic are in the range from 674 to 838 rubles.

Cefixime Express

Cefixim Express is a semi-synthetic antibacterial drug that is a 3-generation cephalosporin. The active substance of this medication is cefixime at a concentration of 400 mg in 1 tablet. The antibiotic Cefixim Express exhibits therapeutic efficacy against most gram-positive and gram-negative microorganisms.

This drug is prescribed for admission to patients who have been diagnosed with the following diseases:

• chronic and acute form of bronchitis;
• gonorrhea without signs of complication;
• tonsillitis;
• sinusitis;
• pharyngitis;
• otitis;
• infections of the genitourinary system.

The therapeutic dosage of Cefixim Express is 400 mg per day. The average duration of treatment is from 7 to 10 days. The price of this medication is within 550 rubles.

Ceftriaxone and its tablet analogs are effective antibacterial drugs actions that are used to treat infectious diseases of the ENT organs, pneumonia, bronchitis, urethritis, cystitis. These drugs belong to the pharmacological group of 2nd and 3rd generation cephalosporins.

Ceftriaxone is available in the form of a white powder, on the basis of which a solution is prepared for intravenous and intramuscular administration. Tablet analogs of this medication are taken orally after meals. The price of cephalosporin antibiotics is affordable for most consumers.

Video about Ceftriaxone

Instructions for using Ceftriaxone: