Tizalud has an analgesic effect, it can reduce the intensity of spasms, clonic convulsions and increase the intensity of arbitrary contractions. The drug belongs to the group of muscle relaxants. The drug is prescribed for diseases related to muscles.
The principle of operation affects presynaptic receptors, which reduces the degree of excitability of amino acids that affect the receptors of M-methyl-B-aspartate. As a result, polysynaptic reactions are extinguished at the level of the neurons of the vertebral brain.
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Composition and Form
Composition and Formulation
1 capsule contains:
- 2 mg Tizanidine( in the form of hydrochloride) - the main active substance;
- stearic acid;
- cellulose;
- is anhydrous lactose.
The blister contains 10 tablets, in one box - 3 blisters.
Pharmacological effects and pharmacokinetics
The drug is able to cause a weak analgesic effect caused by oppression of the neurons of the posterior parts of the spinal cord.
Mechanism of action of muscle relaxants
Also, the drug reduces resistance in passive movements, softens spasmodic reflexes and clonic type cramps.
Also increases the intensity of arbitrary reflexes. At the same time, there is no interaction with neuromuscular transmission.
Tizanidine, the main active ingredient in Tizalud, is very quickly absorbed by the body. Within an hour, in the blood plasma, its concentrate reaches its maximum value.
In this case, bioavailability matters - 34%.
The substance binds to the plasma protein by 30%.The deviation of the pharmaceutical parameters is very low:( C max and AUC), because of this, it is possible to reliably estimate the drug concentrate in the blood plasma orally.
To whom the drug
is prescribed The drug is prescribed for patients of adult age suffering from the disease of the neuromuscular system, ascribed: 2 to 4 mg three times a day. If the patient experiences a particularly severe form of the disease, you can use 2 or 4 mg before bedtime.
Indications for use of Tizalud:
- Multiple Sclerosis ;
- muscle spasm , in conjunction with static and functional diseases of the ridge( cervical and lumbar syndrome), after surgery( for example - removal of a hernia between the vertebrae or pelvic osteoarthritis);
- degenerative diseases of the spinal cord ;
- of myelopathy of chronic type ;
- cerebral palsy for children ;
- dysfunction of the circulatory system of the brain .
Contraindications to the use of
In the following cases, the use of the drug is not recommended:
- hypersensitivity to one of the active substances of the drug;
- acute violations in the work of the liver;
- shared use of ciprofloxacin with fluvoxamine.
More information about contraindications to Tizaluda is found in the official instructions that come with the drug.
Tactics and therapy strategy
Persons who have reached the age of majority take the drug inside, regardless of when the food is taken, the medicine is washed down with water.
The mode of the use and a dosage is appointed or nominated by the doctor taking into account individual features of the patient and such moments, as allergic reactions and age. The maximum general norm of the drug intake for adults is 36 mg per day.
For people who suffer from acute renal failure, the dose must be reduced, for them the daily rate will be already - 2 mg 1 time per day.
Increase the dose slowly, taking into account the effectiveness of the medicine and how the body reacts to it. To obtain a more pronounced effect, initially increase the dosage of the drug, but only then the frequency of adoption per day.
Cases of overdose
Overdose of the drug has not yet been properly studied, therefore it is impossible to say exactly the consequences. In isolated cases, the following symptoms were seen:
- drowsiness;
- nausea;
- worry;
- vomiting attacks;
- arterial hypotension;
- distress;
- bradycardia;
- miosis;
- QT interval elongation;
- dizziness;
- coma.
In cases of overdose, first of all, the stomach is washed many times with solutions of activated charcoal. A forced diuresis is carried out, it helps in the early removal of the remnants of the drug from the body. Further treatment is conducted according to the symptoms.
Possible trouble with taking
When taking the drug, the following side effects were noted:
- serum transaminase;
- predisposition to sleep;
- dysfunction in the digestive system;
- excessive fatigue;
- reduced pressure;
- attacks of dizziness;
- dry mouth.
Symptoms most often manifest only weakly and are visible only in patients who use Tizalud to combat muscle spasms. 
In those people who take a large dosage to treat spasticity, the symptoms of side effects manifest themselves much brighter and more often, but usually never cause concern, are considered normal, concomitant and treatment does not stop.
There are some side effects: hypotension arterial, bradycardia, weakness in the muscles, bad sleep, attacks of hallucinations and even hepatitis.
Special instructions
The preparation may affect the ability to operate the vehicle or mechanism normally. When the central nervous system begins to experience side effects as a result of the action of the drug( a person wants to sleep, etc.), the patient should abandon such works in which increased attention or reaction is required.
For example, the management of various vehicles or other mechanisms. If the symptoms of side effects do not pass for a long time, or even worse, are intensified when taking the drug, you should consult your doctor for advice.
When side effects occur, it can be due to liver weakness( sudden nausea, fatigue, etc.), and in people who use tizanidine over 12 mg per day. In such cases, you need to monitor the liver, through special tests( samples) monthly, in the first half of the treatment.
If the amount of liver transaminases exceeds the prescribed level three times, the drug should be discontinued immediately.
For those who have kidney dysfunction, you can prescribe no more than 2 mg of medication per day. Further, a very accurate dose increase occurs, at which time the patient is under constant medical supervision. Initially, the amount of the drug taken per day is raised, only then the number of receptions.
Interaction with other drugs
If in addition to Tizalud another drug is prescribed, before their joint reception, be sure to consult this possibility with a doctor. It is strictly forbidden to take simultaneously tizanidine and inhibitor fluvoxamine.
Also it is necessary to take with special care a remedy with such preparations, due to which the QT interval increases. A joint use of tizanidine with alcohol will strengthen its effect on the body.
Admission for pregnancy and lactation
There is very little information that explains the effect of the drug on pregnant women, so it is not prescribed during the period of 
pregnancy.
There are exceptions when the drug is still prescribed, in cases where its benefit is more important for the life of the mother than the potential risk for the unborn child.
It is known that the active substance tizanidine in a small amount falls into the mother's milk. That is why, the women who feed the baby with their milk, the medicine is also not prescribed.
From the practice of patients
Tablets Tizalud found their admirers among patients, which is confirmed by numerous reviews on the network.
The drug began to take after it began to disturb the cramps in the soles of the feet. The prerequisites for this were not, no injuries or what, probably just age.
As a result, after consulting with a doctor received a prescription for Tizalud. The treatment complex lasted two months, although after the first two weeks the symptoms passed. After a while I plan to drink again the drug for prevention.
Oksana Dmitrievna 62 years old, Irkutsk
There was a head injury, as a result, the artery was cut and the blood supply in the brain was disrupted, a lot of negative symptoms were, it's a nightmare.
A number of drugs were prescribed for the regional hospital for healing and restoration of the circulatory system and brain function, but after a long reception, I did not see any positive sensations, except for side effects. Now I'm trying this drug. The results I will write necessarily.
Ivan is 44 years old, Tver
He was injured with his husband in a car accident, resulting in a head injury. I was sick for six months just every day, I could neither work nor sleep normally.
Tizalud helped almost immediately, after a month of admission, everything fell into place.
Alice 19 years, Syktyvkar
Terms and storage terms
The medicine must be stored in the original box at a temperature of 15 - 25 ° C.In a place inaccessible to sunlight and children. Shelf life of the drug is three years.
There are analogues of Tizaluda with similar characteristics on the market:
- Baclofen .Indications for use: the drug is used to combat spastic conditions: multiple sclerosis,
disruption of the spinal cord( its puffiness, damage to motoneurons, or trauma). - Tizanidine .Indications for use: weakening of chronic convulsive symptoms, manifested due to incorrect operation of the central nervous system. Severe convulsions in muscles of a local species.
- Sirdalud .Indications for use: spasm in the muscles caused by functional or static damage to the spine after surgery, for example, when removing a hernia from the intervertebral disc.
