Arthrin is a medicinal product and belongs to the group of second generation chondroprotectors.
The international name is artrine. The main active substance of the drug is chondroitin sodium sulfate.
is an ointment for external use. In 1 gram of the drug contains 50 mg of chondroitin sodium sulfate.
Contents of the article
- Pharmacology and pharmacokinetics of the preparation
- Composition of the medical preparation
- Indications for use
- Limitations for medication use
- Scheme of application
- Side effects and special instructions
- Clinical studies
- Expert opinion and patients
- Cost of the drug
- Alternative drugs
Pharmacology and pharmacokinetics of the preparation
The active constituent substance of the drug, chondroitin sulfate, is a mucopolysaccharide with a high molethe body mass, which is obtained from the cartilaginous tissues of the cattle trachea.
Due to some features of the substance, the resorption of bone tissues slows down, which prevents the loss of calcium( Ca2 +).
How Chondroitin Sulfate Affects the Body
Mucopolysaccharide also has a beneficial effect on cartilaginous tissues, optimizes phosphorus-calcium metabolism, thereby accelerating the process of its reduction and inhibiting the degeneration of connective and cartilaginous tissues.
Inhibits( inhibits production) certain enzymes that affect cartilage tissue. There is a stimulation of glycosaminoglycan synthesis.
In addition, the regenerative capacity of the cartilaginous surface and the articular bag increases, normalization occurs and the production of the intra-articular fluid increases.
The formation of bone callus is accelerated and hematomas decrease. The process of healing is accelerated several times.
Due to its similar structure with heparin, Arthrin does not allow the formation of fibrin clots in subchondral and synovial microcircular beds.
Painful symptoms also decrease, and the mobility of the affected joints increases. There is a slowdown in the progression of osteoarthritis.
Dimethyl sulfoxide( DMSO), one of the constituents of the ointment, has anti-inflammatory, fibrinolytic and analgesic effects. DMSO also improves the ability of chondroitin to penetrate the cell membrane.
During a single dose of the mediotherapeutic dose of the drug inside, Cmax in the plasma is reached after about 3-4 hours, in the synovial fluid a little longer - after 4-5 hours.
Bioavailability( digestibility) of the drug - 13%.It is excreted through the kidneys within 24 hours.
Composition of medical preparation
The main active substance is chondroitin sodium sulfate.
Additional components:
- lanolin anhydrous;
- purified water;
- dimethylsulfoxide;
- Vaseline medical.
Indications for use
Arthrin is assigned to patients with the following diseases of the spine and joints:
- Osteoporosis ( Latin osteoporosis) is a chronic progressive systemic metabolic disease of bone tissue. It can also be a clinical syndrome that manifests itself in other ailments characterized by low bone density, impaired microarchitecture and increased brittleness, caused by an impaired metabolism of bone tissues with
increased catabolism in bone formation and with reduced bone strength and a high risk of fracture. - Osteoarthrosis ( osteoartrosis) or deforming osteoarthrosis( DOP) is a degenerative degenerative articular disease in which the cartilage tissues on the joint surface are affected.
- Osteochondrosis and other degenerative-destructive diseases of the spine, in which vertebrae, joint apparatus, ligamentous apparatus and intervertebral discs are affected. As a rule, osteochondrosis occurs in people after 30-35 years.
- Spondylosis is a lesion of the vertebral bones, which is expressed in the fact that the bones of the vertebrae grow and assume a spike shape. Because of what the lumen in the intervertebral canal becomes smaller, the vessels are damaged, and the nerve and tendon tissues are injured. In especially severe cases, the vertebrae can fuse, which leads to even more negative consequences;
- Fractures and varying degrees of spinal injuries .
- Sprain of the muscular tissue of the back .
- Arthritis of individual vertebrae.
For more information about osteoarthritis and medications for its treatment, you can find out from the video:
Restrictions for taking medication
Since Arthrin is an external medicine, its active substances practically do not come into contact with the systemic blood flow, therefore, contraindications to use are minimal:
- allergic reactions toconstituents of the preparation;
- presence of thrombophlebitis in different locations;
- damaged skin at the site of application;
- predisposition to bleeding and hemorrhage;
- pregnancy;
- breast-feeding( during treatment is terminated).
Scheme of application
Arthrin is a drug for external use, it is applied in a thin layer on the skin in places where the diseased vertebrae are located, it should be rubbed for about 3 minutes, every 8-12 hours.
The maximum course of treatment is 3 weeks. If necessary, the course of treatment can be repeated.
Side effects and special instructions
There are rare cases of allergic reactions in the form:
- of pruritus;
- erythrema;
- urticaria;
- dermatitis
During the treatment of elderly people who suffer from atherosclerosis, a decrease in blood plasma levels of triglycerides and cholesterol has been observed. This must be taken into account when prescribing a medicine.
With paradontopathy of any severity, the course of taking the drug should be at least 3 months. Arthrin is used only as directed by a doctor.
Clinical studies of
The preparation Arthrin was clinically tested in such medical institutions as the Moscow Institute of Rheumatology( RAMS) and the Central Moscow Institute of Traumatology and Orthopedics. N. N. Priorova( CITO).
During clinical trials, it was found that in 76-89% of patients suffering from osteoarthritis had a positive reaction to .
During the treatment course, which lasted 2-3 weeks, the patients had painful symptoms in the joints, the swelling was noticeably reduced. All the functions of the joints were normalized.
In addition, the positive effect of the drug in the treatment of hematoma and sprain was also recorded. This effectiveness of the drug is due to the fact that the chondroitin sulfate in the composition of Arthrin is anticoagulant active.
Opinion of experts and patients
Reviews of patients and doctors who use Arthrin in their medical practice.
If applied 2-3 times a day, for two weeks, and if you periodically repeat the course of treatment, the effect is quite good.
Traumatologist, orthopedist, Armyansk
I often appoint my patients with pain in joints. It also removes inflammatory processes.
Rheumatologist, Moscow
I took this medical preparation strictly according to the doctor's prescription, and you know, everything came back to normal.
Alena Trofimovna
Cost of the product
Forms of the drug:
- 30 g - bank;
- 30 g - aluminum tube;
- 50 g - bank;
- 50 g - aluminum tube.
In particular, the price of a 30gram Arthrin jar in the area of 23 rubles.
Alternative preparations of
Arthrin analogues, which are similar to it according to the mechanism of action and indications:
- Alflutop;
- Chondroitin;
- Artradol;
- Alfadol-Ca;
- Aminoarthrin;
- Bondronate;
- Chondrolon;
- Bonefos.
