Fendivia (Fendivia) plaster for cancer patients. Reviews, instructions for use, where to buy, price

Fendivia is medicine in the form of a patch, which is used in the treatment of various diseases, including oncology, to eliminate pain. According to patient reviews, the drug has proven itself well in the treatment of various pathologies.

Patch manufacturer Fendivia

Germany (Andernach) is engaged in the production of the medication.

Fendivia composition for cancer patients

The main component of the patch is fentanyl.

Auxiliary composition:

• outer protective shell - polyethylene film;
• additional shell - adhesive silicone, dimethicone;
• miniature fillers containing the main component - hyprolose, dipropylene glycol;
• release shell - ethylene vinyl acetate;
• dermato-adhesive layer - silicone shell, dimethicone;
• protective shell (removable) - a polyester shell containing fluorine-containing polymer components.

The product is packed in a cardboard box of 5 pcs.

pharmachologic effect

This agent belongs to the group of sedative transdermal drugs that exhibit analgesic effects. In this case, the patch provides a dosed intake of the active component into the body for 3 days.

The main substance is a group of opiate components, the action of which is aimed at increasing the pain threshold. In this case, the ingredient has a negative effect on the patient's respiratory functions, inhibiting them. The condition is accompanied by a slowdown in the heart rate, which leads to excitation of the nervous system and the occurrence of gag reflexes.

There is also a stimulating effect on the smooth muscle of the biliary system. and sphincters, the body's absorptive capacity increases, aimed at absorbing fluid from Gastrointestinal tract. The active ingredient leads to a drop in blood pressure and the development of intestinal obstruction, inhibits (slows down) blood flow in the region of the renal system.

The use of the drug causes an increase in the level of amylase and lipase, leads to a decrease in the concentration of growth hormone. There is also a decrease in the level of catecholamines, adrenocorticotropic hormone, prolactin and cortisol.

The use of the product leads to sleep, causing a feeling of euphoria. At the same time, there is a difference between addiction to the drug and the development of resistance to the analgesic effect. The remedy rarely leads to the development of allergic reactions.

Pharmacokinetics

The maximum analgesic effect from the use of the drug is noted when the active substance enters the blood in a volume of 0.3 to 1.5 ng / ml. The concentration of the active substance of the drug increases gradually, maintaining its indicators in the region of 12-24 hours from the moment the patch is glued.

The maximum level of the active ingredient is reached after 3 days and remains for the next 3 days until the drug is reused.

According to clinical trials, the level of absorption of the active elements of the agent may differ slightly depending on the place of application of the patch. Thus, the highest absorption rate was observed when the patch was applied to the upper arm or back.

A lower level of absorption was observed with the use of the drug in the chest area.

The level of binding of the active ingredient of the agent is 84%. In this case, the ingredient is able to penetrate the placental barrier, entering breast milk. The active ingredient is metabolized mainly in the liver, forming the inactive substance norfentanil.

The half-life of the decay products of the active component varies within 17 hours. In childhood, these indicators are from 22 to 25 hours. At the same time, the time for excretion of metabolites is significantly lower in comparison with the drug produced in the form of an injection solution.

About 75% of the substances of the drug are excreted mainly in the urine. About 10% of substances leave the body in an unchanged form. About 9% of the active substance is excreted by defecation in the form of metabolites. When a patch is prescribed to patients with functional disorders of the kidneys or liver, an increase in the active element in the serum essence is possible.

The use of the drug in old age, as well as with a weakened body, can lead to an increase in the half-life of the active component. The elimination of components from the blood in childhood may differ depending on the child's body weight.

Indications for use

Fendivia is a patch for cancer patients (reviews of the drug are mostly positive), which is prescribed in as part of complex therapy and is aimed at eliminating painful sensations during the development of various diseases.

Indications:

• chronic forms of pronounced pain syndrome requiring the use of an opioid group of drugs;
• chronic pain in children from 2 years of age who need therapy with an opioid group of drugs.

The drug is used only with a confirmed diagnosis and only as directed by the attending specialist.

Contraindications

The medication has some restrictions on its use.

Contraindications:

• the presence of allergic reactions to the components that make up the product;
• violation of respiratory functions - a depressed state of the respiratory system;
• the presence of open wound surfaces in the area of ​​application of the product;
• diarrheal syndrome caused by the development of pseudomembranous colitis, provoked by the use of certain groups of drugs - penicillins, cephalosporins, lincosamides;
• dyspeptic disorders due to toxic damage to the body;
• therapy carried out with the aim of eliminating acute pain sensations that can lead to depression of respiratory functions;
• severe forms of diseases of the central nervous system;
• the combined use of MAO inhibitors, including a 2-week period after their cancellation;
• children's age up to 2 years.

Before using the product, it is necessary to undergo examinations confirming the presence / absence of contraindications.

Use with caution

The drug requires extremely careful use for various diseases and conditions.

Violations:

• intracranial pressure;
• chronic forms of pathologies in the lungs;
• the presence of neoplasms in the brain;
• trauma and damage to the head area;
• liver or kidney failure;
• low pressure;
• the presence of stones in the bile ducts;
• renal or hepatic coma;
• endocrine disorders - hypothyroidism;
• elderly patients, weakened or emaciated;
• the presence of severe operable diseases of the peritoneal organs;
• hypertrophic changes in the prostate gland of a benign nature;
• serious condition of the patient;
• vasoconstriction in the urethra - stricture;
• drug addiction;
• alcoholism;
• depressive conditions, suicide attempts;
• overheating of the body - hyperthermia.

Also, the drug is not prescribed when used in conjunction with insulin, glucocorticosteroids, drugs that lower blood pressure.

Side effect

Fendivia is a patch for cancer patients (reviews of the drug report frequent episodes of negative effects), which can cause various side reactions.

Gastrointestinal tract

The most common development is nausea, vomiting, changes in stool - diarrhea and constipation. Dyspeptic disorders and painful sensations in the gastrointestinal tract may also occur. In rare cases, it is possible to develop complete or partial intestinal obstruction.

Metabolism

Anorexia is extremely rare.

Genitourinary system

Among the disorders of the urinary system, the development of urinary retention is noted. There is a suppression of the reproductive system in the form of a decrease in libido and potency.

CNS

The most common headaches, general weakness in the body, dizziness. There are also signs of paresthesia, tremors throughout the body, hypesthesia.

In rare cases, a convulsive state, episodes of loss of consciousness, amnesia may develop.

Breath

Among the negative reactions, the development of dyspnea, inhibition of the functions of the respiratory system, as well as the development of respiratory failure are distinguished. In isolated cases, it is possible to develop apnea, insufficient ventilation of the lungs, bradypnea.

Skin

Allergic reactions can often occur in the form of erythemal lesions, itching, inflammation, rashes, eczema, or various forms of dermatitis - allergic, contact.

The cardiovascular system

There is an increase in heart rate, the development of bradycardia, cyanosis, low or high blood pressure.

Skeleton and muscles

Muscle cramps are common.

Liver and biliary tract

It is extremely rare to experience episodes of gallstone disease.

Allergic reactions

Allergic manifestations include the formation of hyperemia, rash, dermatitis, and anaphylactic reactions.

Fendivia instructions for use

When using the patch, the prescribed rules and recommendations must be strictly observed.

Where to glue the plaster?

Fendivia is a plaster for cancer patients (reviews of the drug inform about the need for the correct use of the product), which is glued to a clean and undamaged area of ​​the skin.

In this case, the most preferred place to use the drug is in the upper back.

Can you cut it?

The product is not recommended to be cut or divided into parts in any other way.

How to change correctly?

One strip of the patch is worn for 3 days. It is recommended to change it every 3 days. In this case, the strip is glued to another area of ​​the skin, without affecting the previous area. It is allowed to stick the product in its original place after 7 days.

Dosage and course of treatment

The dosage is set individually, based on the patient's age, body weight, and the severity of the disease. For patients who have not previously taken medications belonging to the opioid class, the initial dosage is no more than 25 μg / h.

For patients who have previously taken an opioid group of drugs, the recommended dosage is 12.5 mcg / h. Further dosing rules are calculated according to the tolerability of the drug and the previous use of opioids.

special instructions

When using the product, precautions must be taken.

In childhood

The drug is prescribed for children from 2 years old only if its components are well tolerated. Choose a place to apply that will prevent your child from accidentally peeling off the patch.

In old age

The drug in old age can lead to an increase in the time required for the removal of the drug components. In this connection, it is required to monitor the condition of patients and, if necessary, adjust the dosage downward.

With diabetes mellitus

It is required to exercise caution when using the medication during the illness.

During pregnancy and lactation

It is not recommended to use the drug while carrying a child or during breastfeeding, since its active substance can affect the formation of the fetus and the course of pregnancy.

The possibility of prescribing a patch in a given period of time is determined by the attending specialist, taking into account the potential threat / benefit.

In case of impaired renal function

In case of functional disorders of the kidneys, it is necessary to monitor the level of the active substance in the patient's body. If necessary, the dosage can be adjusted downward.

In case of liver dysfunction

With these pathologies, a slow excretion of the metabolites of the drug is possible, and therefore, constant monitoring of the patient's condition is recommended.

For heart disease

According to patient reviews and the instructions in the official instructions, the Fendivia patch may have a negative effect on the cardiovascular system. For cancer patients with bradyarrhythmia, the drug is prescribed with extreme caution. Great care should be taken when using the patch in patients with low or low blood pressure.

Overdose

The main symptom of an overdose is respiratory depression.

Overdose symptoms:

• inhibited state;
• depressed state of the respiratory system;
• coma;
• muscle flaccidity;
• hypothermia of the body - hypothermia;
• lowering pressure;
• bradycardia;
• ataxic state;
• constriction of the pupils - miosis;
• vegetative state - deep sedation;
• the occurrence of convulsions.

In case of drug overdose, emergency treatment is necessary.

Overdose therapy includes the following measures and drugs:

• complete abolition of the medication;
• the use of an antagonist - naloxone;
• artificial ventilation of the lungs;
• taking muscle relaxants;
• verbal methods of therapy.

With signs of bradycardia, small doses of atropine are prescribed.

It should be borne in mind that the complete cancellation of the remedy can lead to severe pain. In this connection, treatment should be carried out in a hospital setting using intensive care methods.

Influence on the ability to control mechanisms

Fendivia is a patch for cancer patients (drug reviews indicate the development of deep relaxation after using the drug), which can have a negative impact on the psyche and consciousness of a person, in this connection, it is recommended to refrain from driving a car or carrying out work that requires high psychomotor reactions.

Interaction with other drugs

With the combined use of the drug and other drugs that include fentanyl, an enhanced effect is possible the first medication, which can contribute to both enhanced therapeutic efficacy and the development of side actions.

The simultaneous use of the drug with CYP34 inhibitors can lead to various adverse reactions, including an increase in the half-life of metabolites.

Also, joint administration of drugs can lead to a decrease in the therapeutic effect of the first agent. The development of a depressed state of the respiratory system is noted with the combined use of drugs and barbituric acid. Sedatives, including antidepressants, antihistamines, can lead to respiratory depression, coma, and death.

Alcohol compatibility

This drug is not used with alcohol. This combination can lead to coma or death.

Terms of Fendivia's dispensing from the pharmacy

The patch is available with a doctor's prescription.

Shelf life

The shelf life of the drug is 3 years from the date of manufacture.

Fendivia adhesive size and price chart

Dosage of the drug, in μg / h	Area in cm2	Price
12,5	4,2	1800 RUB
25	8,4	RUB 2780
50	16,6	RUB 3120
75	25,2	3750 RUB
100	33,6	4340 RUB

Where to buy quality plasters?

You can buy a quality drug at a public or private pharmacy located at your place of residence. You can also order the product directly from the manufacturer.

How do I switch to Fendivia from other opioid analgesics?

The drug is used constantly with a good therapeutic effect. With a decrease or absence of a therapeutic effect, the agent can be replaced with other drugs.

The transition to the Fendivia patch from other opioids is carried out only under the supervision of a treating specialist. This takes into account the name and dosage form of the opioid drug. According to reviews of cancer patients, the drug is easy to use and has high therapeutic efficacy.

Video about the patch for cancer patients Fendivia

How to apply fentanyl patch: