Lerkamen 10. Instructions, indications for use, price

Lerkamen No. 10 is a medicinal product, which is used for problems with pressure. The agent is indicated only for the treatment of disorders in adult patients.

Release form

The drug is produced in Germany in the form of tablets for systemic use. Description: the tablets have a reddish or pinkish tint, the shape is round and convex on both sides. The medication is packaged in blisters and packed in a cardboard box.

Chemical composition

The main substance of the drug is lercanidipine hydrochloride.

Additional composition:

• milk sugar;
• MCC;
• povidone K30;
• magnesium stearate;
• sodium carboxymethyl starch.

All components are combined with each other and enhance the effect of the main substance.

Pharmacological properties

Lerkamen No. 10 (indications for the use of the agent should be previously studied in the instructions) belongs to the group of calcium channel blockers. It has a pronounced antihypertensive effect, mainly on the vessels.

The drug inhibits the transport of calcium ions in the smooth muscle of the vascular system. In this case, a decrease in pressure occurs due to the relaxation of smooth muscles located in the region of the vessels. The process leads to a decrease in the total resistance of peripheral vessels.

The pressure-lowering effect is due to the ability of the drug to be distributed over the cell membranes. Due to its high vasodilating effect, it does not provoke a sharp decrease in pressure.

The duration of the effect is 1 day.

Pharmacodynamics and pharmacokinetics

After oral administration, the drug is rapidly and completely absorbed from the gastrointestinal tract. The maximum content of the active substance is observed after 1.5-3 hours.

The bioavailability of the drug after its use with meals is about 10%. When using the drug on an empty stomach, this indicator decreased by 1/3. Eating fatty foods resulted in higher bioavailability, which can increase with increasing dosage.

The active ingredient is quickly distributed throughout the tissues and internal organs. The drug interacts with proteins. The interaction rate is over 98%. The drug lends itself to metabolic transformation and breaks down into inactive metabolites. About half of the dose taken is excreted from the body through the kidneys. The half-life in this case varies from 8 to 10 hours. Components are not accumulated, so this indicator remains at the same level.

In elderly people, with failure of the kidneys and liver (mild and moderate forms of impairment), the content of the drug in the blood does not increase. In moderate and severe forms of kidney or liver failure, the content of the active component in the blood may increase.

Indications for use

The tablets are used for the essential form of hypertension of the 1st and 2nd degree of severity. Moreover, they can be prescribed in the complex therapy of other related diseases (according to the testimony of a specialist).

Contraindications

Lerkamen No. 10 (indications for use indicate a narrow area of ​​its use) should be used only as directed by the attending physician (cardiologist).

The tool has a wide list of restrictions that you should familiarize yourself with in advance.

Contraindications:

• intolerance to the components;
• heart failure (in the absence of therapy);
• angina pectoris (unstable form of the disorder);
• combined use with grapefruit juice;
• failure of the kidneys and liver (severe forms of disease);
• condition after a heart attack (within 4 weeks);
• obstructive vascular disease;
• allergy to lactose, lactase deficiency, glucose-galactose malabsorption;
• lactation period;
• carrying a child;
• patients who do not use contraceptives;
• minor patients.
• With extreme caution, the medication can be used in the following cases:
• failure of the kidneys and liver (mild to moderate form of impairment);
• ischemic diseases;
• old age of the patient;
• functional disorders of the left ventricle;
• sick sinus syndrome.

In these conditions, therapy is carried out under the supervision of a physician.

At what age can the drug be used?

The medication is contraindicated for use in pediatric practice. The minimum age for prescribing the drug is 18 years.

Instructions for use, dosage

The tablets are intended for oral use. Dosing features are established by a specialist in accordance with the identified violation.

With chronic renal failure

In chronic renal failure, the drug is taken in a minimum initial dosage of 10 mg (1 tablet) 1 time per day. However, further dose increases are not recommended.

The duration of use is individual, according to the testimony of a specialist.

With diabetes

Patients with diabetes mellitus are prescribed 1 tablet 1 time per day. In this case, it is necessary to systematically monitor the level of the active substance in the blood and the concentration of glucose. The duration of treatment is individual, according to the doctor's recommendations.

With gout

For gout, the medicine is taken according to the general scheme with standard dosages - 10 mg once a day. The course is individual, according to the recommendations of a specialist.

With hypertrophy of the ventricle of the heart

In this case, a standard dosage is recommended (1 tablet per day). Do not increase the dose. During therapy, it is necessary to conduct constant monitoring of cardiac activity. Duration of admission is individual, according to the doctor's indications.

Under pressure

With increased pressure, the initial dosage should be 10 mg per day. If necessary, the dose can be increased to 20 mg per day. Further increase is not required, since the effect does not increase, only the risks of developing side effects increase.

The duration of therapy is individual, until the pressure is completely stabilized.

With pulmonary hypertension

For patients with pulmonary hypertension, the initial dosage should be 10 mg per day. With good tolerance, the dose can be doubled. In this case, it is necessary to constantly monitor the patient's condition. The course of treatment is individual, according to the doctor's recommendation.

With asthma

In bronchial asthma, dosages are calculated individually. At the beginning of therapy, the dose should be no more than 10 mg per day. According to the doctor's recommendations and in the absence of any negative reactions, the dosage can be increased to 2 tablets per day. The duration of treatment is individual, according to the testimony of a specialist.

Side effects

Lerkamen No. 10 in extremely rare cases can lead to undesirable reactions, the development of which depends on the correct use of the drug and the physiological characteristics of the patient. Therefore, it is necessary to strictly adhere to the indications and recommendations of the doctor.

Side effects:

• Nervous system disorders: migraines, dizziness, increased drowsiness.
• Cardiovascular pathologies: a sense of one's own heartbeat, tachycardia, angina pectoris. Hot flashes (in the face area), pain in the chest, and fainting may also occur.
• Digestive organs: nausea and vomiting, diarrheal syndrome, dyspeptic disorders, pain in the epigastric region.
• Skin manifestations: rashes.
• Musculoskeletal tissue: myalgia.
• Urinary system: increased urine production.
• Immune disorders: hypersensitivity reactions.
• General signs: edema, asthenic syndrome, fatigue.
• Other reactions (extremely rare): myocardial infarction, a marked decrease in blood pressure, hyperplasia that develops in the gum region. There was also an increase in transaminase activity, pain in the chest area, and an increased frequency of urination.

If these conditions or other reactions occur that are not noted in the current instructions, you should interrupt further therapy and consult your doctor.

Overdose

At the moment, several cases of exceeding dosages and the development of negative symptoms have been recorded.

Overdose:

• increased sleepiness;
• nausea;
• suicidal tendencies (1 case);
• cardiogenic shock;
• kidney failure (mild);
• increased blood pressure.

In these conditions, you must immediately contact a medical institution for help and symptomatic therapy.

special instructions

Tests on animals have confirmed the absence of toxic and teratogenic effects in the drug. However, it is still recommended to refrain from using it during pregnancy and while breastfeeding.

During the period of using the product, it is necessary to drive a car extremely carefully or do work that requires increased speed of psychomotor functions, since the medication can lead to the development of dizziness and sleepiness.

Drug interactions

The drug is approved for joint use with β-blockers, diuretic drugs and ACE inhibitors.

The combination of the main drug with metoprolol can lead to a decrease in the biological activity of the first drug. If necessary, such a reception requires adjusting the dosage of the main drug.

It is not recommended to take tablets and drugs that inhibit cytochrome P450 3A4 at the same time, because such a combination can lead to metabolic disturbances and excretion of the components of the main medicines. The combination of tablets with cyclosporine can lead to an increased content of the components of both drugs.

In the elderly, the simultaneous use of the main drug at a dosage of 20 mg with midazolam may increase the bioavailability by 40%.

Tablets must be prescribed with extreme caution in patients taking CYP3A4 inhibitors (medicines against seizures, rifampicin), since such a combination can lead to a decrease in the action of the main medication. This requires constant monitoring of blood pressure.

It is not recommended to combine tablets with digoxin, since this can lead to an increase in the concentration of active components in the blood and cause intoxication with this drug.

When using the drug in conjunction with cimetidine (more than 1 g), an increase in bioavailability and an increase in the effect of the original drug may be observed.

The drug can interact with simvastatin and lead to an increase in its activity. If it is necessary to use medications, it is recommended to take these funds at different times of the day. It is allowed to take pills with warfarin at the same time. Grapefruit juice and alcoholic beverages can increase the antihypertensive effect of the tablets.

Analogs

Lerkamen No. 10 (indications for the use of the drug and analogues must coincide in whole or in part) in extreme rare situations can cause the development of allergic reactions.

Substitutes are prescribed if the original product is poorly tolerated. In this case, the specialist must take into account the patient's condition, the severity of the pathology and other physiological characteristics of the patient.

It is not recommended to independently select and take similar drugs, as this can provoke the development of complications and lead to an aggravation of the condition.

Zanidip-Recordati (Ireland)

The main ingredient is lercanidipine hydrochloride. The medication is a representative of the antihypertensive group of drugs and belongs to the class of calcium channel blockers. The medicine is used in the treatment of chronic high blood pressure of the 1st and 2nd degrees of severity.

Dosages: 10 mg orally (1 tablet) per day. If necessary and according to the testimony of a specialist, the dosage can be doubled. Duration of use - according to the doctor's recommendations according to the severity of the violation.

Contraindications:

• intolerance to the components;
• heart failure, proceeding in a chronic form (in the stage of decompensation);
• failure of the kidneys and liver (severe forms of disorders);
• angina pectoris (unstable course of the disease);
• heart attack (including the rehabilitation period for 4 weeks);
• women who do not use contraception;
• pregnancy;
• lactation period;
• minor patients;
• obstructive disorders in the left ventricle;
• grapefruit juice;
• lack of lactase, allergy to lactose, glucose-galactose malabsorption.

Dispensing system - by prescription. Cost - from 285 to 400 rubles.

Amlorus (Russia)

Lerkamen No.10 (indications for the use of similar drugs may differ slightly) can be replaced by such a cheaper drug as Amlorus. The medicine is made in the form of tablets for systemic use. The active substance is amlodipine besylate.

The drug belongs to the group of 2nd generation calcium channel blockers and is used in the treatment of the following diseases:

• chronic high blood pressure;
• stable angina pectoris;
• vasospastic form of angina pectoris.

Dosing features: from 5 to 10 mg per day, depending on the form of the disorder and the severity of its course. A dosage change for the elderly, as well as with kidney or liver failure, is not required. The initial rate in these cases should be no more than 2.5 mg. The course of therapy is individual.

Restrictions on the appointment:

• intolerance to ingredients;
• low blood pressure (pronounced form of violation);
• cardiogenic shock, collapse;
• unstable course of angina pectoris;
• pregnancy;
• lactation period;
• minor age.

The implementation mode is prescription. Cost - from 30 rubles.

Kordafen (Poland)

This medication is produced in the form of tablets for internal use. The active ingredient is nifedipine.

The drug belongs to the group of antihypertensive drugs and is used in the treatment of the following disorders:

• chronic high blood pressure;
• Raynaud's syndrome;
• vasospastic angina.

Dosing regimen: 10 mg 3 times a day. If necessary, the dose can be increased to 20 mg 3 times a day. The maximum daily dose of the drug should not exceed 60 mg. The duration of treatment is individual, according to the doctor's recommendations.

Contraindications:

• chronic heart failure;
• low blood pressure (severe forms of the disorder);
• intolerance to the components;
• cardiogenic shock;
• myocardial infarction (including a period of 4 weeks);
• unstable course of angina pectoris;
• aortic stenosis (pronounced lesion);
• pregnancy;
• lactation period;
• minor age.

Selling system - over the counter. Price - from 100 to 235 rubles.

Terms, conditions of sale and storage

• It is recommended to store the medication in a dark and dry room at temperatures up to 30 ⁰C.
• The shelf life is 2 years from the date of issue.
• Do not use after the expiration date stated on the package.
• Dispensing method - by prescription.

Price

The cost of a medicine may vary slightly depending on the region of sale and the pharmacy trade network. You can clarify the availability of funds, as well as find out its cost at any pharmacy located at the place of residence.

Region / region	Dosage form / dosage	Price
Moscow, Moscow region	Tablets, 10 mg, 60 pcs.	RUB 810-930
St. Petersburg	RUB 840-980
Saint Petersburg (suburbs)	RUB 870-950
Leningrad region	RUB 800-920
Novgorod region	RUB 865-900

Before using Lerkamen No. 10, it is required to read the instructions (special attention should be paid to indications and contraindications) and a specialist consultation. If necessary, it is recommended to study the reviews of patients who have taken the medicine.

Video about the drug Lerkamen

Lerkamen tablets description and instructions: