Cinnarizine is used to improve the supply of blood to the brain. The drug effectively reduces the viscosity of the blood, stimulates the vestibular apparatus, improves the resistance of tissues and body cells to a lack of oxygen.
Well adsorbed in the gastrointestinal tract, metabolized at most six hours. Refers to the group of calcium channel blockers.
Analogues of Cinnarizine - Vertizin, Cinnaron, Cinnasan, Stugeron.
Contents
- Pharmacological action of the drug
- Pharmacokinetics and composition of the drug
- How does the drug work?
- Indications for admission
- Instruction for use
- Overdose and contraindications
- Special instructions
- What they say?
- Tips and conclusions from the reviews
- Buying and storing
Pharmacological action of the drug
The pharmacological properties of Cinnarizine are determined by its ability to block membrane channels of calcium. This helps to suppress( inhibit) the entry of this element into the cell.
The effect of the drug is as follows:
- drug has a positive effect on blood circulation of the brain, heart;
- improves microcirculation, increases erythrocyte plasticity and reduces blood viscosity;
- prolonged intake of the drug promotes blood thinning;
- increases the resistance of body tissues to oxygen starvation;
- is an antispasmodic, relieves spasms of blood vessels, taking the drug reduces the response to some vasoconstrictors;
- enhances the effect of carbon dioxide on brain vessels;
- has antihistaminic action;
- reduces the excitability of the vestibular apparatus responsible for coordinating movements;
- suppresses nystagmus, that is involuntary movement of the eyeball;
- does not affect systemic blood pressure, heart rate.
Pharmacokinetics and Composition of Medication
After oral administration, Cinnarizine is rapidly absorbed. The maximum concentration of the drug in the blood plasma - after one - four hours.
The half-life of the drug is no more than six hours. It is excreted through the intestine, practically unchanged. With urine is excreted in the form of metabolites - products of decay.
The tablet of Cinnarizine 0.025 g contains:
- active substance cinnarizine - 25 mg;
- starch;
- monohydrate of milk sugar;
- excipients - PVP 25, aerosil 200, as well as magnesium stearate.
Form release - tablets of 25 mg. In the blister - 50 tablets.
How does the drug work?
The mechanism of action of the drug consists in blocking calcium channels. It is known that calcium ions provide contractile muscle function. When they enter the cell - the muscle comes into a contraction state, and vice versa. A capture of calcium in muscle contraction is provided by specific proteins - calcium channels.
Upon contact with the calcium channels of Cinnarizine, their blocking occurs: the entry of calcium into the cell decreases. There is a muscle relaxation. And this drug acts primarily on the vessels of the brain, relaxing mainly them.
The drug lowers the tone of smooth muscle arterioles, while improving not only coronary, but also peripheral blood circulation.
Reduces the rate of response to vasoconstrictors( such as Adrenaline or Norepinephrine).Helps reduce blood viscosity.
Has a high degree of influence specifically to the vessels of the brain, which is why it is used in many neurological diseases. Does not affect the systemic blood pressure, contractility and conduction of the heart muscle.
Chemical formula of Cinnarizine
Indications for admission
So, what is the most commonly prescribed Cinnarizine:
- cerebral circulation disorder , associated with blood vessel spasms, in which case the drug is prescribed as a cerebrovascular agent;
- atherosclerosis ;
- transferred craniocerebral trauma ;
- transferred acute cerebral circulatory disorders ;
- headaches, tinnitus ;
- migraine ( helps to reduce pain);
- Meniere's disease ( internal ear pathology caused by an increase in fluid volume in its cavity);
- obliterating endarteritis ( in this case, blood supply to the extremities is improved due to elimination of major vasospasm spasms);
- inflammation of the vascular wall, combined with occlusion of the vessel ;
- acrocyanosis ( blue lips, nose and fingertips).
Instruction for use
The drug is used only inside and after eating. The use of Cinnarizine is recommended in the following dosages:
- In cases of , cerebral circulation disorders of the drug are taken one tablet( 0.025 grams) three times a day, necessarily after a meal.
- For different peripheral circulatory disorders , two to three such tablets must be taken three times a day, also after a meal.
- If a patient develops vestibular disorders , taking a single tablet of 0.025 grams three times a day is recommended.
- Treatment of arterial hypertension is carried out by taking one tablet of the drug twice a day.
The course of taking Cinnarizine is long. Usually it is recommended to take it from several weeks to several months( depending on the degree of neglect of the underlying disease).
Overdose and contraindications
No drug is prescribed in such cases:
- individual sensitivity;
- period of pregnancy and lactation;
- for children( up to 12 years) age.
With special care, the drug is prescribed to persons suffering from Parkinson's disease. Adolescents, when they reach the age of 12, are prescribed a half dose of the drug.
The drug is well tolerated, but in some cases( mainly with an overdose), the side effects of admission are possible:
- of dyspepsia;
- gastric and intestinal pain;
- dryness in the oral cavity;Jaundice
- cholestatic type;
- head pain;
- drowsiness and fatigue;
- trembling of the limbs;
- increased sweating;
- very rarely develops flat lichen;
- allergic reactions( rarely).
Special instructions
Since this drug has some sedative effect, this must be taken into account by persons whose activities are related to driving a car or working with mechanisms. This indication is especially important in the first days of treatment.
The medication enhances the use of sedatives and alcohol. Reduces the effect of drugs prescribed for arterial hypotension. The use of alcohol during treatment is strictly contraindicated. On condition of long reception it is necessary to check the condition of the liver and kidneys, as well as pictures of blood.
Patients with low blood pressure values may experience sharp falls. Therefore, in the case of prolonged use of the drug, you must constantly monitor these indicators.
With Parkinson's disease, Cinnarizine is prescribed if its benefit is higher than the possible risks. The drug gives a false positive result in the anti-doping control.
What are they saying?
Reviews and doctors and patients about the drug Tsinnarizin suggest that it is effective in many neurological pathologies.
I recommend the drug to patients suffering from impaired cerebral circulation to achieve the desired therapeutic effect. This is a reliable and highly effective means for preventing cerebral ischemia in patients at risk.
Ivan Pavlovich, neurologist
For many years of my medical practice, it was Cinnarizin that helped me solve the problems of cerebral circulation in my patients and prevent the development of an apoplexy stroke. With proper administration of the drug according to the recommendations, its risks are minimal.
Anna Sergeevna, neurologist
The doctor prescribed me Cinnarizine for improvement of cerebral and peripheral blood circulation. After a few days, I noticed the effect of this drug: the hands and feet did not freeze and the memory improved noticeably. ..
Alexander, 42 years old
My grandmother diagnosed with type 2 diabetes. The doctor prescribed her Cinnarizine for the prevention of complications of microcirculation. Grandma takes this drug for a long time, and she does not notice any circulatory disorders in the limbs.
Alexey, 26 years
Tips and conclusions from the reviews
Many patients point to a marked improvement in the health status of Cinnarizine, in particular, reduction of headaches, memory improvement, concentration of attention. In this case, adverse reactions were extremely rare.
Most patients indicate that long-term use of the drug is much more effective.
Analysis of feedback on the application of patients and doctors allows us to state that the advantages of Cinnarizine are much greater than the disadvantages. Special mention should be made of data on the small number of side effects and improvement of health status.
The only drawback in the opinion of specialists is the low effectiveness of the medicine in neglected cases: then it is necessary to prescribe more potent drugs.
Purchase and storage of
The drug is available only in tablets. The price is from 28 to 52 rubles depending on the manufacturer.
Available by prescription. Store in a dark, cool and unacceptable place for children. Shelf life of the medicinal product is three years.
