Diseases of joints and spine are treated difficultly and for a long time. Many factors contribute to their development: heredity, chronic diseases, excessive physical exertion and much more. Most often in the treatment of diseases of this kind prescribe painkillers.
There are quite a few medications that have an analgesic effect. In the pharmaceutical market not so long ago appeared universal painkiller Ketorol, capable in a few minutes to remove even the most severe pain.
In addition to its powerful analgesic effect, the drug has anti-inflammatory effect and relieves soft tissue edema.
Contents of the article
- General information about the preparation
- Composition and preparation
- Pharmacological action
- Pharmacokinetics
- Indications for use
- Contraindications and limitations for prescribing
- Schemes and allowable dosages
- Overdose cases
- Possible side effects
- Physician review
- Practical experience with
- Admission advice from patients
- Buying and storing
General information about
Ketorol is not a groupteroidnyh analgesics which have a pronounced analgesic effect, which is achieved by the active agent called ketorolac.
In addition, like many other nonsteroidal pain medications, the drug has an anti-inflammatory effect, which is supported by analgesic action, which is an indispensable feature for joint and spinal diseases.
The main feature of the drug is that, after oral administration, it does not adversely affect the center of the medulla oblongata.
Composition and form of release
Depending on the type and severity of the disease, Ketorol can be given in the following release forms:
- gel , if the patient is concerned about mild joint pain;
- tablets in a thin film shell of green color with a dent S, the drug in this form is used for progressive arthritis and arthrosis;
- injection solution for injections is used for the chronic form of osteochondrosis and other joint diseases.
The preparation of Ketorol regardless of its form of release includes the following elements:
- active substance - ketorolac tromethamine( its concentration in the preparation is not more than 10 milligrams);
- to the excipients include cellulose, lactose, corn starch, silicon, magnesium, sodium.
Pharmacological action
Ketorol is an anti-inflammatory non-steroid drug with predominantly analgesic properties.
The active component of the drug is tromethamine kinorolac, which has an anti-inflammatory and pronounced analgesic effect.
The drug induces an indiscriminate decrease in the activity of enzymes that participate in the production of prostanoids( cyclooxygenases), resulting in a suppression of the synthesis of prostaglandins, which play a significant role in the onset of pain and inflammation in arthritis or arthrosis.
The analgesic effect of the remedy is much stronger than the anti-inflammatory non-steroid drugs of other groups - it can be compared with Morphine by the strength of the analgesic effect.
Pharmacokinetics of
The analgesic effect of the drug begins 30-45 minutes after both oral administration and after intramuscular injection.
Absorption of the drug from the digestive tract is not dependent on food intake. The maximum analgesic effect is achieved after 1-1,5 hours. About 85% of the taken dose of the drug is excreted from the human body with urine, the rest - through the intestine.
The biological withdrawal period of the drug( T1 / 2) is 5-6 hours. In patients with impaired renal function and elderly people, the rate of elimination of the drug decreases, the time of the elimination period increases.
When ingested, the tablets are rapidly absorbed into the gastrointestinal tract. The speed of the drug is more than 80%, and the percentage of absorption is 99%.
Regarding Ketorol intake during pregnancy, the maximum concentration in breast milk is reached after several hours.
To be excreted from the body more slowly, first dissolving in the liver, after which the remedy is excreted by the kidneys through the urine and partly through the feces( only 9% of the given drug is excreted through the latter).
After oral administration and ingestion, the medication begins to be absorbed quickly by the body and, after getting into the blood, an active analgesic effect begins.
Indications for use
Indications for use Ketorol is a pain syndrome that can occur for the following reasons:
- injury( dislocations, sprains, fractures);
- pain after surgery;
- oncology;
- neuralgic diseases;
- diseases of the joints and spine( arthritis, osteochondrosis, arthrosis);
- pain in muscles and joints;
- neuralgia;
- radiculitis;
- rheumatic diseases;
- toothache
Ketorol is intended for use during symptomatic therapy, with the drug several times reducing sensitivity and relieving inflammation from the damaged area of the body. It should be remembered that the drug is only an anesthetic and is not able to cure any disease.
Contraindications and limitations for the appointment of
Ketorol has a rather wide range of contraindications:
- complete or partial intolerance to one of the constituents of the drug( allergy);
- ulcer;
- internal bleeding;
- inflammatory diseases of internal organs;
- poor blood coagulability;
- heart failure;
- hepatic impairment;
- dysfunction of kidney function;
- preparation is not recommended after shunting;
- pregnancy, the period of active lactation;
- is contraindicated to take the drug to children under 16 years of age.
The drug should be taken only after the appointment of a doctor. Such a potent analgesic as Ketorol is incompatible with alcohol.
Schemes and allowable dosages
Application instructions depending on the form of release Ketorol:
- gel is used for injuries and bruises. The gel is applied on disinfected hands on clean skin. Do not use more than 12 milligrams of gel when applied. For better absorption into the skin, the preparation must be rubbed into the problem area with massage movements. Do not apply gel to open wounds and burns.
- Ketorol in ampoules is used for exacerbation of arthritis, osteochondrosis, rheumatism and other articular diseases.
The solution is injected intramuscularly through an ordinary syringe, because due to this application the drug is absorbed more quickly and exerts its analgesic effect. The maximum allowed dose of injection is 1 ml. - Tablets are taken for pain relief for chronic pain. The drug should be taken after meals, washed down with water or milk. With a pronounced pain syndrome, you are allowed to take the medicine 4 times a day( that is, the maximum daily dosage is 40 milligrams).The maximum permissible dosage of the drug is 40 milligrams.
Cases of overdose
Overdose Ketorol is expressed as follows: 
- Gel .If the skin is applied over 12 milligrams of the gel, the patient may receive a moderate burn. In this case, it is necessary to wash the damaged skin with cold water and soap and apply an anti-burn agent.
- Injection solution .If more than 1 ml was administered.solution, in a few minutes the patient may begin to have headaches and a general malaise.
- Tablets .Overdose, can only be achieved after taking the maximum allowed dose( that is, over 40 milligrams).For an overdose is characteristic: dizziness, nausea, vomiting, in such cases it is necessary to immediately call an ambulance.
Possible side effects of
Side effects that are possible with Ketorol:
- liquid stool;
- heartburn;
- increased and frequent urination;
- swelling of the extremities;
- headache.
At the risk of side effects include:
- people over 60 years of age;
- oncological patients.
Side effects of Ketorol
Doctor's review
Says professional.
Ketorol is a non-steroidal anti-inflammatory drug characterized by a pronounced analgesic and moderate antipyretic effect. This drug is most often prescribed for joint diseases.
This analgesic does not affect breathing, does not cause drowsiness and drug dependence on it, while effectively relieving pain in various diseases. That's why, from year to year, I prescribe to patients after operations this drug, since the pain he takes off instantly and for a long time.
Nikita Marchenko, 36,
Surgeon Practical experience of using
We study feedback and advice from patients who have taken or are taking Ketorol.
Due to the fact that for several years I have been suffering with arthritis, I always have a Ketanov tablet in my home medicine chest, and also in my purse. But, that's when I went to the pharmacy, because the tablets were running out and Ketanov was given Ketorol instead of me, they say it's the same thing.
Well, I bought, I come home, I read the instruction, and I think, well, business, and they say that they are the same. There are a lot of side-effects, it is necessary to drink only in emergency cases. Well, I think, let it be, and as if I saw, this incident came. A few days later, the tooth became very sick and I took Ketorol's pill and it literally took 10 minutes.
Alena Kirova
These pills were prescribed to me by the surgeon after I was diagnosed with osteochondrosis and the pains were simply unbearable. I bought the pills immediately after a visit to the doctor and, frankly speaking, they saved me by their analgesic effect.
Sasha Morozov
& gt;
Tips for receiving from patients
Since, the drug is a potent analgesic, judging by the feedback of patients, the drug is not recommended for 
, if the patient needs to drive the car before the day before or engage in this type of exercise.
Those who take the medicine outline the following advantages of the remedy:
- rapid action;
- high efficiency;
- low cost.
And cons:
- a large list of contraindications to the application;
- a considerable list of side effects.
Purchase and storage of
The price of Ketorol for the gel is about 150 rubles, the pills are 100 rubles and the injections are 290 rubles. Keep the drug in a place difficult to reach from children at a temperature of no higher than 25 degrees Celsius.
The drug is dispensed in a pharmacy without a prescription.
