Whether to take medicine Pregabalin: instructions for use, reviews of doctors and patients, the nearest analogues

Pregabalin is a remedy, possessing the antiepileptic effect of .

The agent shows good results in the treatment of anxiety disorders. It stands out among similar drugs with its powerful psychotropic properties, which have a short period of development. High efficiency has been shown in the treatment of chronic diseases such as fibromyalgia.

The drug is also used to treat spinal cord injuries.

Nearest analogues: Lyrics and Algerika

Recently, a new drug such as Lyrics has gained wide popularity.

It is used to effectively eliminate neuropathic pain in adults. The drug is widely used in the field of narcology, which doctors use as an anesthetic.

Algerika is also used in the conduct of therapeutic procedures for epileptic seizures, accompanied by convulsive movements. It also eliminates neuropathic pain and anxiety disorders in humans.

Pharmacological action of the drug

Pharmacology of the drug consists in the elimination and reduction of epileptic seizures in patients.

Pregabalin binds to the calcium channels in the central nervous system, which has a powerful analgesic effect, and also reduces seizures.

Anticonvulsant effect manifests itself at the beginning of the first week of using the drug.

Pharmacokinetics

The specificity of the drug consists in its rapid absorption and swift entry into the blood.

is drunk on an empty stomach , as eating food can slow the action of the medicine.

Pregabalin is bioavailable by more than ninety percent, and this property does not depend on the amount of the drug taken. The product is distributed with a volume of 0.55 liters per kilogram.

"TC" maximum - within one hour as with a single use, and with a repetitive procedure.

"C" maximum will decrease with food intake by approximately thirty percent, and "TC" maximum increase on the contrary in about two and a half hours.

If the drug is administered in a repeat course, the nature of the pharmacokinetics can easily be predicted by having data from the application of the drug for the first time. Pregabalin is not actually metabolized, and therefore has no connection with blood plasma proteins.

In a four-hour session, the amount of the agent that is concentrated in the plasma will decrease by fifty percent. In patients older than sixty-five years, a decrease in clearance is observed.

Almost unchanged drug is excreted by the kidneys in its original form in ninety-eight percent of cases, and also in the form of secondary pregabalin. Concentration of pregabalin does not depend on the patient's sex: in any case, it will be the same.

Indications for use

Instructions for use on the drug Pregabalin indicates that the main factors that indicate the need for taking medications are:

• is widely used to treat the pain of neuropathic content that results from the excitation of neurons rather than from reaction to mechanical stimuli;
• for the treatment of epileptic seizures in complex therapy in adults;
• Pregalabine is effective in treating anxiety disorders characterized by a state of unexplained anxiety that is not associated with any situations;
• also can often be used to treat pain in the skeleton, which are chronic.

Contraindications

Not recommended for people with hypersensitivity to this drug.

The is contraindicated in children of until the age of seventeen.

Drug is prohibited from using for people with lactose intolerance or those with a deficiency of Lactase of the Saami.

Also, the remedy can be dangerous for people with impaired glucose or galactose absorption.

Application of the drug for violations of kidney and liver

For liver diseases and people with kidney failure, the drug can be used only on the recommendations of doctors and do it with extreme caution.

Mechanism of action

Active active component of the drug is pregabalin, which is a substitute for gamma-aminobutyric acid.

The mechanism of action of this is as follows: is reliably known that pregabalin reacts with another unit, such as alpha-delta protein. This unit has a character potentially dependent on the calcium passages of the central nervous system.

Such a reaction presumably may provide an additional analgesic and antisudurative result.

Popular and effective drug Triftazin, reviews of doctors and patients about which are mostly positive, has many contraindications. What separates the REG of the brain among other studies and what indications and contraindications to the study exist.

Instructions for use

Let's study the important points of the instructions for use with Pregabalin Richter.

Method of application

The drug is administered orally. The time of reception is in no way dependent on the acceptance of food. In total for a day should be no more than two receptions on 400 mg on the average.

Form release

The product is available in capsules with an active substance concentration of 25 mg to 500 mg.

Dosages of the drug

Dosages depending on concomitant illness and neglect Disease:

1. With the neuropathic pain of , the dose of pregabalin increases from 150 mg to 600 mg per day. The term of treatment will be approximately seven days.
2. In epilepsy , pregabalin is taken within a week, but the dose increases from 150 mg to 300 mg per day. If the time of taking the medicine has been missed, you need to drink the next dose of the medicine, the faster the better. A double dose is not acceptable. The standard reception of the drug is restored starting the next day.

Overdosage and additional indications

The most frequent cases of overdose of pregabalin are affective disorders, as well as the state of constant sleepiness, depression of any severity, increased anxiety.

No unforeseen and more serious cases were recorded.

Side effect of

Side effects of the drug are not very common among patients, but the most frequent are:

• dizziness;
• feeling sleepy.

These phenomena were not fixed in severe form, they were all quite easy.

Also may:

• may cause neutropenia of the lymphatic system;
• in some cases, anorexia was recorded, or on the contrary, a sharp increased sense of appetite;
• patients can be in a state of euphoria, they may suffer from insomnia, depression, strange dreams, an overly cheerful mood;
• may be completely or partially impaired, loss of coordination or imbalance;
• the nervous system can react with sudden syncope, headaches or cramps;
• is possible partial loss of vision and eye damage, their swelling and dryness;The
• cardiovascular system can respond with arrhythmia or tachycardia;
• difficulty breathing, coughing, dry mouth, snoring and stuffiness, and even bleeding from the nose also have a place to be as side effects.

Special instructions

Also the instruction for the use of Pregabalin indicates:

• Patients who have diabetes mellitus will need to adjust the dose of the remedy, since an increase in weight is possible.
• If swelling of the face or the respiratory tract, taking the drug is urgently prohibited.
• Similar drugs may increase thoughts of suicide or develop manic behavior. Therefore, patients must constantly be supervised.
• Because excessive sleepiness and dizziness are possible, elderly patients need constant monitoring. Possible loss of consciousness.- If there is a deterioration in vision, stopping the taking of the drug will normalize it.

Drug and alcohol

The drug is strictly prohibited from taking with any type of alcoholic beverages.

Interactions with other drugs

The drug is excreted by the kidneys in an unchanged form, so there were no specific prohibitions regarding interactions with other drugs.

Such agents that have in the composition of insulin, topiramate and so on are suitable for simultaneous reception with pregabalin.

Oral contraceptives also do not reduce the effectiveness of this drug.

Coma and respiratory difficulties can be observed with pregabalin simultaneously with drugs that depress the central nervous system.

When pregnant and lactating

During gestation, use pregabalin only on the advice of doctors. During the period of breastfeeding, the use of the drug is strictly prohibited.

Reviews of patients and doctors

Reviews about the drug Pregabalin is basically positive.

Reviews of doctors

Here are the doctors' reviews about Pregabalin:

1. "Pregabalin is a wonderful remedy that can cure epilepsy. I always recommend it in these cases, because it shows high efficiency. However, patients should be cautious when taking such a serious drug, because the list of contraindications is great »( Varezhkin K.U.).
2. "I do not belong to fans of pregabalin. This is a very powerful drug that has recently been used in the treatment of drug addicts. Especially this means can cause the strongest drug addiction »( Vilenskaya RK).

Patient Reviews

Patients also are satisfied with:

1. "I tried to poprinimat this drug. The first course was successful, and during the second the catastrophe began: edema of the face! I had to stop urgently to stop the drug, although it showed itself from a relatively good side! "( Valentina Semenovna).
2. "He treated them with a spinal cord injury. Miracle means! So I did not help any more medicine! First, a terrible allergy started - a rash all over the body. I thought to stop taking the medicine and put a cross on it, no, no! It proved to be quite effective and reduced all the pains »( Constantine).

Tips for receiving patients from

"I recommend that you do not take it with drugs that depress the central nervous system! I had trouble breathing because I neglected this information »( Nikolay Ivanovich).

Pros and cons of reviews and practical experience of using

From the "pluses" you can highlight:

• high efficiency;
• availability of the drug.

A significant "minus" of will be:

• a huge list of its contra-indications;
• ability to cause drug addiction.

Forms and costs

Pregabalin is available in capsules with various active ingredient contents. The price of capsules of Pregabalin 75 mg will cost approximately 500 rubles.

One hundred and fifty-milligram capsules will cost between two and three thousand rubles.

Conditions and storage times

Pregabalin is usually stored in a dark and cool place with a plus, but not too high a temperature( about twenty degrees Celsius).The product is stored for no more than two years.

Leave at pharmacy

The drug is dispensed only by prescription of a specialist doctor.

Analogues

As already mentioned, the well-known analogues of Pregabalin are:

• Lyrics;
• Algerica.

The drug causes dependence in a short time, and the worst thing is that the dependence does not occur in cases of overdose, but at quite acceptable doses prescribed by the doctor.

Lyrics are used in the treatment of epilepsy, seizures , as well as for the treatment of neuropathy, observed in diabetics. Maximum concentration in the body and passes to the effect for an hour.

Algerika is available in capsule form, similar to its counterparts. The tool has a narrow spectrum of action. It has proved to be the best anti-epileptic. Both the dosage and the description of the preparation are similar to pregabalin.

The only difference is that the algary has fewer symptoms in an overdose. And to be precise, such cases have been recorded quite rarely.

"Plus" drugs are their effectiveness and price, and "minus" - narcotic effect.

Video: Lyrics( pregabalin): mechanism of action

The danger of taking Pregabalin systematically. Why it is important to get medical advice before taking the drug.