Dolipran (Doliprane). Instructions for use of Russian (syrup / tablet). Price, analogues, reviews

Dolipran - a narcotic analgesic drug composition of French production (is an analogue of the domestic drug - paracetamol). The dosage of the drug is selected depending on the age, form of release of the medicament and the type of pathology.

Despite the OTC sale, the use of the drug is recommended to be carried out after consultation with the doctor. It is important Dolipran can cause the development of adverse reactions, especially while ignoring contraindications and rules on the use, as specified in the instructions.

Shape and composition of the drug release

Dolipran made in the following dosage forms:

• syrup. Kiseleobraznuyu has a uniform consistency, with a pink color. It contains from 200 to 300 mg of active substance. Packaged in plastic bottles of 100 ml. Enclosed measuring syringe;
• pills. Presented oblong, white. The concentration of the base member 500 mg. The tablets are packed into cell plates 8 pcs. The package of 8.16 tablets;
• effervescent tablets. White circular shape, soluble in water. In 1 pc. contains from 100 to 500 mg of active substance. The tube contains at 8 and 16 tablets;
  
• capsules. Capsules yellow or yellow-red-blue coloration contain from 100 to 500 mg of the active element. Capsules are packed in mesh plate 8 pieces. In a package of capsules 8.16;
• powder crystallized structure represented white. The sachet 1 contains from 100 to 500 mg of base material. The package contains a sachet of 8.12;
• suppository. Tarpeidalnuyu have the form of white color, with the concentration of the active element of 100 to 300 mg. The package contains 10 suppositories.

The active substance in the form of each drug is paracetamol of various concentrations (the amount of active substance stated on the package of the drug, as well as different colors allocated boxes). The structure includes additional components that allow you to make the desired pharmacological form of the drug.

Description of the composition of the drug commonly used types:

dosage form	auxiliary components	Assigning components
Pills	Corn starch	A thickener.
hydroxypropyl	It is used to impart the desired concentration and form of the drug.
Talc	Facilitates swallowing tablets.
magnesium stearate	It integrates components, creating a homogeneous mass.
polyvinyl alcohol	It contributes to unification of components, but under the influence of the fluid allows the tablet to dissolve quickly.
macrogol	It draws the liquid, accelerating disintegration of the tablet in the stomach.
effervescent tablets	Lemon acid	It improves the absorption of the drug and gives the desired taste.
mannitol	Filler. It allows the tablet to dissolve quickly in water.
sodium saccharin	Artificial sweetener.
povidone	It contributes to the unification of the components.
Anhydrous sodium carbonate	baking powder. It allows the tablet to dissolve in the liquid.
Syrup	sorbitol	Sweetener.
Apple acid	Improves the absorption of the components.
xanthan gum	It gives medicament kiseleobraznuyu form.
liquid maltitol	Sweetener.
Lemon acid	Improves the taste and digestion of the drug.
hydroxybenzoate	Preservative.
strawberry flavor	It gives the desired flavor and taste of the medicament.
Vanillin	Softens smell flavoring.

When choosing a drug it is important to pay attention to the concentration of the active substance. The higher the score, the higher the efficiency, but also increases the likelihood of side effects.

pharmacological properties

Narcotic analgesic drug composition.

Pharmacodynamics and Pharmacokinetics

Dolipran (instruction manual comprises the information about the influence of the drug on the body after use and therapeutic action time) all dosage forms provides an analgesic effect by decreasing the synthesis of active fats, which are a major cause of pain symptoms and improve temperature.

Additionally Dolipran promotes temperature reduction and reduces inflammation (anti-inflammatory effect is weak). means components do not violate the water-salt balance and does not irritate the stomach. The therapeutic effect is noted after receiving syrup for 30-60 minutes, when using pellets after 30-90 min. and it takes up to 6 hours.

Metabolism main component is produced in the liver that can trigger the development of pathology in the body (main component has little toxic effect). Excreted in the urine during the day.

Indications

Dolipran appointed physicians and pediatricians in the following pathologies:

• decrease in body temperature at diseases of infectious and inflammatory nature, as well as after vaccination;
• muscle, toothache, headache;
  
• trauma and painful menstruation;
• neurological pain;
• muscle spasms in the digestive tract;
• diseases of the joints;
• pain caused by cancer education;
• preparatory procedures before fluoroscopic examination (with application of contrast);
• pain after surgery;
• with patent ductus arteriosus in children. He should grow over the newborn after birth;
• when hangover;
• together with Suprastinum to reduce the high temperatures that are difficult to knocking;
• in powder form can be used to eliminate acne.

The drug helps only reduce pain and temperature, but does not eliminate the cause.

Contraindications

Dolipran (user of the application prohibits the drug with contraindications) is not used when:

• an allergic reaction to components in the composition or medicament when intolerance;
• kidney disease in severe;
• liver disease (moderate and severe forms);
• blood disorders, including anemia;
• diabetes (when using syrup);
• nasal polyposis (swelling of the mucosa in the nasal cavity);
• violation of the heart and blood vessels;
• erosions and ulcers in the digestive tract;
• lactation, as the product components in small amounts into breast milk;
• alcoholism (Dolipran has a toxic effect on the liver, alcohol is also detrimental effect on body cells);
• advanced age (after 70 years);
• asthma.

During pregnancy, the use of the drug is possible only with the permission of a gynecologist, especially in the first trimester.

At what age can use the drug

The syrup is allowed in children's therapy 1 month, tablet form after 3 years.

Instructions for use, the dosage of the drug

Dolipran recommended to take only after consultation with the doctor, and after exclusion of contraindications. In children, the number of required individual selection on the weight of the formulation. Adults can use the dosage specified in the instructions for use.

Syrup

The tool has a pleasant aroma and taste, so it is best suited to pediatrics than tablet form. For the convenience of dosing the drug attached a specialized syringe.

Intended use	age setting	Single and daily dosage in mg of active substance	The maximum permissible reception rate (in days)
Reducing the temperature characteristics	adults	500 mg 4 times a day	5
children	To 10 mg per 1 kg after 6 hours	3
after vaccination	adults	500 mg 1-2 times a day	1
children	To 10 mg per kg 1-2 times per day	1
Toothache and headache	adults	1000 mg 4 times a day	5
children	To 15 mg per kg every 6 hours	4
menstrual pain	adults	1000 mg 2-3 times a day	3
Muscle pain, including cramps	adults	500 mg 3-4 times a day	5
children	To 10 mg per kg 3 times per day	3
Injuries and bruises	adults	500 mg 2-3 times a day	3
children	To 10 mg per kg 1-2 times per day	2
diseases of the joints	adults	1000 mg 3-4	3
children	To 15 mg per kg 3 times per day	3
Pain caused by the oncology	adults	500 mg 3-4 times a day	5
children	To 15 mg per kg 3-4 times per day	3
In the postoperative period	adults	500 mg 3 times per day	3
children	To 10 mg per kg, 2 times a day	2
hangover	adults	500 mg 2 times a day	1

The syrup is not recommended to dilute the fluid, but if the child is difficult to swallow, it can be diluted with water or juice. Importantly, required to withstand at least 6 hours between repeats reception syrup.

Pills

Tablets (not sparkling) are permitted to 3 years, but have trouble swallowing the drug is allowed to grind and dilute the liquid.

Intended use	age setting	Single and daily dosage in mg of active substance	The maximum permissible reception rate (in days)
Reducing the temperature characteristics	adults	1 tablet 3-4 times a day	4-5
children	0,5-1 tablet 3 times a day	3
after vaccination	adults	1-2 tablets 1-2 times a day	1
children	1 tablet 1 time per day	1
Toothache and headache	adults	2 pills 3 times per day	2
children	1 tablet 3 times daily	2
menstrual pain	adults	2 tablets 2 times a day	3
Muscle pain, including cramps	adults	1 tablet 4 times a day	5
children	0.5-1 tablets 3 times a day	3
Injuries and bruises	adults	1-2 tablets 2-3 times a day	2
children	0,5-1 tablet 2-3 times a day	1
diseases of the joints	adults	2 tablets to 4 times per day	5
children	1 tablet 2-3 times a day	3
Pain caused by the oncology	adults	2 tablets 2 times a day	5
children	1 tablet 2 times per day	5
In the postoperative period	adults	2 tablets 2-3 times a day	3
children	1 tablet 2 times per day	2
hangover	adults	1-2 tablets 1-2 times a day	1

Recommended to take tablets with food or after reception. It is important to observe the minimum required time interval 4 hours between use of drugs.

During pregnancy only after consultation with a doctor is allowed to take on 0,5 tablets 1-2 times a day, no more than 7 days. During lactation, 1 tablet three times a day up to 5 days. Taking tablet immediately after feeding, then through 3 chasa drug concentration in milk will be minimal.

Side effects

Dolipran (instruction manual contains information about the possible side effects that occur even with the rules of admission) can cause development of negative reactions.

They are:

• nausea, possible vomiting;
  
• abdominal pain. They can be caused by abnormalities in the gastrointestinal tract in the acute form;
• allergy symptoms (itching, swelling of internal organs, rash);
• lack of platelet production. Danger of bleeding, including internal;
• reduction in leukocyte concentration. Implies a decrease of immunity and frequent colds;
• iron deficiency in the blood;
• disruption of the liver;
• deterioration of kidney function;
• lowering the pressure indicator;
• increased heart rate;
• change the concentration of sugar in the blood;
• lack of air due to respiratory failure;
• asthma;
• inflammation of blood vessels.

Long-term use may cause severe changes in blood composition and irrevocable changes in the liver.

Overdose

If accidentally increasing or single daily dose or in excess of the duration of the treatment may include the following reactions of the organism:

• dizziness and disorientation in space;
• decreased alertness, stupor;
• critical changes in blood glucose levels with the development of coma;
• severe pain in the abdomen;
  
• profuse vomiting and diarrhea;
• increase in the amount of sweat secretions;
• liver failure (a fatal);
• muscle cramps;
• respiratory impairment;
• swelling of the brain tissue;
• pale skin;
• drowsiness.

Symptoms observed after 6-14 hours after exceeding the dose. After overdose important to gastric lavage immediately. After the cessation of vomiting is required to take activated charcoal or polisorb. If the time has passed more than 4 hours, you should go to the hospital.

Permanently introduced antidote (N-acetylcysteine) methionine intravenously or orally. The dosage is adjusted individually. It is important to keep track of the victims of at least 6 days, even in the absence of symptoms. Liver damage can not be immediately apparent.

special instructions

Before taking this medication Dolipran important to become familiar with the nuances of its application:

• drug forbidden to receive in the evening, and especially before bedtime. Since when possible vomiting person can choke vomit;
• in the presence of liver and kidney abnormalities dosage is chosen by the attending physician. What is important is regular monitoring of the condition of the patient and monitoring the activities of bodies;
• prolonged therapy is required to keep track of the blood;
• components of the drug to penetrate through the placenta to the fetus. The negative impact on the child is not mentioned, but a high risk of developmental disorders of the liver and kidneys. Therefore the medication in a given period is not desirable;
• Dolipran also passes into breast milk, so the drug is not used during lactation;

  

• alcohol backlash medicament enhances the liver. Per course of treatment Alcoholic beverages are excluded;
• the therapy is not recommended Dolipranom transport driving and performing hazardous and require high concentration of work;
• the presence of diabetes mellitus receiving syrup prohibited.

In old age, the dosage prescribed to adults, but decreases the amount of daily medication.

drug interactions

Dolipran (instructions for use are not always in Russian, so it is important to consult a doctor if need for an integrated receiving medication) should be taken with some caution medicines.

For example:

• medications for nausea and for lowering cholesterol may provoke disturbances in the liver;
• medications, blood thinning and Dolipran increase the risk of bleeding;
• preparations sedative effect reduced efficiency Doliprana;
• medicaments based on alcohol increases the risk of malfunction of the liver and pancreas;
• Dolipran reduces efficiency Diazepam (tranquilizer);
• when using other non-steroidal antiinflammatory and analgesic medications required to withstand the time interval is not less than 40 minutes;
• chelators (activated carbon, Polysorb) and drugs for the prevention of kidney stones reduce the therapeutic effect of Doliprana;
  
• drugs hormonal composition contribute to the rapid conclusion Doliprana from the body, which reduces its effectiveness.

In simultaneous treatment with antibiotics is also required to withstand timeslot.

analogs

If you experience side effects after taking Doliprana can be made to replace it by the following medicines:

analogue name and dosage form	Especially in the use	Restrictions and dangerous backlash	The average price for Russia (in rubles).
Phenacetin (tablets and powder for oral administration)	Recommended taken in combination with aspirin for 1-2 tablets / sachet 3 times a day.	In the pathology of kidney diseases and blood means not allowed to receive. The treatment may be accompanied by a change in the composition of blood and allergic reactions.	100
Kombigripp (tablets and ointment)	Appointed by ½ tablets 3-4 times a day for 7 days. Ointment is used externally are not more than 4 times a day.	Kombigripp is contraindicated in patients with renal and hepatic failure and diabetes. The drug may cause increased heart, worsening anemia and liver and kidney pathology.	1300
Fervex (powder for oral administration)	Take 1 sachet 2-3 times a day for 5 days.	Alcoholism, pregnancy and liver diseases use is prohibited. Therapy can cause in rare cases, an allergic reaction.	250
Efferalgan (effervescent tablets, syrup, suppositories for rectal administration)	Take 1-2 tablets 2-3 times a day for 3-5 days. Dosage is calculated on the syrup patient weight. Suppositories are accepted similar tablet form.	Not assigned allergies, diseases of liver and kidneys. Treatment may involve a breach structure of blood and exacerbations kidney and liver.	200
Panadol (coated tablets and effervescent tablets)	Take 1-2 tablet up to 4 times per day is not more than 5 days.	It has conditional contraindications (allergy and diseases of liver or kidneys). The negative reaction is rare.	100

For children and in the presence of chronic diseases (especially liver and kidney) replacement drug produced by the attending specialist.

Terms, conditions of sale and storage

Dolipran required stored at a temperature of from 5 to 25 degrees in a dark place. Subject to the conditions the shelf life of the tablets is 3 years, syrup 2 years from date of manufacture. With package integrity is damaged in tablets or absence of the lid on the bottle with the syrup, the storage period is reduced. Acquire the drug can be without a prescription.

Price in drugstores of Moscow, St. Petersburg, regions

Purchase Dolipran can not in every pharmacy. Depending on the region, the place of sale and the form of the drug, the average price in Russia is (in rbl.).

Cities	Pills	Syrup
Moscow	160	180
Saint Petersburg	155	180
Sverdlovsk	165	190
Permian	150	180
Volgograd	140	175
Sochi	175	190
Khabarovsk	170	185

Dolipran is a drug produced in France and analogue paracetamol. The preparation is easy to use, as is available in different dosage forms and with different concentrations of the active element.

Exceed the dosage of medication or course of therapy is dangerous violation of the liver. Therefore in childhood and old age, as well as liver and kidney pathologies requires individual dose adjustments. In the absence of restrictions permitted use according to the rules specified in the instructions.

Author: Svetlana Kotlyachkova

Registration of the article: Lozinski Oleg

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