The powerful neuroleptic Chlorprothixen - the instruction on application is obligatory for studying, responses of doctors and patients ambiguous

This is a strong enough neuroleptic, has a wide range of effects.

Thioxanthene derivative very effectively helps to overcome both weak and pronounced disorders of mental state, as well as nervous breakdown and consequences of alcohol intake.

Pharmacological actionpreparation

This drug with antipsychotic, neuroleptic ( inhibits the action of the central nervous system), anticonvulsant, anti-emetic ( countertnym), tranquilizing ( sedative) effect.

Also has the property of enhancing the action of analgesic( anesthetic) agents.

Has a good timoleptic effect ( antidepressant effect, which is achieved through the activation of noradrenergic transmission): the speed of thinking, initiative, the feeling of fatigue in unusual conditions disappears.

Antipsychotic effect of the drug is associated with its ability to block dopamine receptors, mesocortical and mesolimbic systems( eliminates delirium, hallucinations).

Also, Chlorprotixen has the property of to block adenomine and histamine receptors of , which determines its adrenoblocking and antihistamine action.

The anti-emetic property is explained by the possibility of depressing the trigger region of the emetic center.

Suppresses the release of most pituitary hormones and the hypothalamus.

What happens after taking the medicine

When taking the drug orally, the active components are absorbed quickly enough. Chlorprothixen begins to act as early as 20 minutes after ingestion, absorbed quickly enough in the intestine.

The maximum concentration in the blood is detected after 2-3 hours after taking the drug.

The half-life of the body is approximately 10-16 hours.

Chlorprotixen has the property of penetrating the placenta, excreted in breast milk in small amounts.

Excreted from the body with feces and urine. Accordingly, the organs that metabolize this drug are the kidneys and intestines.

Assuming that the daily dose of 300 mg, the content in the metabolites of chlorprotixen is 29%, chlorprotixene sulfoxide - 41%.

Indications for use

The drug is a group of fairly effective sedative neuroleptics and has an extensive group of indications:

• disorders of behavioral reactions in children;
• neurotic states, psychoses accompanied by a sense of fear, aggressiveness, anxiety;
• sleep disorders( regular rhythm disturbances, one-time insomnia);
• somatic diseases, which manifest themselves in the form of nerve-like disorders, itchy skin;
• more severe forms of psychosis, for example, schizophrenia, manic seizures;
• is depressed;
• irritability, confusion, hyperactivity in elderly people;
• withdrawal symptoms for alcoholism and drug addiction of medium and extreme severity( "hangover" syndrome);
• sclerosis;
• brain injury;
• pain( the drug is used as one of the components of general therapy, enhances the action of analgesics);
• is used as an adjuvant for psychotherapeutic intervention;
• premedication( preparation for general anesthesia);
• with probability of miscarriage or premature birth;
• postoperative and post-burn conditions;
• neurotic dermatoses, accompanied by itching;
• acclimatization;
• convulsive cough;
• vomiting, spasms of the gastrointestinal tract;
• dyscirculatory encephalopathy.

Contraindications to admission

Instruction for use of Chloroprotoxen indicates that the use of the drug categorically is prohibited:

• state of intoxication or intoxication;
• when consumed or overdosed with narcotic drugs;
• CNS action is inhibited by any other factors;
• increased sensitivity to the component( s) of the drug;
• coma;
• severe diseases of the hematopoiesis;
• bone marrow suppression;
• for children under 6 years;
• vascular collapse( sharp drops in blood pressure);
• pregnancy;
• Parkinsonism.

Before you decide to take the antipsychotic drug Truksal, the instructions for use should be studied, - the medicine has many side effects.

What mrt brain shows you can look at our video and read the detailed explanation for what is happening.

Take with care

The instructions for use indicate that the chlorprotixen tablets also have a relative contraindication( the drug is possible, but with great care) that is made up of:

• combination with other drugs and substances( for more details see "Interaction with other drugs");
• epilepsy of the clinical stage or at the stage of complications;
• of renal and hepatic parenchyma;
• decompensated defect;
• is a physical exhaustion;
• tachycardia;
• old age;
• diseases of the cardiovascular system( possibly transient increase in blood pressure);
• atherosclerosis of cerebral vessels at a pronounced stage;
• stomach ulcer;
• of duodenal lesion;
• glaucoma or predisposition to its occurrence;
• breathing disorders caused by asthma, the course of acute infectious diseases, pulmonary emphysema;
• diabetes mellitus;
• benign or malignant proliferation of the prostatic mucosa, which has clinical manifestations( the drug may cause a delay in urine).

In case of impaired renal and hepatic function

It is especially worthwhile to be attentive in the presence of the following related diseases:

• pheochromocytoma( a hormonally active tumor in the adrenal glands);
• Reye syndrome( taking the drug increases the risk of developing hepatotoxicity);
• urinary retention.

The preparation is strictly prohibited with pronounced impairment of kidney or liver function.

How to use

General indications for use Chlorprothioxene Zentiva, which are listed in instructions:

Take by mouth according to 25-50 milligrams 3-4 times a day. If necessary, it is possible to administer 60 grams per day( with a subsequent reduction in dosage), intramuscularly - up to 25-50 milligrams 2-3 times per day .

Usually, the greatest dose of the drug is prescribed before bedtime.

Dosage depending on the disease and the concomitant state of

The size of the dose is largely dependent on the of the patient's condition:

1. Psychosomatic disorders and severe depressive conditions: Chlorprothixen is used as an auxiliary medicine( as part of a comprehensive therapy).Usually, 60 to 90 mg per day is prescribed( the dose is divided into several doses).
2. Psychoses, schizophrenia, manic states : first the drug is taken at 50-200 mg per day, then the daily rate increases to 250-300 mg. With advanced disease states, it is possible to increase the dosage to 1200 milligrams( the daily dose is divided into 3 to 4 doses, about 40% falls on the evening time).
3. Maintenance therapy : 100-200 milligrams per day.
4. Neuroses : 10-15 mg before bedtime, less often - 30 mg at bedtime, in extreme cases - 45 mg at bedtime.
5. Abstinence syndrome ( "hangover" or postnarcotic condition): the drug is taken 3 times a day, with a volume of 500 mg( divided into 3 equal portions).In this case, the course lasts 5-7 days. After the completion of the course, the dose of the drug is reduced to 15-45 milligrams per day( as a maintenance therapy, to prevent breakdowns).
6. Irritability, hyperactivity, nervous excitement, confusion in elderly patients: therapy starts at a dosage of 15-90 mg per day, the dose rises gradually until an appropriate effect is achieved.
7. Insomnia: take 15-30 milligrams of medication an hour before bedtime.
8. Behavioral disorders in children: dosage is calculated by the formula 0.5-2 mg X weight of the child( kg).On the average it is prescribed: with neuroses 5-30 mg per day, with psychoses from 100 to 200 mg per day.
9. Pain ( to enhance the action of analgesics): take 15-300 mg of the drug a day, along with pain medications.
10. Cutaneous itch ( of different origins): 15-100 milligrams per day, the dose is divided into 4 doses.
11. P claim of abortion, premature delivery: 15 mg portionwise( 2-3 times per day), for 2-3 days. Then 7-10 days are prescribed reduced doses of the drug.

Injective administration of the drug is prescribed if the patient refuses to take the pills or at the beginning of the course( for the fastest action of the drug).

Composition and form of the preparation

Tablets: biconvex, covered with a thin film-sheath, 15 mg( orange tablets), 50 mg( light brown tablets), available in blisters, 1 blister 10 tablets. In one pack of 50 pieces.

Ingredients: active ingredient - chloroproticsen hydrochloride.

Auxiliary components: lactose monohydrate, talc, corn starch, calcium stearate, sucrose.

Composition of the shell: macrogol 6000, 300, talc, aluminum varnish, hypromellose 2910-5.

Solution for injection: ampoules of 1 ml of 2.5% solution, 2 ml of 5% solution.1 pack contains 10 or 100 ampoules.

Drops: for ingestion

Side effects of

As an individual reaction of the body, the following symptoms are possible:

1. Central nervous system: mild extrapyramidal syndrome, inhibition, fatigue, dizziness, drowsiness. In the first 6 hours after taking the drug, acacia( an irresistible desire to move, an inability to sit still) is possible. Single cases of late dystonia. It is extremely rare to increase the level of anxiety, especially in patients with schizophrenia.
2. Digestive system: increased frequency of urination, constipation, dry mouth. After prolonged use of the drug, cholestatic jaundice may occur.
3. Cardiovascular system: blood flushes to the face, tachycardia( rapid heart beat), orthostatic hypotension, changes on the echocardiogram( QT interval).
4. Vision: sometimes patients experience blurred vision, the inability to quickly focus.
5. Hematopoiesis system: leukocytosis, hemolytic anemia, agranulocytosis( 4-10 week of treatment), benign leukopenia are possible.
6. Endocrine system: possible amanorrhea, frequent hot flashes, galactorrhea, gynecomastia, weakening of sexual desire and potency( with prolonged intake of the drug), diabetes mellitus.
7. Metabolism: Sometimes there is an increase in sweating, increased appetite, a violation of carbohydrate metabolism, accompanied by a set of mass( with long-term drug intake).
8. Epidermis: photodermatitis or photosensitivity possible.
9. Vestibular apparatus: in some cases, the coordination of movements( jitter, slowness) is possible.

Overdose with

Symptoms: breathing disorder, seizures, severe drowsiness, fever, tachycardia, lowering of blood pressure, shock, coma, uncontrolled movements, excessive excitability.

Treatment: can be used to wash the stomach, give laxatives or absorbents. Also, supportive therapy should be conducted in parallel, depending on the symptomatology.

The dialysis procedure will not be effective.

In case of cardiovascular symptoms, do not give adrenaline( this can cause a drop in blood pressure).

Seizures can be eliminated with diazepam.

Bioperiden will effectively help in case of motor neuropathic disorders.

Special instructions

Instructions for use on the preparation Chlorprothiksen Zentiva indicates that should also be remembered:

1. Chlorprotixen therapy may give false results of the pregnancy test of the urine, the blood test for bilirubin level.
2. During the course of treatment it is advisable not to drink alcohol, avoid a significant amount of ultraviolet radiation.
3. For the period of intensive treatment, it is necessary to refrain from actions that require a high rate of physical and mental reactions( this includes high-altitude work, driving, crane. ..).
4. In order to avoid the syndrome of "cancellation"( leveling the results of treatment), it is necessary to withdraw the drug gradually from the body, gradually reducing the dosage.
5. The probability of fluctuating blood pressure is higher in adolescents than in adults.
6. In the presence of diseases listed in the list of relative contraindications, the need for treatment with this drug and possible risks should be carefully compared.
7. Prolonged use of the drug causes addiction and addiction.

Interaction with other medications

Interaction of the drug with other drugs quite well studied:

• using Chlorprotixen in parallel with neuroleptics, hypnotics, anesthetic and sedative drugs, etenolosoderzhaschimi, they can strengthen the effect of Chloroproticsen on the CNS;
• combination with antihistamine and anticholinergic drugs may lead to a slowing down of nerve impulses;
• Chloroprotoxen enhances the effect of antihypertensive drugs;
• combination of medication with adrenaline can provoke tachycardia, arterial hypotension;
• Chloroprotoxen reduces the effectiveness of levodopa;
• combination of the drug with phenothiazines, haloperidol, reserpine, metoclopramide can cause movement disorders( against neurological complications).

To be used during pregnancy and lactation.

If possible, do not prescribe the drug in the period of fetal and lactation.

Reviews about the drug

Reviews about Chlorprothixen are ambiguous. We suggest you to familiarize yourself with the reviews of the drug Chlorprothixen Zentiva.

1. Patient Jan: "I have taken the drug for a little more than a year. Well, it's addictive! But everything will depend on the dosage. After discharge, the saw drank 200 mg per day, now - 100. I recently missed the pill before going to bed and could not sleep! Now she started to sleep in the daytime. .. But I do not want to! There are also side effects - emotions are dulled, constant drowsiness. But it eliminates hyperactivity well. "
2. Patient Andrew: "I decided to take Chloroproticsen when the strongest depression and anxiety started. Generally did not help. Has ceased to accept a preparation. The feeling of anxiety was removed by alprazalam( although he had interesting short-term memory loss).
3. Patient Anna: "I was literally forced by a psychiatrist to take this Chloroprotein, and now I'm very grateful to her. I have a psychosis, if I do not sleep for several days. Sometimes even hypnotic drugs are ineffective. After one tablet slept for 20 hours, woke up full of energy. I recommend to everyone! It's better than lying in hospital for 2 months. "
4. Dr. Maxim: "This is quite a good antipsychotic, it does a good job with sleep disorders, but it is not advisable to break the dosage. Sometimes the permissible standards of the drug must be determined individually. "
5. Dr. Anton: "The drug is good because the effectiveness is combined with minimal manifestations of side effects. However, at the same dosage, different patients can react differently. Do not in any way stop the treatment dramatically. During the use of the drug, it is desirable to regularly give tests of liver and kidney function. "

Advantages and disadvantages of the drug based on the practical use of

Pros:

• , the occurrence of side effects from taking the medication is infrequent with a mild dosage;
• is especially effective in combating manic and panic conditions, unrest.

Cons:

• causes a strong dependence: with Chloroproticsen it is difficult to "jump" to another drug;
• questionable effectiveness in severe stages of mental disorders;
• may have side effects.
• individual hypersensitivity( some patients, after relatively small doses, felt extremely sluggish and lifeless).

How much is the preparation

The price for Chlorprothioxene Zentiva is:

• tablets, 15 mg, 30 pieces: from 135 rubles per package;
• tablets, 50 mg, 30 pieces: from 219 to 271 rubles per pack;
• injection, 10 ampoules: from 140 rubles.

Storage conditions

Store in a dry place at a temperature of 10-25 ° C.

Shelf life

The drug is suitable for 3 years from the date of manufacture.

Leave at pharmacy

The drug is dispensed in a pharmacy under the prescription of a doctor.

Analogues available in the Russian market

The only available analog of Chlorprothixen is the drug Truksal.

Since the active substance of Chlorprothixen and Truksala is the same - "chlorprotixen", then the pharmacology, indications, contraindications will in fact be identical.

The only difference is the concentration of the active substance and, accordingly, the price of the drug.

Truksal is available only in tablets, 25 and 50 mg( Chlorprothixen - 15 mg, 50 mg) for 50 or 100 pieces per pack.

Also in Truksal, the shelf life is 5 years( unlike Chlorprothixen - 3 years).

The price for the analog of Chlorprothixen, 50 tablets, 50 mg: from 430 rubles.

This is more expensive than the average price for the drug Chlorprotixen.

Video: Neuroleptics and their effect on children

About what side effects have second-generation antipsychotics. Studies based on four of the most famous drugs opened a terrible secret, which the producers hid.