The drug Promax has an anti-inflammatory effect. The effect is supplemented by an effective reduction in heat, which may be present during inflammation.
The product is actively used in medicine, as a preventive and curative, it is prescribed for ARVI, as well as diseases associated with joints. Refers to a group of non-steroidal agents with anti-inflammatory effect, does not contain narcotic components. The main active substance is Naproxen.
Article Contents
- Pharmacological action
- Pharmacokinetics means
- Composition
- means
- mechanism of action when given the means
- Contraindications
- Instructions for use and dosage
- Overdose and the additional guidance
- From the experience of the practical application of
- physician Council
- Advantages and disadvantages
Pharmacological action
The drug is used as the main means for anesthetizing, relieving inflammation, reducing heat. Included in the category of anti-aggregate substances, does not contain steroids and narcotic additives. Actively reduces the activity of enzyme synthesis, resulting in a marked decrease in the development of inflammatory processes in the body, including joints and tissues.
Rapid inhibition of some biochemical reactions leads to a decrease in heat and normalization of body temperature. The pain disappears after 20-45 minutes after taking the drug.
The drug actively promotes the removal of stiffness and swelling in the joints, which returns the ability to move normally without feeling uncomfortable.
The removal of inflammation completely goes through 5-7 days after the start of the course.
Pharmacokinetics of the drug
The drug is taken internally. Feature - rapid absorption in the digestive tract. One hour after admission, the maximum concentration of the agent in the blood occurs.
If Promax is used for therapeutic purposes, it binds to proteins that form part of the blood plasma almost completely - only 1% remains.
Another feature of the drug - the concentration gradually increases, if doses up to 500 mg are taken, if they exceed this value, then there is an increase in clearance, as the saturation of proteins contained in the plasma occurs.
After this the preparation gradually passes into the synovial fluid. In the same way, it can get into the placenta, is excreted with milk during the lactation period, but in small amounts. The half-life period averages 10 hours. Almost 95% of the accepted dose is excreted naturally - with urine and as conjugates. The remaining 5% - with feces.
Composition of the preparation
The form of the product is round tablets of small size, in a white film shell. One Promax tablet contains 
of the active substance 250/500 mg. Auxiliary components that also form part of the medicine:
- silica;
- Povidone;
- cellulose;
- emulsion of simethicone;
- vegetable oil;
- lactose;
- talcum purified.
Mechanism of action
The drug actively prevents the further development of enzymes that affect the processes of the formation and then the initiation of inflammation of varying degrees of intensity.
After using the drug, the synthesis of such substances gradually decreases, and then ceases. Accordingly, a person feels considerable relief. The suppression process lasts up to 8 hours.
When the
is assigned Assignment of the Promax can be effective if it is diagnosed:
- pain of varying degrees of intensity, including joint pain;
- back pain;
- rheumatoid arthritis;
- gout and other joint related diseases;
- dysmenorrhea;
- in addition, the drug is good for headaches of various kinds, migraines and toothache.
Contraindications to the use of
The drug, due to its composition, has a number of contraindications:
hypersensitivity to one, several or all components that make up the remedy;
- asthma;
- various diseases of the nasopharynx;
- nasal polyps;
- allergy or urticaria;
- ulcers in the digestive tract;
- dysfunction of the formation of blood cells;
- impaired renal and / or liver function;
- heart failure.
Also, the drug is contraindicated in people whose age is under 16 years. Refuse treatment Promax should be in the III trimester of pregnancy and during lactation.
Instruction for use and dosage
In order to obtain a prompt effect from taking Promax without the slightest harm to the body, it is necessary to take it exclusively after eating.
If the drug is intended as an anesthetic, then the first dose should be 500 mg, then 250 mg every 6-8 hours. The total daily dose is no more than 1.5 g of active ingredient.
If taken as an anti-rheumatic remedy, the daily dose can not exceed 1 g, while it should not be accepted immediately, but with a two-part separation - in the morning and in the evening.
If the drug is used during exacerbations of joint and rheumatic diseases, the daily dose can reach 1.5 grams per day.
With arthritis, the condition improves for 2 weeks. The maximum daily dose is allowed up to 1.75 g.
Overdose and additional indications
No cases of overdose have been fixed, but there may be side effects:
- heartburn;
- flatulence;
- nausea;
- diarrhea;
- stomatitis;
- gastritis;
- of jaundice;
- meningitis;
- thrombosis.
In case of an overdose of the drug, the patient loses consciousness, breathing is broken, and convulsions sometimes appear. It is necessary to wash the stomach and take activated charcoal.
It is not recommended to use the drug during treatment with certain drugs, including - Ciclosporin, analgesics, anticoagulants, inhibitors or Aspirin. Diuretics will not have the desired effect. It is best not to perform work that requires attention.
From the experience of practical application of
The word to patients who somehow encountered the drug.
To take the drug began recently, there was an exacerbation of rheumatic disease. The effect quite suits me, I can perform more than half of the usual cases. There are practically no side effects. I recommend to all who experience such problems.
Alina, 30
The effectiveness of the drug was first tested for toothache - forgot about it after 10 minutes, then at the time of exacerbation of rheumatism. Activity movements returned the next day, and a week later I was able to even go to the country house - in general, the drug met my expectations.
Taken from the forum
For all its dislike for medicines I had to use Promak someday - I was glad that enough tablets were enough to make joint pain, even the strongest passed. The usual painkillers do not act so quickly and their effect lasts from a couple of hours, and here for 10 hours is quite good.
Valery
Very good medicine. We had to look for it a bit, because in our city it is sold only in one pharmacy, but I never regretted the time spent. The effect is almost instantaneous - after breakfast she accepted and remembered the pain only in the evening. I liked very much that Promax is taken after a meal, because my stomach is sensitive to all kinds of tablets.
Karina Sergeevna
I used Promax last year - I was very pleased. The joint was inflamed, which began to ache badly, in addition, the temperature also jumped - the doctor prescribed a remedy, I bought it the same day.
In less than 3 days, all negative things are in the past. The joint pain has passed, the lightness of movements has returned, forces have appeared for various kinds of affairs, which are always quite a lot.
In general, the evaluation is positive and my recommendations to anyone who faces similar problems - to see a doctor and a pharmacy for Promax, you will not regret, as I did not regret, even if it costs a little more than analogues, but it works perfectly.
Larion
doctor's advice I want to give advice: as a doctor, I have repeatedly seen how patients strive to increase efficacy by taking Promax over and above the prescribed 
according to the dosage instructions.
As a result - problems with the gastrointestinal tract with mandatory gastric lavage. Also it is fraught with the discovery of an ulcer.
Do not exceed the dose, since the active substance will work in any case, and its overabundance, on the contrary, loads the body, which is not useful for it.
Advantages and disadvantages of
The advantages of using the drug are:
- fast and long-lasting effect;
- is an opportunity not only to remove inflammation, but also a fever that can accompany it;
- no obvious overdose;
- reasonable cost.
Disadvantages of the remedy:
- age restriction:
- inability to receive during pregnancy;
- availability of contraindications to use.
The product is in the form of tablets - in a package of 10 pcs. Keep in a place inaccessible to children, the optimum temperature - up to +25 degrees.
Shelf life is no more than 3 years from the date of manufacture. From pharmacies is dispensed without a doctor's prescription. The cost of 180 - 380 rubles. Analogues: Nalgezin, Naproff.
