Medication for gout Colchicine: user manual, reviews

Colchicine( lat. Colchicinum) is an organic derivative derived from the bulbs of a cedar-tree of a magnificent family of timeless ones.

Modern, versatile counter-dandruff medicine.

Colchicine is able to limit the progress of leukocytes to the core of inflammation. It reduces the production of lactate and glycoproteins, reducing the process of phagocytosis of uric acid crystals.

In part, either to the fullest, restrains the fragmentation of cells in the phase of mitotic division, inhibits the intensive growth of granular leukocytes and other cells, interacting with their protein.

Blocking the formation of amyloidosis, reduces the appearance of amyloid fibrillar proteins. Effectively prevents gouty attacks in the peak stage.

Farmakodinamika medicines

When oral colchicine is well digested digestive tract, recycled through the intestinal-hepatic area.

The drug is mostly connected with the fibrous tissue, as well as in the tissues of internal organs such as the kidneys, liver, spleen, concentrating in them in large doses.

Only a partial drug is metabolized in the liver. The main way of excretion through the feces and urine.

Virtually does not stay in the circulatory system and does not interact with plasma proteins. Does not interact with the lungs, heart muscle and skeletal muscle tissue.

Causes a violation of neuromuscular communication, activates the functioning of the digestive tract, suppresses the respiratory center, produces a narrowing of the blood vessels, promotes increased blood pressure, lowering body temperature.

When is the drug irreplaceable?

Indications for use Colchicine:

• gout, gouty arthritis ( prevention of recurrence of gouty crises in the critical phase), mainly in the first days of treatment with uricosuric agents and allopurinol;reduction, localization of pain syndrome, relieves phlebitis of joints, reduces uric acid level to normative indices);
• acute attacks of chondrocalcinosis ( pseudo-fallas);
• systemic scleroderma ( reduces dryness, irritation, softens the skin, antifibrotic property);
• Mediterranean familial fever : prevents symptoms of the disease before exacerbation, reduces DBG activity;
• Behçet's disease ( carries anti-inflammatory and anti-dandruff effects);
• symptoms are inflammatory in ENT - practice;
• phlebitis ( relieves venous inflammation);
• amyloidosis ( suppression of disease activity).

Taking medication is recommended after consulting a doctor.

Drug administration is prohibited.

Contraindications:

• is particularly susceptible to the drug;
• chronic liver and kidney dysfunction;
• neuropathy;
• serious pathology of functioning of the CCC;
• disorder of bone marrow activity of special severity;
• gastrointestinal lesion;
• purulent infections.

Mechanism of action

Reduces the formation of lactates, preventing the shift of acidity in cells, thereby localizing the formation of urates and uric acidity.

Dosage and route of administration of the drug

Colchicine is available in the form of tablets or dragees.

Tablets are taken orally.

During the treatment of gouty arthritis in the acute stage and the existence of the inflammatory process, there are 2 regimens prescribed by the doctor:

1. Scheme # 1 : on the first day of treatment, 0.003 g / day.(1 tab., In the morning, 1 tab., Per day,
   1 tab. In the evening);On the second and third days, 0.002 g / day( 1 tab. In the morning and 1 tab. In the evening);on the fourth and the last.days-0.001 g / day( 1 tab., preferably in the evening).
2. Scheme №2 : 1 tab., Then with a period of 1-2 hours.on the floor tab.or 1 tab.until the disappearance of attacks of acute pain.
   Maximum permissible dosing: 6-8 tab./ day, but not more than 8.

For prophylactic purposes, one tablet is prescribed 1 time / day, the duration of taking up to 3 months.

In case of family mediterranean fever( FMF) disease, take 0.5 - 2 tab.(0.0005 - 0.001 mg) during the day.

A similar dosage regimen is used for other indications.

With amyloidosis: taken from the 1st to the 3rd tab./sut. Duration of treatment is five years.

Overdose and additional indications

During an overdose, the following symptoms may occur:

• diarrhea;
• vomiting;
• in the area of ​​the stomach;
• dry skin;
• gastroenteritis of hemorrhoids;
• dehydration of the body;
• hypotension( hypovelmic shock possible);
• convulsions;
• hemoglobinuria;
• increase in the ECG segment;
• weakened urination;
• weakening of myocardial contractions;
• difficulty breathing;
• paralysis of an ascending type.

According to reviews of some patients after the administration of Colchicine, pulmonary infiltrates, hepatocellular disorders, and OPN - renal failure could occur.

At the first manifestations of drug overdose, a doctor must be called at home, since there is no specific antidote.

Out-of-purity cleansing has no effect. Treatment should be performed in the infectious department.

It is necessary to control the patency of the airways, monitor vital functions, perform additional ventilation of the lungs, regulate the gas composition of the arterial blood, balance electrolytes, and apply anti-shock measures.

Side effect of the drug

Side effect:

• CNS - depression, neuritis, neuropathy;
• digestive system : dyspeptic manifestations( anorexia, nausea, vomiting, abdominal pain, decreased appetite, diarrhea), especially in individuals with ulcerative bowel and stomach lesions, liver function deficiency, vitamin B12 deficiency, impaired normal liver function;
• allergic reactions : rash, like measles, urticaria;
• hematopoietic system : leuko-, neutropenia, agranulocytosis, aplastic anemia;
• with prolonged admission of thrombocytopenia ;
• other : azoospermia, reversible alopecia, myopathy, changes in the natural functioning of the liver and kidneys, elevation of alkaline phosphatase and GGTP, itching during intravenous administration and hemorrhage - acute pain, necrosis, muscle weakness.

Special instructions

Treatment with medication should be conducted with monitoring of clinical and hematological picture of the patient's condition, to conduct a study of feces for latent blood.

If there are any serious side effects from the GI tract, then the drug should be canceled or reduced in dosage.

If the level of white blood cells in the blood drops below 3-109 / l and platelets below 100-109 / L decrease reception until the normalization of the blood picture. Probably false positive results of urine on erythrocytes and hemoglobin.

Simultaneously with Allopurinol, you can take a dragee( Colchicum-dispersant).

A one-time use of a drug with alcoholic beverages is undesirable, because it is likely to provoke intoxication of the gastrointestinal tract, especially in persons suffering from alcoholism.

And it can also reduce the effectiveness of the drug, since alcohol has the property of increasing the concentration of uric acid.

It is not advisable to take the drug in doses with a large volume of people suffering from impaired renal function, but at small dosages it can be well tolerated by patients with renal pathology.

Therefore, treatment with colchicine should be carried out by monitoring the hematological and clinical picture of the patient's condition.

The drug during pregnancy should be used only after consultation with the doctor in case of emergency. It is recommended to abort breastfeeding.

If you need to prescribe a medicine for a child

The dosage of the drug when used by children should be calculated based on the body weight and the area of ​​the plane of the body of the child's , which should be 0.00003 - 0.00002 g / kg / day.and 0.00116-0.00045 g / m2 / day.respectively.

For children up to the age of five, the daily dose will be 0.00007 g / kg / day.and 0.0019 g / m2 / day.similarly( and this is 2-3 times higher than the average daily dose for adolescents 16-20 years).

In general, the response to the drug is observed in children in 95-97% of cases.

Interaction with other drugs

It should be noted that:

1. One-time administration with phenylbutazone: multiplies the risk of leukemia, thrombocytopenia.
2. Drinking with NPP increases the risk of bleeding from the digestive tract.
3. Co-administration with drugs that are used to treat tumors can affect the increase in the concentration of uric acid in the serum, thereby contributing to a decrease in the effectiveness of preventive therapy.
4. Reducing the number of platelets, as well as leukocytes in the blood on the background of taking the drug, are intensified when applied simultaneously with drugs that cause a hypersensitive reaction.
5. When taken together with sedatives, the drug can increase the susceptibility of the central nervous system.
6. Reception with sympathomimetic drugs enhances effectiveness.
7. Taking with cyanocobalamin reduces the absorption of the drug from the digestive tract.

Colchicine in questions and answers

The most frequent questions that arise in patients about Colchicine, and for which there is no response in the instructions for use, are answered by doctors.

Patients for

Patients who take or take Colchicine.

Advantages and disadvantages from the practical application experience

Pros:

• well removes salts;
• is effective for preventing gouty attacks;
• quickly relieves pain;
• relieves of tumors.

Cons:

• difficult to buy at the pharmacy;
• has a number of contraindications.

Medication cost

Colchicine is available in the form of tablets, price from 1150 rubles per 60 tabs .

The place of storage of the preparation must be a damp, darkened, inaccessible place for children. Store at room temperature t.

Shelf life - 4 years. Unacceptable use at the end of the statute of limitations. Leave in pharmacies strictly according to the recipe.

How can I replace a medicine?

Analogues Colchicine:

• Colchicum - Dyspert;
• Colchicine;
• Colchimine.