Amoxiclav (Amoksiklav) during pregnancy 1-2-3 trimester. Instructions for use, effect on the fetus, consequences, reviews

Amoxiclav is a popular antibacterial a drug that is used during pregnancy and in the treatment of non-pregnant patients. It has pronounced therapeutic properties, helps to destroy the most common microorganisms that provoke inflammatory pathologies.

Quite often, the 3rd trimester of gestation is accompanied by pathologies from the respiratory system, therefore, antibiotics are required to prevent complications.

Pharmacological properties, composition

The medicine can be found on pharmacy shelves in the form of tablets for oral use and a lyophilisate to obtain a solution that is administered parenterally. Tablets can have a standard dosage of the active substance or an increased one. The second option is more often used for severe disorders.

The lyophilisate is packaged in transparent glass vials, each containing 1.2 g of the drug. The tablets are placed in individual cardboard boxes.

Each bottle can also have individual packaging, but when you purchase a large amount of funds at once, it is packaged in cardboard boxes of 10 bottles. The medicine in any dosage form is accompanied by instructions for correct use, describing in detail all the features.

The preparation contains 2 active components - amoxicillin and clavulanic acid. They have a major therapeutic effect.

The tablets additionally contain auxiliary substances:

• Talc.
• Aspartame.
• Flavors.
• Anhydrous silicon dioxide.
• Iron oxide.
• Microcrystalline cellulose.
• Castor oil.

The lyophilisate also contains the main components, there are no excipients in its composition. In the composition of tablets, amoxicillin and clavulanic acid can be in different quantities: 250 and 125, 500 and 125, 875 and 125 mg. Depending on this, the number of tablets that must be taken during the day is determined.

Amoxiclav during pregnancy (the 3rd trimester of gestation in many women is rather difficult) is used quite often, if there are indications. This is due to the pronounced antibacterial and anti-inflammatory properties of its active ingredients.

The agent is active against many gram-positive and gram-negative bacteria, which quite often lead to the development of a bacterial infection.

The tool belongs to a wide spectrum of drugs, is a representative of the antibiotics of the penicillin series. When applied, the death of staphylococci and some other bacteria is noted, which lead to damage to soft tissues, organs of the respiratory system.

The drug has bactericidal properties, that is, it quickly destroys bacteria, destroys their shell and stops reproduction and development. As a result, there is a rapid cleansing of tissues from the waste products of bacteria, which facilitates the condition and prevents complications.

The tool has other properties:

• Relieves inflammation in the area of ​​tissue damage by microorganisms. In many diseases, the multiplication of microbes leads to the appearance of edema and related manifestations. Using an antibiotic helps prevent this.
• Helps reduce body temperature. With inflammation, prolonged hyperthermia is observed, but the use of an antibiotic helps to quickly normalize the condition, and the body temperature decreases.
• Improves tissue health by destroying microbes that infect it.

The tool also prevents the re-development of inflammation as a result of the reproduction of the same microbes. It is considered more effective than other penicillin drugs, since many microbes are unable to develop resistance to the agent, which is observed when using agents that do not contain clavulanic acid.

The drug, when used orally, is rather quickly absorbed in the digestive tract, and its bioavailability is approximately 90%, which is considered a high indicator.

Absorption occurs through the walls of the small intestine, the agent enters the bloodstream and spreads throughout the body, concentrating in the area of ​​the greatest accumulation of microbes. There is an increased concentration of components in the tissue of the lungs and bronchi, articular joints, synovial fluid and even in the pelvic organs.

The maximum concentration of the component is reached 1 hour after oral administration. The agent is metabolized in the liver, after which it is excreted with the help of the kidneys and with feces. The evacuation period takes up to 6 hours, depending on the specific characteristics of the patient's body. The active ingredient of the composition does not penetrate the membranes of the brain if there is no damage or inflammation.

Pharmacokinetic features may differ from patient to patient:

• With damage to the digestive tract, there is a slowdown in the absorption of the active substance and a decrease in the effectiveness of therapy. In such cases, parenteral dosage forms are prescribed, which do not require absorption through the walls of the small intestine.
• In the case of diagnosing diseases of the large intestine, there is a deterioration in the evacuation of components with feces. In this case, the effectiveness of therapy is almost not weakened.
• Food intake slows down the absorption of the active component, which does not reduce the effectiveness of therapy.

The active components of the composition penetrate the placental barrier and enter breast milk in sufficient quantities. With kidney damage, there is a slight slowdown in the elimination of the components of the composition from the body, which can lead to the accumulation of substances in the tissues and the development of an overdose. When used correctly in the prescribed dose, the drug almost does not accumulate in the blood and tissues.

When using a lyophilisate to prepare a solution, active substances immediately enter the patient's blood, which reduces stress on the digestive tract and allows you to achieve maximum efficiency within a few weeks after the start use.

Indications for pregnancy

Amoxiclav can be used during pregnancy for various reasons. Especially often the 1st and 3rd trimester of gestation is accompanied by various abnormalities of inflammatory origin.

Usually, a medicine is prescribed if the following indications are present:

• Infections of the upper and lower respiratory tract, occurring in an acute form with an increase in body temperature, and other severe symptoms. The remedy is used for sinusitis, sinusitis, pharyngitis and sore throat. It can be prescribed for severe acute laryngitis, when there is a risk of suffocation as a result of edema of the vaginal mucous membranes. The drug helps to eliminate the symptoms of bronchitis and pneumonia.
• Hearing system pathologies, for example, acute otitis media with signs of the development of a purulent process. The disease can negatively affect the condition of the mother and child, so it is better to prescribe antibiotics that provoke fewer complications.
• Infectious pathologies of the biliary tract. Often, such complications occur during pregnancy.
• Infectious diseases of bone and cartilage tissue. Funds are taken only when it is impossible to improve the condition in other ways.
• Inflammatory infected lesions of soft tissues. After animal bites and other injuries, wounds may form that cannot be cured with local medicines. Only in this case are systemic medications used during pregnancy.
• Gynecological diseases provoked by microorganisms that are sensitive to the active component of the drug.

The drug is used when it is impossible to eliminate the symptoms of pathology in other ways.

How safe is Amoxiclav during pregnancy?

Amoxiclav during pregnancy (the 3rd trimester is not considered a contraindication for the use of the medication) is considered a relatively safe remedy. The drug does not belong to dangerous drugs during gestation, but it is important to follow all the rules and take the drug only as directed by a doctor.

In the early stages

Tablets and lyophilisate are not recommended for use in the 1st trimester of pregnancy, but this time is not considered an absolute contraindication. If necessary, the medicine is prescribed in short courses. After 3 months of gestation, the drug does not have a negative effect on the mother's body if it is used strictly as directed and in the right dosage.

The drug does not have a negative effect on the development of the fetus. Experts note the absence of teratogenic and carcinogenic effects on the child, which is considered an advantage over other drugs. Even when used for long courses, there is no negative effect on the fetus and the mother's body, only strict adherence to the rules of therapy is required.

At a later date

In the 2nd and 3rd trimester of pregnancy, the drug is allowed to be used. Depending on the condition and the degree of its neglect, the specialist selects the most convenient dosage form. During the studies, there was no negative effect of the drug on the body of the mother and child.

When used in high doses, the drug can provoke negative reactions from internal organs and systems, but the drug does not affect the development of the child.

Instructions for use during pregnancy

Amoxiclav during pregnancy (the 3rd trimester occurs in many patients with complications, therefore a preliminary examination is required before prescribing a medicine) is used after an examination, which allows you to assess the condition and degree of neglect diseases. At different periods of gestation, the instruction may differ.

1 trimester

If there is an urgent need to use the product, specialists prescribe short courses and the minimum effective dosage. Typically, therapy lasts no more than 7 days. During this period, the patient takes 1 tablet of the drug in the morning and in the evening. In this case, it is important to take tablets with a dosage of 250 mg amoxicillin.

The medicine is taken after meals with plenty of water. After completing the therapeutic course, the woman re-visits the doctor, who assesses its effectiveness. If necessary, medications are prescribed to restore the intestinal microflora.

2 trimester

In the 2nd trimester of gestation, tablets or a parenteral dosage form are prescribed. Depending on the disease, the therapy regimen may differ.

Disease	Application features
Upper respiratory tract pathologies (tonsillitis, tonsillitis, laryngitis, sinusitis)	With such violations, a woman is prescribed pills for a course of 10 days. Every day they take 1 piece 2 times a day. When treating, it is worth choosing tablets, the dosage of amoxicillin in which is 625 mg. If necessary, the doctor extends the course up to 2 weeks, but only if indicated. Throughout the treatment, the patient regularly visits the doctor, who assesses the effectiveness of the therapy.
Acute bronchitis of bacterial origin	When diagnosing such a disease, tablets with a dosage of 875 mg of amoxicillin are prescribed. Treatment lasts 7-14 days, depending on the degree of neglect of the disorder. Often, in combination with the remedy, medicines are used to improve the discharge of sputum from the bronchi.
Pneumonia of various forms with severe acute manifestations	When a disease is diagnosed, a parenteral dosage form is usually prescribed. The lyophilisate is dissolved in 15-20 ml of sodium chloride 0.9% before intravenous administration. For one procedure, you need 1 bottle of the drug, repeat it 2 times a day. The treatment lasts from 5 to 10 days, depending on the degree of damage to the lung tissue.
Otitis media in acute form	The drug is used for bilateral and unilateral otitis media in courses of 10 days. In this case, the patient takes 1 tablet of the drug daily 2 times a day. The dosage of amoxicillin in each tablet is 500 or 875 mg, depending on the severity of the symptoms. Usually, when treating with a remedy, additional local medicines are used, which enhance the effectiveness of therapy. After completing the treatment course, a second examination is carried out by an otolaryngologist.

For other violations, the agent can be used according to the standard scheme or on an individual basis, which is determined by a specialist separately in each case.

3 trimester

Amoxiclav during pregnancy (the 3rd trimester of gestation requires careful monitoring of the condition women) in recent weeks is not used so often, but the official instruction does not prohibit application.

The remedy is taken for inflammatory infectious pathologies with acute manifestations and in the absence of an effect from the use of other drugs. A single dosage of the drug is 1 tablet, the amount of amoxicillin in which is 500 mg. The drug is taken 2 times a day for 10-14 days, depending on the degree of neglect of the disorder.

After the end of the therapeutic course, the patient visits the doctor again, who examines and evaluates the result of the application.

If, after using the drug, there is no therapeutic effect and an aggravation of the condition is observed, antibiotics from other groups are prescribed, which are more effective. This is usually required when the pathology is provoked by a microorganism that is not sensitive to amoxicillin.

Overdose and consequences

The drug can provoke a severe overdose if a woman takes it in high doses for a long period without a doctor's prescription.

The most common manifestations of an overdose affect the work of all internal organs and systems:

• From the side of the nervous system, headache, dizziness, weakness and drowsiness may occur. Patients may talk about increased irritability, sleep disturbance, depression. As the disorder progresses, complete apathy, seizures, and severe headache are observed. The condition is aggravated by the flashing of flies in front of the eyes and a temporary deterioration in vision.
• On the part of the respiratory system, there is difficulty in breathing, up to choking, shortness of breath during exercise or during an emotional disorder.
• On the part of the digestive tract, the most pronounced disorders are observed with the development of an overdose. Patients report pain in the stomach and intestines, nausea and repeated vomiting after eating. Stool disorder is also observed, manifested in the form of diarrhea. This complication develops against the background of a violation of the intestinal microflora.
• From the side of the pelvic organs, pain may appear, especially in the lower abdomen. Women note the severity, especially with the development of an overdose in the case of taking the medication at a later date.
• On the part of the skin, rash, irritation and peeling may occur. In different patients, the severity of manifestations may differ. Quite often, a woman combs the affected area, which leads to a violation of the integrity of the skin and increases the risk of pathogens entering the bloodstream.
• In some cases, an overdose is accompanied by a malfunction of the taste buds. Usually the condition returns to normal within a few days after stopping the use of medications.

Sometimes an overdose can provoke disorders in the fetus. With ultrasound diagnostics, an increase in heart rate is detected, as well as a slight deviation in development, underweight and some other disorders.

In case of an overdose, the patient may develop an acute allergic reaction, which is accompanied by swelling of the mucous membranes of the throat and the development of suffocation. The most dangerous consequence of this condition is the death, which also leads to the death of the child.

If symptoms of an overdose appear, it is important to immediately stop using the medication and visit a doctor. In a hospital setting, the patient is provided with assistance that allows you to improve the condition and maintain the pregnancy.

If the condition is serious and there is a threat to life, emergency resuscitation measures are taken with the use of the necessary medicines.

Amoxiclav is considered a fairly popular antibacterial drug used during pregnancy and for the treatment of non-pregnant patients, men, children.

Often the 1st and 3rd trimester of gestation is accompanied by various disorders, so the appointment of the drug helps to avoid the development of complications. It is strictly forbidden to take the medication without a doctor's prescription, increase the dosage or prolong the therapeutic course.

Video about the drug Amoxiclav

Instructions for use of Amoxiclav: