Rezoklastina application: indications, instructions and reviews

Resoclastine refers to drugs that suppress or delay the damaging physiological and chemical processes in bone tissues, belongs to the class of bisphosphonates.

The effect of this drug is selective, due to substances such as osteoclasts contained in the drug.

This medicine is the representative of a new generation of effective medicines that have the ability to selectively act on destructive processes in bone tissue.

Composition

The chemical composition of Resoclastin includes:

• zoledronic acid , as the main active substance;
• additional : mannitol( diuretic), as well as sodium citrate with distilled water.

A drug is available in the form of a solution for infusion injections in flacons. Only the bottles of Resoclastic are 5 ml and 6.25 ml each with 4 and 5 mg of active ingredient, respectively.

Each bottle is made of dark glass. And it contains a remedy in the form of a liquid without color. Packages come in light cardboard or plastic.

Depending on the form of release, the price of Resoclastin is different. The drug, produced in a 5 ml bottle costs 4000-5000 rubles, and concentrated Resoclastin in bottles with a capacity of 6.25 ml has a price from 11,000 to 12,500 rubles.

The price depends on where the drug itself purchases this drug. Where the medicine comes directly from the manufacturer, the cost is significantly lower.

Pharmacokinetics and pharmacodynamics of

After the infusion in the blood, the concentration of the drug rises and, having reached a maximum, begins to decline quickly enough. The substance binds to the cells of the protein in the blood plasma by 56%.And the result of the action does not depend on the amount of medication administered.

Up to 50% of the substance is removed from the body of the kidney, and almost unchanged. There is no accumulation of the drug if the infusion is repeated after 28 days. Within a day, 23-55% of the drug administered is excreted in the urine.

The remainder binds to cells of bone tissue, beneficially acting on them. Then this part of the drug is excreted in the urine.

The acid that is contained in the preparation has an overwhelming effect on osteoclasts without affecting the development of bones. This medicated substance strengthens the bones. In addition to the retarding effect on destructive processes in bone tissues, the drug has antitumor properties that guarantee a positive effect in the development of bone metastases.

Zoledronic acid induces cell death by slowing it down, which has a direct effect on suppressing myeloma tumors and breast cancer, and reduces the risk of metastasis.

The effect of the drug leads to:

• to a decrease in the growth of cancer cells;
• increased anti-angiogenic and analgesic activity;
• suppression of endothelial cell growth;
• lowering the level of calcium in the blood.

People taking the drug experienced a decrease in the risk of fractures of the bones, including the spine.

In the treatment of patients suffering from Paget's pathology, a prolonged therapeutic effect, a concentration of alkaline phosphatases in plasma, normalized metabolic processes in bone tissues. And the result of treatment remained about 2 years.

Who benefits, and to whom and to the detriment of

The drug is prescribed in the case of:

• is a mixed type of bone metastasis caused by the development of a large tumor volume;
• the presence of multiple cancers in the bones of blood cancer;
• high calcium content in plasma, caused, as a rule, by the growth of malignant tumors;
• deep bone injury in myeloma and cancer;
• compression of the spine and spinal cord;
• postmenopausal primary and secondary type of osteoporosis;
• Paget's disease.

Cases of contraindications:

• child-bearing;
• breast-feeding;
• is an allergy to zoledronic acid or other auxiliaries;
• renal or hepatic insufficiency;
• not for children and teenagers;
• asthma caused by an allergic condition from aspirin.

How to use

This medication is administered intravenously with the aid of a dropper. The time of drip introduction is a quarter of an hour.

Doctors recommend a single dose of the drug not more than 8 mg. The timing and frequency of the procedure depends on the degree of the disease.

For each case, its own regimen is used with Resoclastic:

1. If diagnosed: hypercalcemia , which is caused by malignant formation, administration of 4 mg of the drug is given once. But this drug is prescribed only in the case when the patient normally undergoes a hydration process.
2. In case of involvement of bone tissue with myeloma metastases, the medication is administered at 4 mg several times: at the 3-4 th week. In addition to the medicine, doctors prescribe calcium in an amount of 500 mg per day and a vitamin D tablet of 400 mg.
3. During the detection of primary or secondary osteoporosis to strengthen bone tissue, reduce the risk of vertebral fractures and other support bones, a dose of 5 mg is recommended, but only once a year. In parallel, a complex of vitamin D and calcium is prescribed, which are taken until the body requires it.
4. With the pathology of the Paget , doctors prescribe intravenous administration of the drug in an amount of 5 mg once. In addition, this pathology prescribes calcium and vitamin D for the first week and a half after the administration of the drug.

Solution preparation

The preparation solution is prepared under sterile conditions. Before introducing the drug in a drip fashion, it is diluted with a special solution, for example, adding to saline.

Prepared vial should be used immediately. If the whole bottle is not used, it can be put in the refrigerator, but not more than for a day. After the refrigerator before the introduction, the solution is kept in the room until it warms to room temperature.

Interaction with other

agents Simultaneous use of bisphosphonates and aminoglycosides in the course of treatment can decrease calcium levels in bone cells and blood.

Side effects and cases of overdose

As side effects, thrombocytopenia and anemia, as well as leukopenia, may occur as a result of side effects of nephrotic drugs.

Headaches, sensation of weakness and blurred vision may also appear, but more often a development of conjunctivitis occurs.

Gastrointestinal disorders are also common: nausea with vomiting, which occurs quite often. Less common are diarrhea, stool disorders, a feeling of dryness in the mouth or stomatitis. Side-effects in the lungs are sometimes in the form of cough or dyspnea.

Some patients have itching, rashes, sweating. Often, patients complain of pain in the bones and chest, muscle cramps, and even less often - baricades or swelling.

Kidney or liver failure may occur. Allergic reactions appear, as a rule, in those who have a tendency to this disease.

In the case of diseases that involve severe kidney pathologies, it is better not to use the drug. And if he is still appointed, the time of administration of the drug should be reduced.

Since the patient is always under the care of medical personnel when administering the medication, such cases rarely occur, but in this case there may be signs of a drop in the calcium level. When there are signs of hypocalcemia, additional administration of calcium gluconate is necessary.

Special instructions

Before the introduction of the drug, dehydration in the patient should be avoided. This is usually done by pouring saline before introducing the medication or during its infusion.

If the drug is prescribed to a patient who has a disorder of kidney function, strict control over his condition and accelerated administration of the drug are necessary.

In bronchial asthma, the administration of a drug can cause bronchospasm. Such disorders of the organism as necrosis of the jaw can also appear. Therefore it is necessary to check with a dentist before infusion. After the administration of the drug, transport management is possible, but with great care.

From the practice of

Testimonials of patients who have been swallowed by Resoclastin.

Storage

The medicine is stored in a dry place, protected from light. The temperature at which it is stored should not exceed 25 ° C.

Term of application: no more than two years.

Other medicines have a similar chemical composition.

There are several such analogues in Resoclastica, then Aklasta, Veroclast and some others.

Analogs are somewhat cheaper, and some of them can be assigned for free.