Triticot( Trazodone) is an antidepressant that belongs to the triazolopyridine group. Produced in the form of biconvex tablets of prolonged action, white, 75 and 150 mg of active ingredient.
The composition contains the active ingredient trazodone hydrochloride and impurity components: wax, cane sugar, magnesium stearate, povidone.
Contents
- Pharmacological action
- Pharmacokinetics of medication
- Indications and contraindications for use
- Instruction for use
- Overdose and side effects
- Drug interaction
- Practical experience with
- Drug purchase and its analogues
Pharmacological action of
The active ingredient of the drug is trazodone, which has antidepressant effectwith a soothing and anxiolytic effect.
The drug differs from other antidepressants with a tricyclic structure and the lack of monoamine oxidase. The active ingredient trazodone quickly eliminates somatic and mental symptoms, especially effective in the spread of sleep.
Also the drug is able to normalize an excited pathetic state, restores potency and improves mood.
Trazodone has some similarities with certain types of serotonin receptors. Medpreparat removes the pathogenetic cause of depression( serotonin deficiency), which has an antidepressant effect.
When exposed to an active substance on the body, emotional tension is eliminated, a sense of panic disappears, sleep is accelerated. The medication eliminates symptoms such as headache, tachycardia, myalgia and signs of heightened anxiety and anxiety.
As a result of the drug restores normal sleep. During the passage of the therapeutic course, the emotional state is stabilized and the craving for alcohol decreases with the presence of an abstinence syndrome.
No addiction to this medication was recorded. The active element does not have anticholinergic activity, so it does not have any effects on the function of the heart, not 
.
The algorithm of Trittico's functioning lies in its ability to influence the serotonergic system. The active substance selectively blocks the recurrent rejection of serotonin.
The medication provokes an adrenergic blocking effect and reduces the susceptibility of beta-adrenergic receptors. Effective components affect the neuronal capture of dopamine and norepinephrine. The drug is particularly effective for sleep disturbances in patients who are in a state of apathy. The medication significantly improves mood and general pathetic state.
Pharmacokinetics of
Medication has a high level of absorption from the digestive tract. Simultaneous reception of the drug with food slows the suction time.
The maximum accumulation of constituents of the drug in the blood plasma is noted 1-2 hours after its internal administration. The ability to switch components of the drug and plasma proteins is 90-95%.The active ingredient is able to penetrate the granulocyte barriers and can enter the breast milk.
The metabolic process takes place in the liver, followed by the release of the active metabolite of chlorophenylpiperazine. The half-life of the drug is 3-6 hours. A significant number of antrolov is excreted by the kidneys( 75%).The total output is stopped 98 hours after the drug is consumed. Nearly twenty percent of the drug is excreted with bile.
Indications and contraindications for use
Trittico is prescribed for the following diseases:
- hypothetical apathy;
- manifestation of involutional depressions;
- presence of impotence;
- cerebral arteriosclerosis;
- apathy with long pain syndrome;
- senile dementia;
- alcoholic depression;
- benzodiazepine dependence;
- presence of anxiety syndrome;
- manifestation of psychogenic spleen;
- apathy in the background of Alzheimer's disease;
- anxiety;
- phobia;
- bulimia;
- violation of libido;
- for the prevention of migraine.
Contraindications to prescribing:
- hypersensitivity to the active ingredient of the medication;
- gestation period;
- children under six;
- hepatic or renal insufficiency;
- the presence of priapismoma in the anamnesis;
- symptoms of ventricular extrasystole;
- arterial hypertension;
- initial remission period after a heart attack;
- presence of tachycardia.
Instructions for use
Triticot tablets are prescribed for internal use, 30 minutes before meals, or four hours after eating.
Tablets are recommended to eat without chewing, as the integrity of the film membrane may be impaired. The course of treatment should start with a dose of 50-100 mg at a time. This amount should be used during the first three days of the therapeutic course.
Starting from the fourth day, the dose of the drug should be increased to 150 milligrams per day. Further, the amount of the drug should be increased by 50 mg per day, until the desired therapeutic dose is established.
In general, the total daily amount of medication should not exceed 150 mg per dose. Diagrams of drug use differ depending on the age group of patients:
- Age 18 years .The daily dose is calculated in an amount of 1-2 mg per body weight. The set amount is divided into several methods. If necessary, the daily amount of the medicine can be gradually increased every three days to a total dose of 6 mg per 1 kg of body weight.
- Elderly and debilitated patients .The course of therapy for this category of patients begins with a dose of 100 mg per day. Further, the amount of the drug is increased to a total daily dose of 300 mg.
The drug is not recommended for use during pregnancy and during breastfeeding. Patients with impaired renal and hepatic function should be treated with caution. Trittico is also not prescribed in childhood( up to six years).When taking a course of treatment with this medication, it is not recommended to drink alcohol.
Overdose and side effects of
In an overdose of Trittico, such reactions are manifested from the nervous system: tremor, drowsiness, agitation and headaches. There is also a disturbed digestion, resulting in nausea, bitterness, etc. 
Of the side effects of such reactions:
- cardiovascular system - decrease in blood pressure, leukopenia, neutropenia, bradycardia, impaired conductivity;
- digestive system - diarrhea, vomiting, nausea, loss of appetite;
- trunk and peripheral nervous system - severe fatigue, disorientation, trembling, dizziness, numbness of limbs and general weakness.
Drug Interaction
The active ingredient trazodone can enhance the effect of certain antihypertensive medications. In this case, 
is required to lower the doses of both medications.
When used synchronously with drugs that suppress the central nervous system, the effect of the latter is significantly augmented.
Antihistaminic drugs and drugs with anticholinergic efficacy provoke an increase in the anticholinergic effect of trazadone. When parrallelnom admission with tricyclic stimulants, there is an increase in sedative and anticholinergic effect.
When taken concomitantly with MAO blockers and carbamazepine, the likelihood of unwanted effects increases.
Practical experience of using
Reviews of doctors and patients who have been treated with Trittico.
Very effective drug. With depression, I appoint it in conjunction with other medications. During the time of her medical practice she observed little side effects.
If you follow all the necessary instructions of the doctor, the therapeutic effect comes within seven days after the start of the use of the medication.
Galina Aleksandrovna, psychotherapist
I prescribe this medication quite seldom. This is due to the fact that in some cases, too long a sedative effect may occur. Everything depends on the hypersensitivity of the body.
Boris Evgenievich, neurologist
I took half a pill twice a day. His mouth was constantly dry, his breath was somehow uneven and constantly vomiting. Decided not to take anymore. The doctor advised me to replace the drug, which I did.
Alla, 39
At one time I also took Trittico for three weeks. The drug helped me a lot, but I was always sleepy. I did not observe other adverse reactions in myself.
Valery
It can be seen from the reviews that the medication is effective, the only drawback is a frequent manifestation of side effects. Before using the medication, you must first consult with your doctor.
Purchase of the drug and its analogues
Trittico is available in the form of tablets, in blisters and cardboard packs, the average price for the drug is 650-700 rubles.
The medication should be stored at a temperature not exceeding 25 degrees. Shelf life of the drug is three years. It is released in pharmacies only according to the prescribed prescription from the doctor.
Analogues of antidepressant Trittico:
- Alventa;
- Velaxin;
- Venlift;
- Depressor;
- Medofaxine;
- Prefaxin;
- Brintellix.
