Etamsylate tablets. Price, instructions for use, analogs, where to buy, reviews

The prices of drugs vary depending on the form of release and the manufacturer. Medicines in tablets are usually cheaper due to the fact that they require a longer amount of time for the absorption of active substances into the body and subsequent activation of therapeutic action.

Such drugs, in particular Etamsilat, have expensive analogs, but they still remain the most popular and effective in their niche.

Forms of release and composition of the drug

Etamsylate tablets (the price of the medicine is fixed in all pharmacies, regardless of whether they are public or private) supplied to the consumer market in several versions:

Packing option	Short description
50 pcs., Carton	In this case, the tablets are placed in several blisters, which are a blister strip packaging.
10 pcs., Carton	The tablets in this case are placed in one blister, which is a blister strip packaging. They are found in pharmacies less often because of the unfavorable price.
10 pcs., Carton	Tablets in this case are placed in 5 pieces in 2 blisters, which are blisters.
10 pcs., Blister	Etamsylate is also in some cases sold without packaging, in separate blisters of 10 tablets.
50 pcs, glass jar	In this case, the tablets are packed in a dark glass jar. Despite the fact that tablets in such packaging are usually sold cheaper, it is not recommended to make a choice in their favor due to insufficient tightness.

Despite the difference in appearance, the composition of Etamsylate is standard in each case - one tablet contains 250 mg of the active substance (Etamsylate).

Pharmacological properties

Etamsylate, according to its pharmacological properties, is classified as an antihemorrhagic type of drugs. This means that the main action of the drug is aimed at stopping bleeding (regardless of its type) and normalizing blood clotting (with diagnosed disorders).

Among the secondary properties of Etamsilat, one can also note:

• normalization of the permeability of the vascular walls;
• improvement of blood microcirculation;
• activation of thromboplastin formation.

Despite active intervention in blood circulation, Etamsylate does not affect prothrombin time (a key parameter used for assessing the quality of blood clotting), and also minimizes the likelihood of blood clots, which are the objective advantages of medicinal funds.

Subject to the recommendations related to the dosage of the drug, the risk of hypercoagulable properties is minimal. Due to this, Etamsilat is prescribed by doctors for various purposes to most patients who do not have serious pathologies in the work of the cardiovascular system.

The appointment of Etamzilat is possible only after a specialist has formed a complete understanding of the state of health of a particular person.

Pharmacodynamics and pharmacokinetics

Etamsylate in tablets (the price of the drug is acceptable for the vast majority of capable people) promotes the manifestation of a hemostatic effect after 30-40 minutes. after taking the medicine inside in the dosage correctly determined by the doctor.

The maximum effect of the active substance is achieved after 2 hours. The effect of Etamsilat on the body lasts for 5-7 hours. After the specified time, the effect of the drug gradually begins to decrease. Repeated administration of the drug, if necessary, should be prescribed no earlier than 6 hours after the initial administration.

During the first 24 hours after taking the pill, more than half of the dose of ethamsylate is excreted in the urine unchanged (at least 55%). The duration of the partial elimination of the substance from the blood plasma, according to research, is no more than 3 hours.

Etamsylate is completely excreted in breast milk, and also tends to penetrate the placental barrier.

These characteristics necessitate careful use of the drug during pregnancy (regardless of the trimester) and lactation (the benefits to the mother must outweigh the potential harm to the fetus inside the womb, or has already been born child).

Indications for use

The main indications for the use of Etamsilat are:

• prevention of capillary bleeding (used for planned surgical interventions in the body, for example, before and after plastic surgery);
• elimination of bleeding during manipulations in gynecology and urology;
• stopping bleeding after operations in ENT practice;
• stopping bleeding after surgical manipulations with the organs of vision;
• elimination of bleeding during operations in dentistry;
• hematuria;
• hypermenorrhea (relevant for the primary condition);
• nose bleed;
• uterine bleeding of unknown etiology (despite the relative safety of the drug, it is highly discouraged to use it without a doctor's prescription);
• metrorrhagia;
• prevention and treatment of periventricular bleeding in premature infants (in this case, intramuscular or intravenous injections are most often used);
• emergency cases with pulmonary hemorrhage;
• emergency cases with intestinal bleeding.

If it is necessary to urgently correct a person's condition, doctors use etamsylate in injections.

Contraindications

Etamsylate in tablets (the price of the drug allows you to have it in your home medicine cabinet just in case) has a number of contraindications:

• hypersensitivity to the active substance (etamsylate) or minor components of the drug composition;
• intolerance to sodium sulfite;
• diseases of the respiratory system (regardless of what stage the disease is in - remission or exacerbation);
• acute form of porphyria (violation of pigment metabolism in the body);
• violation of blood clotting (excessively high speed);
• a tendency to hemorrhage, which most often occurs when taking anticoagulants (a predisposition to bleeding of the mucous membranes due to violations at the level of hemostasis);
• leukemia;
• osteosarcoma;
• neoplasms in children (regardless of whether they are benign or malignant);
• tendency to allergic reactions. In the presence of this contraindication, it is necessary to make sure that the body does not react sharply to the active component of the tablets before starting to take Etamsilat. Otherwise, taking the drug can provoke an attack of suffocation or Quincke's edema, which can be removed only with the help of antihistamines.

At what age can the drug be used?

Etamsylate, as an active substance, is suitable for medicinal purposes in pediatrics and neonatology. Intravenous and intramuscular injections can be given to children within the first 2 hours after birth. At the same time, doctors should assess the possible risks, and also correlate the benefits and potential harm of introducing the drug into the vulnerable body of the newborn.

The tablet form of Etamzilat can be used in the treatment of children over 5 years old. Pediatricians recommend crushing the tablets and dissolving them in a little water before giving them to babies.

To neutralize the bitter taste of the tablets, the medicine can be taken with plenty of water. This does not reduce the effectiveness of the drug, but, on the contrary, increases the rate of absorption of the active substance into the blood.

If it is not necessary for the child to take Etamsilat inside, it is permissible to make compresses with it. This is especially true in the case of bleeding that has begun during surgical interventions in dentistry.

Instructions for use, dosage

The scheme for taking Etamsilat and its dosage should be determined by the therapist, taking into account the form of release of the prescribed the drug, the current state of the patient, the characteristics of his health, as well as the age at the time of admission medicines.

Independent decision-making on the advisability of using Etamzilat to correct the current health conditions can not only be ineffective, but also provoke a deterioration in a person's condition.

The dosage of Etamsilate in tablets according to the manufacturer's instructions looks like this:

Patient's age	Recommended amount of Etamsilat
Adult	In the absence of a critical situation - 1 - 2 tab. up to 3-4 times a day. If an emergency effect on the body is necessary, it is permissible to increase a single primary dosage for an adult to 3 tab. (750 mg).
Children	The dosage should be calculated based on the child's body weight - no more than 15 mg per 1 kg of body weight. The daily frequency of taking Etamsilat by children should be 2-3 times at intervals of 4-5 hours.

If Etamsilat is used as a solution for external use (it should be diluted in a proportion of 1 tablet per 100 ml of filtered water), then it can be applied to wounds an unlimited number of times, focusing on the patient's condition (usually 5-7 times for 15-20 minutes, depending on the absorbing properties tampon).

Side effects

Etamsylate in tablets (the price of the drug allows you to refuse to save it when used externally) has a number of side effects:

• headache;
• clouding of consciousness;
• sensations of hot flashes in the face;
• paresthesia of the lower extremities;
• thromboembolism (in the most rare cases);
• arterial hypotension (rare and in the vast majority of cases due to an incorrectly selected dosage);
• nausea, in some cases flowing into vomiting;
• abdominal discomfort;
• stool disorders;
• allergic reactions (in people prone to them);
• increased body temperature (in rare cases);
• bronchospasm;
• acute porphyria (rare);
• back discomfort, most often in the lumbar region;
• skin rashes (urticaria);
• severe leukopenia (in the study occurred in children with leukemia, in the treatment of bleeding in whom Etamsilate was used).

Overdose

 An overdose while taking Etamsilat is unlikely if the patient:

• follows the dosage prescribed by the doctor;
• observes the recommendations affecting the rate of assimilation of the active substance and its absorption into the blood;
• takes into account the concomitant advice of a doctor related to taking other medications (Etamsilat is incompatible with most other medications).

Symptoms of an ethamsylate overdose are:

• nausea;
• vomit;
• dizziness (in some cases, this condition is as close as possible to fainting);
• headache (in this case, drugs that, by their action, should reduce the severity of pain, in this case, will, on the contrary, increase it).

special instructions

Etamsylate, produced by the manufacturer in tablets, has a number of special instructions, which should be read before starting treatment (the price of the product does not determine the quality, product efficiency, as well as the concentration of the active substance):

• with caution Etamsilate should be taken by people whose bleeding is caused by anticoagulants;
• control of the condition throughout the treatment is also required by patients with previously diagnosed thromboembolism;
• the effectiveness of taking Etamsilat has not been proven in patients with a reduced number of platelets in the blood;
• before starting treatment with Etamsilat, it is recommended to make sure that there are no serious pathologies that could provoke bleeding (for example, in the field of gynecology, this can be an ovarian rupture or cystic neoplasms);
• before starting to take Etamsilat, it is recommended to identify the real state of blood clotting of the patient, and also, if necessary, correct it;
• during treatment with a drug, care must be taken when driving vehicles, as well as performing work that requires special attention and concentration (the recommendation is due to the fact that taking Etamsilat can provoke severe dizziness and the occurrence of lightheadedness state).

Drug interactions

When Etamsilat is administered intravenously or intramuscularly, it is unacceptable to mix it in the same syringe with other drugs. When using this agent in tablets, it is necessary to consider the possibility of its drug interaction from the point of view of the general history of a particular patient.

The combined use of Etamsilat with formulations, whose action is aimed at reducing blood clotting, is practiced. Etamsylate improves the condition of a person with hemorrhagic syndrome, which was provoked by acetylsalicylic acid and indirect anticoagulants.

If Etamsilat is used in the treatment of a child, then it is strictly forbidden to take other drugs of a similar action in parallel.

Analogs

Tablets of Etamsilate analogs are:

• Dicinon (the active substance of the drug is etamsylate at a dosage of 250 mg) is allowed to be taken from 3 years old;

  

• Etamsilat – escom (the active substance of the drug is etamsylate at a dosage of 125 mg), which is approved for use by children from 3 years of age. The dosage is calculated by the pediatrician based on the weight of the child;
• Etamsilat – ferein (solution for injection, the main active ingredient of the composition in which is etamsylate, at a dosage of 125 mg per 1 ml), that is approved for admission in pediatrics, neonatology in the treatment of newborns, 2 hours after their command to light.

Terms, conditions of sale and storage

It is necessary to store Etamsilat in the original packaging of the manufacturer, without violating the integrity of the blister with an unused tablet. The optimum storage temperature for the drug is no higher than 25 ° C. The shelf life of the product is 3 years from the date of production. Etamsilate is dispensed from pharmacies strictly by prescription.

Such conditions for implementation are due to the fact that with incorrect use of the drug, the patient's condition can be critically aggravated in the shortest possible time.

Price

The cost of Etamsilat varies from 80 to 150 rubles. for packing tablets or ampoules.

The markup for a drug is determined by a specific pharmacy, based on standard parameters:

• the amount of the rent;
• the prestige of the campaign (which segment does the management of a particular pharmacy belong to);
• location (the farther the city where the pharmacy is located is from the place of manufacture of the medicine, the more expensive the supplies will be).

Etamsilate, in cases that do not require emergency intervention, are recommended to be used in the form of tablets. The price of the drug depends on the policy of the particular pharmacy, as well as the original cost set by the manufacturer.

Despite the proven effectiveness of the drug, as well as its availability, Etamsilat should be used only with the permission of a doctor who has a holistic view of the state of health of a particular person.

Video about the drug

Indications and instructions for Etamsilat tablets: