Tablets from migraine Relpax - instructions for use, reviews of doctors and patients, drugs analogues

Relpax is a medicine intended for immediate to alleviate seizures of migraine of varying severity.

contains : the main substance is eletriptan hydrobromide and auxiliary components: lactose monohydrate, microcrystalline cellulose, magnesium stearate, croscarmellose sodium.

Composition of the coating: orange opadrai( lactose monohydrate, hypromellose, triacetin, titanium dioxide, colorant);transparent opadrai( triacetin, hypromellose).

Relpaks pharmacological action of the drug - drug which possesses protivomigrenoznym action. Eletriptan, which is part of the drug, creates a narrowing effect on the intracranial blood vessels.

The inhibitory effect of this drug causes antimigraine activity against neurogenic inflammation.

Pharmacokinetics

Relpax is the triptan of the latest generation with all the ensuing circumstances. It has a high selective ability for neuronal and vascular seratonin receptors. As a result, he received high pharmacokinetics in comparison with the oldest analogs.

The degree of absorption of the drug through the gastrointestinal tract is about 81%.Bioavailability for men and women will be 50%.The half-life of this medicine from the body does not exceed 4-5 hours.

The process of metabolism of the medicine by the body proceeds in the liver, excretion is performed through the kidneys and the gastrointestinal tract.

Read more about the triptans read in our article.

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Indications for use

The instruction for use indicates that Relpax tablets are used to calm severe attacks of migraine, both without aura and with aura.

Contraindications to the use of the drug

Contraindications very lot:

• very high susceptibility to each of the constituent components of the drug;
• acute liver dysfunction;
• is contraindicated for children and individuals who are under 18 years of age;
• is absolutely contraindicated in parallel with various inhibitors, namely: clarithromycin, nelfinavir, itraconazole, erythromycin, ketoconazole, josamycin, ritonavir, indinavir;
• uncontrolled arterial hypertension;
• angina of prinzmetal, angina, the period after a previous myocardial infarction, myocardial ischemia( asymptomatic), both suspicion and confirmed;
• concurrent use with other agonists of the receptors of this group, namely 5HT1;
• occlusive diseases of peripheral vessels;
• relief of ophthalmoplegic, hemiplegic, and basilar migraine;
• rare ancestral diseases( lactose intolerance, glucose-lactose malabsorption, lack of lactase,);
• may develop seratonin syndrome when using similar drugs along with this drug, namely those that are selective for seratonin.

Mechanism of action

The components that make up the drug have strong selective properties for some receptors, so they can irritate these receptors.

After their irritation, the process of narrowing absolutely all the vessels of the brain takes place, due to which the migraine gradually ceases.

Instruction for use

The tablet should be taken with a glass of warm water.

The initial dose of for adults who are 18 years of age and up to 65 years of age is recommended in the amount of 40 milligrams.

With the resumption of headache and migraine during the day after taking the medication, it is possible to re-accept it, but with an interval of two hours after the first act, and in the same dosage.

In the event that this drug does not have any effect on the resulting headache, that is, does not stop it, should not be re-taken.

The whole point is that the effectiveness and effectiveness of this method has not been confirmed during clinical tests of this drug, and therefore it is better to replace it.

Forms of release of this preparation

The drug is manufactured by Pfizer( Germany).

The form of this preparation is a tablet placed in a blister plate.

Blister is a transparent protruding cavity in which a tablet is placed and sealed with foil. Tablets of this drug can be of different volumes - this is either 20 mg, or 40 mg.

The preparation itself is supplied in cardboard boxes, the number of blister plates in which depends on the volume of the active substance in the tablet. is produced on 2, 3, 4, 6 and 10 tablets in a blister, from 1 to 10 blisters in a cardboard bundle.

Medication and dosage methods

The therapeutic dosage of this medication for adults between the ages of 18 and 65 years of is about 40 milligrams of .

This dose is initial. If the result is not good enough, it is permissible to increase the dose of the drug up to 80 mg with a subsequent attack of acute migraine.

Additional information and overdose

For those who suffer from mild or moderate impairment of certain liver functions, the dose can not be increased.

In case of an overdose of the drug, the appearance of of the following symptoms may occur: development of hypertension( arterial), as well as other disorders associated with the cardiovascular system.

Treatment for an overdose of this drug should be carried out in the following way: gastric lavage, as well as therapy associated with manifested symptoms.

The observation should take at least about twenty hours. This period is directly related to the half-life of the drug from the human body, which is four hours.

Alternative: monitoring the patient until the symptoms of the drug overdose disappear.

Admission of children

Children under the age of 18 are absolutely prohibited from taking this medication, due to the insufficient ability of the liver to cope with the stresses.

Reviews of doctors and patients

Reviews of the tablets Relpax indicate that they are very good at migraine headaches.

Reviews of doctors

Reviews of experienced physicians:

1. Vasiliev KR, therapeutist. A drug like Relpax completely removes the strongest migraine attack. Approximately in half an hour the pain passes or takes place, and attacks do not repeat any more. In the package of this drug you will find 2 tablets, but sometimes one half of the tablet can suffice. After taking the medicine, it's best to rest for about an hour in complete silence. After the disappearance of the headache, you can pull into sleep. Relax! But you should not forget about a large number of side effects.
2. Parkhomenko PR, therapeutist. The drug is not always predictable. In some cases it acts instantly, in others it does not produce the desired effect at all. It is also difficult to predict side effects. However, the treatment of migraine is not interchangeable.

Patient Reviews

Patients echo to doctors:

1. Margarita, 35 years old. This drug works well, completely removes an early attack, but not fast enough. Sometimes there are unpleasant feelings. After the loss of the headache, there is a slight tingling in the face and tremor. It is best to lie down and sleep immediately. Sometimes the drug is accompanied by vomiting.
2. Victoria, 41 years old. I have such migraines that sparks from the eyes just sypyatsya! Especially on individual days of the month! Therefore, ordinary painkillers do not help, we need superstrong ones, so I drink rhelpaks. Only he saves me, an excellent medicine!
3. Edward, 45 years old. After a head injury, very often there are severe migraines, which are accompanied by even nausea and vomiting. So, in one of such attacks, the doctor recommended me to try rhelpaks. Indeed, headaches subsided for 30-40 minutes immediately after using the drug. Now I use it during periods of exacerbation of migraine.

Tips from patients on taking the drug

It should be noted, that:

• is best to try first with half a single tablet;
• carefully read the instructions to the drug, there are many limitations and contraindications;
• is a very mild effect.

Cons and advantages, based on experience and feedback from the practical application of

. Cons:

• if there is no result from the use of this drug, it is better to immediately look for another medicine;
• too many restrictions on admission;
• is not always a stable result;
• increase in dosage does not lead to relief.

Pros:

• the effect of the drug is carried over an order of magnitude easier than the effects of analogues;
• is rapidly excreted from the body;
• quickly removes the attack of pain.

About migraine treatment in earnest:

Price and Release Forms

Price Relksa:

• tablets, completely coated with 20 mg, 100 pieces, a pack of cardboard 10, blister 10 - 1174 rubles;
• tablets, completely coated in a film shell 40 mg, 2 pieces, a pack of cardboard 1, blister 2 - 450 rubles;
• tablets, in a shell of 40 mg, 100 pieces, a pack of cardboard 10, blister 10 - 380 rubles.

Terms and Conditions of Storage

Keep the preparation at a temperature of no higher than 29 - 30 degrees Celsius. Shelf life is 36 months.

Leave at pharmacies

In pharmacies is only released with a doctor's prescription.

Analogues of the preparation

The analogues replacing Relpax include such most effective drugs as:

• Amigrenin;
• Cofetamine;
• Imigran;
• sumatriptan;
• Zomig.

It should be noted that the price fork of most analogs almost does not differ from the price of Relpax and fluctuates within 170 - 370 rubles.

However, there are exceptions. The price for such a drug as Zomig is 780 rubles , which is almost double the price of both Relpaksa and other analogues.

But the presence of contra-indications and side effects in Zomig is an order of magnitude less than after using Relpax.

Such a drug as Cofetamine is significantly cheaper than Relpax ( within 75 rubles), and if you prefer to take this analogue, you should carefully read the instructions, since contraindications and side effects can occur significantly more:

• inhibition;
• hallucinations;
• euphoria;
• feeling of separation from the body;
• nightmares, etc.

All the remaining drugs are absolutely identical both in price and in all characteristics, including side effects and contraindications.