Acathinol Memantine in the treatment of Alzheimer's and dementia

akatinol Acathinol( Memantine) is a drug specifically designed for the therapy of dementia and associated disorders of the type of Alzheimer's disease.

This disease leads to serious intellectual and behavioral disorders, which result in the loss of basic skills in everyday life. The drug Akatinol helps to stop or stop the progress of these disorders.

Contents

Formulation and Composition
Pharmacological profile
Scope
When the administration of the product is contraindicated
Application and dosage regimen
Special patient groups
Overdose cases and possible "pobochki"
Special instructions
Practical application
Purchase of funds and its analogues

Formand composition

The drug Akatinol Memantine is available in the form of tablets with a coating and in the form of drops for internal use. The tablets are placed in blisters, each containing 10 capsules. Blisters are placed in packs of cardboard base. Each pack contains 3 to 9 blisters.

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Drops for internal use are placed in vials of glass base. Above there is a lid-pipette. The volume of the vials is 50 and 100 ml.

Ingredients of the tablet components:

active element - memantine hydrochloride, preparations are available with the following dosages of this substance - 5 mg, 10 mg, 15 mg, 20 mg;
additional elements - cellulose in microcrystalline form, lactose, silicon dioxide colloidal type, magnesium stearate, talc;
components of the shell - sodium lauryl sulfate, methacrylic acid copolymer, triacetin, polysorbate 80, talc, simethicone emulsion.

memantine hydrochloride

Pharmacological profile

The drug has an adverse effect. Acatinol is a therapeutic drug that is an antagonist of a noncompetitive type of NMDA( N-methyl-D-aspartate).The positive effect of memantine is due to its effect on glutamate NMDA receptors of the inotropic type. As a result, an effect of a modulating-type drug occurs, which has a direction on the glutamatergic type system.

Memantine takes an active part in the processes of regulating ion transport, improving the membrane potential, blocking the channels of the calcium type. When the drug is taken due to the effect, the spread of nerve impulses in the cerebral cortex is improved, the cognitive functioning of the brain increases and the daily activity of the patient increases.

When taken orally, a rapid and complete absorption of the drug is observed. The maximum level of plasma concentration of the drug occurs in the period from 2 to 6 hours. The half-life in the two phases of excretion is 4 to 9 hours in the first phase and from 40 to 65 hours in the second phase. The active component is excreted through the kidneys.

The effect of memantine

Scope of application

Memantine is used to treat the following disorders:

of dementia of severe and middle course that is accompanied by Alzheimer's disease;
dementia with Levy bodies;
senile dementia at any stage of development;
dementia with vascular type in any severity.

In addition, the use of Akatinol is justified in such cases:

Spastic syndrome of the spinal and cerebral type;
for head injuries, multiple sclerosis, strokes, craniocerebral trauma, paraplegia;
with a decrease in the level of mental abilities, which are accompanied by a decrease in concentration, memory, learning ability.

When the use of the drug is contraindicated

Acatinol can not be used in the presence of the following conditions and diseases:

if there is an individual hypersensitivity to the active constituent element, as well as additional elements;
during breastfeeding;
if there are pronounced symptoms of impaired renal function;
during pregnancy;
can not be taken until age 18.

Caution is necessary to take the drug in such conditions:

in case of seizures, even if they have a history;
during thyrotoxicosis;
if there is heart failure;
with epilepsy in the anamnesis;
with myocardial infarction.

Application and dosage regimen of

The medication should be taken orally at the time of eating. The optimal dosing regimen is established for each patient individually. It is necessary to start taking the drug with a small dosage.

The medicine for dementia For dementia in elderly patients, it is recommended to take Acatinol during the first 7 days of therapy at a dosage of 5 mg daily, during the second 7 days at a dosage of 10 mg daily, during the third 7 days for 15-20 mg of medication daily.

If suddenly there is a need, in the following weeks the dose of the drug should be increased by 10 mg per week, but the maximum daily dose should not be more than 30 mg.

During the treatment of spastic type syndrome, which is caused by abnormalities in the CNS, during the first week of therapeutic treatment with drug Akatinol is recommended at 10 mg daily, during 2 weeks at 20 mg daily, during the third week for 20-30 mg daily.

If you suddenly have this need, then you can increase the dosage of the drug by 10 mg every 7 days, the maximum dose of the drug should not be more than 60 mg per day.

The dosage level for maintenance therapy should be 10-20 mg per day.

Special patient groups

During pregnancy, it is not recommended to take this medication, because the constituent components can have a harmful effect on fetal development.

During breastfeeding, medication is also contraindicated, since the constituent elements are included in the milk composition.

Medication Acatinol is contraindicated in children and adolescents under 18 years of age. Information on the safety and efficacy of this group of patients is not available.

Cases of overdose and possible "pobochki"

The following side effects may occur during medication administration:

occurrence of headaches;
occurrence of rapid fatigue;
constipation;
may have fungal infections;
appearance of dizziness;
venous thrombosis;
state of drowsiness;
problems with gait;
occurrence of nausea, vomiting;
state of confusion;
occurrence of hypertension;
manifestations of hallucinations;
thromboembolism;In rare cases,
develops psychic reactions;
state of pancreatitis( rarely);
in rare cases, there are seizures.

With the increased dosage taken, the side effects that this drug may cause may increase.

If you have symptoms of an overdose, you should immediately clean the digestive tract, it is recommended to take sorbents. After this, further symptomatic treatment is provided.

Special instructions

The following conditions must be observed during the time of drug use. During the joint use of Akatinol with Baclofen or Dantrolene, the effect on the body of the last drugs may change. Therefore, the dosage should be selected by a specialist.

The optimal dosage should be achieved gradually, with an increase in dose every 7 days.

Memantine can affect the rate of response, so patients who undergo outpatient treatment with this drug should take special care when operating machinery and vehicles.

Practical application of

A review of the doctor and feedback from relatives of elderly patients who received Acathinol( Memantine).

The drug Akatinol I appoint to patients for a long time. It has a positive effect on moderate to severe dementia.

During the reception, there is an improvement in consciousness, there is clarity of mind, memory is normalized. Basically, we had to appoint old people who had symptoms of insanity.

In these cases, I prescribe to take the drug according to this scheme - 5 mg in the first week, in the subsequent 10 mg, at week 3 15. More than 20 mg was not necessary.

However, this tool helps only to maintain the condition of patients, but it does not cure the disease. Therefore, sooner or later, but marasmus will still overtake the patient, even with the reception of this remedy, and the drug only helps to prolong the social existence.

The doctor neurologist

At the girlfriend the grandmother already old, to her already 89 years. Of course, as often happens at this age, she developed a state of dementia, she became distracted, forgetful, her consciousness somewhere far from reality. My friend was worried, and I advised her to take my grandmother to the doctor.

After the examination, she was prescribed to take a number of drugs, among which was the drug Akatinol. After she started taking medicine her condition began to improve. At least, absent-mindedness has disappeared, clarity of mind has appeared. But it's a pity that the medicine helps only to maintain a normal state, but does not completely cure the disease.

Anna, 35 years old

Mom is 75 years old and has symptoms of absent-mindedness, forgetfulness, sometimes talking to her, and she seems to be in a different reality. I immediately took her to the doctor's office, after the examination the doctor said that her dementia, caused by Alzheimer's disease, immediately warned that it was not worth waiting for.

To maintain prescribing to take medicine Acatinol. After reception the condition has improved, now though with it it is possible to talk normally.

Maria, 48 years

Purchase of funds and its analogues

Maruksa The price of packing Memantine tablets with a 10 mg dose in an amount of 10 pieces is 1600 rubles. Sets of tablets 5 mg, 10 mg, 15 mg, 20 mg 7x4 are from 1800 rubles.