Vigamox eye drops. Price, instructions for use, analogues, reviews

Vigamox - drug in the form of eye drops, the price of which does not exceed the average for this type of drug. Manufacturer - Belgian pharmaceutical company Alcon-Couvreur N.V. S.A.

Forms of release and composition of the drug

The drug is available in the form of a solution for topical use and contains an antimicrobial component, moxifloxacin, as an active ingredient. Pharmacologically, it belongs to the group of fluoroquinolones, IV generation antibacterial drugs.

Packaging - a plastic bottle with a dosing dropper. To ensure sterility, the drug is produced with a control ring for the first opening. Externally, the drug is a clear solution without foreign inclusions of a greenish-yellow hue.

The composition includes the following components:

• moxifloxacin hydrochloride 5.45 mg, equivalent to moxifloxacin 5 mg.

Excipients:

• sodium chloride - 6.4 mg;
• boric acid - 3 mg;
• water - up to 1 ml.

It also contains sufficient HCl or NaOH to bring the ph up to the required level.

Pharmacological properties

Vigamox - eye drops, the price of which, on average, does not exceed the cost of other analogues. They have a number of active actions. Fluoroquinolones are effective against a wide range of various microorganisms, anaerobes, atypical bacterial agents that are resistant to the effects of acids.

In terms of the breadth of the therapeutic effect, they are close to the activity of antibacterial drugs, but the fluoroquinolones differ in chemical structure and origin. They have no natural counterparts in nature.

The mechanism of therapeutic activity is the inhibition of 2 vital enzymes that are characteristic of the cells of microorganisms. Under their influence, DNA gyrase and topoisomerase-4 are neutralized.

This leads to disruption of DNA production and further death of bacteria. Thus, a pronounced bactericidal effect develops. Additionally, fluoroquinolones destabilize the condition of membrane septa and affect other vital processes in bacteria.

Pharmacodynamics and pharmacokinetics

When used topically for the treatment of eye diseases, moxifloxacin undergoes systemic absorption. The highest blood concentrations reach 2.7 ng / ml.

This value is up to 1600 times lower than with oral administration of drugs with a similar active ingredient. The half-life of moxifloxacin from the blood is an average of 13 hours.

Indications for use

Vigamox - eye drops, the price of which depends on the manufacturer and a number of other intermediaries.

They are intended for use in the following indications:

• inflammatory processes and bacterial infections of the conjunctiva and mucous membranes;
• infiltrates due to infection of the follicular areas of the eyelashes;
• swelling and blockage of the sebaceous ducts;
• inflammation of the cornea, cartilaginous zones of the eyelid;
• violations of the outflow of lacrimal fluid;
• purulent inflammatory processes.

Also, the drug is recommended for use in viral conjunctivitis as a prophylaxis against the addition of a bacterial infection.

Contraindications

The drug should not be used with hypersensitivity and intolerance to the components that make up it. The drops are not intended for pregnant or lactating women.

Studies have shown that moxifloxacin, in general, does not have a teratogenic effect in doses reaching 500 mg per 1 kg of body weight per day. This figure is significantly higher than the recommended dosage.

During the carrying of a child, the use of the drug is possible if the intended benefit to the woman is higher than the possible harm to the fetus. Studies have shown that small amounts of the active substance are excreted in breast milk. When used in therapeutic doses, they should not lead to undesirable effects in the child.

At what age can the drug be used?

It is prohibited to use the drug in children less than 1 year of age. After reaching 1 year, it is allowed to use the medicinal solution in the same dosages as for adults.

Instructions for use, dosage

The solution must be used topically, after carrying out the usual eye hygiene:

• adults and children from 1 year old should dose the drug 1 drop into the sore eye 3 times a day;
• after 5 days, there should be a significant improvement in well-being;
• after that, it is necessary to continue the course of therapy for another 2-3 days.

If no improvement is observed, the appointment should be reviewed and the issue of the accuracy of the diagnosis should be discussed. In some cases, longer therapy may be required.

To quickly achieve a therapeutic effect from the use of eye drops, you should adhere to the following recommendations:

• before starting the procedure, you must thoroughly wash your hands with warm water and antibacterial soap;
• then they will need to be wiped off with a dry, clean towel without long nap until all excess moisture has been absorbed;
• also, when washing your hands, you should wash your face well, paying special attention to your eyes;
• in this case, it is necessary to completely remove all secretions and soak the dried crusts characteristic of conjunctivitis;
• in the case of using lenses, before the first use of drops, you will need to carefully remove them and put them in a ready-made solution;
• throughout the course of treatment, you should temporarily stop wearing them, placing them in normal storage conditions at all times;
• the procedure will require a mirror to accurately instill the drug directly into the conjunctiva;
• this should be done by slightly pulling the lower eyelid with a clean finger and lifting the eye up;
• then you need to drip the solution, after which it is recommended to rotate the eyeballs in all directions;
• after that, it is necessary to close the eyelids several times to evenly distribute the solution;
• then it is recommended to lie on your back and remain in this position for several minutes.

For additional distribution of the solution over the entire surface of the mucous membrane, gently massage your closed eyes with your fingertips. After completing the procedure, you can return to your usual business.

In between uses of the drug, do not touch the eyes unnecessarily.. This will avoid additional infection. The mucous membrane in an inflamed state will be especially susceptible to reinfection for a long time.

Side effects

During treatment, in some cases, the following undesirable effects are observed:

• irritation of the mucous membrane of the eye;
• burning and tingling in the limbs;
• lowering hemoglobin levels;
• hemorrhage in the conjunctiva;
• decrease in visual acuity;
• redness of the eyes and eyelids;
• discomfort in the eyes;
• dizziness;
• headache;
• dry eyes.

Sometimes there may be other disorders associated with other organs. If symptoms are severe, treatment should be interrupted. Continue therapy in such cases should be other drugs after consultation with the supervising specialist.

Overdose

Overdose cases were not recorded. In case of accidental instillation of excessive amounts of the medicinal solution into the eyes, rinse them with warm water.

special instructions

Vigamox - eye drops, the price of which in some pharmacies is significantly lower than the average market value. They are intended solely for ophthalmic purposes. The drug is prohibited for use as a solution for subconjunctival administration.

Also, data were obtained on lethal cases when using quinolones as a result of the development of anaphylactic reactions after the first dose. A number of such cases have been associated with the systematic administration of the drug. Some of them were accompanied by dysfunction of the heart muscle, loss of consciousness, Quincke's edema and obstructive changes in the airways.

With unjustified prolonged use of the drug, the development of immunity of pathogens to the action of the antibacterial component in its composition is likely. In this case, pathological reproduction of fungi and the development of superinfection are almost always observed.

Due to the listed risks, the use of the drug should be limited to recommendations for medical use.

Patients who normally wear contact lenses should stop wearing them during treatment. It is also forbidden to touch the tip of the dropper bottle to any surfaces, including the mucous membrane of the eye.

This is necessary to maintain the maximum biological purity of the medicinal solution. After each use, it is necessary to tighten the bottle cap tightly.

In the course of the course of treatment, it is likely that a certain decrease in vision clarity will develop. This must be taken into account by patients who, during therapy, work with complex mechanisms and in road transport, requiring a high speed of response.

Drug interactions

Local interactions have not been studied. At the systemic level, moxifloxacin also does not react with drugs.

Analogs

Vigamox - eye drops, the price of which also depends on the place of purchase. They can be replaced by a number of similar, no less effective means.

Moxifloxacin-Optic

The drug is produced by ZAO Lekko in Russia. The cost of 1 bottle is about 150 rubles. The volume of the product in 1 package is 5 ml of a 0.5% medicinal solution. The bottle is equipped with a convenient dropper for precise dosing of the drug directly into the conjunctival sac.

The composition includes a similar active ingredient that is contained in the Vigamox solution. The mechanism of action is the same features that can quickly suppress bacterial infections of the mucous membranes of the eye. Outwardly, the solution looks like a transparent or slightly opalescent liquid of a greenish-yellow hue.

Recommendations for medical use:

• the drug must be instilled into the conjunctival sac, 1 drop 3 times a day;
• the duration of treatment should be at least 7-8 days.

The last recommendation is due to the fact that after visible improvements, it is strongly recommended to continue the course use to completely suppress the infection. In cases where no improvement is observed, it is necessary to consult a doctor again to confirm the diagnosis or additional examination to establish the correct diagnosis.

Levomycetin - eye drops 0.25%

The drug is manufactured by many pharmaceutical companies. The cost of the most affordable options does not exceed 18-20 rubles. The volume of the bottle is 5-10 ml. The drug contains the active ingredient chloramphenicol.

A broad-spectrum antibiotic disrupts the synthesis of protein elements in the structure of microorganisms. At the same time, it is not active enough to completely destroy bacteria, but it effectively stops the processes their vital activity and the reproduction of strains resistant to the action of penicillin, streptomycin and sulfonamides.

In case of bacterial conjunctivitis, the drug is recommended to be used by instilling the solution into the conjunctival sac 1 drop up to 4 times a day. Unless otherwise prescribed by the supervising physician, the drug should be used for no more than 3 days.

The drug is highly toxic, therefore it is not recommended to use it without thorough indications. However, in severe cases, the solution quickly and effectively suppresses infectious processes that can lead to the development of serious consequences for the functions of the eye.

Tobrex

A solution in the form of drops for the treatment of eye diseases is manufactured by the pharmaceutical company Alcon-Couvreur N.V. S.A., the same company that produces the drug Vigamox. The difference lies in the active ingredient. Tobrex contains tobramycin - a 0.3% solution in purified water containing additional substances.

The active ingredient belongs to the pharmacological group - aminoglycosides. The action manifests itself in the form of a bacteriostatic effect. The drug blocks specific ribosome subunits and interrupts the normal production cycle of protein structures.

Tobramycin is highly active against the following bacterial strains:

• coagulase-positive;
• penicillin resistant;
• coagulase negative;
• indole positive;
• indole negative;
• non-hemolytic;
• streptococcal types of bacterial agents.

Recommendations for the medical use of the drug:

• the solution must be instilled in 1-2 drops into the conjunctiva of the diseased eye;
• the optimal mode of using the solution is every 4 hours;
• for severe symptoms, every 30-60 minutes.

As the severity of symptoms decreases, it is recommended to reduce the frequency of use. This is due to the fact that excessive amounts of the active substance in some cases can cause the development of superinfection.

Sulfacil sodium

Previously, the drug was produced under the name Albucid. Now it is customary to write the name of the active substance directly on the package. The drug is produced in several forms.

Quantity in 1 package	Vial volume
5 vials	0.5 ml
2 bottles	1.5 ml
2 bottles	2 ml
2 bottles	5 ml
1 bottle	10 ml
1 bottle	5 ml

This feature of the drug is associated with the fact that after the first opening, the solution is allowed to be stored for no more than 1 month, after which it must be disposed of. Also, the drug during the entire shelf life requires storage at a temperature of 2 to 8 ° C.

Pharmacologically, sodium sulfacil is sulfacetamide, an antimicrobial bacteriostatic agent obtained as an intermediate product in the process of streptocide synthesis. This explains its high therapeutic activity against microbes, bacteria and viruses.

On the latter, it acts at the very first symptoms, itching in the eyes, when viruses are just beginning to penetrate the mucous membrane. Using the drug at this stage helps prevent infection of the whole body and avoid the development of a general disease.

Recommendations for the medical use of the solution:

• on day 1, the drug is instilled into the conjunctival sac every hour, 1-2 drops;
• with further treatment, it is allowed to reduce the frequency to 5-6 times a day;
• the total duration of the course therapy is 3-7 days.

The duration depends on the severity of the symptoms, the effectiveness and speed of achieving the therapeutic effect.

Terms, conditions of sale and storage

The drug does not require a prescription from a doctor when making a purchase at a pharmacy. The guaranteed shelf life is at least 2 years if stored at an ambient temperature of no more than 30 ° C.

During the entire shelf life, avoid direct sunlight on the packaging. You should also exclude access to the drug for young children. After the expiration date, the solution bottle must be disposed of with household waste.

Price

Vigamox is a drug that is not included in the list of vital and essential drugs, so the manufacturer and the end seller can set the price at their discretion. Most other eye drops can also vary significantly in cost across drugstore chains. On average, it is about 220 rubles. for 1 bottle of medicinal solution.

Taking into account its pharmacological activity, Vigamox belongs to those drugs that in most cases have a quick and pronounced therapeutic effect. The price of eye drops in most cases cannot be a decisive factor in order to refuse a purchase, since neglected pathologies may well cause a decrease and subsequent loss of vision.

Video about Vigamox drops

Overview and indications of Vigamox drops: