Atypical neuroleptic Quetiron in the therapy of psychosis and schizophrenia

In the process of treatment of mental disorders, antipsychotic drugs( antipsychotics) with prolonged action are actively used.

One of the effective drugs of this group is Quetiron. The medication is produced in tablets, which have a round, biconvex form and are covered with milk-white shell. The drug is available in cardboard packages.

Ingredients

The main active ingredientthe drug is quetiapine. As auxiliary substances, the tablets contain the following components:

• ethylcellulose;
• polyethylene glycol;
• hypromellose;
• titanium dioxide;
• silica colloidal;
• talc;
• ammonium methacrylate copolymer type B;
• magnesium stearate;
• polyvinyl alcohol;
• film composition for coating Opadry II White.

One tablet contains 0.025, 0.1 or 0.2 g of active ingredient.

Pharmacological properties of

Medication refers to atypical neuroleptics and effectively reduces the manifestations of schizophrenia and other psychiatric disorders.

The drug has the ability to be absorbed well, reaching a maximum concentration in the blood after 1.5 hours after ingestion. You can drink it regardless of the time you eat.

After absorption, the components of the drug are actively metabolized. The effectiveness of the drug is preserved on condition of reception twice a day.

About 70% of the active substance is excreted when urinating, and about 20% - with a caloric mass. No more than 5% of the substances come out in an unchanged state.

Indications and limitations for the appointment of

Quetiron is used in the following cases:

• for acute and chronic psychoses that develop against a background of schizophrenic disease;
• for the therapy of psychoses of different etiology;
• for manic conditions associated with bipolar disorder.

The drug is not recommended for use in such cases:

• the patient has an increased susceptibility to the constituents of the medication;
• was assigned simultaneous reception of HIV protease inhibitors and cytochrome P450 3A4, azole antifungal agents, Erythromycin, Nefazodone, Clarithromycin.

There are also a number of other limitations in the appointment of Quetronone:

1. Pregnancy and lactation .Medicine has no information about the effects of active substances on the woman's body and the condition of the fetus, and there is no evidence that quetiapine is excreted in breast milk. For this reason, the drug is prescribed to pregnant women only if the benefits to the mother exceed the risks to the fetus. When taking medication during lactation, breastfeeding should be discarded.
2. Child age .Studies on the effect of quetiapine on the child's body was not conducted, for this reason it is prohibited to prescribe a drug to persons under the age of 18 years.
3. Diseases of the liver and kidneys .There is no prohibition on taking medication by patients suffering from these disorders, but in these cases, medical control and careful calculation of dosage is necessary.

Instructions for Use

The drug should be taken twice a day. The treatment regimen and dosages are determined depending on the patient's condition and age:

1. Manic manifestations in the background of bipolar disorders .Treatment begins with 0.1 g per day, and then increases daily by 0.1 g until the amount of the active ingredient reaches 0.4 g. After that, the dose can be increased by 0.2 g per day, the maximum daily volume of the substance is 0, 8 g.
2. Acute and chronic forms of psychosis .In this case, you should adhere to this scheme of reception: the first day - 0.05 g;the second day - 0.1 g;the third day - 0.2 g;the fourth day - 0.3 g. Subsequently, the dose can be increased to 0.45 g daily volume. The maximum allowable amount is 750 mg.
3. The elderly .For such patients, the initial dose should not exceed 0.025 g daily intake. The increase in volume is carried out in small amounts, from 0.025 to 0.05 g per day.

According to assessments of the patient's condition, the attending physician can adjust the dosage regimen and dosage of the drug.

Interaction with other medicines and alcohol

Quetiron can influence active components of medicines, whose action is directed at affecting the central nervous system.

For this reason, it is better not to use these medicines together, and also completely eliminate alcohol during the course of therapy.

With the simultaneous use of ketoconazole and quetron, the effect of the latter is increased several times. These drugs should not be prescribed together.

The active ingredient of the Quetronone tablets is able to significantly reduce the effect of carbamazepine-based drugs in the conditions of simultaneous administration.

The interaction of quetiapine with the active substances that make up the cardiovascular system has not been studied. In cases when the patient is forced to take these drugs at the same time, medical control is required.

Special instructions

Observe precautionary measures and, if necessary, stop taking the medication immediately should patients who have such conditions:

• heart and vascular disease;
• convulsions;
• manifestations of malignant neuroleptic syndrome;
• presence of late discenezia;
• is an individual galactose intolerance.

The drug may affect the reaction and attention, so during the treatment should not engage in hazardous sports and drive.

It is also not recommended to abruptly abolish medications, it is better to gradually reduce the dose before completely stopping treatment.

Side effects and cases of overdose

The most common adverse events resulting from medication are:

• drowsiness and lethargy;
• sensation of dry mouth;
• heart rhythm disturbances;
• constipation.

Other negative signs from different systems may occur, namely:

• circulatory disorders;
• disturbing sleep and nightmares;
• depression, in some cases - thoughts of suicide;
• manifestations of anaphylactic nature;
• headaches;
• syncope and convulsions;
• increased motor activity;
• disorders of the organs of vision;
• appearance of rhinitis and respiratory distress;
• edema and skin allergic reactions;
• endocrine disorders;
• nausea and vomiting;
• increase in blood sugar;
• jaundice and hepatitis;
• menstrual cycle disorder in women;
• a sharp increase in weight and increased appetite.

With a slight overdose, the patient has every chance of rehabilitation without serious consequences. Excess dose is indicated by the following symptoms:

• weakness and drowsiness;
• cardiac rhythm disturbance;
• increase in blood pressure.

Treatment for overdose is performed on symptoms, most often the patient is quickly restored. However, cases of lethal outcome and coma are known as a result of exceeding the recommended amount of medication.

Independent opinion of

A doctor's opinion and feedback from patients who have completed or are undergoing treatment with Quetiron.

Purchase of funds, selection of analogues

Quetiron is produced in cardboard packages of 30 tablets each, depending on the content of the active component, the price of the drug will differ:

• 30 tablets of 0.025 grams - from 220 to 240 rubles;
• 30 tablets of 0.1 g - from 590 to 620 rubles;
• 30 tablets of 0.2 grams - from 920 to 940 rubles;
• 60 tablets of 0.1 g - from 1,020 to 1,040 rubles;
• 60 tablets of 0.2 grams - from 1,500 to 1,600 rubles.

A medicinal preparation is released only upon presentation of a prescription. Shelf life of the drug is 3 years. The should be stored out of the reach of children, in a dark place with a moderate level of humidity, at temperatures up to 25 degrees.

Similar in the way of exposure to drugs are:

• Ziprex;
• Quetiapine;
• Olanzapine;
• Ketilept;
• Zalast.