Cefixime is a drugt, often prescribed to children with infectious and bacterial lesions of the body. This suspension has a high cost, but shows a high therapeutic effect.
Record content:
- 1 Pharmacological group
- 2 The composition of the drug Cefixim
- 3 Release form for children
- 4 Properties, action
- 5 Pharmacodynamics and pharmacokinetics
- 6 Indications for use
- 7 Contraindications
- 8 At what age is it allowed?
- 9 Instructions for the use of Cefixime suspension, dosage for children
- 10 Side effect
- 11 Overdose
- 12 special instructions
- 13 Drug interactions
- 14 Analogs
- 15 Storage
- 16 Terms of sale
- 17 Price
- 18 Video about the drug with cefixime
Pharmacological group
This medicine belongs to the group of cephalosporins and has a pronounced antibacterial and bactericidal effect.
The composition of the drug Cefixim
The main substance of the remedy is the eponymous component cefixime - a broad-spectrum antibiotic.
Additional substances:
- sucrose;
- sodium benzoate;
- MCC;
- xanthan gum;
- food additive E551;
- flavoring.
Cefixime suspension for children
The drug is contained in a special container (bottle), which is designed for the preparation and storage of the suspension. The bottle is packed in a cardboard container and is accompanied by a package insert.
Release form for children
The drug has several dosage forms, however, for children, powder is most often used for preparing a suspension, since this form is the most convenient and does not cause problems when used.
Properties, action
Cefixime is a suspension for children (the price of the product is much lower than other forms of the drug), which exhibits broad antibacterial activity.
The main substance inhibits the production of peptidoglycan, which is a structural component of the cell walls of pathogenic microorganisms. The component is highly effective against most gram-positive and gram-negative pathogens.
The effect of the active substance on the following bacteria:
- streptococcus;
- the causative agent of hemophilic infection;
- moraxella;
- proteas;
- colibacillus;
- the causative agent of gonococcal infection.
The drug does not affect most varieties of staphylococcal pathogen, enterobacteria, bacteroids, shigella, salmonella, clostridia.
Pharmacodynamics and pharmacokinetics
The drug has an average level of absorption. For oral administration, the absorption rate is 40 to 50%. At the same time, food intake does not affect the maximum concentration. However, when eating food, the rate of absorption may slightly decrease.
The maximum concentration of the active substance is reached after 2-6 hours.
The active component interacts with proteins. The binding rate is 65%. In elderly patients, the accumulation time of the main ingredient is 40% longer than in other adult patients.
About 50% of substances are excreted by the renal system in unchanged form. According to laboratory studies on animals, some of the drug is excreted in the bile. In this case, the concentration of excreted substances is about 10%.
The half-life of the drug is from 3 to 4 hours. In some cases, regardless of the dosage taken, the half-life of the disintegrated components is 9 hours. The half-life of the active component in patients with functional disorders of the kidneys can increase and ranges from 6.5 to 11.5 hours.
According to animal tests, the drug is not mutagenic. The carcinogenic effect on humans or animals has not been studied.
The medication does not adversely affect human reproductive function.
Indications for use
The agent is prescribed in the treatment of various bacterial lesions occurring in the area of the respiratory tract or mucous membranes.
Indications:
- the presence of pharyngitis, tonsillitis;
- various types of sinusitis;
- an exacerbated form of chronic bronchitis;
- acute course of bronchitis;
- otitis media in acute form;
- infectious processes in the urinary system, which have an uncomplicated form;
- gonorrhea;
- defeat by shigella.
The medicine is allowed to be used only after confirmation of the diagnosis.
Contraindications
Cefixime is a suspension for children (the price of the medication is affordable for most patients), which has some restrictions on admission associated with the physiological characteristics of the patient or the presence of provoking factors.
Contraindications:
- intolerance to the components that make up the powder;
- chronic renal failure;
- children weighing less than 25 kg.
With extreme caution, the drug can be used in the presence of colitis, the development of kidney failure, as well as in old age or during the period of bearing a child.
At what age is it allowed?
In this dosage form (suspension), the drug is approved for use starting from 6 months of age. However, this requires constant monitoring by a pediatric specialist.
Instructions for the use of Cefixime suspension, dosage for children
The medicine is intended for oral administration.
To prepare the product, you must open the bottle and fill it halfway with warm boiled water. Then close the lid tightly and shake the bottle. Then it is necessary to reopen the bottle with the product and add water to the volume indicated on the bottle.
Shake well before each use. The suspension is taken before or after meals. In childhood from six months to 12 years, the dosage is calculated at the rate of 8 mg / kg of the child's weight per day. In some cases, it is allowed to use the agent at 4 mg / kg every 12 hours.
The duration of the course is determined individually. On average, therapy takes from 3 days to 2 weeks.
Side effect
In some cases, the agent can lead to the development of negative manifestations associated with the effect of the main substance on the patient's body.
Side effect:
- Disorders from the digestive system: dyspeptic disorders in the form of nausea and vomiting, a feeling of dry mouth, diarrheal syndrome, pain in the epigastric region. Very rarely, taking the drug can lead to the development of pseudomembranous colitis, as well as to an increase in the concentration of liver enzymes.
- Disturbances from the hematopoietic system: a decrease in the number of leukocytes, platelets, and neutrophils. In some cases, there is an increase in the number of eosinophils, as well as the development of conditions associated with the destruction of red blood cells.
- Failures of the central nervous system (CNS): the development of dizziness or headaches.
- Disturbances from the urinary system: an increase in the level of creatinine or nitrogenous urea compounds. In extremely rare cases, the process can lead to the development of interstitial nephritis.
- Allergic manifestations: skin rash, itching, urticaria, Stevens-Joson disease. Often, against the background of the use of the drug, various forms of erythema may occur.
- Other disorders: mycosis in the genital area, candidiasis, development of vaginitis.
In the event of side effects, including unrecorded reactions, it is recommended to discontinue treatment with the drug and consult a treating specialist.
Overdose
If the prescribed dosages are exceeded, an increased development of side effects is possible.
Overdose symptoms treatment methods:
- gastric lavage;
- the use of sorbents;
- glucocorticosteroid drugs;
- antihistamines;
- artificial ventilation of the lungs;
- oxygen treatment.
Dialysis use is minor. The name of the specific antidote is unknown.
special instructions
Pediatric suspension should be used according to the prescribed dosages. Cefixime has a very affordable price, so it cannot be replaced with similar drugs based on this factor.
Before using the product in childhood, you must make sure that the child does not have allergic reactions to the penicillin and cephalosporin group of drugs.
When using the drug in patients with a high sensitivity to penicillin, treatment should be carried out with extreme caution and only under the supervision of a specialist. With the development of allergic reactions, therapy should be discontinued.
With the development of acute allergic manifestations, it is necessary to carry out emergency treatment, which includes drug therapy and oxygen treatment. With great care, the suspension can be used for colitis or other gastrointestinal diseases.
It should be borne in mind that prolonged use of the drug can lead to an imbalance in the intestinal microflora, against which diarrhea (severe form) or pseudomembranous colitis may develop.
The use of the product can lead to a deficiency of B vitamins. Taking the suspension can cause a false positive reaction to the presence of glucose in the urine. Also, the remedy can lead to a positive result of the Coombs reaction.
Taking the drug during pregnancy is possible only after prior consultation with a specialist, taking into account the possible risks / benefits. The tool does not affect the ability to drive a car or carry out work that requires high psychomotor reactions.
Drug interactions
Food intake can reduce the rate of absorption of the components of the product.
Drugs that suppress the production of tubular fluid, as well as diuretics, can delay the elimination of the main component of the suspension. This process can lead to the accumulation of the active substance in the blood.
Antacids containing magnesium or aluminum hydroxide can reduce the absorption of the suspension. Therefore, it is recommended that the interval between taking medications be at least 2-4 hours.
The combined use of a suspension and indirect anticoagulants can lead to an enhanced effect of the second group of drugs.
The simultaneous administration of the drug and nephrotoxic drugs can lead to inhibition of renal function. Preparations related to salicylates can cause low absorption of suspension components.
Analogs
Cefixin is a suspension for children (the price of the drug seems overpriced to some buyers), which can lead to the development of intolerance to the components. In this case, the medication should be replaced with other similar remedies.
Analogs:
-
Ceftibuten. This medicinal product is a representative of the 3rd generation cephalosporins group, which exhibit pronounced bactericidal and antibacterial properties. The drug is dispensed in oral forms, the active ingredient of which is the eponymous component of ceftibuten. The drug has a wide degree of activity aimed at suppressing gram-positive and gram-negative microflora. Indications for taking the suspension: infectious and inflammatory diseases provoked by the development of pathogenic microorganisms. Thus, the agent is effective in the treatment of ENT diseases (pharyngitis, otitis media, tonsillitis, sinusitis), with organ pathologies Gastrointestinal tract (enteritis, gastroenteritis), as well as in the presence of diseases of the urinary tract and the respiratory system (bronchitis, pneumonia). Dosages and reception features are determined by the attending physician. Do not use the medication in the presence of allergic reactions, as well as in children up to six months. The medicine is dispensed with a doctor's prescription. The cost in pharmacies varies around 500-700 rubles.
- Ixim Lupine. This drug is being developed on the basis of cefixime by an Indian pharmaceutical company. The medication is available in the form of a powder for the preparation of an oral suspension. It exhibits high antibacterial and bactericidal properties aimed at combating provocateurs of inflammatory and infectious diseases. The tool is intended for the treatment of the following infections: tonsillitis, pharyngitis, otitis media, acute course of chronic bronchitis. The suspension is also prescribed for uncomplicated forms of urinary tract infections. The daily rate of the drug is calculated according to the patient's age and body weight. The form of the pathological process also affects the regimen. The medicine is contraindicated in the presence of intolerance to cephalosporins and penicillins. With extreme caution, you can use the suspension in childhood up to six months. The medication is dispensed strictly according to the prescription (prescription) of the doctor. The cost of the suspension is from 278 to 328 rubles.
- Supraks Salyutab. The manufacturer of this medication is Jordan. The dispensed dosage form is capsules for oral administration. The active ingredient is a semi-synthetic cephalosporin - cefixime. This substance has pronounced antibacterial and bactericidal properties. Indications for the use of pills: acute and chronic form of bronchitis, the development of sinusitis, tonsillitis, pharyngitis. The medicine can be used in the treatment of otitis media, gonorrhea, as well as in the development of uncomplicated infectious diseases occurring in the area of the urinary system. The medication should be limited if the patient has a high sensitivity to the active composition. With extreme caution, capsules can be used with the development of pseudomembranous colitis, in old age, in newborns up to six months, and also in the presence of kidney failure. Dispensing from pharmacies is by prescription. The cost of the medicine is 634-687 rubles. per packing.
Cefixin is a suspension for children (the price of the product should not affect the selection of a similar medicine), which can be replaced with similar agents only if the attending physician is destroyed.
Storage
- It is recommended to store the product in a dry place at a temperature not exceeding 25 0C. The shelf life of the prepared portion should not exceed 10 days.
- The shelf life of the drug is 2 years from the date of manufacture.
- It is forbidden to use the product after the expiration date indicated on the package.
Terms of sale
The medicine is dispensed with a doctor's prescription.
Price
The cost of a drug may differ based on its dosage form and region of sale.
| Region / region | Form / dosage | Price |
| Moscow, Moscow region | Powder, 100 mg | RUB 790-830 |
| St. Petersburg | Tablets, 400 mg | RUB 470-1290 |
| Saint Petersburg (suburbs) | Powder, 100 mg | RUB 810-940 |
| Leningrad region | Powder, 100 mg | RUB 830-10120 |
| Novgorod region | Powder, 100 mg | RUB 820-980 |
Before taking the suspension, you must carefully read the rules for taking it indicated in the instructions, and also consult a pediatric specialist. Additionally, it is recommended to study the reviews of parents who used Cefixime in therapy in children. You can find out the exact cost of the drug at any pharmacy located in your place of residence.
Video about the drug with cefixime
Cefix powder preparation:
