Glidiab MV 30 mg. Price, instructions for use

Glidiab MV is part of the group hypoglycemic or antidiabetic agentsthat help lower blood glucose levels and are used to treat diabetes mellitus. The cost of this 30 mg modified-release drug ranges from RUB 114 to RUB 160.

On the basis of laboratory studies, it was revealed that the effectiveness of this drug when taken orally use is no worse than the use of insulin, the preparations of which are suitable only for parenteral introduction.

Composition and form of release

The main active component of flat-cylindrical tablets, which are distinguished by their white color or white with creamy blotches, is gliclazide - a derivative of sulfonylurea of ​​the second generation.

In addition, each capsule contains:

• hydroxypropyl methylcellulose, or hypromellose - semi-synthetic, inert viscoelastic polymer (44 mg);
insta story viewer
• MCC - microcrystalline cellulose, characterized by a high degree of purity and a high content of an ordered part of cellulose with a crystallographic orientation of macromolecules (123 mg);
• silicon dioxide (colloidal), the pharmacological properties of which are the capture, retention and elimination from the body of toxic compounds of any origin (1 mg);
• stearic acid (With 2 mg).

The tablets are sold in blisters made of thermoplastic polymer polyvinyl chloride. 3 to 6 flexible blisters consisting of two layers, one of which is thermoformed cells that repeat the shape of the packaged medicinal product, together with the instructions, are placed in a cardboard packaging. The drug is removed from the package by squeezing or opening.

Pharmacological properties

Glidiab MV has a hypoglycemic effect. Thanks to this drug, the secretion of the hormone insulin by the endocrine part of the pancreas is stimulated, the activity of intracellular enzymes is increased, minimizes the risks of developing glycogen disease, minimizes the development of a postprandial increase in glucose levels (when blood sugar rises after meal).

Pharmacodynamics and pharmacokinetics

Glidiab MB 30 mg, the price of which was indicated earlier, shortens the time interval from the moment of eating to the start of insulin production. Normally, the secretion of a hormone of a protein nature, which, under the influence of electrolytes and amino acids, is formed in the beta cells of the islets Langerhans pancreas, in response to food intake occurs in 2 phases: the first fast phase (1-3 minutes) and the second slow (from 20 minutes. up to half an hour).

In diabetes mellitus, failures first occur in the first (rapid) phase, and Glidiab, in addition to affecting the metabolism of carbohydrates, stimulates such interrelated processes such as blood flow in the vessels of the microvasculature (MCB) and the inextricably linked exchange of various substances in blood and tissues and the formation lymph.

Features of the pharmacodynamics of the drug are also as follows:

• inhibition of the properties of platelets to connect with each other and adhere to the damaged inner layer of the artery / vein located under the outer membrane (elastic membrane) and the muscular membrane;
• normalization of vascular permeability;
• an obstacle to the formation of blood clots (thrombi) inside the blood vessels, which impede the free flow of blood through the circulatory system;
• restoration of an important biochemical process responsible for the destruction of fibrin clots formed as a result of the clotting system;
• a decrease in the sensitivity of receptors of tubular organs to epinephrine.

Glidiab CF, in addition, helps to slow down the damage to the retina of the eye of diabetic origin, which is called diabetic retinopathy in medicine. Modified-release tablets 30 mg, the price of which is indicated above, with diabetic glomerulosclerosis against the background of prolonged use, reduces the level of protein concentration in the urine.

Glidiab is not included in the group of hypoglycemic drugs that potentially increase body weight, since predominantly the effect is on the early peak of insulin secretion (the glucose level is not exceeds). If overweight patients take this drug and follow an appropriate diet, it will even contribute to weight loss.

With regard to pharmacokinetics, after oral administration, the drug is absorbed from the gastrointestinal tract. The maximum concentration of the active ingredient in plasma is reached 6-12 hours after taking Glidiab.

The chemical composition of food has no effect on the pharmacological activity of the drug. Binding to albumin, lipoproteins, glycoproteins and globulins is approximately 95%, and biotransformation (physico-biochemical changes, to which the drug is exposed to reduce fat solubility and changes in biological activity) occurs in the liver with the formation of inactive metabolites.

The half-life, or the time during which the serum concentration of a substance (or its total content in the body) is halved, is 16 hours. The main organ for excretion of drug metabolites from the body is the kidneys.

Indications for use

An antidiabetic agent is prescribed for the treatment of patients with a history of type II diabetes mellitus. It is a metabolic disease characterized by chronic hyperglycemia (increased glucose in blood), which develops as a result of a violation of the mechanisms of interaction of insulin with tissue cells or its secretion.

The drug is no less effective in the prevention of hemorheological disorders, the initial forms of generalized lesions of large (macroangiopathy) and small (primarily capillaries - microangiopathy) blood vessels in diabetes mellitus.

This diagnosis is manifested by damage to the walls of blood vessels in combination with a violation of the hemostasis system - a biological system in the body, the function of which consists in maintaining the liquid state of blood, stopping bleeding in case of damage to the walls of tubular organs and dissolution of blood clots that have fulfilled their function.

Contraindications

Endocrinologists prohibit taking Glidiab CF for insulin-dependent or juvenile diabetes, which is a member of the group of autoimmune diseases of the endocrine system.

The main diagnostic sign of pathology is represented by chronic hyperglycemia, which results in thirst, weight loss, excessive or decreased appetite, and severe general fatigue of the body. In metabolic acidosis associated with a carbohydrate metabolism disorder resulting from insulin deficiency, the drug should also not be included in the list of drugs for treatment.

Glidiab MV 30 mg, the price of which is low, is strictly forbidden to take under the following conditions:

• diabetic ketoacidotic coma, in which metabolic acidosis develops, the anion difference increases, and the patient feels severe weakness, hunger, dizziness, rapid heartbeat;
• a decrease in the number of leukocytes per unit of blood volume (less than 4000 in 1 μl) - the so-called syndrome of "lazy leukocytes", or leukopenia;
• non-konemic coma;
• intestinal obstruction;
• severe hepatic and / or renal failure;
• gastroparesis - a clinical syndrome characterized by a violation of the passage of food through the stomach due to a decrease in the contractile activity of the muscular wall of the organ;
• pregnancy and lactation.

It is also forbidden to take Glidiab during extensive surgical operations (resection of the stomach and intestines, for example), extensive thermal burns, injuries, and individual intolerance to the components that make up medication.

Patients with febrile syndrome, pathologies of the endocrine organ located on the anterior surface of the neck (thyroid gland) and alcoholic substance abuse - chronic mental illness, a type of substance abuse characterized by an addiction to alcohol (ethyl alcohol), should take Glidiab under strict control the doctors.

Method of administration and dosage

The dosage regimen should be drawn up by an endocrinologist based on the tests performed, clinical manifestations of the diagnosis, blood glucose levels for patients who have not eaten for at least 8 hours, and after 2 hours after meal. It is recommended to start taking it with an initial daily dose of 30 mg, that is, one capsule. In the future, if necessary, the dose should be increased with a time interval of at least 14 days.

The maximum harmless daily dose of a hypoglycemic drug is 120 mg. Patients with mild / moderate disruption of the bean-shaped parenchymal organs (kidneys), in which their function is insufficient, that is, filtration, formation and excretion of urine are impaired, and creatinine clearance is from 15 to 80 ml / min, Glidiab is prescribed in the same doses.

Side effects

Glidiab MB 30 mg, the price of which is fully justified, can cause a number of side effects.

On the part of the digestive system, this can be a violation of the normal activity of the stomach, difficult and painful digestion; eating disorder characterized by significantly reduced body weight, deliberately caused or maintained by the patient himself, in order to lose weight or to prevent excess weight gain; intrahepatic cholestasis; increasing the activity of enzymes-catalysts for chemical reactions of nitrogen metabolism, the main task of which is the transport of amino groups for the formation of new amino acids.

Other side effects include:

• itchy rash, which may appear suddenly after 7-10 days from the start of taking the drug;
• partial or complete loss of already formed speech, which is caused by local organic damage to the speech areas of the brain;
• excessive daytime sleepiness or excessive sleep;
• slowing your heart rate to less than 60 beats per minute;
• inattention, aggressiveness;
• hyperhidrosis.

Sometimes, while taking a second-generation sulfonylurea derivative in patients, the number of red blood cells in the blood decreases, pancytopenia develops - pathological a condition characterized by a decrease in the composition of all elements of circulating blood (platelets, leukocytes, platelets and erythrocytes), which are its main composition.

Overdose

The most common symptom that occurs when taking Glidiab at a dose higher than the recommended or usual for the body is a decrease blood glucose concentration below 3.5 mmol / l, peripheral blood below normal (3.3 mmol / l) with subsequent possible development diabetic coma.

If the patient is conscious, can chew and swallow, it is necessary to give him fast, easily digestible carbohydrates with a high glycemic index. They have a predominantly simple structure, and they usually consist of one or two molecules (fructose, glucose, lactose) - such carbohydrates have a sweet taste and must be dissolved in water.

If a person has an attack of short-term loss of consciousness due to a temporary disturbance of cerebral blood flow, A 40% glucose solution should be administered intravenously, and the hormone involved in blood sugar control (glucagon) should intramuscularly.

special instructions

Glidiab MV 30 mg, the price of which was indicated at the beginning of the article, implies the obligatory presence of a regular breakfast in the patient's diet. Adequate intake of carbohydrates from food is extremely important because irregular or malnutrition, as well as the consumption of foods poor in carbohydrates, can be fraught with the development hypoglycemia.

In the case of surgical interventions or at the decompensated stage of diabetes mellitus, when the body has no reserves to compensate for harm, caused by the disease, and without radical medical intervention, the prognosis is extremely unfavorable, it is necessary to take into account the possibility of using drugs insulin.

With non-purposefulness of actions, excessive speech production and affective disorders arising from repeated non-compliance load to the initial functional level and characterized by a violation of the regulatory function of the central nervous system, which is manifested in the imbalance of anabolism and catabolism, as well as inadequacy of recovery processes, the daily dose of the drug is necessary correct.

At the initial stage of therapy, in the process of drawing up the optimal dosing regimen for patients with a tendency to reduce the concentration of glucose in the blood, it is extremely it is undesirable to drive a vehicle and engage in potentially hazardous activities that require increased concentration of attention and quick psychomotor skills.

Drug interactions

To enhance the hypoglycemic effect of Glidiab, you can combine it with angiotensin-converting enzyme inhibitors; substances whose action is aimed at enhancing anabolic processes in the body (formation and renewal of structural parts of cells, tissues and muscle structures); pharmacological products, when introduced into the human body, beta-adrenergic receptors are blocked.

The second generation sulfonylurea derivative interacts well with fibrates - medicinal agents that help lower blood cholesterol levels and prevent the appearance atherosclerotic plaques; with monoamine oxidase inhibitors capable of inhibiting the action of MAO, used in psychiatry and neurology to treat depression.

Simultaneous reception of Glidiab with ethanol is fraught with the development of a teturam-like effect. If the complex treatment regimen includes cardiac glycosides that provide cardiotonic and antiarrhythmic action, may develop (VES) - premature excitation of the heart with premature contractions ventricles.

Analogs

Before buying an analogue of the original pharmacological product, it is imperative to consult a doctor or pharmacist. Only a specialist will tell you whether a generic or group analogue can serve as a full-fledged replacement for the prescribed / sought drug. Some Glidiab analogs with their approximate cost are listed in the table below.

A drug	Price
Diabefarm	from 120 rubles.
Gliclazide	from 142 to 202 rubles
Maninil	from 123 to 157 rubles.
Glibenclamide	within 270-350 rubles.
Diabetone	209 r
Amaryl	363 r
Oltar	RUB 410

Analogues of Glidiab are selected in composition, but the dose of active ingredients and the chemical structure of the drug may differ slightly. It is worth paying attention to the fact that some generics, as well as the original drug, are dispensed strictly by prescription.

Storage conditions

It is best to store hypoglycemic tablets in their original packaging, which protects the contents from the sun. light and mechanical damage, and also contains a name (usually in large print), which will facilitate the search for a drug in first aid kit. The storage place should be dry, out of reach of children, and the temperature should not exceed 25 ° C. Taking the medication after the expiration date, which is 2 years, is strictly prohibited.

Glidiab MB, which is a 30 mg modified release tablet, is an effective treatment for early forms of diabetic microangiopathy. Due to its low price, almost everyone can afford it.

Video about the drug Glidiab MV

Glidiab MV tablets instructions for use: