Cifran CT tablets. Price, instructions for use, what helps, reviews

Medication Cifran ST - combined antibiotic of the fluoroquinolone category. Tablets are used to suppress mixed bacterial microflora of a complex composition. The price of the medicine is affordable. This allows it to be widely used for the treatment of seasonal ARVI with attached microbial pathogens.

Terms of dispensing from pharmacies, drug price

Tsifran ST is a prescription medication. To purchase it at a pharmacy, a medical form is required, filled out by a doctor in accordance with all the rules. The drug costs about 280 rubles. for a pack of 20 tablets. For a package of 10 blisters of 10 units of the drug in each, you will have to pay 600-700 rubles.

Composition, release form

Tsifran ST - tablets, the price of which is democratic. Their antimicrobial effects are successfully combined with analgesic and anti-inflammatory properties. The drug is produced in the form of large oval yellow tablets, coated with a water-soluble shell.

It facilitates the swallowing of the drug and acts as a barrier to prevent contact pharmacologically active components with negative environmental factors and providing complete sterility. Each tablet has a dividing line for taking the drug at a lower dosage.

The drug is sold in a cardboard box. Inside there are multilayer blisters made of purified, absolutely sterile medical contour plastic and aluminum foil with tablets and instructions for use. The main active ingredients of the drug are ciprofloxacin and tinidazole.

Depending on the dosage, their concentration is 250 and 300 mg or 500 and 600 mg, respectively. Ciprofloxacin is a chemical compound from the group of fluoroquinolones that has antibiotic properties against most known pathogenic pathogens.

Hypersensitivity to the pharmacologically active component have the following gram-positive and gram-negative disease agents:

• Yersinia, affecting the gastrointestinal tract in a multifocal way;
• Escherichia, belonging to the class of enterobacteria;
• vibrios - facultative anaerobes that provoke cholera and sepsis in immunocompromised patients;
• salmonella is a dangerous causative agent of intestinal infections;
• morganella is a conditionally pathogenic agent that is part of the natural intestinal microflora, but under certain factors it can cause inflammatory processes and aggravate the course of diseases;
• streptococci - gram-positive chemoorganotrophic bacteria of the anaerobic-facultative type that live in the respiratory canals and the digestive cavity;
• staphylococci are microorganisms that provoke inflammatory processes in the digestive system, internal organs, mucous membrane.

An important advantage of ciprofloxacin is that bacteria very slowly develop resistance to this antibiotic. Another pharmacologically active component of the combination drug is tinidazole.

It is a potent antiprotozoal chemical compound with pronounced antibacterial activity and a mechanism of action that is different from ciprofloxacin. These components complement each other well.

Tinidazole inhibits vital functions:

• lamblia;
• Trichomonas;
• dysentery amoeba;
• fusobacteria;
• clostridium;
• peptostreptococci;
• bacteroids and other pathogenic microorganisms.

An important pharmacological role in the medicinal composition is played by auxiliary components that complement the main active ingredients, enhance their therapeutic effect, facilitate absorption into the intestinal lumen and systemic blood flow.

Tsifran ST - tablets (the price of the medication makes it the first choice for patients of various social status) of a wide spectrum of antimicrobial action, which is achieved due to a balanced chemical formula.

Auxiliary components of the drug:

Chemical compound	Properties and action
Sodium laureth sulfate	Anionic surfactant. It is semi-soluble in water, oils, monohydric alcohols. Detergent with disinfecting properties.
Sodium starch glycolate	Typical disintegrant for solid dosage forms. Gives tablets good disintegration in the stomach, improves the bioavailability of the main active ingredients of the pharmacological formulation.
Microcrystalline cellulose	Provides intestinal microbial balance. In the gastrointestinal tract, it forms a dispersion or stabilizing colloidal gel. Promotes the elimination of toxins without disturbing the biochemical balance. Binds to heavy lipid molecules, preventing their penetration into the bloodstream.
Dehydrated colloidal silicon	Mineral supplement with adsorbing and regenerating properties. Facilitates the cleaning of the body from toxins, antigens and tissue breakdown products during the inflammatory process. Suppresses the vital activity of some bacteria and decomposes allergens.
Magnesium stearate	Improves cardiac activity and strengthens the nervous system. Has a calming and anti-inflammatory effect. Favorably affects the condition of the musculoskeletal fibers.
Purified talc	A component of the water-soluble tablet coating that stabilizes the acidity in the gastrointestinal tract. Talc provides a homogeneous drug structure. Has antibacterial and drying properties, reduces the secretion of pathological exudate during inflammation.

The water-soluble shell contains natural food coloring, which gives it a yellow tint. The precisely calculated and well-balanced formula of a potent medication allows it to be used to treat patients with certain comorbidities.

Principle of operation and efficiency

The pharmacological mechanism of a tablet antibiotic is based on the ability of the main and auxiliary components to inhibit the vital activity of pathogenic microorganisms. Ciprofloxacin inhibits the DNA structure of pathogenic bacteria.

It blocks the production of the main enzyme of the biological scaffold of unicellular agents - type 2 topomerase. This waste product of bacteria catalyzes duplication - chromosomal rearrangement with duplication of some parts of the DNA chain.

The basic enzyme activates transcription - the synthesis of an RNA construct with the transfer of genetic information. When the production of type 2 topomerase ceases, replication of microorganisms becomes impossible, which leads to a decrease and death of the population.

Ciprofloxacin is active against pathogenic pathogens with acquired resistance to antibiotics of the penicillin, cephalosporin and aminoglycoside series. This explains the high clinical efficacy of Tsifran CT.

Ciprofloxacin not only inhibits the synthesis of enzymes necessary for the reproduction of pathogenic strains. It blocks metabolic processes in the cells of pathogens, accelerating their death.

Easily penetrating through the membrane membrane, the active substance of the antibacterial drug stops the production of beta-lactamases, which play an essential role in the biology of pathogens.

With respect to anaerobic microorganisms, tinidazole demonstrates high inhibitory activity. It damages the DNA of disease-causing agents and inhibits the production of key enzymes.

It is a highly proliferative chemical compound that easily crosses the membrane barrier. The active ingredients of the drug are completely absorbed in the gastrointestinal tract and do not accumulate in pharmacologically significant volumes.

Tsifran ST are tablets, the price of which, together with a high safety profile and effectiveness, explains their popularity. The limiting concentration of active substances in blood plasma is recorded 1-2 hours after oral administration.

An important therapeutic advantage of the drug is the record bioavailability of pharmacologically active components. For tinidazole, it is 100%. The active substance is 12% bound to blood proteins.

The half-life of tinidazole from the body is in the range of 12-14 hours. The physiologically active substance is absorbed into the cerebrospinal fluid in volumes equal to the plasma concentration.

Tinidazole is eliminated through the urinary tract by 25% unchanged. The pharmacokinetic properties of this antimicrobial component are also based on the ability to be excreted in bile and feces.

Metabolic products of tinidazole have negligible pharmacological activity. Ciprofloxacin binds to plasma protein fragments by 20-40%. This substance easily penetrates into the liquid biological media of the body, where pathogenic microflora is concentrated.

A high content of ciprofloxacin is found in skin, lung, and bronchial tissues. The active substance penetrates into adipose tissue, cartilage, musculoskeletal fibers.

Ciprofloxacin is concentrated in the organs of the genitourinary system, suppressing inflammatory processes and inhibiting pathogenic microflora.

A significant content of the pharmacologically active component was found in test samples:

• saliva;
• bronchial mucus, which is released in response to bacterial invasion;
• the mucous membrane of the nasal cavity, which performs a barrier function on the path of pathogenic agents;
• lymphatic secretion;
• peritoneal secretions, moisturizing the abdominal walls and the surface of internal organs;
• seminal fluid of men of reproductive age;
• bile.

Such a comprehensive effect on the body ensures the high therapeutic efficacy of Tsifran ST in the treatment of diseases of bacterial genesis. Ciprofloxacin is eliminated in the liver and kidneys. The effect of reabsorption through bile is negligible.

Indications for use

The complex antibiotic is used in the etiotropic therapy of diseases provoked by a mixed pathogenic microflora of unknown composition. It effectively suppresses inflammatory processes and eliminates the painful symptoms of seasonal acute respiratory infections. The drug has an extensive list of indications for use.

It is prescribed for the following diseases of the ENT organs, provoked by bacterial infections:

• sinusitis of chronic and acute course, characterized by purulent deposits in the maxillary sinuses and signs of microbial intoxication;
• otitis media - inflammation of the ear cavity between the tympanic membrane and the lumen of the Eustachian tube;
• tonsillitis - inflammatory lesion of the pharyngeal and palatine tonsils, which develops as a result of an infectious process;

  

• pharyngitis - inflammation of the mucous membrane of the lymphoid tissue caused by chemical irritation of an exogenous nature or toxic waste products of pathogenic microorganisms;
• mastoiditis - an acute inflammatory process with purulent fusion of the mastoid process of the temporal bone;
• frontal and lateral sinusitis - inflammation of the epithelium of the frontal cavities and paranasal sinuses.

Cifran ST is prescribed for infection of the soft and connective tissues of the skin. The tablets do a good job of suppressing the activity of typical dermatological bacteria. The affordable price of the drug allows its active and versatile use in clinical practice.

The complex antibiotic has proven itself in the treatment of the following infectious diseases of the skin:

• affected by ulcerative destruction sensitive to the active ingredients of the drug;
• syndrome of diabetic foot with purulent wounds of the epidermis;
• bedsores - soft tissue necrosis due to constant mechanical compression, accompanied by a violation blood circulation, nerve conduction and creating favorable conditions for the invasion of pathogenic pathogens;
• purulent abscesses of the epidermis and subcutaneous tissues;
• burn injuries;
• phlegmon - acute inflammation of adipose tissue without clear boundaries and contours.

An antibiotic of a wide range of pharmacological effects is used to eliminate a number of infections of the dental cavity. These include periostitis and ulcerative gingivitis.

Cifran ST demonstrates good clinical efficacy in suppressing bacterial infections affecting the pelvic organs and the genitourinary system.

In urological and gynecological practice, tablets are used in combined drug therapy:

• trichomoniasis;
• salpingitis - inflammation of the fallopian tubes, provoked by pathogenic hematologically transmitted strains;
• tubular abscesses;
• pelvioperitonitis - limited infection of the serous membrane of the pelvic cavity;
• oophoritis - an inflammatory process in the ovaries;
• endometritis;
• prostatitis.

With the help of a combined antibiotic, various infectious diseases of the bones and joints are treated. Among the indications for the use of Tsifran ST are osteomyelitis and arthritis of septic pathogenesis.

The tablets are effective against the pathogenic microflora that lives in the cavities of the gastrointestinal tract. The active ingredients of the drug are highly active against almost all known enterobacteriaceae.

The complex antibiotic is used to treat shigellosis, typhoid fever and amebiasis. It is used in the combination therapy of cystitis and pyelonephritis. In surgical practice, Cifran ST is prescribed to patients with suppressed immunity during the postoperative rehabilitation period to prevent microbial contamination.

The tablets do a good job of suppressing intra-abdominal infections that colonize the abdominal cavity. Tsifran ST is prescribed for diseases of the lower respiratory canals - bronchiectasis, pneumonia, and others.

Contraindications and side effects

A potent drug has an extensive list of clinical limitations and adverse effects.

The absolute contraindications are:

• chronic hematological pathologies;
• oppression of the bone marrow hematopoiesis system;
• acute porphyric syndrome is a hereditary disease characterized by dysfunctions of the central nervous system and peripheral nervous activity;
• biological intolerance to lactic acid, called glucose-galactose malabsorption;
• minor age;
• violation of cerebral circulation;
• severe dystrophy of the arteries of the brain;
• chronic diseases of the heart apparatus;
• mental disorders;
• tendency to epileptic seizures;
• renal failure;
• liver pathology.

Tsifran ST - tablets (the price of the medication is low, which to some extent compensates for the impressive list of contraindications and side effects) that should not be taken when carrying a child and lactation.

The drug is not prescribed for treatment with drugs containing tizanidine. This can lead to a sharp rise in blood pressure. Among the contraindications for use are tendon lesions after therapy with other fluoroquinolone-based medicines.

Patients with congenital long QT interval syndrome should be taken under strict medical supervision. The medicine is not prescribed to elderly people.

List of side effects by frequency of manifestations:

1. Vertigo.
2. Locomotor ataxia.
3. Xerostomia.
4. Tachycardia.
5. Granulocytopenia.
6. Short-term bronchial spasm.
7. Increased muscle tone.

The nervous system can react to the antibiotic with impaired coordination of movements, dizziness, convulsive condition. On the part of the gastrointestinal tract, dyspeptic symptoms were recorded. After taking the drug, serum blood sickness, vasodilation, and thrombocytopenia may develop.

How to use the medicine correctly?

The tablets are used exclusively by the oral route. You need to take the medicine with meals, drinking plenty of water. Do not chew or crush the tablet in any other way.

This can disrupt the pharmacokinetic characteristics of the drug. The dosage, frequency of admission and the duration of the course of treatment are selected by the doctor individually.

The average therapeutic norm is 2 tablets 2 times a day for a medication with a concentration of active ingredients of 250 and 300 mg. A medicine containing 500 and 600 mg of ciprofloxacin and tinidazole, respectively, is taken 2 times a day, 1 tablet.

Interaction with other drugs

It is forbidden to combine tablets with inhibitors of isoenzymes of the CYP4501A2 class. Tsifran ST enhances the therapeutic effect of the use of indirect anticoagulants.

When you cross-use an antibiotic with drugs containing ethanol, there is a risk of disulfiram-like reactions. It is not recommended to combine tablets with anti-tuberculosis medicines based on ethionamide.

Phenobarbital accelerates the metabolism of tinidazole. It is permissible to combine Cifran CT with erythromycin-based antibacterial agents. Iron-containing medicines, medicines with calcium, magnesium and aluminum ions reduce the rate of absorption of ciprofloxacin.

It is impossible to combine Tsifran ST with non-steroidal anti-inflammatory drugs. This increases the likelihood of muscle spasms as a side effect.

The complex antibiotic Cifran CT is suitable for use within 24 months from the date of production. The tablets should be stored in a dark place and protected from moisture at a temperature not exceeding + 25 ° C. The drug's price and effectiveness make it a popular treatment for bacterial infections.

Video about Cifran tablets

Indications for the use of Cifran tablets: