Amoxiclav. Instructions for use, tablets, suspension, for adults and for children. Price, reviews, analogues

Amoxiclav drug designed to kill bacteria. all forms of the drug are described in the instructions for use, as well as for what and to whom it should be consumed.

In what forms is produced

Amoxiclav - instruction manual describes several forms of drug release:

• Amoksiklava tablet form - with varying dosage;
• Amoxiclav Kviktab - with different dosages;
• fine particles, for the preparation of oral liquid - with different dosages;
  
• Amoxiclav powder - for injection, intravenous drug - with different dosages:

Powdery

used by:

1. For suspensions. Amoxiclav fine particles of the drug are used for the preparation of liquid to be administered orally. Content dry part Amoksiklava stored in a glass bottle for the manufacture of 0,1 l water. The drug is stowed in a box out of construction paper.
2. For injection. Amoksiklav medicament in the form of finely divided particles for use as an injection, an intravenous formulation. The drug is packaged in glass bottles. In block 1 - 5 bottles.

Pills

Amoxiclav, according to the instructions for use, has several medicinal dosages:

1. Preparation Amoksiklav 250 mg - roundish, coated dry substance extruded from two sides convex tablets. The drug is packaged in glass bottles of 15 tablets each, placed in boxes made of thick paper.
   
2. Amoksiklav 500 mg - rounded, convex tablets from two sides, which are dry, compacted coating. In 1 bottle - 15 tablets, boxed out of construction paper.
3. The medicament Amoksiklav 0.85 g - round, milky, convex on both sides of the tablet. Are compacted dry coating. On one side of the dividing line with engraving - 875/125, on the other hand - engraved "AMS".

The tablets are stacked in a plate of steel foil 5 pcs. or 7 pcs. Packaged in a box made of thick paper on the plate 2 with a recommendation for use.

Kviktab

Amoksiklav (instruction manual describes it as an innovative drug) tablets have Kviktab polygonal shape, yellowish uncoated - suckable or fast dissolving in water, with a pleasant aroma.

The drug is packaged in blister packs of PVC film from the steel foil coated on 5 pieces. and 10 pieces. in the plate. Each box of paper contained a thick layer on 2 plates.

Chemical composition

Pharmaceutical industry produces drug in 4 ways - a tablet with a different dose, Amoxiclav Kviklab - pills resorption fine particles for the preparation of oral liquids and fine powder, from which to make a solution for intravenous injection.

Structure:

1. 250 mg tablet formulation. The medicament of 250 mg of semi-synthetic antibacterial agent amoxycillin and 125 mg clavulanate, also cellulose microfibrils carboxymethylcellulose.
2. 500 mg tablet formulation. The medicament comprises 500 mg of semi-synthetic antibacterial agent omoksitsillin inhibitor, clavulanate 125 mg, sweetener E951, a substance having a smell of citrus agent, food stabilizer iron silicate mineral crystals, microfibrils cellulose.
3. Form tablets 0,875 mg. The drug consists of the semisynthetic antibiotic amoxycillin 0.875 g, clavulanate 125 mg, polysorb, sweetener, perfume odor citrus perfume odor few exotic fruit, food, inorganic iron supplement, water-soluble castor oil, silicate mineral oxide particles silicon.
4. Amoxiclav Kviktab. A medicament composed of semi-synthetic penicillin antibacterial 500 mg or 875 mg, 125 mg clavulanate, polisorb, sweetener, flavor with a citrus scent, perfume with the scent of several tropical fruit, lime microfiber cellulose.
   
5. The mixture fine powder substances or for the preparation of oral liquid. In the powder composition includes a semisynthetic antibiotic penicillin 250 mg or 125 mg clavulanate 0.062 g, acid sodium citrate, cellulose microfibrils, food additive E211, sweetener hexahydroxyalcohols aldid.
6. Melkodisperny powder for intravenous solution. The composition of the powder is a semisynthetic antibiotic penicillin 500 mg or 1200 mg, or 100 mg of clavulanate 200 mg, bacterial enzymes.

Effect on the body

Amoksiklav (User application describes the properties of the drug to drug) has the following medical and biological effects on human body. It is a semi-synthetic penicillin antibiotics, which includes clavulanate - disintegration preventing antibacterial activity and exhibits destructive to bacteria and infections.

The list:

• Pneumococcus;
• streptococcus;
• catalase - inactive streptococcus;
• anaerobic facultative bacteria;
• gonococcus;
• Pasteurella multotsida;
• bacteroides;
• spore forming bacteria are not;
• spore-forming anaerobes;
• rod-shaped bacteria;
• peptostreptokokki.

In some cases, prescribe

Amoxiclav drug should be used under the following pathological conditions:

• acute inflammation of the sinuses;
• During prolonged inflammatory disease of the sinuses;
• retrofaringialny abscess;
• mezotimpanit;
• inflammation of the lung tissue;
• prolonged inflammation of the bronchial tissue;
• prolonged inflammation of the bronchi in the acute stage;
• cystitis;
• urethritis;
• pyelonephritis;
• renal abscess;
• necrotizing pyelitis;
• multiple abscesses in the kidneys;
• inflammation of the oral cavity;
• dental inflammatory processes;
• inflammatory gynecological diseases;
• gonorrhea;
• cellulite;
• furunculosis;
• kurbunkul;
• bed sores;
• chronic and acute tonsillitis;
• diabetic foot;
• venereal ulcer;
• osteomyelitis;
• purulent arthritis;
• synovitis;
  
• arthritis;
• during surgery, to prevent secondary infections;
• gastritis;
• cholecystitis;
• inflammatory deformities of bones and muscles in the body;
• complicated by spontaneous abortion.

The possible negative consequences

Amoksiklav (instruction manual describes medicament disadvantages) has special instructions to be followed.

They are:

• urge to vomit;
• violation of a chair;
• indigestion;
• bloating;
• inflammation of the digestive tract;
• mucosal candidiasis;
• intestinal damage Clostridium difficile;
• allergic reactions;
• purpura;
• pemphigus;
• urticaria;
• peeling of the skin;
• exudative erythema;
• Lyell's syndrome;
• excitement;
• excitation;
• restlessness;
• migraine;
• manifestation of mental disorders;
• lack of sleep;
• painful muscle contractions;
• decreased platelet blood;
• decreased hemoglobin;
• a reduced level of white blood cells;
• an increase of eosinophils;
• decrease in lymphocytes;
• increase in liver enzymes;
• inflammation of the liver;
• intrahepatic cholestasis;
• blood in urine;
• the defeat of the renal tubules;
• candidiasis;
• increase in body temperature.

Overdose

Overdose may have the following symptoms:

• irritation;
• excitement;
• unsteadiness;
• painful spasms.

If you encounter such situations, you need to wash the stomach.

Doses for children

Amoksiklava greatest number of children is 45 mg per each 1000 g of weight of the child. The smallest amount of clavulanate - 10 mg per 1000 g of weight of the child.

The correct calculation of the suspension

Amoxiclav fine powder for the preparation of oral liquid is calculated from the age and weight of the child:

• age from 0 to 90 days - 0,030 mg per each 1 kg baby weight. The resulting slurry dose to drink for 24 hours;
• child's age 90 days or more, but the weight must not exceed 40 kg - 25 mg dose suspended per each 1 kg baby weight. The volume of the drug is intended for use within 24 hours;
• age from 90 days or more, but the weight must not exceed 40 kg - in severe diseases slurry dose of 45 mg per each 1 kg baby weight. Amount is calculated on 24 hours.

Up to 3 months

The average weight of the child from 0 days to 90 days is from 2800 g to 5600 g Receiving Amoksiklava for oral administration designed for 24 hours.

Child's weight, g	125 mg / 5 ml	250 mg / 5 ml
2800	3,4	1,6
3000	3,6	1,8
3200	3,8	2,0
3400	4,0	2,0
3600	4,4	2,2
3800	4,6	2,2
4000	4,8	2,4
4200	5,0	2,6
4400	5,2	2,6
4600	5,6	2,8
4800	5,8	2,8
5000	6,1	3,0
5200	6,3	3,1
5400	6,6	3,3
5600	7,0	3,5

Over the age of three

Instructions for use of the oral form of the drug Amoxiclav describes to what the child's weight in kg is necessary to calculate a dose of powder.

Dosage forms with uncomplicated disease for 1 day:

Child's weight in kg	125 mg / 5 ml	250 mg / 5 ml
5	3,9	2,1
6	4,8	2,4
7	5,7	2,7
8	6,3	3,3
9	7,2	3,6
10	8,1	3,9
11	8,7	4,5
12	9,6	4,8
13	10,5	5,1
14	11,1	5,7
15	12,0	6,0
16	12,9	6,3
17	13,5	6,9
18	14,4	7,2
19	15,3	7,9
20	15,9	8,1
21	16,8	8,4
22	17,7	8,7
23	18.3	9,3
24	19,3	9,6
25	20,1	9,9
26	20,7	10,5
27	21,6	10,8
28	22,5	11,1
29	23,1	11,7
30	24,0	12,0
31	24,9	12,3
32	25,5	12,9
33	26,4	13,2
34	27,3	13,5
35	27,9	14,1
36	28,8	14,4
37	29,7	14,7
38	30,3	15,3
39	31,2	15,6
40	32,1	15,9

Dosage of oral fluid for complex forms of the disease for 24 hours:

Child's weight in kg	0.125 g mL	0.250 g mL
5	8,1	3,9
6	9,6	4,8
7	11,1	5,7
8	12,9	6,3
9	14,4	7,2
10	15,9	8,1
11	17,7	8,7
12	19,2	9,6
13	20,7	10,5
14	22,5	11,1
15	24,0	12,0
16	25,5	12,9
17	27,3	13,5
18	28,8	14,4
19	30,3	15,3
20	32,1	15,9
21	33,6	16,8
22	35,1	17,7
23	36,9	18,3
24	38,4	19,2
25	39,9	20,1
26	41,7	20,7
27	43,2	21,6
28	44,7	22,5
29	46,5	23,1
30	48,0	24,0
31	49,5	24,9
32	51,3	25,5
33	52,8	26,4
34	54,3	27,3
35	56,1	27,9
36	57,6	28,8
37	59,1	29,7
38	60,9	30,3
39	62,4	31,2
40	63,9	32,1

The use of powder

Amoksiklav (instruction manual gives a recommendation on how to use the drug) requires proper preparation of fine particles.

Instructions:

• For this purpose, the bottle of powder should be shaken to dry, compacted structure crumbled.
  
• Next, add a bottle 90 mL lukewarm liquid and mix very well to the fine particles joined with a liquid without formation of lumps.

Instructions for use of the suspension

Amoksiklav drug having a form of fine powder, for use as an oral suspension should be administered to children from 0 days up to the age at which the child's body weight shall not exceed 40 kg.

Instructions for use

Children age from 0 days to 90 days:

• should be administered 30 mg of drug per 1000 g of slurry baby weight;
• the resulting calculated amount of drug for 24 hours;
• the resulting slurry must be consumed in 2 hours;
• intervals between the application of the suspension should be the same.

The child's age from 90 days and up to the age at which weight does not exceed 40 kg for non-severe forms of the disease:

• necessary to use 25 mg dosage rate of slurry per 1000 g of weight of the infant;
• the drug is intended for use within 1 day;
• slurry prepared dosage necessary to use up to 2 times every 12 hours;
• may have a suspension in a dose of 0,020 g per 1 kg of weight of the child;
• the drug must be consumed within 1 day;
• the resulting suspension must drink in 3 divided doses;
• You need to use the medicine at regular intervals.

The child's age from 3 months to a maximum weight of not more than 40 kg in severe forms of disease:

• you need to take 45 mg of the drug per 1000 g weight of the child;
• the resulting formulation is intended for use within 24 hours;
• cooked slurry should be eaten in the morning and evening;
• maintaining regular intervals between the application of the drug;
• the amount of drug necessary to use a 3-admission;
• maintaining regular intervals between the reception of a medicament.

Amoksiklav as a fine powder is necessary to use at least 7 days to prepare oral liquid (depending on the type and form of the disease). After the visible manifestations of the disease disappear, drug use is still a few days.

Powder for injection

Amoxiclav for intravenous administration can be administered to adults and children. Powder for injection was used as for intravenous injections and for droppers.

Intravenous injection:

• the bottle with the powder in a dose of 500 mg is necessary to add 10 ml of liquid for intravenous injection;
• the bottle with the powder in a dose of 1200 mg is necessary to add 20 ml of liquid for intravenous injection;
• mix thoroughly - solution;
• select a drug into the syringe 10 cu. or 20 cc .;
• administered intravenously must slowly - up to 5 minutes.

Drip:

• for drip administration, the preparation of medicaments for intravenous injections, must enter into the vial with liquid for droplet injection;
• The procedure lasts for about 50 minutes.
• body weight more than 40 kg - 1200 mg of diluted drug to be administered into a vein - morning, afternoon, evening at regular intervals;
• during severe illness injection quantity should be increased to 4 times for 24 hours at regular time intervals;
• before surgery is necessary to appoint a single fold - 1200 mg of the prepared solution;
• for possible connection of secondary infections after surgery postoperative therapy is repeated.

Amoxiclav in the form of injections should be administered to adults and children who weight more than 40 kg.

Instructions for use of tablets

Amoksiklava tablet form to be taken orally before a meal, do not chew. Wash down with plenty of water is necessary.

Application Guide:

• age of 12 years (body weight - 40 kg or more) and an adult is necessary to use the medicine in a dosage of 0.25 g three times a day at regular intervals (with simple forms of the disease);
• use of the drug at a dose of 500 mg is necessary in cases of severe illness - 3 times a day;
• maintaining regular time intervals between drug intake;
• receiving lodging alternative - a drug at a dosage of 0.875 g;
• need to be taken in the morning and evening.

Use in children

Children who are not reached the age of 6 years, does not provide for the use of Amoxiclav tablets. In this age it is necessary to use oral fluid Amoxiclav.

From 6 years to 12 years to use the tablet, you can:

• age category of children up to 12 years - 0.04 g drug per 1000 g of body weight;
• amount is calculated at 24 hours;
• obtained amount of drug necessary to consume 2-3 doses at regular intervals.

Application Amoksikla Kviktab

Form tablets Amoksiklav Kviktab designed for use for sucking, chewing and dissolution in water.

The drug should be administered only under the age of 12 years and adults:

• for non-severe course of the disease the drug at a dose of 500 mg or chewed resolves the morning, afternoon and evening;
• before eating at regular intervals;
• severity of disease require drug administration at a dosage of 875 mg;
• be applied 2 times a day every 12 hours.

with angina

Amoxiclav pharmacological agents is well established in the treatment of all forms of tonsillitis, both children and adults.

Age greater than 12 years:

• In chronic tonsillitis occurring is necessary to use the drug at a dose of 0.25 g - morning, afternoon, evening;
• before eating at regular intervals;
• alternative medicines three times a day application dose of 0.5 g of 2 times every 12 hours;
• acute forms of angina should take the drug at a dose of 0.5 g - morning, afternoon, evening - every 8 hours.
• for non-severe or chronic tonsillitis measuring spoon of the drug - 5 cc. (0.125 g active ingredient) - at a time;
• the required amount of suspension is calculated from the weight of the child;
• Amoksiklava liquid form has a good smell and taste - the children, as a rule, do not resist treatment, even if strongly throat hurts.

Children from 6 years to 12 years should be administered in the form of tablets Amoxiclav.

Children aged 6 (weighing - 40 kg) - liquid form Amoksiklava

when sinusitis

In the treatment of all types of sinus inflammation is necessary to prescribe a drug Amoxiclav in any kinds.

Tablet form Amoksiklava Kviktab:

• under non-severe forms of inflammation is necessary to apply 250 mg of the drug in the morning, afternoon and evening;
• for complicated or severe sinusitis - Amoksiklav at a dose of 0.5 g - morning, afternoon, evening;
• Thrice alternative use - 0.875 g of drug after 12 hours - in the morning and evening;
• apply to food, to chew;
• tablets should be taken with plenty of fluids;
• the drug can be dissolved in water and the resulting agent to drink.

Microfine powder for oral administration:

• children need to apply at the rate of weight gain;
• It can be applied to adults if you can not swallow the tablet;
• children need to appoint 0,045 grams of drug per 1000 g baby weight;
• number of adaptations must be used with regard of the disease.

Amoxiclav injection:

• powder for intravenous use should be prescribed for severe sinus inflammation varieties, in both adults and children (greater than 6 years of age)
• daily 1.2 g of fine powder for injection was diluted with a special solution;
• administered by drip for about 50 min .;
• course of injection therapy - to improve the overall condition;
• in the future you need to go to the tablet form of the drug.

If abnormal liver function

Amoxiclav can be applied to patients with minor variations in liver function tests. But during amoxiclav therapy in such patients need to constantly monitor the amount of liver enzymes. In severe pathologies Amoksiklav liver (in any form) can not be used.

If the kidney function

Pharmacological preparation Amoksiklav can and should be used for kidney diseases. But we should take into account the state of the kidney tissue and to treat inflammatory processes in the body Amoxiclav drug under the strict control of ultrasound and laboratory parameters of renal creatinine.

For example:

• creatinine of 10 mmol / l - the amount of drug necessary to reduce;
• in the absence of kidney urine output - the drug can not be used more than once in 1 to 2 days;
• creatinine of 75 ml / min, and more - preparation should be applied up to 3 times a day;
• while reducing creatinine to 50 ml / min - in the morning and evening.

Pregnancy and lactation

To date, no scientific evidence about the negative effects of the drug Amoxiclav fetal development in the womb during pregnancy and during the pregnancy itself.

It follows that the drug can and must be prescribed during pregnancy and lactation in case of acute need.

Features of treatment in infants

Amoxiclav drug can be used in the treatment of children from birth. It all depends on the weight and the correct calculation of the drug. The calculated dose is divided into morning and evening reception pipette and introduced into the oral cavity infant. It will be quite a small amount of oral fluid Amoxiclav.

In old age,

Specific guidance on the application for people instruction in advanced age is not. The only thing you should pay attention - this is on the kidneys and liver. If pathological changes on this side there is, the amount of the drug does not need correction.

The duration of the drug

All forms of drug Amoxiclav have approximately the same indication in the application. The recommendations to the drug it is written that the drug should be used from 7 days to 14 days. But it all depends on the disease, the individual case and doctor's appointments.

Amoxiclav and alcohol

Amoxiclav - a serious anti-microbial. When applying it with alcohol intensifies the toxic effects on the liver and the damaging effects on the kidneys. Which can lead to serious consequences.

lnPoetomu combination of any kind of alcoholic beverage with admission Amoksiklava (all its forms) is strictly forbidden.

Drug compatibility

Amoxiclav is not compatible with the drugs (injection), which contain fruit sugar or polysaccharide. When intravenous injection need to be mixed with sterile injectable water, saline, a potassium salt of hydrochloric acid. More than with any drugs for injection must not be mixed Amoxiclav.

Approximate cost and analogues

All forms of drug Amoxiclav have their price:

1. Pills - the price depends on the dose and ranges from 220 rubles. up to 450 rubles for 1 pack.
2. amoxiclav Kviktab - the price depends on the dose and ranges from 350 rubles. up to 470 rubles. 1 pack.
3. Microfine powder for intravenous injections - approximate price for a box of 800 rubles. to 900 rubles.
4. Microfine powder for oral solution - the price varies from 115 rubles. to 280 rubles. 1 bottles.

Analogs Amoxiclav preparation:

1. augmentin - the price of the drug varies from 140 rubles. to 500 rubles. depending on the species of the drug.
2. flemoksin Soljutab - the cost of the drug varies from 200 rubles. up to 600 rubles. depending on the form of the drug.
3. amoxicillin - the drug can be purchased at a price of 50 rubles. to 200 rubles. depending on the release form.

Modern pharmacological drug Amoxiclav can be applied to pregnant women, infants, the elderly, it is written in the instructions for use. And as confirmed by scientific studies, positive feedback from patients and doctors.

Registration of the article: Lozinski Oleg

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Indications for use, reception, side effects and analogues: