Baseline antirheumatic drug Elafra: instructions and reviews

elaphras Elafra refers to a class of basic drugs that have antirheumatic effects.

Elaphra has antiproliferative, immunomodulating( immunosuppressive) and anti-inflammatory effects. The main component of the drug - leflunomide, has an inhibitory effect on the enzyme dehydroorotate dehydrogenase. And also this substance has an antiproliferative effect.

During oral administration, the absorption level ranges from 82% to 95%.The maximum process of drug distribution starts from an hour to a day after a single dose.

The drug removal process is slow, characterized by a clearance of 31 ml / h. The half-life of the drug lasts approximately 14 days. Excretion occurs with urine and feces.

This medication should be taken during an arthritis of the rheumatoid type in active form.

Article Contents

Release form and composition of the drug
When it is not recommended to take the drug
scheme of application and dosage
Symptoms
overdose special status and patients
Side effects

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Because doctors and patients the practice
- Opinion rheumatologist
- He was echoed by the therapist
- Practical experience of patients
Price

The form and composition of the preparation

Elaphra is available in the form of tablets with a biconvex round shape, which are covered from above with filmth shell. The structure of Preparation for rheumatoid arthritis tablets is white. Tablets are placed in bottles of polyethylene base for 30 pieces. The bottles are contained in a carton.

One tablet contains the following components:

active substance - leflunomide 20 mg;
160 mg lactose monohydrate;
10 mg of low-substituted giprolose;
6 mg tartaric acid;
1 mg of sodium lauryl sulfate;
3 mg magnesium stearate.

Ingredients of the shell:

2.7 mg of polyvinyl alcohol;
1.9 mg titanium dioxide;
1.2 mg of talc;
1.2 mg of lecithin;
0.03 gum xanthan.

When it is not recommended to take the drug

The medicine should not be taken in the following cases:

in case of liver failure;
during immunodeficiency states in severe form, namely AIDS;
in the presence of severe disorders in the functioning of the bone marrow, as well as the state of anemia, leukopenia, neutropenia, thrombocytopenia;
in the event of severe infectious lesions;
in the presence of renal failure in severe or moderate form;
during severe hypoproteinemia;
during pregnancy( it is also recommended to exclude conception during Elaphore treatment);
when breastfeeding;
children and adolescents under 18;
the presence of hypersensitivity to the constituents of the drug.

Application and dosage regimen

The medication is taken orally by oral route. Tablets should be swallowed in their entirety. To facilitate swallowing, the medicine should be taken with a sufficient amount of water. Eating does not affect the absorption of leflunomide.

The entire Elaphore therapy process should be performed under the supervision of a physician who has experience in the treatment of rheumatoid arthritis.

The beginning of therapy should begin with a high dose of the drug in an amount of 100 mg and a duration of 3 days. The maintenance dosage for rheumatoid arthritis should be about 10-20 mg per day.

The therapeutic benefit from taking the medication is observed after 4-6 days and in the subsequent period lasts approximately six months.

Joint affected by rheumatoid arthritis

Symptoms of overdose

When taking the drug at a dosage higher than recommended, the following symptomatology may appear:

diarrhea;
occurrence of pain in the stomach and intestines;
state of leukopenia, anemia.

With this symptomatology, it is recommended to take activated charcoal to accelerate the cleansing of the body. You can also take Kolestyramin. It is recommended to carry out further symptomatic treatment.

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Special conditions and patients

taking the drug during pregnancy Medication is not recommended during pregnancy and breastfeeding. It is also not recommended to use for the treatment of women of childbearing age who do not use reliable methods of contraception.

Women need to abstain from pregnancy after taking Elaphra for about 2 years. In addition, you need to make sure before starting treatment in the absence of pregnancy.

Women who want to become pregnant or have become pregnant need to carry out procedures for "laundering" a drug that will speed up the process of removing metabolites of the drug from the body.

After the completion of Elafra's therapy, you should take Kolyastramine at a dose of 8 g every 8 hours for about 11 days or 50 g of activated carbon every 6 hours for about 11 days.

Because the constituent components are included in the composition of breast milk, the use of the drug is not recommended during breastfeeding.

Side effects of

During the use of the drug, the following side effects may appear:

, there is often a rise in blood pressure;
occurrence of diarrhea, nausea, vomiting, anorexia, damage to the mucous layer of the mouth, the development of pain in the abdominal cavity, increased activity of liver enzymes;
in rare cases, there may be signs of hepatitis, jaundice, cholestasis;
sometimes shows hepatic insufficiency and liver necrosis in acute form;
frequent phenomena of tendovaginitis, sometimes there are ligament ruptures;
can begin to drop out the hair, the appearance of eczema, increased dryness of the skin;
occurrence of Stevens-Johnson syndrome, Lyell syndrome, erythema multiforme;
frequent phenomena of leukopenia, sometimes anemia, thrombocytopenia, in rare cases, manifestations of eosinophilia, leukopenia;
may cause rash, redness, scabies, itching sensation among allergic events;
sometimes there may be a state of mild hyperlipidemia, hypophosphatemia, a decrease in the level of uric acid;
in rare cases, severe infections and sepsis are observed.

From the practice of doctors and patients

Reviews of doctors and those patients who took Elafra's remedy for a long time.

The opinion of the rheumatologist

The thoughts of an experienced doctor about the use of this drug in rheumatoid arthritis are of the utmost importance.

Treatment of rheumatoid arthritis always takes a lot of time and requires an individual approach. Since this disease is very serious, it is difficult to cure and do not think that after drinking the coveted pill, everything will go away right away. Of course this is not so.

I often prescribe to take the drug Elafra. Since it has a slow action, the effect of it does not come in the first week, usually the result is visible in a month. But it is necessary to follow the scheme of treatment otherwise the positive result may not be.

But before you use it, you should always consult your doctor. Therefore, appoint a drug and a plan for its administration should only be a doctor.

Karim Talinovich

He is echoed by the therapist

Rheumatoid arthritis is a serious illness that requires long-term treatment. But no medicine can provide a 100% guarantee for the cure of the disease.

Often even with complex treatment it is not possible to cure the disease completely. Often for the treatment of the disease, Elafra is prescribed. Yes, it is highly effective, but only if it is properly taken.

Be sure to adhere to strict dosages. Do not skip doses or reduce them without the knowledge of your doctor. It is best to see a doctor so that he can prescribe a treatment regimen and write out this remedy for treatment.

Alexey Borisovich, the head of therapy

Practical experience of patients

Rheumatoid arthritis has been diagnosed for a long time. How much he already brought problems to me, just do not list. For his treatment had to use a variety of drugs, only that the excretion from the body they have a very long time.

After the next appointment the doctor advised to try the drug Elafra. I immediately prescribed a prescription and prescribed a treatment regimen. In principle, the medicine is good, and "laundering" is easy. It is enough to use the activated carbon for a week after use. And the disease does not bother!

Raisa, 45 years old

Father 65 years old and already 10 years old he has rheumatoid arthritis. For his treatment had to use different medications, only they had a temporary effect, and the withdrawal was long. And when the illness worsens, the father has severe pain in the joints.

Which we muffle with various anesthetic drugs related to NSAIDs. But of course this is not a cure. After consultation in the clinic, the doctor ordered to take Elafra.

Has written out the prescription and has painted the detailed scheme or plan of treatment. After a full course of treatment, his father became much better, the disease has not bothered for a year already!

Michael, 39 years old