For the treatment of infectious and inflammatory diseases, agents which are pathogenic microorganisms used antimicrobials. Quite often the treatment is carried out using cephalosporin and many patients want to know what is best Ceftazidime or Ceftriaxone?
Let's face it. First of all, consider the pharmacological action of ceftazidime and ceftriaxone.
pharmacological properties
All antibiotics related to the cephalosporin group exhibit bactericidal effect, which manifests itself in violation of the cell walls of microorganisms functions. Also cephalosporins are resistant to beta-lactamases. Ceftazidime and Ceftriaxone, like all third-generation cephalosporins are the minimum number of contraindications, high efficiency, and well tolerated by patients.
If we compare with ceftazidime ceftriaxone, the first shows high activity against streptococci (Streptococcus spp) and pneumococcus (Streptococcus pneumoniae), penicillin-resistant, and a second less active against pneumococci. Another difference of these drugs is the active effect of ceftazidime in Pseudomonas aeruginosa (P.aeruginosa).
testimony
Indications for use of all antibiotic belonging to the cephalosporin group, is absolutely similar and are as follows:
- bacterial infections of internal organs, stomach and intestines (e.g., peritonitis, etc.);
- infectious-inflammatory processes in the airways (e.g., pneumonia, bronchitis, acute and chronic nature, sinusitis, abscesses);
- infection of the joint, and bone;
- infections of skin bacterial etiology;
- infectious and inflammatory diseases of the urogenital system;
- blood poisoning (sepsis), meningitis, endocarditis, and others;
- prevention of infection in the postoperative period.
As can be seen, in the appointment of antibacterial drugs, the difference between ceftriaxone and ceftazidime is not observed.
Contraindications
Contraindications to all antibacterial agents belonging to the cephalosporin group, is the presence of individual intolerance of cephalosporin and penicillin group of drugs. Features to restrict or ceftazidime Ceftriaxone than those described above, do not exist.
Interaction
Since both antibiotics belong to the same group of drugs, their combined use is prohibited. And the question of whether concomitant use of ceftazidime and Ceftriaxone is possible, the only answer - no, as this may cause an overdose of active substances.
Overdose
Symptoms of an overdose of the active substance are: feeling dizzy, headaches, convulsive state, sensory disturbances.
For the treatment of symptomatic treatment is carried out.
conclusion
According to the instructions, Ceftazidime and Ceftriaxone have the same indications for use and, therefore, are drugs analogs.
However, the pharmacological effect of the drug have a slight difference. The use of ceftazidime due to its increased activity against Pseudomonas aeruginosa, so he often appointed for the treatment of infectious and inflammatory diseases caused by it P.aeruginosa. Ceftriaxone - is the basic cephalosporin exhibiting active effect against Streptococcus pneumoniae and other pathogenic microorganisms.
To say which of the antibiotics is better - it is impossible, because each of them is assigned for the treatment of those diseases to the agents which is very active.
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